Respiratory system disorder

This phase 2 trial tests whether a vaccine made from immune cell-derived exosomes can slow cancer growth in people with advanced non-small cell lung cancer who have responded to initial chemotherapy. Participants receive low-dose cyclophosphamide followed by weekly injections of …

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This trial evaluates a new five-component vaccine (Tdcp) designed to protect against diphtheria, tetanus, and pertussis (whooping cough). It includes about 1,820 participants aged 7 and older, who receive either the experimental vaccine or a control vaccine. The study measures ho…

This trial evaluates an experimental vaccine designed to protect against respiratory syncytial virus (RSV), a common virus that can be severe in older adults. The study includes healthy adults aged 18 to 50 in an early phase, and adults 60 and older in a later phase. Participants…

This trial is testing three experimental mRNA-based flu vaccines in healthy adults aged 18 and older. The goal is to see how safe they are and how well they trigger an immune response compared to standard flu vaccines. Participants receive a single injection, and researchers moni…

This early-stage trial tests an experimental nasal spray vaccine called BW-1014, designed to protect against pandemic flu. Healthy adults aged 18 to 45 receive two doses of the spray, with or without a nanoemulsion adjuvant, followed by a standard flu shot six months later. Resea…

This trial is testing whether a high-dose flu vaccine is safe and triggers a stronger immune response in adults aged 60 and older compared to the standard-dose vaccine. Participants receive a single injection and are monitored for side effects and antibody levels. The goal is to …

This trial investigates how well routine childhood vaccines work in children who have recently finished chemotherapy for cancer. The goal is to see if revaccination can restore protective immunity against diseases like measles, mumps, and whooping cough. Participants receive a se…

This study compares two approved flu vaccines—Flucelvax (made in animal cells) and Flublok (made using a recombinant protein)—in adults aged 18 to 64. Researchers will measure immune responses from blood samples taken before vaccination, one month later, and six months later. The…

This study evaluates the safety of a quadrivalent subunit influenza vaccine in over 3,000 healthy individuals aged 3 years and older in Jiangsu Province, China. Researchers track rare adverse reactions, including cerebral infarction, and monitor side effects within 30 minutes, 7 …

This study tests a single dose of a live but weakened RSV vaccine, given as nose drops, in infants and children aged 6 to 24 months who have no prior RSV antibodies. The goal is to see if the vaccine is safe, infects the nose without causing severe illness, and triggers an immune…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This phase 2b trial tests several versions of an experimental flu vaccine that includes an adjuvant (MF59) to strengthen the immune response. The vaccine is made from cells, not eggs, and targets four flu strains. Around 1,000 adults aged 50 and older receive a single shot and ar…

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with early-stage non-small cell lung cancer. The study includes adults with stage IB to IIIA (non-N2) disease who are eligible for surgery. Participants receive one dose of ate…

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger …

This study follows over 14,000 adults with sleep apnea who are prescribed positive airway pressure (PAP) therapy. It investigates whether using telemonitoring—where the device sends usage data to their doctor remotely—helps people use the therapy more consistently and effectively…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This trial tests whether high-flow nasal oxygenation (HFNO) keeps breathing and oxygen levels steadier than standard low-flow nasal oxygenation (LFNO) in patients undergoing sedated vitrectomy, a type of eye surgery. Participants are normal-weight adults with different anesthesia…

This early-phase trial tested the drug everolimus (RAD001) alongside radiation therapy in 26 people with advanced non-small cell lung cancer that could not be surgically removed. The goal was to find a safe dose and check for side effects. Participants received everolimus weekly …

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase 2 study tested a combination of three drugs in 46 people with a specific type of lung cancer (EGFR-mutated) that had spread to the lining of the brain and spinal cord (meningeal metastasis). The treatment included a high-dose targeted pill (furmonertinib), an intraveno…

This study looks at whether using a breathing machine (non-invasive ventilation) at home, with remote monitoring, can help people with advanced COPD avoid hospital visits. It tracks how often patients need unplanned hospital care and whether the monitoring data can predict proble…

This study tested a new way of giving radiation therapy combined with immunotherapy for people with advanced non-small cell lung cancer that does not have certain genetic mutations. The goal was to see if mixing high-dose and low-dose radiation could help the immune system fight …

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This phase II trial is testing whether the immunotherapy drug tislelizumab can help control locally advanced non-small cell lung cancer when given after radiation therapy or sequential chemoradiation. The study enrolls people with stage III lung cancer who cannot tolerate the sta…

This early-phase study tests a new oral drug, furmonertinib, in 30 people with advanced non-small cell lung cancer that has a specific EGFR exon 20 insertion mutation. Some participants have already tried other treatments, while others are newly diagnosed. The goal is to see if t…

This trial compares the antibiotic rifapentine against the standard drug rifampin during the first 8 weeks of treatment for pulmonary tuberculosis. About 334 adults with TB bacteria in their sputum are randomly assigned to receive either the standard regimen or one with rifapenti…

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This study tests a drug called TQH2722, a lab-made antibody that blocks inflammation, for people with severe chronic sinusitis (with or without nasal polyps). About 120 adults who completed a prior TQH2722 study will receive either 300mg or 600mg injections over a long period. Re…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This trial tests whether giving an inhaled steroid (budesonide) to newborns with meconium aspiration syndrome can speed up their recovery. Meconium aspiration happens when a baby breathes in a mixture of meconium and amniotic fluid during birth, causing lung inflammation and brea…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This study tests whether wet cupping therapy, an ancient practice of drawing blood through small skin incisions, can help adults with asthma. Researchers will compare lung function, asthma control, fatigue, and quality of life between a group receiving two cupping sessions and a …

This trial tests whether adding the beta-blocker metoprolol to standard care can reduce a combined risk of death, COPD flare-ups, and heart-related hospitalizations in people with COPD who do not have known heart disease. About 1,700 adults with COPD will receive either metoprolo…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This Phase 2 trial tests whether adding chemotherapy (carboplatin and pemetrexed) to the targeted drug osimertinib works better than osimertinib alone for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The study enrolls 80 patients w…

This phase 2 trial is testing whether two investigational drugs, AD109 and AD504, taken as a pill at bedtime, can reduce the number of breathing pauses in people with obstructive sleep apnea. The study compares these drugs against atomoxetine (an existing medication) and a placeb…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-stage trial is testing whether an immunotherapy drug called tislelizumab can be given as a simple injection under the skin instead of through an IV drip for people with advanced non-small cell lung cancer. The study will compare how well the body absorbs the drug in bo…

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This study looks at whether giving less radiation after surgery for HPV-positive throat cancer can still prevent the cancer from coming back while causing fewer long-term side effects. About 83 adults with HPV-positive oropharyngeal cancer will receive either a standard or reduce…

This study compares two different mandibular advancement devices—oral appliances that hold the jaw forward during sleep—to see which works better for people with mild-to-moderate obstructive sleep apnea. Participants will wear each device for three months, with a two-week break i…

This early-stage trial is testing an experimental inhaled medication called TQC3721 in people with moderate to severe chronic obstructive pulmonary disease (COPD). The study aims to see how safe and tolerable the drug is, how it moves through the body, and what effects it has on …

This study looked at whether adding special breathing muscle training to a swimming program could improve asthma control in children with mild asthma. Thirty children aged 8-11 took part in a 4-week swimming program, with half also doing breathing exercises twice daily. Researche…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare genetic mutations not currently approved for this treatment. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin …

This early-phase trial is testing whether adding an experimental drug called alisertib to the standard treatment osimertinib can help people with stage IV EGFR-mutant lung cancer. The study aims to find the safest dose of alisertib when given with osimertinib and to see how the c…

This early-phase study tested a new drug called BAY 2862789 in 45 people with advanced solid tumors, including non-small cell lung cancer. The drug works by activating immune cells to fight cancer. The main goals were to check safety, find the best dose, and see how the drug move…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This early-stage study tests the safety and how the body handles a new drug called VX-828, alone or combined with other CF medicines. It involves about 165 healthy adults and people with cystic fibrosis. The goal is to see if VX-828 is safe enough for further testing.

This trial tests whether continuous pulse oximetry with wireless alerts to clinicians can reduce serious breathing complications (respiratory depression) after surgery. Patients on two surgical wards will be monitored continuously instead of every four hours. The goal is to see i…

This trial compares two widely used combination inhalers—Foster (beclomethasone plus formoterol) and Seretide (fluticasone plus salmeterol)—in people with chronic obstructive pulmonary disease (COPD). The goal is to see if Foster works better at improving lung function right afte…

This trial tests whether a breath-activated dry powder inhaler (NEXThaler) delivers the same asthma control as a traditional pressurized inhaler (pMDI), both containing the same combination of medications (beclometasone and formoterol). Adults with well-controlled asthma will use…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This trial tests whether a series of allergy shots, called PURETHAL Mites, can reduce symptoms like sneezing, runny nose, and congestion in adults with moderate to severe house dust mite allergies, with or without asthma. Participants receive either the active treatment or a plac…

This trial tests a personalized approach to radiation therapy for people with HPV-related oropharynx cancer. Doctors use PET-CT scans taken before and during treatment to see how well the tumor is responding. If the response is good, the radiation dose is reduced, which may lesse…

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This trial tests whether implanting small valves in the airways—a procedure called lung volume reduction—can improve heart and skeletal muscle function in people with severe chronic obstructive pulmonary disease (COPD). Participants will undergo the procedure and be followed for …

This early-stage trial is testing an experimental drug called AEB1102 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The main goal is to find the highest dose that is safe and to understand the drug's…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This trial is testing a new radiation technique called CT-STAR for people with early-stage non-small cell lung cancer located near the center of the chest, where treatment is tricky. The approach uses a machine that takes CT images during each session and adapts the radiation pla…

This trial tests whether a standardized respiratory physiotherapy program, delivered in primary care over six months, can improve quality of life and key health measures in adults aged 40 to 74 with mild COPD. Participants are randomly assigned to either the physiotherapy program…

This trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy can help people with advanced non-small cell lung cancer whose tumors have a specific EGFR mutation and have stopped responding to TKI targeted therapy. About 440 participants will be…

This study tested an inhaled drug called ARO-MMP7 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to check safety and how the body handles the drug. About 105 participants took p…

This trial is testing whether adding the traditional herbal remedy Bojungikki-tang to the immunotherapy drug pembrolizumab can help people with advanced non-small cell lung cancer. The study includes adults with stage IV disease whose tumors are PD-L1 positive and who have no EGF…

This trial examines whether using a quick nasal swab to check for MRSA bacteria can help doctors decide how long to treat pneumonia patients with the antibiotic vancomycin. The study compares the duration of therapy and costs before and after implementing this screening test. Par…

This study looked at how dupilumab, a drug that blocks certain immune signals, improves smell in adults with chronic sinusitis and nasal polyps. Researchers measured changes in inflammation in the smell region using CT scans, endoscopy, and mucus samples over three months. The go…

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, wh…

This trial tests whether a 6-week program of high-intensity interval training using an arm ergometer can improve oxygen consumption, muscle oxygenation, and physical activity in people with interstitial lung disease. Participants will be randomly assigned to receive the supervise…

This trial tests whether adding a procedure to shrink the inferior turbinates—small structures inside the nose—during adenoidectomy gives children aged 9 to 18 better relief from nasal blockage and sleep-disordered breathing than adenoidectomy alone. Participants have both adenoi…

This trial is testing a new inhaler that combines two asthma medications—fluticasone propionate and albuterol sulfate—in a single device with an electronic module. The study involves children aged 4 to 11 with stable asthma. The goal is to measure how much of the medication gets …

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This trial compares the antibiotic faropenem to a standard combination of co-amoxiclav and clarithromycin in adults with community-acquired bacterial pneumonia. Participants are randomly assigned to one of two treatment groups for seven days, then followed for four weeks. The stu…

This trial tests whether a program using a consumer wearable device—which tracks oxygen levels during sleep—along with personalized weekly reports can help adults with obstructive sleep apnea use their positive airway pressure (PAP) therapy more consistently. Participants who are…

This trial asks whether animated video lessons can help people with asthma or COPD manage their condition at home better than traditional paper brochures. Participants receive a home-based pulmonary rehabilitation program in either format, and researchers compare how well each gr…

This trial tests whether a single dose of risedronate, a bone-strengthening drug, given before stereotactic body radiation therapy (SBRT) for peripheral lung tumors can prevent the rapid bone loss that radiation can cause in nearby ribs. Adults with lung tumors within 2 cm of the…

This study tests whether adding thymosin alpha 1 to standard chemoradiation and immunotherapy helps patients with advanced non-small cell lung cancer complete a full year of immunotherapy. About 114 adults will participate. The goal is to see if this approach improves survival an…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This early-stage trial is testing an experimental stem cell therapy called VUM02 in people with idiopathic pulmonary fibrosis (IPF), a condition that causes progressive lung scarring and breathing difficulty. The study aims to see if the treatment is safe and tolerable, and wheth…

This trial is testing whether adding an experimental drug called HBI-8000 to the immunotherapy nivolumab can safely control advanced melanoma, kidney cancer, and non-small cell lung cancer. The study enrolls adults whose cancers have not responded to prior treatments. Researchers…

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This early-phase trial is testing an experimental drug called SPYK04 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look for early signs that SPYK…

This trial tests whether a home monitoring tool — combining daily lung function measurements and symptom surveys — can help doctors better manage cystic fibrosis patients who are waiting for a lung transplant. The tool sends data to the clinic, which may trigger earlier adjustmen…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This phase 2 trial tests whether adding lenvatinib to a standard chemotherapy-plus-immunotherapy regimen can shrink tumors in people with advanced non-squamous non-small cell lung cancer that has a specific EGFR mutation. Participants will receive lenvatinib capsules daily along …

This trial tests an experimental drug, BI 1291583, in adults with bronchiectasis who produce sputum and have a history of flare-ups. Participants are randomly assigned to one of three doses of the drug or a placebo, taken once daily for at least 24 weeks. The study measures how l…

This study investigates the safety and how the body processes intravenous (IV) zanamivir in hospitalized infants under 6 months old with complicated influenza. Currently, no antiviral is approved for this age group, leaving them vulnerable. The trial will measure drug levels in t…

This trial tests whether a two-day course of intravenous dexamethasone works as well as a standard five-day course of methylprednisolone for children having a severe asthma attack. Children aged 2 to 18 with a severe exacerbation are randomly assigned to one of the two treatments…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial tests whether a drug called IHL-42X can reduce breathing pauses during sleep in people with obstructive sleep apnea who cannot tolerate or do not use a CPAP machine. The study has two parts: first, a short dose-finding phase to pick the best dose, then a longer phase c…

This trial compares a home-based exercise program, guided by a workbook and weekly phone calls, to supervised center-based rehabilitation for people recovering from a long ICU stay. The goal is to see if the home program can improve muscle strength, endurance, and daily function …

This trial tests whether a pharmacist, at the time of hospital admission, can review a patient's prescribed inhaler for insurance coverage and clinical appropriateness. The goal is to see if this simple check helps patients get the most cost-effective inhaler and reduces the chan…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This phase 3 trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can improve outcomes for people with stage II-III non-small cell lung cancer. Participants receive either toripalimab plus chemotherapy or a placebo plus chemotherap…

This trial investigates whether custom-made stents, designed using 3D computer modeling and printing, can safely treat complex airway narrowing that standard stents cannot fit. Ten adults with symptomatic, anatomically complex airway stenosis will receive a personalized stent and…

This trial tests whether children aged 6 to 17 with asthma can manage their condition remotely using an artificial intelligence tool called the Asthma-Guidance and Prediction System, combined with a home monitoring device (AsthmaTuner). The goal is to see if this approach improve…

This phase 3 trial tests whether mepolizumab, an injectable antibody that calms a type of immune cell, can reduce nasal polyp size and improve breathing when added to standard nasal spray therapy. About 400 adults with severe bilateral nasal polyps will receive either mepolizumab…

This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The stu…

This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and …

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This study tests whether injecting a diluted hydrogen peroxide solution or steroids into the chest can break up scar tissue and free a trapped lung, compared to a standard surgical scraping procedure (thoracoscopy). The trial enrolls adults aged 18-62 with a lung infection that h…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This study tests an experimental drug called lebrikizumab in people whose asthma remains uncontrolled despite daily use of inhaled steroids and a second controller medication. Participants receive either lebrikizumab or a placebo injection every 4 weeks for a year, while continui…

This trial tests a device called the aura6000 that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. Participants are randomly assigned to have the devic…

This trial investigates whether combining stereotactic body radiotherapy (SBRT), a precise form of radiation, with the immunotherapy drug nivolumab is safe and tolerable for people with early-stage non-small cell lung cancer. Participants receive SBRT followed by nivolumab infusi…

This study tests whether adding whole-body vibration to standard pulmonary rehabilitation can improve lung function, exercise capacity, and quality of life in adults aged 40–80 with fibrotic interstitial lung disease. Participants are randomly assigned to either rehab alone or re…

This study investigates whether high- or low-intensity inspiratory muscle training (IMT) better improves diaphragm function in patients who have been on mechanical ventilation for over 21 days. Using ultrasound, researchers will measure changes in diaphragm movement and thickness…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This phase 3 trial tests whether lebrikizumab, an injectable drug that blocks a protein involved in asthma inflammation, can improve lung function in adults with mild to moderate asthma. Participants receive either lebrikizumab injections, a placebo, or an open-label montelukast …

This trial tests an experimental drug called enfortumab vedotin, which is designed to seek out and destroy cancer cells that have a specific protein called Nectin-4 on their surface. The study includes people with metastatic urothelial cancer (a type of bladder cancer) and other …

This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researche…

This study looks at whether giving targeted drugs called ROS1 inhibitors before surgery can help people with a rare form of lung cancer. The drugs, entrectinib or crizotinib, are designed to attack cancer cells with a specific genetic change. Researchers will check how much the t…

This trial compares two approaches to voice care after surgery for benign vocal cord lesions like polyps or cysts. One group stays completely silent for five days, while the other uses soft, low-effort whispering. Both groups then receive the same voice therapy. The study measure…

This study tests whether a new drug called RPH-075, a biosimilar of pembrolizumab (Keytruda), works as well as the original in people with skin melanoma, lung cancer, or head and neck cancer. Participants receive a single dose of either RPH-075 or Keytruda, and researchers compar…

This trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups,…

This phase 2 trial tests a needle-free epinephrine nasal spray (ARS-1) for managing asthma symptoms. People with persistent asthma receive a single dose of ARS-1, albuterol, or placebo in random order. The study measures how well the spray improves lung function compared to stand…

This phase 2 trial tests the experimental drug LDK378 in adults with advanced non-small cell lung cancer that has a specific genetic change called a ROS1 rearrangement. Participants must have already received at least one platinum-based chemotherapy and their cancer must have pro…

This study looks at how allergy shots (subcutaneous allergen immunotherapy) affect immune markers in adults with allergic asthma. Researchers will measure changes in eosinophil cationic protein and sputum eosinophils over six months, along with asthma symptom scores. The goal is …

This study tests whether adding delpazolid to standard treatment can reduce bacterial levels in people with hard-to-treat Mycobacterium abscessus lung infections. Participants take delpazolid tablets daily for 12 weeks, with the option to continue up to one year if there is clini…

This early-stage trial tests an inhaled drug called CMR316 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The study's main goal is to check the drug's safety and how the body processes it. Participants r…

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which …

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This phase 3 trial tests whether tezepelumab, an injectable drug, can reverse airway wall thickening (remodeling) in adults with asthma. Participants, aged 18 to 85 with moderate-to-severe asthma, will receive either tezepelumab or a placebo for about a year. Researchers will use…

This trial investigates whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (carboplatin and etoposide) helps people with a rare and aggressive lung cancer called large cell neuroendocrine carcinoma (LCNEC). The study enrolls adults with advanc…

This phase II trial tests whether adding canakinumab, an anti-inflammatory drug, to standard chemoradiation and immunotherapy (durvalumab) helps control locally advanced non-small cell lung cancer. About 41 participants will receive the combination to see if it improves progressi…

This trial investigates whether exposing preterm infants to their mother's natural body odor can reduce apnea episodes (pauses in breathing) and improve heart rate, oxygen levels, and weight gain. Sixty preterm babies in the NICU are randomly assigned to either receive a cloth ca…

This study tests whether giving doctors a personalized infographic showing a COPD patient's predicted lung function decline over 15 years can increase smoking cessation counseling and medication prescriptions. The tool uses individual patient data like age, sex, and lung function…

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This phase I study is testing a subcutaneous (under the skin) injection of toripalimab, an immunotherapy drug, for people with advanced nasopharyngeal carcinoma. The trial compares the new injection to the standard intravenous (IV) version, looking at safety, tolerability, and ho…

This study tests whether virtual or in-person care transition programs are better at helping people with COPD avoid emergency room visits and hospital readmissions within 30 days of discharge. The trial enrolls hospital sites across the U.S., not individual patients, and compares…

This study investigates whether 4DCT scans—which capture how a tumor moves when a person breathes—can be used to design radiation plans that avoid high-functioning healthy lung tissue. People with non-small cell lung cancer who are scheduled for radiation therapy may join. The go…

This study compares two widely used asthma inhalers—Advair and Symbicort—to see if they have different effects on airway constriction. Researchers use a methacholine challenge test to measure how sensitive the airways are after four weeks of treatment. The study includes 20 adult…

This study tests a device called the LungVision system, which uses artificial intelligence to help surgeons locate small lung nodules during minimally invasive surgery. The system combines CT scans with live X-ray images to guide a tool to the nodule, then injects a dye to mark i…

This study tests whether a high dose of montelukast (Singulair), given by mouth, can help children aged 4 to 12 who are in the hospital with a moderate or severe asthma attack. The goal is to find the best dose for a future larger study. Children receive either the high-dose mont…

This study tests whether combining two targeted drugs, avutometinib and adagrasib, can shrink tumors in people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants must have already tried a KRAS G12C inhibitor and seen their c…

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study investigates whether following the DASH diet—a heart-healthy eating plan—can improve quality of life for adults whose asthma is not well controlled by medication. Participants are randomly assigned to either a DASH-focused behavioral coaching program or standard asthma…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two-drug inhalers for people aged 12 to 80 with asthma that is not well controlled by their current treatment. Participants receive either the triple inhaler, a two-drug…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This trial tests whether a gentler suction level (-2 cmH2O) on chest tubes after keyhole lung cancer surgery works as well as the standard stronger suction (-10 cmH2O). The goal is to see which setting allows tubes to be removed sooner and causes fewer complications. About 230 ad…

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study tests whether washing the infected chest cavity with povidone-iodine (an antiseptic) helps adults with pleural empyema recover faster than using normal saline alone. Participants receive chest tube drainage plus daily irrigation with either povidone-iodine or saline. T…

This study tests whether adding visual and sound reminders to a standard breathing exercise device (incentive spirometer) helps patients use it more often after surgery. About 231 adults who had surgery under general anesthesia will be split into two groups: one using the device …

This phase II trial tests whether a low-dose, frequent schedule of the chemotherapy drug vinorelbine, taken orally, can boost the effects of the immunotherapy atezolizumab in people with stage IV non-small cell lung cancer. The study enrolls adults whose cancer has progressed aft…

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The g…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the tripl…

This study tests whether combining semi-occluded vocal tract exercises (like phonating through a pipette) with breathing exercises (pursed-lip, segmental, and diaphragmatic breathing) can improve how long conservatory students can sustain a note and their overall lung function. P…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) against a standard two-medicine inhaler in over 1,100 adults with asthma that was not well controlled. The goal was to see if the triple combination improves lung functio…

This phase 2 study tested a combination of two drugs—ivonescimab (AK112) and irinotecan liposome—in 60 people with extensive-stage small-cell lung cancer whose disease had worsened after standard first-line therapy. The goal was to see if the combo could slow cancer growth and sh…

This large phase III trial tested whether adding bevacizumab (Avastin) to standard chemotherapy after complete lung cancer surgery could help patients live longer. Over 1,500 patients with stage IB to IIIA non-small cell lung cancer took part. The study found that adding bevacizu…

This phase II trial studied 168 people with extensive-stage small cell lung cancer. Researchers added either vismodegib or cixutumumab to standard chemotherapy (cisplatin and etoposide) to see if these combinations worked better than chemo alone. The goal was to slow cancer growt…

This study tested whether adding veliparib (a PARP inhibitor) to standard chemotherapy (cisplatin and etoposide) helps people with extensive stage small cell lung cancer or certain other lung cancers that have spread. In the first phase, researchers found the best dose of velipar…

This phase 2 trial tests the drug crizotinib (XALKORI) in people with advanced non-small cell lung cancer that has spread and carries a change in the ROS1 or MET gene. Participants take crizotinib by mouth twice daily. The study aims to see how well the drug shrinks tumors and de…

This phase III trial investigates whether sunitinib, a drug that blocks tumor blood vessel growth, can help patients with advanced non-small cell lung cancer maintain their response after initial chemotherapy. Participants who did not worsen after four cycles of platinum-based ch…

This study looked at whether the Buteyko breathing technique can help control asthma and improve quality of life in children aged 7 to 12. Sixty-five children with asthma participated, learning specific breathing exercises. The goal was to see if this non-drug approach could redu…

This large phase 3 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help people with a specific type of advanced lung cancer live longer than standard chemotherapy. Over 1,200 participants with PD-L1 positive non-small cell lung cancer were randomly assi…

This trial tests a 12-week virtual program called Conmigo, designed to help Latina girls aged 8-11 and their mothers become more physically active together. The program includes weekly 1.5-hour sessions with teaching, skill-building, and at least 30 minutes of exercise. Researche…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested a new drug, JYB1904, in 69 adults with allergic asthma. Participants received either JYB1904 every 8 weeks or the standard drug omalizumab every 2 to 4 weeks for 24 weeks. The goal was to see how the drug behaves in the body, how safe it is, and how well it cont…

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This study looked at adding sunitinib malate (a drug that blocks tumor blood flow) to standard chemotherapy for people with extensive-stage small cell lung cancer. The trial involved 156 participants and aimed to find the best dose and see if maintenance sunitinib after chemo cou…

This study tested whether a smartphone chatbot called Vik-Asthme can teach adults with asthma how to manage their condition as well as the usual in-person training. 73 adults with asthma were split into two groups: one received standard education, the other used the chatbot. Rese…

This study tested the safety and effectiveness of Vizimpro (dacomitinib) in 40 Japanese patients with EGFR-mutated non-small cell lung cancer that could not be surgically removed or had returned. Researchers tracked side effects, especially interstitial lung disease, and measured…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested giving immunotherapy drugs (nivolumab alone or with relatlimab) for four weeks before surgery in 90 people with early-stage non-small cell lung cancer. The goal was to see if this approach is feasible and helps shrink tumors before removal. Results help determin…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…

This study tested a new type of breathing machine that automatically adjusts its settings to match each person's breathing in real time. Fifteen people with severe COPD who already use a ventilator at home tried the device for six weeks. The goal was to see if the smart ventilato…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study looks at children aged 5 to 18 who had an exercise challenge test to see if certain symptoms, like wheezing or coughing during exercise, can predict a positive result. The goal is to find simpler ways to diagnose exercise-induced bronchoconstriction, a condition where …

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study tests whether a non-invasive light-based monitor, called near-infrared spectroscopy (NIRS), can detect kidney injury early in newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. The monitor measures oxygen levels in the kidneys and b…

This study investigates whether a liquid biopsy taken from the airways during a bronchoscopy can help diagnose lung cancer and identify genetic mutations. The approach aims to be less invasive and faster than traditional tissue biopsies. Researchers will compare the accuracy of t…

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tests a new, ultra-sensitive blood test (NGS) to detect EGFR gene mutations in patients with advanced lung cancer. Researchers will compare it to the current standard test using stored blood samples from 130 patients. The goal is to see if the new method finds more mut…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study compares two techniques for evaluating upper airway collapse in people with obstructive sleep apnea: the standard office-based Müller's maneuver and drug-induced sleep endoscopy (DISE), which is performed under light sedation. The goal is to see whether DISE provides m…

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

This study investigates whether 'showering cells' — a specific type of cell seen under a microscope in fluid from the lungs — can help diagnose aspiration pneumonia, a lung infection caused by inhaling food or stomach contents. Researchers will compare cell samples from 430 hospi…

This study investigates whether patterns in speech and breathing can indicate the presence of obstructive respiratory diseases like COPD. Researchers will collect short voice recordings from patients with and without lung disease and compare them to standard lung function tests. …

This study evaluates whether a smartwatch and smartphone can accurately screen for obstructive sleep apnea (OSA). Adults suspected of having OSA will wear a smartwatch and smartphone while undergoing standard overnight sleep monitoring in a hospital. The results from the devices …

This study evaluates a rapid viability test for tuberculosis bacteria in sputum samples. The goal is to see if this test can accurately tell whether a patient is still contagious, compared to the standard culture method that takes weeks. If the test works, it could help doctors d…

This study is testing a new breath test called OWL-EVO1 to see if it can accurately tell the difference between people who have lung cancer and those who do not. The test involves breathing into a device after taking a special probe. Researchers are enrolling adults aged 45-85 wh…

This study tests whether a simple lung ultrasound can accurately detect heart failure in people with chronic obstructive pulmonary disease (COPD) who come to the emergency room with shortness of breath. Heart failure is a common but often missed cause of worsening COPD symptoms. …

This study evaluates an artificial intelligence (AI) software that analyzes chest X-rays to detect signs of interstitial lung disease (ILD), a group of conditions that scar the lungs. Researchers are checking how often the AI's flags for lung abnormalities turn out to be real dis…

This study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…

This study tested a new way to diagnose cystic fibrosis in unborn babies using a simple blood sample from the mother. Instead of using a needle to take fluid from around the baby, researchers used advanced DNA sequencing to read the baby's genes from tiny bits of fetal DNA floati…

This completed Phase 1 study tested a new radioactive imaging agent called [123I]I-DARPIN-Ec1 in 10 people with lung or ovarian cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors on SPECT scans. Researchers compared the new scan resu…

This study explores whether ultrasound can identify the reasons some patients fail to come off a mechanical ventilator. Researchers will scan the heart, lungs, and diaphragm of adults who have been on a ventilator for at least 24 hours and have not passed a spontaneous breathing …

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a new rapid test (LumiraDx Influenza A/B + RSV Test) that uses a nasal swab to quickly detect flu A, flu B, and RSV. Over 500 people with cold or flu-like symptoms took part. The test was performed by healthcare workers at point-of-care sites and compared to sta…

This study looked at whether a simple saliva test could help doctors quickly assess the current health status of people with cystic fibrosis. Researchers measured markers of inflammation in saliva from 273 participants aged 6 and older. The goal was to develop a point-of-care dia…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study tested whether a special MRI technique can measure airway thickness in asthma patients as well as CT scans do, but without radiation. Thirty adults with asthma underwent both scans. The goal is to find a safer way to monitor airway changes over time.

This study investigates whether a machine that analyzes exhaled breath can identify a unique chemical signature for lung cancer. Researchers will compare breath samples from people with lung cancer (before and after surgery) and healthy controls. The goal is to develop a non-inva…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This early-stage trial is testing an experimental vaccine designed to protect people aged 6 and older against diphtheria, tetanus, and pertussis (whooping cough). The study will enroll 180 participants to check the vaccine's safety and how well it triggers an immune response. Som…

This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications tha…

This study tested whether special UV light devices placed in common areas of nursing homes can reduce the number of severe respiratory infections (like pneumonia or COVID-19) in elderly residents. Over 1,600 residents in 12 French nursing homes took part. The devices were either …

This trial tests whether a recombinant flu vaccine (made in insect cells) works better than the standard egg-based flu shot at preventing flu illness in adults aged 18 to 64. About 4,000 college students and frontline workers will receive either vaccine and be monitored during fl…

This trial tests whether giving the steroid budesonide directly into the windpipe, together with surfactant, can prevent bronchopulmonary dysplasia — a chronic lung disease — in very preterm infants (born before 32 weeks or weighing under 1500 grams) who have respiratory distress…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study explores whether a mobile app, adapted from the Thinking Healthy Program and tailored for Chinese culture and language, can support the mental well-being of Chinese immigrant pregnant women in Canada. Participants, who are at least 22 weeks pregnant and speak Mandarin,…

This study tested a structured physiotherapy program for 60 people who had lung cancer surgery. The program included breathing exercises, early walking, and posture training during their hospital stay. Researchers measured how long people stayed in the hospital and checked vital …

This pilot study is testing whether a device called a 'scare ventilator' can help preterm babies breathe more regularly and sleep better. Ten healthy preterm babies will be observed for two hours without the device, then for two hours with the device set at 20 air puffs per minut…

This trial tests a new inflatable cushion called the BathMat, designed to help reposition patients lying on their stomachs (proned) in the ICU. Proning helps patients with severe breathing problems get more oxygen, but repositioning them every few hours currently requires at leas…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This pilot study tests whether a daily herbal supplement made from Lindera obtusiloba can improve quality of life for people with non-small cell lung cancer who are receiving PD-1 or PD-L1 inhibitor immunotherapy. About 20 adults will take the supplement for 8 weeks alongside the…

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This trial tests whether adding breathing exercises to standard physiotherapy improves lung function, pain, and quality of life in people with thoracic discopathy, a condition affecting the upper spine. Forty participants will be randomly assigned to receive either 15 sessions of…

This trial investigates whether Su Jok therapy, a complementary technique that stimulates specific points on the hands, can reduce dyspnea (breathlessness) and fatigue in people with chronic obstructive pulmonary disease (COPD). The study will include 30 hospitalized adults with …

This study tests whether teaching family caregivers about lung cancer care—through a handbook and personalized guidance—can reduce stress and improve quality of life for patients undergoing lung cancer surgery. The trial involves 160 patients and their caregivers, with some recei…

This study tests a psychosocial program called Conquer Fear Support (CFS) for people with stage III or IV lung or gynecologic cancer who are experiencing fear of cancer progression. The program includes psychoeducation, attention training, worry management, and detached mindfulne…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This study asks whether Su Jok therapy, a complementary technique that gently stimulates specific points on the hands, can reduce shortness of breath and improve sleep in adults with asthma. Participants will be randomly assigned to receive either Su Jok therapy alongside their u…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This trial tests whether ciprofol, a newer sedative, provides better and safer sedation than the standard drug propofol for people undergoing bronchoscopy, a procedure to examine the airways. Both are given with a low dose of sufentanil for pain relief. The study involves 100 adu…

This early-stage study is testing an extended-release tablet called nalbuphine ER in 10 people with idiopathic pulmonary fibrosis (IPF). The main goal is to see if the drug is safe and whether it affects breathing function. Researchers will monitor oxygen levels, breathing rate, …

This trial tests whether adding nebulized ketamine to lidocaine before a fiberoptic bronchoscopy reduces coughing and discomfort compared to lidocaine alone or standard spray. About 134 adults scheduled for bronchoscopy will receive one of three premedication approaches. The stud…

This trial compares two breathing techniques—Active Cycle of Breathing Technique (ACBT) and Pursed-Lip Breathing (PLB)—to see which better improves lung function, reduces breathlessness, and enhances quality of life in people with moderate to severe COPD. Forty adults aged 40 to …

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

This trial tests whether distraction techniques—like drawing, reading a story, watching a cartoon, or using a toy nebulizer and mask—can lower fear and anxiety in children aged 3 to 6 during inhalation therapy for respiratory infections. Children are randomly assigned to one of t…

This trial tests whether taking zinc supplements for five days before a Botox injection into the vocal cords can extend the treatment's benefits for people with spasmodic dysphonia, a condition that causes involuntary voice spasms. Participants will take a 50 mg zinc gluconate pi…

This trial tests whether low-intensity body weight exercises combined with blood flow restriction (BFR) are safe and acceptable for people with COPD. Participants perform simple moves like sit-to-stand and knee raises at home, wearing inflatable cuffs on their thighs. The study f…

This study tests whether a device called oscillatory positive expiratory pressure (OPEP) therapy can reduce cough symptoms and improve lung mechanics in people with COPD. Participants use the device at home twice daily for four weeks. Researchers compare lung function and symptom…

This phase 3 trial tests whether a once-daily pill combining desloratadine (an antihistamine) and betamethasone (a corticosteroid) relieves nasal allergy symptoms better than desloratadine alone. About 70 adults with moderate-to-severe allergic rhinitis will take either the combo…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tested a small vibrating device worn on the neck to see if it could make speaking easier for people with spasmodic dysphonia, a rare voice disorder. Forty participants used the device at home for 20 minutes a day over 8 weeks. They reported how much effort it took to s…

This study tests an experimental drug called BLU-5937 (camlipixant) in adults with refractory chronic cough, including unexplained chronic cough, that has lasted at least a year. Participants take the drug or a placebo daily for 52 weeks to see if it reduces coughing frequency an…

This study tests whether osteopathic manipulation—a hands-on therapy—can reduce chronic chest, neck, or back pain in adults with cystic fibrosis. Participants are randomly assigned to receive real osteopathic treatment, a sham version, or standard pain care. The goal is to see if…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This trial tests whether daily bright light therapy can improve sleep and reduce biological aging in people with lung cancer. Participants wear a light visor for 4 weeks and track sleep, fatigue, and stress. The study compares bright light to usual light exposure to see if it hel…

This trial investigates whether an 8-week systematic symptom management nursing program can improve quality of life, self-management skills, and psychological resilience in people with advanced (stage IIIB–IV) lung cancer. Participants are randomly assigned to receive either rout…

This trial investigates whether adding high-flow nasal oxygen during exercise training can improve endurance and quality of life for people with chronic fibrotic interstitial lung disease (ILD). Participants undergo a 4-week pulmonary rehabilitation program, receiving either high…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This pilot study tests a breathing method called percussive ventilation breathhold (PVB) to help people hold still during lung cancer radiation. The goal is to see if the technique can be used successfully by healthy volunteers and lung cancer patients. If it works, it may allow …

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested two simple treatments for snoring in people with mild sleep apnea: low-level laser therapy applied to the mouth and soft palate, and oropharyngeal exercises (like tongue and throat workouts). 180 adults aged 40-55 took part. The goal was to see which approach re…

This study tested two types of radiation therapy for nasopharyngeal cancer (a cancer in the upper throat). One group received standard photon radiation plus carbon ion therapy, and the other received proton radiation plus carbon ion therapy. The main goal was to see which approac…

This study tested whether a mild electrical current applied to the head (called transcranial electrostimulation, or TES) can help control pain after major sleep apnea surgery. 45 patients received TES along with standard care. The goal was to see if TES reduces pain and the need …

This pilot study tested whether adding a vibrating chest vest to a standard cough-assist machine could reduce lung infections and hospital stays in people with ALS who use breathing support. Fourteen patients were randomly assigned to use either the vest plus cough assist or the …

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study compared two ways to remove tonsils in 66 people with chronic tonsillitis: using a harmonic scalpel (ultrasonic energy) versus traditional cold steel instruments. The main goal was to see if the harmonic scalpel causes less pain three days after surgery. Researchers al…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study tested whether a 4-week home exercise program, guided by a wearable fitness device and supervised remotely, could help lung cancer patients get in better shape before surgery. Thirty people with early-stage non-small cell lung cancer participated. The goal was to see i…

This study looked at 300 infants under 6 months old with severe bronchiolitis in the pediatric ICU. Researchers compared two flow rates of high-flow nasal cannula (2 vs 3 liters per minute per kilogram) to see which one reduced breathing failure within 24 hours. The goal is to fi…

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or…

This study tested whether giving extra oxygen through a small tube in the nose during breathing tube placement can prevent dangerous drops in oxygen levels in newborns. About 110 infants in the NICU took part. The approach is simple and could make a common emergency procedure saf…

This study tested a device called NEUROMARK that uses radiofrequency energy to disrupt nerves in the nose. It included 36 adults with moderate to severe chronic rhinitis. The goal was to see if the procedure safely reduces symptoms like runny nose and congestion over 3 months.

This study looked at whether breathing exercises can improve quality of life for adults with asthma who also have dysfunctional breathing (a pattern of breathing that causes shortness of breath). About 190 adults with poorly controlled asthma took part. Half received usual care, …

This completed study looked at 83 adults of African, African American, or African Caribbean descent to find genetic and environmental factors linked to asthma. Participants provided blood, skin, and breathing test data. The goal was to build a resource for future research, not to…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This trial is testing whether using whole-body PET/CT scans and liquid biopsies (blood tests that detect cancer DNA) can improve the follow-up care of people who have completed treatment for early-stage non-small cell lung cancer. The goal is to see if these advanced tools can fi…

This study examined whether a chemical called TGF-Beta, which is more common in the lungs of people with asthma, makes them more vulnerable to respiratory syncytial virus (RSV). Researchers collected lung cells from 113 healthy adults and mild asthmatics using a bronchoscopy. The…

This international survey asks practicing physicians how they diagnose and treat acute asthma exacerbations—sudden worsening of asthma symptoms. It aims to uncover variations in clinical practice, including medication choices and use of breathing support. The findings could revea…

This study looks at 377 adults with severe lung failure (ARDS) who were treated with prone positioning (lying face down to help breathing). Researchers will use computer models to predict which patients are at highest risk of dying in the ICU. The goal is to help doctors make bet…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study follows 1,200 people in China newly diagnosed with advanced non-small-cell lung cancer (stage IIIB/IV) that cannot be removed by surgery. Researchers will collect information from medical records and follow patients over time to see what treatments they receive, how lo…

This study investigates whether zinc oxide nanoparticles can inhibit the growth and biofilm formation of Acinetobacter baumannii, a bacterium that causes severe hospital-acquired infections like pneumonia and bloodstream infections. Researchers will collect samples from 150 patie…

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This study investigates how the airways respond to two different challenge tests—mannitol inhalation and a controlled hyperventilation exercise—in people with cough variant asthma, those with chronic cough but normal airway sensitivity, and healthy controls. The goal is to see if…

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This study evaluates whether prismaLINE PAP devices accurately count breathing events (apneas and hypopneas) compared to the gold-standard polysomnography (PSG) in people with sleep apnea. Participants will use a full face mask during a titration night, where the device briefly l…

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This study investigates the link between the physical structure of the upper airway and its tendency to collapse during sleep, which is a key factor in obstructive sleep apnea. Researchers will measure airway collapsibility using a special pressure device, and assess anatomy via …

This pilot study aims to test the feasibility of creating a large-scale cohort of tuberculosis (TB) patients in northern Paris, an area with high TB rates. Researchers will collect blood samples and clinical data from 30 participants over the course of their treatment to understa…

This study is testing whether a simple lung ultrasound can tell the difference between a sudden COPD flare-up and stable disease. It will compare ultrasound images, breathing tests, and exercise ability in about 60 people—those with an acute exacerbation, those with stable COPD, …

This study will observe how many eligible infants in Czechia receive nirsevimab, a monoclonal antibody that helps prevent RSV, during their first RSV season. Researchers will survey parents of about 250 infants born between April 2025 and March 2027 to understand immunization rat…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This study collected fluid and cells from the lungs of 574 people with asthma and healthy volunteers using a thin tube called a bronchoscope. The goal was to learn more about airway inflammation and what causes it. The findings may help identify new targets for future asthma trea…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study looked at whether a lung rehab program done over video calls can help people recover after lung cancer surgery. 36 patients aged 55-75 who had part or all of a lung removed took part. They did exercises and tests like the 6-minute walk and breathing tests, all guided b…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study looks at how natural variations in the frontal sinus recess—a narrow passage that drains the frontal sinus—might affect endoscopic sinus surgery for people with frontal sinus disorders. Researchers will use CT scans and surgical observation to map these variations in 4…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study surveys senior managers at companies in Zambia with silica dust exposure to assess their knowledge, attitudes, and practices regarding tuberculosis. Since these leaders shape workplace policies, their understanding is key to protecting workers. The findings could highl…

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This study tested a special MRI technique using a harmless gas to see how well it can show changes in the lungs of people with interstitial lung disease. Researchers worked with 46 volunteers to find the best way to use this scan. The goal is to create a standard method that doct…

This study looked at whether a special breathing maneuver during gallbladder surgery can reduce lung collapse (atelectasis) after the operation. Researchers used lung ultrasound to check lung aeration in 80 adults before and after surgery. The goal was to gather information, not …

This 100% remote study surveys 250 people diagnosed with non-small cell lung cancer before age 50. Participants answer questions about their environment, lifestyle, and family history, and may donate blood. The goal is to uncover factors linked to genetic changes that drive young…

This study interviews 55 patients with resectable non-small cell lung cancer and their doctors in the US, Germany, and Japan. The goal is to understand what treatment features they value most, such as effectiveness or side effects. Results may help align care with patient priorit…

This study looks at whether anxiety about climate change is linked to worse sinusitis symptoms and lower quality of life in adults with chronic rhinosinusitis. Researchers will ask about 134 adults to complete questionnaires measuring sinus symptoms, quality of life, and climate …

This study looks at whether taking hot spring baths can help young athletes recover their thinking skills and physical performance while training at simulated high altitudes. Twenty-seven healthy teens who already train regularly will be randomly assigned to hot spring baths, pla…

This study is testing whether a CT-free electromagnetic navigation system can accurately locate small lung nodules before surgery, compared to the standard CT-guided method. The goal is to see if the new approach can mark nodules within 10 millimeters of their center, which is cr…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study observes people in Belgium with non-invasive pneumococcal infections like pneumonia, ear infections, and sinusitis. Researchers will collect bacterial samples to see which strains are circulating and how they compare to invasive infections. The goal is to understand ho…

This study investigates whether individual physiological traits that cause obstructive sleep apnea (OSA) can predict how well CPAP therapy works. Researchers will follow adults newly diagnosed with OSA who are starting CPAP, measuring factors like arousal threshold and breathing …

This study looks back at tissue samples from patients with nasopharyngeal carcinoma who took part in an earlier treatment trial. Researchers are using advanced genetic testing and protein analysis to look for markers linked to how long patients survive. The goal is to better unde…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study tests a new AI tool called GAPS-Agent that helps doctors plan surgeries for lung cancer. The tool is designed to assist less experienced doctors in making complex decisions. Researchers will compare AI-generated plans to those from a standard AI, and expert surgeons wi…

This study follows people with cystic fibrosis who are taking a highly effective medication called elexacaftor/tezacaftor/ivacaftor (ETI). Participants use a mobile app to report their daily symptoms, medication use, and any changes in their health over 12 months. The goal is to …

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

This study uses ultrasound to measure diaphragm movement and breathing in 15 adults receiving a stellate ganglion block — a nerve injection for certain pain conditions. The goal is to see how often the block temporarily paralyzes one side of the diaphragm. Researchers also check …

This study looks at how anti-tumor T-cell responses change in people with lung or head-and-neck cancer who are receiving radiochemotherapy. Researchers will collect blood and tumor samples to track immune markers. The goal is to understand whether this standard treatment can boos…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study looks back at medical records of adults who were sent home from the emergency department to receive hospital-level care for common infections like pneumonia, urinary tract infections, or skin infections. The goal is to understand why some of these patients end up needi…

This study tests whether a very short sleep survey, called the Sleep Vital Sign, can help primary care doctors recognize sleep disorders like sleep apnea, insomnia, and restless leg syndrome. About 1,260 adults visiting their Kaiser Permanente doctor will fill out the survey, whi…

This study looks at whether an artificial intelligence program can detect early signs of idiopathic pulmonary fibrosis (IPF) on chest X-rays earlier than radiologists. IPF is a serious lung disease that causes scarring and is often diagnosed late. Researchers will compare the dat…

This study examines how children under 18 with cancer or a history of a stem cell transplant do when they need a machine called ECMO to help them breathe. Researchers looked at bleeding, infections, and survival rates in children treated at one hospital, and compared survival wit…

This study tracks how often swallowing difficulties (dysphagia) and voice changes (dysphonia) happen after anterior cervical spine surgery — a common procedure to treat a narrow spinal canal. Researchers will follow 36 patients for one year after surgery, using questionnaires and…

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This study explores whether artificial intelligence can predict the stage and survival of non-small cell lung cancer by analyzing CT and PET scans. Researchers will train a deep learning model using existing medical records from 156 patients who had lung cancer surgery. The goal …

This study looks at how children born preterm with chronic lung disease respond to different inhaled bronchodilators. Participants will have their lung function tested before and after using three types of inhalers: salbutamol, ipratropium bromide, and a combination of fenoterol …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study investigates whether closing the mouth during sleep improves or worsens breathing in people with obstructive sleep apnea. Researchers use drug-induced sleep endoscopy to measure airflow through the nose and mouth separately, then briefly close the mouth every other bre…

This study tests whether machine learning can predict death in the intensive care unit for patients with acute hypoxemic respiratory failure (AHRF), a common cause of ICU admission. Researchers will analyze data from over 1,200 patients, using several machine learning algorithms …

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study tests whether machine learning can predict if a patient with acute hypoxemic respiratory failure will need a breathing machine for a week or longer. Researchers analyzed data from over 1,200 ICU patients in Spain, using information from the first 48 hours to build a pr…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting …

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This trial tests whether presenting a cancer screening appointment as a pre-selected default option (opt-out) makes people at high risk for lung or stomach cancer more likely to accept it, compared to a standard opt-in approach. Participants complete an online questionnaire and d…

This study tests whether a laryngeal mask airway (LMA) can be inserted during continuous chest compressions in a newborn resuscitation simulation. Standard guidelines recommend pausing compressions to insert an airway, but this interrupts blood flow. Thirty-two anesthesiologists …

This study explores whether analyzing the chemicals in exhaled breath can detect early changes in children with cystic fibrosis who start taking a medication called Kaftrio. Researchers will collect breath samples from 50 children under 12 before and after they begin treatment, l…

This study develops and tests a tool designed to help lung cancer nurses talk to patients about clinical trials. The tool provides information on available trials, communication tips, and practical guidance. Researchers will test it in four UK hospitals to see if it improves nurs…

This study aims to develop and test a tool that helps lung cancer nurses talk to patients about clinical trials. Only about 8% of lung cancer patients in the UK join trials, and nurses often lack the time or confidence to discuss them. The tool will be tested in four UK hospitals…

This study investigates whether a simple blood test (liquid biopsy) can track how advanced non-small cell lung cancer changes during immunotherapy or targeted therapy. Researchers will analyze tumor DNA circulating in the blood to see if it can predict treatment response and dete…

This pilot study tracks changes in a specific inflammatory marker (IL-1β) in the nasal passages of adolescents during an asthma attack. Researchers collect nasal fluid samples daily for five days during an attack and compare them to baseline samples taken when the participant is …

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at whether chronic lung inflammation from bronchiectasis raises the risk of heart disease and accelerates aging. Researchers will measure heart function, artery stiffness, bone density, muscle mass, and blood markers in 110 adults aged 40 to 80 with confirmed bro…

This observational study looks at why some people with severe asthma continue to have flare-ups even while taking tezepelumab, an approved treatment. Researchers will track 150 patients over a year, measuring changes in inflammatory cells and markers in blood and airways during a…

This study follows 1500 adults with interstitial lung disease to understand how the condition changes over time. Researchers will track symptoms, lung function, and treatments used. The goal is to build a detailed picture of the disease's course and improve future care.

This study looked at 30 people with early-stage non-small cell lung cancer who had surgery. Researchers collected blood from a vein near the tumor and from a regular arm vein to study tiny particles called exosomes. The goal was to see if these particles could help predict whethe…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study tracked 60 children aged 5 to 15 who survived a near fatal asthma attack in the UK and Ireland. Researchers collected data on risk factors, medical care, and social and environmental influences. The goal is to create better care guidelines and reduce future risks.

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This study used ultrasound to measure how much the diaphragm thickens during a sniff in 60 healthy adults. The goal was to define a normal range for this measurement, which could help doctors spot diaphragm problems in the future. Participants were grouped by age and gender to se…

This completed study in Greece enrolled 200 people with stage 4 non-small cell lung cancer. Researchers used genetic testing to map each tumor's unique features and gave half the patients access to a digital platform to report side effects. The goal was to see if combining person…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This study followed 39 lung cancer patients who received radiation therapy to see how it affected their breathing. Researchers measured lung volume and gas exchange capacity before and after treatment, looking for a 20% or greater drop in diffusion capacity at 3 months. The goal …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This study tests an artificial intelligence program designed to predict the best time to remove a breathing tube (extubation) from patients in intensive care. Researchers will use data from 1500 adults who were on a ventilator for at least 72 hours across four hospitals. The AI a…

This study uses lung ultrasound to measure how the lungs change after surgery to remove part of a lung due to cancer. Researchers will check lung aeration before surgery, right after, and 24 hours later in about 32 adults. They aim to see if ultrasound findings relate to oxygen l…

This completed study enrolled 336 people with non-small cell lung cancer to collect detailed family cancer histories using a questionnaire. Researchers want to see if certain patterns of cancer in relatives, along with smoking and other risk factors, can help identify patients wh…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study tested whether a short animated video program could help first-graders learn how to prevent respiratory infections like colds. Forty-eight children in Turkey watched a 15-minute cartoon and practiced handwashing and coughing/sneezing etiquette over three weeks. Researc…

This study looked at whether a blood test called ISET can find circulating tumor cells in people with early-stage non-small cell lung cancer. Researchers checked blood samples from 256 patients before surgery to see if these cells were linked to cancer stage, type, and survival. …

This study tested whether a protein called GLUT1 could help doctors better classify lung neuroendocrine tumors. Researchers analyzed tumor samples from 36 patients to see if GLUT1 staining patterns matched tumor type. The goal was to find a more reliable diagnostic tool than curr…

This study looked at how sleep quality improves when people with obstructive sleep apnea start using a CPAP machine. Researchers used a special headband to track deep sleep at home for 7 nights before and 9 nights after starting treatment. The goal was to see how quickly sleep ge…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study tested whether a CT scan of the lungs could predict which patients with severe eosinophilic asthma would respond well to the drug benralizumab. 59 adults received benralizumab for 48 weeks and had CT scans at the start, middle, and end of treatment. The goal was to see…

This study tested two different injection devices (a safety syringe and an autoinjector) to see how the body absorbs depemokimab, a potential asthma treatment. 140 healthy adults received a single dose. The goal was to compare the drug levels in the blood, not to treat asthma.

This study examined whether a marker of cellular aging called p16Ink4a is linked to bronchopulmonary dysplasia (BPD), a serious lung disease in premature babies. Researchers measured p16 levels in blood from 80 newborns and children, comparing those with and without BPD. The goal…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This completed study looked at whether a breathing treatment called Intrapulmonary Percussive Ventilation (IPV) can improve lung stiffness (compliance) in critically ill children who are on breathing machines. Researchers measured lung function before and after one IPV session in…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looks at why some people develop pneumonia after accidentally inhaling food, drink, or stomach contents. Researchers will track patients in intensive care and general medicine who have had a known or suspected inhalation event. The goal is to identify risk factors and …

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at whether measuring procalcitonin (PCT) levels in the blood could help detect infections earlier in people with stage IV non-small cell lung cancer starting chemotherapy. Researchers enrolled 45 patients and took a PCT blood sample before their first chemo sess…

This study looked at two ways to help patients breathe during throat surgery: a newer method called flow-controlled ventilation and a standard method. Researchers measured how well each method worked in 71 adults having elective throat surgery. The goal was to see if the newer me…

This study analyzed health records from over 229,000 people with newly diagnosed lung cancer in Korea to see if getting a brain MRI every year helps find cancer that has spread to the brain. The goal was to learn whether these scans catch brain metastases earlier, when they might…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This study investigates whether tiny molecules in the blood, called miRNAs, can act as markers of lung disease in people with cystic fibrosis. Researchers will compare miRNA patterns between cystic fibrosis patients and healthy volunteers, and also between patients with mild vers…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This completed study tested different ways to use a nebulizer for asthma medication. 36 people with mild to moderate asthma received the drug salbutamol through various nebulization modes. The goal was to see which mode delivers more medication to the lungs and reduces waste. Res…

This study collected leftover tissue, fluid, and bacteria from 400 cystic fibrosis patients after their routine medical tests. Researchers will use these samples to study lung diseases and explore new treatments. No genetic testing was done on the samples.