New drug CS5007 targets tough cancers in first human trial

NCT ID NCT07622524

Recruiting now Disease control Sponsor: CStone Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This early-stage trial tests a new drug called CS5007 in people with advanced solid tumors that cannot be removed by surgery. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The study will first find the safest dose and then check if the drug shrinks tumors. About 310 participants will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CS5007 (a bispecific antibody-drug conjugate targeting EGFR and HER3)
What this could lead to: If successful, this could lead to a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong: This is a very early Phase I trial, so the drug may not be safe or effective. Side effects are unknown, and it will take years before any potential benefit is confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADVANCED SOLID TUMOR are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Icon Cancer Centre South Brisbane
RECRUITING

South Brisbane, Queensland, 4101, Australia
Linear Clinical Research Ltd
RECRUITING

Nedlands, Western Australia, 6009, Australia
Macquarie University
RECRUITING

North Ryde, New South Wales, 2109, Australia
Shanghai Chest Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
St Vincent's Hospital Melbourne
NOT_YET_RECRUITING

Fitzroy, Victoria, 3065, Australia
St Vincent's Hospital Sydney
NOT_YET_RECRUITING

Darlinghurst, New South Wales, 2010, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.