New combo therapy aims to shrink Hard-to-Treat colorectal tumors before surgery
NCT ID NCT07403877
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) or immunotherapy plus radiotherapy before surgery can improve outcomes for people with a specific genetic type of colorectal cancer called MSI-H/dMMR. About 114 participants will be randomly assigned to one of three treatment groups. The goal is to see which approach leads to more complete tumor shrinkage, potentially allowing some patients to avoid surgery altogether.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab and ipilimumab (immunotherapy drugs), plus radiotherapy
- What this could lead to
- If successful, this could show that combining immunotherapy with or without radiotherapy before surgery helps shrink tumors more effectively in MSI-H colorectal cancer, potentially allowing some patients to avoid surgery.
- What could go wrong
- This is an early phase II trial with only 114 participants, so results may not apply to all patients. Immunotherapy can cause serious immune-related side effects, and adding radiotherapy may increase toxicity.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fudan University Shanghai Cancer Center
Shanghai, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a lower dose of immunotherapy shrink colorectal tumors before surgery?
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- Can fiber and probiotics boost immunity in colorectal cancer patients?