Chemo-Immuno cocktail shows promise in early cancer trial

NCT ID NCT05276284

Completed Disease control Sponsor: Kristoffer Rohrberg Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested whether adding two chemotherapy drugs (6-mercaptopurine and 6-thioguanine) to an immunotherapy drug (Atezolizumab) could help treat advanced solid tumors that have stopped responding to standard treatments. The study enrolled 18 adults with metastatic cancer and aimed to find the safest dose and check for any tumor shrinkage. The trial is now complete, but results are not yet reported.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (immunotherapy) combined with 6-mercaptopurine and 6-thioguanine (chemotherapy drugs)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
What could go wrong: This is a very early, small trial (18 participants) focused on safety and dosing. The combination may cause significant side effects, and it is unknown if it will effectively shrink tumors or extend survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CANCER SOLID TUMOR, ADULT

Contacts and locations

Locations

University Hospital of Copenhagen, Rigshospitalet

Copenhagen, 2100, Denmark

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