New drug shows promise for Hard-to-Treat cancers with p53 gene

NCT ID NCT02264613

First seen Jan 14, 2026 · Last updated May 01, 2026 · Updated 18 times

Summary

This study tested a new drug, ALRN-6924, in 142 people with advanced solid tumors or lymphomas that have a normal p53 gene. The goal was to see if the drug is safe and can shrink tumors. Participants had cancers that did not respond to standard treatments. The study found the drug's safety and best dose, but it is not a cure and ongoing management is needed.

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Contacts and locations

Locations

  • Study site

    Birmingham, Alabama, 35294, United States

  • Study site

    Duarte, California, 91010, United States

  • Study site

    Denver, Colorado, 80218, United States

  • Study site

    Sarasota, Florida, 34232, United States

  • Study site

    Tampa, Florida, 33612, United States

  • Study site

    Boston, Massachusetts, 02114, United States

  • Study site

    Boston, Massachusetts, 02215, United States

  • Study site

    New York, New York, 10065, United States

  • Study site

    The Bronx, New York, 10461, United States

  • Study site

    Greenville, South Carolina, 29605, United States

  • Study site

    Nashville, Tennessee, 37203, United States

  • Study site

    Houston, Texas, 77030, United States

  • Study site

    Seattle, Washington, 98105, United States

Conditions

Explore the condition pages connected to this study.