New cocktail of drugs aims to tackle tough lung cancer

NCT ID NCT04924101

Completed Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combinations as their first treatment. The study measures how many tumors shrink or disappear and how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab, MK-4830, boserolimab, lenvatinib, etoposide, cisplatin, carboplatin
What this could lead to: If successful, this combination could improve response rates and delay cancer progression for people with advanced small cell lung cancer.
What could go wrong: This is an early-phase trial with no formal hypothesis testing, so results may not confirm benefit. Adding multiple drugs also raises the risk of side effects.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Locations

Asan Medical Center-Department of Oncology ( Site 1103)

Seoul, 05505, South Korea
Banner MD Anderson Cancer Center ( Site 0102)

Gilbert, Arizona, 85234, United States
Baptist Health Lexington-Research ( Site 0108)

Lexington, Kentucky, 40503, United States
Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2502)

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
Chungbuk National University Hospital ( Site 1107)

Cheongju-si, North Chungcheong, 28644, South Korea
Cleveland Clinic-Taussig Cancer Center ( Site 0116)

Cleveland, Ohio, 44195, United States
GBUZ "SPb CRPCstmc(o)" ( Site 2705)

Saint Petersburg, Sankt-Peterburg, 197758, Russia
Georgia Cancer Specialists ( Site 0106)

Atlanta, Georgia, 30341, United States
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2003)

Hamilton, Ontario, L8V 4X2, Canada
Hospital Insular de Gran Canaria ( Site 2402)

Las Palmas de Gran Canaria, Las Palmas, 35001, Spain
Hospital Universitari Vall d'Hebron-Oncology ( Site 2401)

Barcelona, 08035, Spain
Instituto Catalan de Oncologia - Hospital Duran i Reynals ( Site 2403)

L'Hospitalet de Llobregat, Catalonia, 08908, Spain
Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 2304)

Milan, 20141, Italy
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 2800)

Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2005)

Kingston, Ontario, K7L 2V7, Canada
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2100)

Vienna, 1210, Austria
Klinik Penzing-2. Lungenabteilung ( Site 2101)

Vienna, State of Vienna, 1140, Austria
Krasnoyarsk Regional Oncology Dispensary, Named after Krizhanovsky ( Site 2708)

Krasnoyarsk, Krasnoyarsk Krai, 660133, Russia
MFSMC-HJWCI-Oncology Research ( Site 0128)

Baltimore, Maryland, 21237, United States
Meir Medical Center ( Site 2601)

Kfar Saba, 4428164, Israel
Memorial Sloan Kettering Cancer Center ( Site 0115)

New York, New York, 10065, United States
N.N.Petrov Research Institute of Oncology-Department of Chemotherapy and Innovative Technologies ( S

Saint Petersburg, Sankt-Peterburg, 197758, Russia
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier

Warsaw, Masovian Voivodeship, 02-781, Poland
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0122)

Omaha, Nebraska, 68130, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0129)

Omaha, Nebraska, 68130, United States
Országos Korányi Pulmonológiai Intézet-XIV. Tüdöbelgyógyászat ( Site 2806)

Budapest, Pest County, 1121, Hungary
Ospedale San Raffaele-Oncologia Medica ( Site 2303)

Milan, Lombardy, 20132, Italy
Parkview Research Center at Parkview Regional Medical Center ( Site 0130)

Fort Wayne, Indiana, 46845, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0114)

Mineola, New York, 11501, United States
Rabin Medical Center-Oncology ( Site 2604)

Petah Tikva, 4941492, Israel
Rambam Health Care Campus-Oncology ( Site 2600)

Haifa, 3109601, Israel
Samodzielny Publiczny Zespó Grulicy i Chorób Puc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemi

Olsztyn, Warmian-Masurian Voivodeship, 10-357, Poland
Samsung Medical Center ( Site 1100)

Seoul, 06351, South Korea
Scientific research institution of oncology named after N.N. Petrov-Thoracic oncology ( Site 2704)

Saint Petersburg, 197758, Russia
Semmelweis University-Pulmonológiai Klinika ( Site 2802)

Budapest, 1083, Hungary
Seoul National University Bundang Hospital ( Site 1104)

Seongnam, Kyonggi-do, 13620, South Korea
Seoul National University Hospital ( Site 1101)

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1105)

Seoul, 03722, South Korea
Shaare Zedek Medical Center ( Site 2602)

Jerusalem, 9103102, Israel
Sheba Medical Center-ONCOLOGY ( Site 2603)

Ramat Gan, 5262100, Israel
St Francis Cancer Center-Research Office ( Site 0117)

Greenville, South Carolina, 29607, United States
St. Marys Hospital Center ( Site 2000)

Montreal, Quebec, H3T 1M5, Canada
The Catholic University Of Korea St. Vincent's Hospital ( Site 1106)

Suwon, Kyonggi-do, 16247, South Korea
Torokbalint Tudogyogyintezet-Onkopulmonologiai Jarobeteg Centrum ( Site 2801)

Törökbálint, Pest County, 2045, Hungary
UPMC Hillman Cancer Center ( Site 0127)

Pittsburgh, Pennsylvania, 15232, United States
University of Colorado Anschutz Medical Campus ( Site 0104)

Aurora, Colorado, 80045, United States
Virginia Cancer Institute ( Site 0119)

Richmond, Virginia, 23229, United States
Zala Megyei Szent Rafael Kórház-Pulmonológia ( Site 2805)

Zalaegerszeg, Zala County, 8900, Hungary
ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 2300)

Siena, Tuscany, 53100, Italy

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