Poop pills plus chemo: new hope for stubborn colon cancer?
NCT ID NCT07486492
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether transplanting gut bacteria from young donors (via capsules or a tube) can help immunotherapy work better in people with a type of advanced colorectal cancer that usually doesn't respond to immunotherapy. Ten patients who have already tried standard treatments will receive the bacteria transplant, a PD-1 inhibitor, and chemotherapy every two weeks for three months. The main goal is to check safety, but researchers will also track tumor shrinkage and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fecal microbiota transplant (FMT) from young donors, combined with a PD-1 inhibitor immunotherapy and FOLFIRI chemotherapy
- What this could lead to
- If it works, this could point toward a new way to make immunotherapy effective in a hard-to-treat type of colorectal cancer.
- What could go wrong
- This is a very early, small trial (10 people) focused on safety, not proof of benefit. The combination may cause serious side effects or fail to improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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