Can a drug reverse Asthma's hidden airway damage?
NCT ID NCT05651841
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether tezepelumab, an injectable drug, can reverse airway wall thickening (remodeling) in adults with asthma. Participants, aged 18 to 85 with moderate-to-severe asthma, will receive either tezepelumab or a placebo for about a year. Researchers will use CT scans to measure changes in airway structure and also study genetic activity to understand the repair process.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tezepelumab
- What this could lead to
- If it works, this could show that tezepelumab reverses structural airway damage in asthma, pointing toward a treatment that repairs rather than just manages symptoms.
- What could go wrong
- This is an early-stage trial with only 90 participants, so results may not apply to all asthma patients. Tezepelumab may not reverse remodeling, and side effects from the drug are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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APHP Bichat
Paris, France
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APHP Bicêtre
Le Kremlin-Bicêtre, France
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CHRU Strasbourg
Strasbourg, France
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CHU Dijon
Dijon, France
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CHU Grenoble Alpes La Tronche
Grenoble, France
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CHU Toulouse
Toulouse, France
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CHU de Montpelier
Montpellier, France
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Hôpital Foch
Paris, France
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Hôpital Haut-Lévêque
Pessac, France
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Hôpital Nord Marseille
Marseille, France
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Hôpital de la Croix Rousse
Lyon, France