Cancer drug side effect under the microscope: muscle enzyme spike studied

NCT ID NCT01248429

Completed Knowledge-focused Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests from 154 patients and checked if high levels were linked to muscle pain. The goal was to better understand this side effect, not to test a new treatment.

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Conditions

The condition(s) this trial relates to.

cancer Myalgia neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER SOLID TUMOR

Contacts and locations

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Locations

CHU Bordeaux

Bordeaux, 33076, France
CHU Limoges

Limoges, 87042, France
CHU Robert Debré

Reims, 51092, France
Centre Alexis Vautrin

Vandœuvre-lès-Nancy, 54511, France
Centre Antoine Lacassagne

Nice, 06189, France
Centre Eugène Marquis

Rennes, 35042, France
Centre François Baclesse

Caen, 14076, France
Centre Henri Becquerel

Rouen, 76000, France
Centre Jean Perrin

Clermont-Ferrand, 63011, France
Centre Léon Bérard

Lyon, 69008, France
Centre Oscar Lambret

Lille, 59020, France
Centre Paul Papin

Angers, 49000, France
Centre René Huguenin

Saint-Cloud, 92211, France
Centre Val d'Aurelle

Montpellier, 34298, France
Hôpital Cochin - APHP

Paris, 75014, France
Hôpital Edouard Herriot

Lyon, 69003, France
Hôpital Henri Mondor - APHP

Créteil, 94010, France
Hôpital Jean Minjoz

Besançon, 25030, France
Hôpital Saint-Louis - APHP

Paris, 75010, France
Hôpital Tenon - APHP

Paris, 75020, France
Institut Bergonié

Bordeaux, 33076, France
Institut Claudius Régaud

Toulouse, 31052, France
Institut Curie

Paris, 75248, France
Institut Gustave Roussy

Villejuif, 94805, France
Institut Jean Godinot

Reims, 51056, France
Institut Paoli Calmettes

Marseille, 13273, France
Institut de Cancérologie de la Loire

Saint-Priest-en-Jarez, 42271, France

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