New pill targets rare gene in Hard-to-Treat cancers

NCT ID NCT02122913

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a new pill called larotrectinib in 75 adults with advanced cancers that have a specific gene change (NTRK fusion). The main goals were to check the drug's safety, find the best dose, and see how the body processes it. Participants had no other good treatment options left.

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Conditions

The condition(s) this trial relates to.

neoplasm NTRK fusion positive cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hospital of the University of Pennsylvania - Radiology

    Philadelphia, Pennsylvania, 19104, United States

  • Mass General Cancer Center

    Boston, Massachusetts, 02114, United States

  • OHSU Hospital - Neurology

    Portland, Oregon, 97239, United States

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203, United States

  • The University of Texas MD Anderson Cancer Center - Texas Medical Center

    Houston, Texas, 77030, United States

  • UCHealth Cancer Center - Anschutz Medical Campus - University of Colorado Cancer Center

    Aurora, Colorado, 80045, United States

  • UH Seidman Cancer Center

    Cleveland, Ohio, 44106, United States

  • UPMC Mercy - Oncology

    Pittsburgh, Pennsylvania, 15219, United States