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Could early antibiotic stop be safe for kids with cancer?

NCT ID NCT07590648

Not yet recruiting Disease control Sponsor: Hospital Universitari Vall d'Hebron Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial looks at whether children with cancer who develop a fever and low white blood cells can safely stop antibiotics earlier than usual. About 136 children will be randomly assigned to either stop antibiotics within 24 hours or continue standard treatment. The goal is to see if early stopping reduces antibiotic use without increasing serious infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
antibiotics (piperacillin-tazobactam, amikacin, meropenem, cefepime, ceftazidime, vancomycin, teicoplanin, ciprofloxacin, levofloxacin, metronidazole)
What this could lead to
If successful, this could show that stopping antibiotics early is safe for certain children with cancer, reducing unnecessary antibiotic use and side effects.
What could go wrong
This is a relatively small Phase 4 trial (136 participants) and only includes children who meet strict stability criteria. Results may not apply to all patients, and there is a risk of missed infections.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute lymphoblastic leukemia acute myeloid leukemia B-cell neoplasm childhood malignant neoplasm Febrile Neutropenia hematopoietic and lymphoid system neoplasm lymphoblastic lymphoma neoplasm neutropenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEBRILE NEUTROPENIA (FN) HEMATOLOGIC MALIGNANCIES INVASIVE BACTERIAL INFECTION PEDIATRIC CANCER SOLID TUMORS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hospital Infantil Universitario Niño Jesús

    Madrid, Madrid, 28009, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Sant Joan de Déu

    Esplugues de Llobregat, Barcelona, 08950, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona, 08035, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Universitario La Paz

    Madrid, Madrid, 28046, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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