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Could a cheaper copy of keytruda work just as well against cancer?

NCT ID NCT06307093

Completed Disease control Sponsor: R-Pharm Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study tests whether a new drug called RPH-075, a biosimilar of pembrolizumab (Keytruda), works as well as the original in people with skin melanoma, lung cancer, or head and neck cancer. Participants receive a single dose of either RPH-075 or Keytruda, and researchers compare how the drug moves through the body, its safety, and its immune response. The goal is to see if RPH-075 could be a more affordable alternative to Keytruda.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a biosimilar version of pembrolizumab called RPH-075
What this could lead to
If RPH-075 works as well as Keytruda, it could offer a more affordable treatment option for certain cancers.
What could go wrong
This is an early-phase trial with only 90 participants, so results may not confirm equivalence. Biosimilars can sometimes differ in effectiveness or side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoma cutaneous melanoma head and neck squamous cell carcinoma lung neoplasm melanoma neoplasm non-small cell squamous lung carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK SQUAMOUS CELL CARCINOMA SKIN MELANOMA SQUAMOUS NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • "Av Medical Group" LLC

    Saint Petersburg, 196006, Russia

  • "New Clinic" LLC

    Pyatigorsk, Stavropol Territory, 357500, Russia

  • "Research lab" LLC

    Moscow, 127521, Russia

  • Autonomous Institution of the Chuvash Republic "Republican Clinical Oncological Dispensary" of the Ministry of Health of the Chuvash Republic

    Cheboksary, The Chuvash Republic, 428020, Russia

  • Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

    Moscow, 119991, Russia

  • Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation

    Moscow, 115478, Russia

  • Federal State Budgetary Institution "N.N. Petrov National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation

    Saint Petersburg, 197758, Russia

  • Federal State Budgetary Scientific Institution "Russian Scientific Center of Surgery named after Academician B.V. Petrovsky"

    Moscow, 119435, Russia

  • Medsi Group of Companies JSC

    Moscow, 123056, Russia

  • Private healthcare institution "Clinical Hospital "Russian Railways-Medicine" of the city of St. Petersburg"

    Saint Petersburg, 195271, Russia

  • Regional State Budgetary Healthcare Institution "Altai Regional Oncological Dispensary"

    Barnaul, The Altai Republic, 656045, Russia

  • Regional budgetary healthcare institution "Ivanovo Regional Oncological Dispensary"

    Ivanovo, 153040, Russia

  • St. Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"

    Saint Petersburg, 197022, Russia

  • State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Bashkortostan

    Ufa, The Republic of Bashkortostan, 450054, Russia

  • State Budgetary Healthcare Institution "Samara Regional Clinical Oncological Dispensary"

    Samara, 443031, Russia

  • State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital

    Saint Petersburg, 188300, Russia

  • State Budgetary Healthcare Institution of the Arkhangelsk region "Arkhangelsk Clinical Oncological Dispensary"

    Arkhangelsk, 163045, Russia

  • State Budgetary Healthcare Institution of the Perm Territory "Perm Regional Oncological Dispensary"

    Perm, 614066, Russia

  • State Budgetary Healthcare Institution of the city of Moscow "City Clinical Oncological Hospital No. 1 of the Department of Health of the City of Moscow"

    Moscow, 105005, Russia

  • State Budgetary Healthcare Institution of the city of Moscow "Moscow City Oncological Hospital No. 62 of the Department of Health of the City of Moscow"

    Istra, Moscow Oblast, 143423, Russia

  • State Budgetary Institution of Healthcare of the city of Moscow "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow"

    Moscow, 111123, Russia

  • State Budgetary healthcare Institution "Kuzbass Clinical Oncological Dispensary named after M.S. Rappoport"

    Kemerovo, 650036, Russia

  • The State Autonomous healthcare Institution of the Tyumen region "Multidisciplinary clinical Medical Center "Medical City"

    Tyumen, 625041, Russia

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