New combo shows promise for tough lung cancer
NCT ID NCT06478043
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 study tested a combination of two drugs—ivonescimab (AK112) and irinotecan liposome—in 60 people with extensive-stage small-cell lung cancer whose disease had worsened after standard first-line therapy. The goal was to see if the combo could slow cancer growth and shrink tumors. Participants received the drugs intravenously every 2 to 3 weeks. The study is now complete, and results will show how well the treatment worked and what side effects occurred.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ivonescimab (AK112) and irinotecan liposome
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced small-cell lung cancer who have run out of standard therapies.
What could go wrong
This is a small, early-phase study with only 60 participants and no comparison group, so results may not apply broadly. The drugs can cause serious side effects like low blood cell counts and immune-related reactions.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China