New drug combo may help avoid surgery in rectal cancer patients
NCT ID NCT07381777
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (XELOX) after chemoradiation improves outcomes for people with locally advanced rectal cancer. About 270 participants will be randomly assigned to receive either the combination or chemotherapy alone. Those who have a complete response may choose to skip surgery and be monitored instead.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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A.O. Oncologia S. Croce e Carle - presidio Ospedaliero A. Carle
Cuneo, Italy
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AOU di Modena - Policlinico di Modena - DH Oncologico
Modena, Italy
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AOUC Azienda Ospedaliero - Universitaria Careggi Oncologia Medica
Florence, Italy
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ASST Brianza
Vimercate, Italy
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Fondazione Policlinico Universitario Campus Bio-Medico
Roma, Italy
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola (FC), Italy
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IRCCS Istituto clinico humanitas
Rozzano, Italy
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Oncologia Clinica Sperimentale Addome Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale
Naples, Italy
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Oncologia Falck - ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
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Oncologia Medica - Policlinico Universitario Gemelli IRCCS
Roma, Italy
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Oncologia Medica 1, A.O.U. Città della Salute e della Scienza di Torino Ospedale Molinette
Torino, Italy
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Oncologia Medica 2 Universitaria
Pisa, Italy
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Oncologia Medica Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Italy
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Oncologia Ricerca Clinica - IRCCS Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy
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Oncologia medica e prevenzione oncologica - Centro di Riferimento Oncologico
Aviano, Italy
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Ospedale San Donato - UOC Oncologia Medica dell'Aretino, Casentino, Valtiberina, Valdichiana Aretina
Arezzo, Italy
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S.C. Oncologia Medica, Ospedale Felettino
La Spezia, Italy
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SC Oncologia, Fondazione IRCCS Policlinico S. Matteo
Pavia, Italy
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SOC Oncologia Azienda sanitaria Universitaria Friuli Centrale - P.O. S. Maria della Misericordia
Udine, Italy
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SOC di Oncologia Provinciale, AUSL IRCCS di Reggio Emilia
Reggio Emilia, Italy
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Struttura Complessa Oncologia Medica 1 - Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
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U.O. C. di Oncologia Medica - OSPEDALE CIVILE SS ANNUNZIATA
Sassari, Italy
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U.O. Oncologia Medica 1 IRCCS Ospedale Policlinico San Martino
Genova, Italy
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UOC Di Oncologia Medica AOU Federico II
Naples, Italy
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UOC Oncoematologia AOU Vanvitelli
Naples, Italy
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UOC Oncologia 1 - Ospedale Busonera - IRCCS Istituto Oncologico Veneto
Padova, Italy
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UOC Oncologia Medica - ARNAS Garibaldi PO Nesima
Catania, Italy
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UOC Oncologia Medica Azienda Ospedaliero Universitaria di Parma
Parma, Italy
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UOC Oncologia Medica IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
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UOC Oncologia Ravenna Dipartimento di Oncologia ed Ematologia - AUSL Romagna
Ravenna, Italy
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Other studies related to the condition(s) this trial covers.
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