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Silence or whisper? study tests which helps vocal cords heal best after surgery

NCT ID NCT07704125

Disease control Sponsor: Celal Emre Çavlan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial compares two approaches to voice care after surgery for benign vocal cord lesions like polyps or cysts. One group stays completely silent for five days, while the other uses soft, low-effort whispering. Both groups then receive the same voice therapy. The study measures voice quality and patient well-being at one and three months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
absolute voice rest or hypofunctional whispering
What this could lead to
If soft whispering proves as effective as complete silence, patients may have a more comfortable recovery without compromising healing.
What could go wrong
This is a small, early-stage trial with only 16 participants, so results may not apply to everyone. Whispering might still strain the vocal cords in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Feb 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Diagnosis of a benign vocal fold lesion (vocal fold polyp, cyst, or Reinke's edema) * Scheduled for microlaryngeal (phonosurgery) surgery under general anesthesia * Able to complete voice assessments and comply with the assigned postoperative voice behavior protocol * Provided written informed consent Exclusion Criteria: * Malignant or premalignant vocal fold lesions * Previous laryngeal surgery or radiotherapy to the head and neck * Neurological voice disorders (e.g., vocal fold paralysis, spasmodic dysphonia) * Significant psychiatric or cognitive impairment preventing protocol compliance * Active smoking without cessation in Reinke's edema cases where required (if applicable) * Inability or unwillingness to attend follow-up assessments

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Conditions

The condition(s) this trial relates to.

polyp of vocal cord spasmodic dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bening vocal cord lesions Dysphonia Reinke edema Vocal cord cyst Vocal cord polyp

Contacts and locations

Locations

  • Marmara University School of Medicine, Department of Otorhinolaryngology - Head and Neck Surgery

    Istanbul, Istanbul, 34854, Turkey (Türkiye)

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