Experimental CAR-T therapy targets Hard-to-Treat solid tumors
NCT ID NCT04627740
First seen Jan 23, 2026 · Last updated Jun 23, 2026 · Updated 27 times
Summary
This pilot study tested a new type of immune cell therapy called anti-ALPP CAR-T cells in 5 patients with advanced solid tumors that have a specific marker (ALPP). The goal was to see if the treatment is safe and can shrink tumors. Patients first received chemotherapy to prepare their bodies, then the modified immune cells were infused. The study is complete, but results are not yet widely reported.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SOLID TUMORS are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Department of Oncology, Xinqiao Hospital
Chongqing, Chongqing Municipality, 400037, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Anti-ALPP CAR-T cells (a type of immune cell therapy)
What this could lead to
If it works, this could point toward a new treatment option for certain advanced solid tumors that express ALPP.
What could go wrong
This is a very early, small study with only 5 participants, so results may not apply to larger groups. CAR-T therapy can cause serious side effects like cytokine release syndrome.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.