New drug cocktail aims to tackle childhood cancers that Won't quit
NCT ID NCT03611595
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a combination of two drugs, cabozantinib and 13-cis-retinoic acid, in 15 children whose solid tumors had come back or were not responding to standard treatments. The main goal was to find the safest dose and understand side effects. The study did not aim to cure the cancer, but to see if this drug pair could be a future option for controlling the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cabozantinib and 13-cis-retinoic acid (isotretinoin)
What this could lead to
If successful, this could point toward a new treatment option for children with hard-to-treat solid tumors that have come back or not responded to standard therapy.
What could go wrong
This is a very early phase I trial with only 15 children, focused on safety and dosing, not on effectiveness. The drug combination may not shrink tumors or may cause significant side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Rady Children's Hospital - San Diego
San Diego, California, 92123, United States