Breath sniffing may reveal early clues to cystic fibrosis drug success
NCT ID NCT05726994
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This study explores whether analyzing the chemicals in exhaled breath can detect early changes in children with cystic fibrosis who start taking a medication called Kaftrio. Researchers will collect breath samples from 50 children under 12 before and after they begin treatment, looking for shifts in volatile organic compounds (VOCs) that might signal the drug is working. The goal is to develop a non-invasive way to monitor treatment response without needles or scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
exhaled breath collection
What this could lead to
If successful, this could lead to a simple breath test to monitor how well CFTR modulators are working in young children with cystic fibrosis.
What could go wrong
This is a small pilot study, so results may not apply broadly. The breath profile changes may be too subtle or variable to be clinically useful.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hôpital Necker - Enfants malades
Paris, Île-de-France Region, 75015, France