New cancer drug interaction study: will antibiotics or antifungals change its effects?

NCT ID NCT05372367

Completed Knowledge-focused Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how two common drugs—rifampicin (an antibiotic) and itraconazole (an antifungal)—affect the levels of a new cancer drug called BI 907828 in the blood. It involves 33 adults with advanced solid tumors who have not responded to previous treatments. Participants take BI 907828 alone and then with either rifampicin or itraconazole to see if the combination changes drug levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 907828 (brigimadlin), rifampicin, itraconazole
What this could lead to: If successful, this study will help doctors understand how to safely combine BI 907828 with other common medications, potentially improving treatment for advanced solid tumors.
What could go wrong: This is a small, early-phase study focused on drug interactions, not on proving the drug works. The results may not apply to all patients or lead to a new treatment.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS

Contacts and locations

Locations

CIO Clara Campal

Madrid, 28050, Spain
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Fundación Jiménez Díaz

Madrid, 28040, Spain
Hospital Quiron. I.C.U.

Barcelona, 08023, Spain
Hospital Quirónsalud Madrid

Madrid, 28223, Spain
Hospital Universitari Vall D Hebron

Barcelona, 08035, Spain
Wilrijk - HOSP GZA (St-Augustinus)

Wilrijk, 2610, Belgium

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