Experimental combo targets Hard-to-Treat colorectal liver metastases
NCT ID NCT07357220
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a combination of two experimental treatments—AK112 (given through a vein) and VG2025 (injected directly into liver tumors)—in 72 adults with advanced colorectal cancer that has spread to the liver and hasn't responded to prior therapy. The goal is to see if the combo is safe and can shrink tumors. It's an early-phase trial, so the main focus is on safety and finding the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AK112 (a drug) and VG2025 (a biologic injected into the tumor)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced colorectal cancer that has spread to the liver and hasn't responded to standard therapy.
- What could go wrong
- This is an early-phase trial with only 72 participants, so results may not apply to everyone. The combination could cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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The First Affiliated Hospital, Zhejiang University School of Medicine，No. 79, Qingchun Road, Shangcheng District, Hangzhou City, Zhejiang Province
Hangzhou, Zhejiang, China
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