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New drug shows promise in helping immune system fight advanced cancers

NCT ID NCT04181788

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called PF-06801591 in 155 people with advanced solid tumors or non-small-cell lung cancer. The drug works by blocking a protein that stops the immune system from attacking cancer cells. The goal was to check safety, how the drug moves through the body, and whether it can shrink tumors. Results will help decide if larger studies are worthwhile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PF-06801591 (a drug that helps the immune system attack cancer cells)
What this could lead to
If successful, this could provide a new treatment option for advanced cancers, especially non-small-cell lung cancer, by helping the immune system fight tumors.
What could go wrong
This is an early-phase trial (Phase 1b/2) with a small number of participants, so results may not apply to all patients. Immune-related side effects are possible, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MALIGNANCIES NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • "Medeya Sumy" LLC

    Sumy, Sumska Oblast, 40021, Ukraine

  • Ars Medika Center, LLC

    Kaliningrad, 236006, Russia

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asklepion Medical Center

    Khodosovka, Kyivska Oblast, 08173, Ukraine

  • Beijing Cancer hospital

    Beijing, Beijing Municipality, 100142, China

  • Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine

    Chelyabinsk, 454087, Russia

  • Chongqing Cancer Hospital

    Chongqing, Chongqing Municipality, 400030, China

  • Communal Non-profit Enterprise City Clinical Hospital #4 of Dnipro City Council

    Dnipro, 49102, Ukraine

  • Enlimed Llc

    Kopeysk, 456620, Russia

  • Evimed Llc

    Chelyabinsk, 454048, Russia

  • GBUZ Regional Clinical Hospital of Kaliningrad region

    Kaliningrad, 236016, Russia

  • Gachon University Gil Medical Center

    Incheon, 21656, South Korea

  • Huashan Hospital Affiliated to Fudan University

    Shanghai, Shanghai Municipality, 201107, China

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Klinika UZI 4D, LLC

    Pyatigorsk, Stavropol Kray, 357502, Russia

  • LLC "AR DI PI Ukraine"

    Dnipro, 49102, Ukraine

  • LLC "Diagnostic center "Energo"

    Saint Petersburg, 196247, Russia

  • LLC Medical Center "Magnit"

    Saint Petersburg, 190005, Russia

  • Limited Liability Company "MedX-ray International Group"

    Pliuty Village, Kyiv Oblast, Ukraine

  • Llc "Mdc Expert"

    Dnipro, 49102, Ukraine

  • Llc "Mss"

    Saint Petersburg, 191025, Russia

  • Llc Lidermed

    Odesa, 65062, Ukraine

  • Llc Medical Center Diamed

    Uzhhorod, 88000, Ukraine

  • Llc Medical Centre

    Odesa, 65006, Ukraine

  • MNPE Central City Clinical Hospital of Uzhhorod City Council

    Uzhhorod, 88000, Ukraine

  • Medical University REAVIZ

    Samara, 443001, Russia

  • Medical University REAVIZ

    Samara, 443011, Russia

  • Medical centre "Verum" Limited Liability Company

    Kyiv, 03039, Ukraine

  • Municipal Non Profit enterprise of Sumy Regional Council "Sumy Regional Clinical Oncology Center"

    Sumy, 40022, Ukraine

  • Municipal Non-profit Enterprise "SubCarpathian Clinical Oncological Centre of Ivano-Frankivsk RC"

    Ivano-Frankivsk, 76018, Ukraine

  • Municipal Non-profit Enterprise Odesa Regional Clinical Hospital of Odesa Regional Council

    Odesa, 65025, Ukraine

  • NS HI "Road Clinical Hospital of JSC "Russian Railways""

    Saint Petersburg, 195271, Russia

  • Nanjing Drum Tower Hospital

    Nanjing, Jiangsu, 210008, China

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • North-West Medical Center

    Saint Petersburg, 191119, Russia

  • Orenburg Regional Clinical Oncological Dispensary

    Orenburg, 460021, Russia

  • Private Enterprise of Private Manufacturing Company "Acinus", Medical and Diagnostic Center

    Kropyvnytskyi, 25006, Ukraine

  • Private Healthcare Institution "Clinical Hospital "RZD-Medicine" of St. Petersburg

    Saint Petersburg, 195271, Russia

  • Private Medical Institution "Euromedservice"

    Pushkin, Sankt-Peterburg, 196603, Russia

  • Road clinical clinic of JSC "RZD"

    Saint Petersburg, 192007, Russia

  • Russian Research Centre for Radiology and Surgical Technologies

    Saint Petersburg, Pesochny, 197758, Russia

  • Russian Scientific Center For Radiology and Surgical Technologies

    Pesochny, 197758, Russia

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Severance Hospital, Yonsei Univ. Health System

    Seoul, 03722, South Korea

  • State budgetary institution of healthcare of Yaroslavl region "Clinical oncology hospital"

    Yaroslavl, Yaroslavl Oblast, 150054, Russia

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The State Institution "Romodanov Neurosurgery Institute,

    Kyiv, 04050, Ukraine

  • Vita Сom LLC

    Kyiv, 03141, Ukraine

  • Мunicipal non-profit enterprise "Zhytomyr Regional Oncology Dispensary" of Zhytomyr Regional Council

    Zhytomyr, 10002, Ukraine

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