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New hope for hard-to-treat colon cancer: targeted drug shrinks tumors

NCT ID NCT04744831

Completed Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called trastuzumab deruxtecan (T-DXd) in 122 people with advanced colorectal cancer that has too much HER2 protein. The goal was to see if the drug could shrink tumors. About 45% of patients had their tumors shrink. This treatment is not a cure, but it may help control the disease for a while.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED COLORECTAL CANCER

Contacts and locations

Locations

  • Aichi Cancer Center Hospital

    Aichi, Japan

  • Aienda Ospedaliera San Camillo Forlanini

    Rome, Italy

  • Asan Medical Center

    Seoul, South Korea

  • Asst Grande Ospedale Metropolitano Niguarda

    Milan, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Italy

  • Azienda ULSS 8 Berica

    Vicenza, Italy

  • Beatson Glasgow

    Glasgow, United Kingdom

  • Blacktown Hospital

    Blacktown, Australia

  • Centre Antoine Lacassagne

    Nice, France

  • Centre de Lutte Contre le Cancer CLCC - Institut Curie

    Saint-Cloud, France

  • Chang Gung Memorial Hospital CGMH - Kaohsiung Branch

    Taoyuan, Taiwan

  • Chang Gung Memorial Hospital-LinKou

    Taoyuan, Taiwan

  • China Medical University Hospital

    Taichung, Taiwan

  • Chu Toulouse

    Toulouse, France

  • Clinica Universitaria de Navarra

    Pamplona, Spain

  • Clinica Universitaria de Navarra - Madrid

    Madrid, Spain

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Flinders Medical Centre (FMC)

    Bedford Park, Australia

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

  • Hokkaido University Hospital

    Hokkaido, Japan

  • Hopital Edouard Herriot

    Lyon, France

  • Hopital Jean Minjoz

    Besançon, France

  • Hopital St Antoine

    Paris, France

  • Hospital Clinico y Provincial de Barcelona

    Barcelona, Spain

  • Hospital Universitari Vall dHebron

    Barcelona, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • ICM-Val d'Aurelle

    Montpellier, France

  • Istituto Oncologico Veneto Irccs

    Padova, Italy

  • Kanagawa Cancer Center

    Kanagawa, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital KMUH

    Kaohsiung City, Taiwan

  • Kindai University Hospital

    Osaka, Japan

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Cancer Center (MSKCC)

    New York, New York, 10065, United States

  • Monash Medical Centre

    Clayton, Australia

  • National Cancer Center (NCC)

    Goyang-si, South Korea

  • National Cancer Center Hospital

    Tokyo, Japan

  • National Cancer Center Hospital East

    Chiba, Japan

  • National Cheng Kung University Hospital

    Tainan, Taiwan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, Japan

  • National Hospital Organization Osaka National Hospital

    Osaka, Japan

  • National Hospital Organization Shikoku Cancer Center

    Ehime, Japan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • Norton Cancer Institute Audubon

    Louisville, Kentucky, 40217, United States

  • Peter MacCallum Cancer Centre

    Melbourne, Australia

  • Royal Brisbane & Women's Hospital

    Brisbane, Australia

  • Samsung Medical Center

    Seoul, South Korea

  • Sarah Cannon (Tennessee Oncology - Nashville)

    Nashville, Tennessee, 37203, United States

  • Seoul National University Bundang Hospital

    Gyeonggi-do, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, South Korea

  • The Cancer Institute Hospital of JFCR

    Tokyo, Japan

  • The Christie

    Manchester, United Kingdom

  • The Royal Marsden Hospital

    London, United Kingdom

  • The Royal Marsden Hospital

    Sutton, United Kingdom

  • The University of Chicago

    Chicago, Illinois, 60637, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UCL St-Luc

    Brussels, Belgium

  • UCLH Trust

    London, United Kingdom

  • UZ Antwerpen

    Edegem, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, Belgium

  • University Hospital of nantes

    Nantes, France

  • University of Michigan Health System

    Ann Arbor, Michigan, 48109, United States

More trials for these conditions

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