Poop pills plus chemo: new hope for stubborn colon cancer?
NCT ID NCT07486492
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether transplanting gut bacteria from young donors (via capsules or a tube) can help immunotherapy work better in people with a type of advanced colorectal cancer that usually doesn't respond to immunotherapy. Ten patients who have already tried standard treatments will receive the bacteria transplant, a PD-1 inhibitor, and chemotherapy every two weeks for three months. The main goal is to check safety, but researchers will also track tumor shrinkage and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fecal microbiota transplant (FMT) from young donors, combined with a PD-1 inhibitor immunotherapy and FOLFIRI chemotherapy
What this could lead to
If it works, this could point toward a new way to make immunotherapy effective in a hard-to-treat type of colorectal cancer.
What could go wrong
This is a very early, small trial (10 people) focused on safety, not proof of benefit. The combination may cause serious side effects or fail to improve outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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