LOCALLY ADVANCED RECTAL CANCER (LARC)
Clinical trials for LOCALLY ADVANCED RECTAL CANCER (LARC) explained in plain language.
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New combo therapy aims to shrink rectal tumors before surgery
Disease control Not yet recruitingThis study tests a new treatment plan for people with a certain type of advanced rectal cancer. The plan combines a short course of radiation with chemotherapy, targeted drugs, and immunotherapy before any surgery. The goal is to see if this approach can make the tumor disappear …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: Chinese PLA General Hospital • Aim: Disease control
Last updated May 17, 2026 08:03 UTC
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Could a diabetes drug boost rectal cancer treatment?
Disease control Not yet recruitingThis study tests whether adding a GLP-1 weight-loss drug (like semaglutide) to standard chemo-radiation before surgery helps rectal cancer patients with a high BMI. Researchers will measure weight loss, tumor response, and survival in 42 participants. The goal is to see if the dr…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: St. James's Hospital, Ireland • Aim: Disease control
Last updated May 13, 2026 16:02 UTC
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New combo therapy aims to shrink rectal tumors before surgery
Disease control Not yet recruitingThis study tests a new approach for people with a certain type of advanced rectal cancer (pMMR/MSS). Participants first get a short course of radiation, then a combination of an experimental immunotherapy (QL1706) and chemotherapy. The goal is to shrink the tumor enough that surg…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated May 13, 2026 16:01 UTC
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Shorter radiation plus immunotherapy may improve rectal cancer outcomes
Disease control Not yet recruitingThis study tests a new treatment approach for people with high-risk locally advanced rectal cancer. It compares short-course radiation followed by chemotherapy plus an immunotherapy drug (serplulimab) against the standard long-course chemoradiation followed by chemotherapy. The g…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE3 • Sponsor: Fudan University • Aim: Disease control
Last updated May 11, 2026 20:50 UTC
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Immunotherapy plus chemo may let some rectal cancer patients skip surgery
Disease control Not yet recruitingThis study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (XELOX) after radiation therapy can improve outcomes for people with locally advanced rectal cancer. About 270 participants will be randomly assigned to receive either the combination or c…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica • Aim: Disease control
Last updated May 07, 2026 18:43 UTC
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New drug duo targets hard-to-treat HER2 cancers in groundbreaking trial
Disease control Not yet recruitingThis study tests two drugs, zanidatamab and tislelizumab, together with chemotherapy or radiation for people with HER2-positive gastrointestinal cancers like rectal, stomach, and colon cancer. About 70 adults will receive the treatment to see if it can shrink tumors before surger…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: Tao Zhang • Aim: Disease control
Last updated May 01, 2026 15:58 UTC