New cocktail of drugs and viruses aims to shrink rectal tumors without surgery
NCT ID NCT07543848
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a mix of immunotherapy, a cancer-killing virus, short-course radiation, and chemotherapy in 20 people with locally advanced low rectal cancer. The goal is to see if this combination can make the tumor disappear completely for at least a year, potentially allowing patients to avoid major surgery. The study will closely monitor tumor response and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- serplulimab (PD-1 inhibitor), oncolytic virus H101, short-course radiotherapy, and XELOX chemotherapy
- What this could lead to
- If successful, this combination could increase the chance of a complete response and allow more patients to avoid surgery, preserving the rectum.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply widely. The combination of multiple treatments also raises the risk of serious side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, 400030, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can diet and vitamin c supercharge rectal cancer treatment?
- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- Could cutting one amino acid make rectal cancer treatment more effective?
- A new radiation combo may spare the rectum in early cancer
- Can a triple-drug cocktail after short radiation eliminate rectal cancer without surgery?
- Metabolic MRI may reveal hidden cancer responses and spare patients from surgery