New pill targets tough cancers with DNA mutations

NCT ID NCT04905914

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 24 times

Summary

This study tests an experimental pill called ATRN-119 in people with advanced solid tumors that have certain DNA repair mutations. The goal is to see if the drug is safe and can shrink tumors. About 132 participants will take the drug by mouth, and researchers will monitor side effects and how well the cancer responds.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Jordan Center for Gynecologic Oncology at Penn Perelman Center for Advanced Medicine

    Philadelphia, Pennsylvania, 19104, United States

  • Mary Crowley Cancer Research

    Dallas, Texas, 75230, United States

  • NEXT Oncology- San Antonio

    San Antonio, Texas, 78229, United States

  • NEXT Oncology- Virginia

    Fairfax, Virginia, 22031, United States

  • NEXT- Oncology Dallas

    Irving, Texas, 75039, United States

  • University Hospitals, Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06520-8028, United States

Conditions

Explore the condition pages connected to this study.