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Breathing new life: tailored ventilation for ARDS patients

NCT ID NCT06808438

Knowledge-focused Sponsor: West China Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting the ventilator and measure how well the lungs are ventilated and perfused. The goal is to understand which approach works best for individual patients, potentially leading to more personalized and effective breathing support.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
esophageal pressure catheter
What this could lead to
If successful, this research could lead to more personalized ventilator settings for ARDS patients, potentially improving outcomes and reducing lung injury.
What could go wrong
This is a small observational study, not a treatment trial. The findings may not apply to all ARDS patients, and the approach may not improve survival or recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

31 people

The number who actually took part.

Started

Dec 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

ntubated and mechanical ventilated patients over 18 years with moderate-severe ARDS (PaO2 /FIO2 ,200 mm Hg) admitted to the ICU within 48 hours were enrolled from October 2022 to July 2024.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Intubated and mechanical ventilated patients in ICU within 48 hours * Be over 18 years old * With moderate-severe ARDS (PaO2 /FIO2 ,200 mm Hg) Exclusion Criteria: * Severe chronic obstructive pulmonary diseases * Pulmonary bulla(\>1CM) or pneumothorax or pneumomediastinum or subcutaneous emphysema * Pregnancy * BMI≥35kg/m2 * Suspected pulmonary vascular hemorrhage * Disturbance of consciousness or intracranial hypertension * Severe cardiac dysfunction (New York Heart Association Class III or IV, acute -Coronary syndrome or persistent ventricular tachyarrhythmia), cardiogenic shock or after major cardiac surgery * Hemodynamic instability (i.e., mean arterial pressure \[MAP\]\<60 mm Hg despite vasopressor use * The medical team considering short periods of high pressure to be unsafe * Contraindications for placement of esophageal pressure catheters (e.g., esophageal varix or fracture of skull base) * Contraindications for EIT monitoring (including pacemaker, or cutaneous diseases which limiting electrode placement) * Agonal stage or end-stages of diseases

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS

Contacts and locations

Locations

  • West China Hospital of Sichuan University, Chengdu

    Chengdu, Sichuan, 610041, China

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