Breath sniffing may reveal early clues to cystic fibrosis drug success
NCT ID NCT05726994
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study explores whether analyzing the chemicals in exhaled breath can detect early changes in children with cystic fibrosis who start taking a medication called Kaftrio. Researchers will collect breath samples from 50 children under 12 before and after they begin treatment, looking for shifts in volatile organic compounds (VOCs) that might signal the drug is working. The goal is to develop a non-invasive way to monitor treatment response without needles or scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- exhaled breath collection
- What this could lead to
- If successful, this could lead to a simple breath test to monitor how well CFTR modulators are working in young children with cystic fibrosis.
- What could go wrong
- This is a small pilot study, so results may not apply broadly. The breath profile changes may be too subtle or variable to be clinically useful.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hôpital Necker - Enfants malades
Paris, Île-de-France Region, 75015, France
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Other studies related to the condition(s) this trial covers.
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