Old chemo drug gets new partner in fight against lung cancer

NCT ID NCT03801304

Completed Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This phase II trial tests whether a low-dose, frequent schedule of the chemotherapy drug vinorelbine, taken orally, can boost the effects of the immunotherapy atezolizumab in people with stage IV non-small cell lung cancer. The study enrolls adults whose cancer has progressed after initial treatment and who do not have certain genetic mutations. The goal is to see if this combination can delay disease progression or death better than current second-line options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vinorelbine and atezolizumab
What this could lead to: If successful, this combination could offer a new second-line treatment option for advanced lung cancer patients who have limited choices.
What could go wrong: This is an early-phase trial with only 80 participants, so results may not apply broadly. The combination may cause side effects or fail to improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

CH Aix en Provence

Aix-en-Provence, France, France
CH MEAUX

Meaux, France, France
CH Pringy

Pringy, France, France
CH Quimper

Quimper, France, France
CH Saint-Brieuc

Saint-Brieuc, France, France
CH de Créteil

Créteil, France, 94010, France
CHRU de Brest - Hôpital Morvan

Brest, France, 29609, France
CHU Rouen

Rouen, France, France
CHU de Limoges - Hôpital DUPUYTREN

Limoges, France, 87042, France
CHU de Rennes

Rennes, France, 35033, France
CLCC Caen

Caen, France, France
Ch La Roche Sur Yon

La Roche-sur-Yon, France, 85000, France
Hia Saint Anne

Toulon, France, 83041, France

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