Triple threat: immunotherapy, chemo, and radiation take on rectal cancer
NCT ID NCT07622771
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether adding an immunotherapy drug (adebrelimab) to a chemotherapy combo (NALIRIFOX) and radiation can improve outcomes for people with a certain type of locally advanced rectal cancer (pMMR/MSS). About 84 participants will be randomly assigned to receive either short-course or long-course radiation along with the drugs. The main goal is to see how many patients have no cancer left after treatment, either from surgery or from a watch-and-wait approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Adebrelimab (an immunotherapy drug) plus NALIRIFOX (a combination of chemotherapy drugs: oxaliplatin, liposomal irinotecan, leucovorin, and fluorouracil) plus radiotherapy
- What this could lead to
- If this works, it could offer a more effective way to shrink rectal tumors before surgery, potentially allowing some patients to avoid surgery altogether.
- What could go wrong
- This is an early phase 2 trial with only 84 people, so results are not definitive. The combination of drugs and radiation may cause significant side effects, and it may not work better than standard treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, P. R. China
Guangzhou, Guangdong, 510000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can precision protons spare rectal cancer patients from harsh side effects?
- Could a single drug replace surgery for rectal cancer?
- Can adding chemo after radiation help older adults with rectal cancer avoid surgery?
- Can a common muscle relaxant make radiation deadlier for rectal cancer?
- Timing of chemo may boost rectal cancer remission
- Immunotherapy combo may boost rectal cancer treatment