New hope for Hard-to-Treat colorectal cancer: targeted drug TQB2102 enters phase 3 trial
NCT ID NCT07483684
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests a new drug called TQB2102, which delivers chemotherapy directly to HER2-positive cancer cells, in people with advanced colorectal cancer that has stopped responding to standard treatments. About 142 participants will be randomly assigned to receive either TQB2102 or one of several standard chemotherapy options. The study aims to see if TQB2102 can delay cancer growth and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TQB2102 (a next-generation antibody-drug conjugate targeting HER2)
- What this could lead to
- If successful, this could offer a new treatment option for people with HER2-positive advanced colorectal cancer who have run out of standard therapies.
- What could go wrong
- This is an early Phase 3 trial with only 142 participants, so results may not apply to everyone. The drug may not improve survival or could have side effects like other cancer treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Cancer Hospital of Harbin Medical University
Harbin, Heilongjiang, 150081, China
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Affiliated Hospital of Jining Medical University
Jining, Shandong, 272029, China
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Affiliated Tumor Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830000, China
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Anhui Provincial Cancer Hospital
Hefei, Anhui, 230000, China
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Anhui Provincial Cancer Hospital
Hefei, Anhui, 230000, China
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Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
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Cancer Hospital Chinese Academy pf Medical Seciences
Langfang, Hebei, 650000, China
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Cancer Hospital of Shandong First Medical University(Shandong Cancer Institute, Shandong Cancer Hospital)
Jinan, Shandong, 250117, China
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First Hospital of Shanxi Medical University
Taiyuan, Shanxi, 300010, China
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Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, 201321, China
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Fujian Cancer Hospital
Fuzhou, Fujian, 350000, China
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Gansu Provincial Cancer Hospital
Lanzhou, Gansu, 730050, China
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Guangxi Medical University Cancer Hospital
Nanning, Guangxi, 530000, China
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Harbin Medical University Affiliated Fourth Hospital
Harbin, Heilongjiang, 150006, China
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Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
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Hubei Cancer Hospital
Wuhan, Hubei, 430079, China
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Hunan Cancer Hospital
Changsha, Hunan, 410000, China
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Introduction Of Shanxi Cancer Hospital
Taiyuan, Shanxi, 300000, China
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Jiangsu Cancer Hospital
Nanjing, Jiangsu, 210000, China
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Jiangsu Province Hospital
Nanjing, Jiangsu, 210029, China
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Jilin Cancer Hospital
Changchun, Jilin, 130000, China
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Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, 110801, China
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Linyi Cancer Hospital
Linyi, Shandong, 276034, China
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Linyi people's Hospital
Linyi, Shandong, 276000, China
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Meizhou People's Hospital(Huangtang Hospital) Meizhou Academy of Medical Sciences
Meizhou, Guangdong, 514000, China
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People's Hospital of Tianjin
Tianjin, Tianjin Municipality, 300121, China
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Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
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Qinghai University Affiliated Hospital
Xining, Qinghai, 810000, China
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Shaanxi Provincial People's Hospital
Xi'an, Shaanxi, 710061, China
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Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, 200072, China
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Sichuan Academy of Medical Science&Sichuan Provincial People' Hospital
Chengdu, Sichuan, 610000, China
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Sichuan Provincial Cancer Hospital (Sichuan Provincial Cancer Prevention and Treatment Center of the Second People's Hospital of Sichuan Province)
Chengdu, Sichuan, 610041, China
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Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310016, China
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Sun Yat-sen university cancer center
Guangzhou, Guangdong, 510050, China
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The First Affiliated Hospital Of Nanchang University
Nanchang, Jiangxi, 330000, China
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The First Affiliated Hospital of China Medical University
Shenyang, Liaoning, 110801, China
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400010, China
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The First Affiliated Hospital of Xi 'An Jiaotong University
Xi'an, Shaanxi, 710061, China
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The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, 361000, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
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The People's Hospital of Guizhou Province
Guiyang, Guizhou, 550002, China
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The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310017, China
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The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, 570311, China
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The Second Affiliated Hospital of Xi'an Jiaotong University(Xibei Hospital )
Xi'an, Shaanxi, 710004, China
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The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
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The first affiliated hostpital of guangzhou medical university (national center for respiratory medicine)
Guangzhou, Guangdong, 510000, China
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Yunnan Cancer Hospital
Kunming, Yunnan, 650000, China
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ZhongShan Hospital
Shanghai, Shanghai Municipality, 200030, China