LOCALLY ADVANCED RECTAL CANCER (LARC)
Clinical trials for LOCALLY ADVANCED RECTAL CANCER (LARC) explained in plain language.
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New combo therapy aims to shrink rectal tumors before surgery
Disease control Recruiting nowThis study tests a new treatment plan for people with a certain type of locally advanced rectal cancer (MSS-type). The plan combines short-course radiation, chemotherapy, and two drugs (serplulimab and bevacizumab) before surgery. The goal is to see if this approach can eliminate…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated May 17, 2026 03:28 UTC
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New hope for rectal cancer: Real-World test of dostarlimab begins
Disease control Recruiting nowThis study is tracking 50 people with a specific type of advanced rectal cancer (dMMR/MSI-H) who are getting the drug dostarlimab before surgery. The goal is to see how well the drug shrinks tumors and how safe it is in everyday medical practice, not just in a controlled research…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Sponsor: National Cancer Institute, Naples • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New hope for rectal cancer patients: combo therapy aims to save organs and improve survival
Disease control Recruiting nowThis study tests a new treatment for people with locally advanced rectal cancer that has not spread. The treatment combines short-course radiation with chemotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab). The goal is to shrink the tumor enough to avoid surgery…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Zhejiang University • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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Virus therapy joins chemo to fight rectal cancer
Disease control Recruiting nowThis trial tests a new treatment called NG-350A, a virus that targets tumor cells and boosts the immune system, combined with standard chemoradiotherapy. It is for adults with locally advanced rectal cancer who have a high risk of the cancer coming back. The goal is to see if thi…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE1 • Sponsor: Akamis Bio • Aim: Disease control
Last updated Apr 24, 2026 16:17 UTC
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New blood test may predict rectal cancer treatment outcomes
Knowledge-focused Recruiting nowThis study is testing a personalized blood test that looks for cancer DNA to predict how well pre-surgery treatment works for people with locally advanced rectal cancer. Researchers will collect blood and tissue samples from 60 participants over time to build a model that forecas…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated May 15, 2026 11:55 UTC