Experimental immune therapy takes aim at Hard-to-Treat cancers
NCT ID NCT06556108
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested a new type of immunotherapy called ALPP CAR-T cells in 5 adults with advanced solid tumors that had not responded to standard treatments. The therapy involves genetically modifying a patient's own immune cells to recognize and attack cancer cells that carry a protein called ALPP. The main goals were to check safety and see if the treatment could shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ALPP CAR-T cells (genetically engineered immune cells targeting a protein on tumor cells), along with chemotherapy drugs fludarabine and cyclophosphamide
- What this could lead to
- If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This was a very small pilot study with only 5 participants, so results may not apply broadly. CAR-T therapy can cause serious side effects, and it is unclear if targeting ALPP will be effective or safe in larger groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Hematology, Xinqiao Hospital
Chongqing, Chongqing Municipality, 400037, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a protein calm the immune System's overreaction to cancer treatment?