Can a new vaccine shield older adults from RSV?

NCT ID NCT05639894

Completed ⭐️ VACCINE ⭐️ Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial evaluates an experimental vaccine designed to protect against respiratory syncytial virus (RSV), a common virus that can be severe in older adults. The study includes healthy adults aged 18 to 50 in an early phase, and adults 60 and older in a later phase. Participants receive either one of several vaccine doses or a placebo, and researchers monitor safety and measure the immune response, including neutralizing antibodies against RSV types A and B. The goal is to find a dose that is both safe and effective for further development.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: An experimental RSV vaccine candidate formulated with lipid nanoparticles, given as an injection
What this could lead to: If successful, this could lead to a new vaccine that protects older adults from severe RSV infections.
What could go wrong: This is an early-stage trial, so the vaccine may not produce a strong immune response or could cause side effects. Results may not generalize to the broader population.

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Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY SYNCYTIAL VIRUS IMMUNIZATION

Contacts and locations

Locations

AES Peoria Site Number : 8400030

Peoria, Illinois, 61614, United States
Aventiv Research Columbus Site Number : 8400007

Columbus, Ohio, 43213, United States
Aventiv Research Mesa Site Number : 8400020

Mesa, Arizona, 85210, United States
Be Well Clinical Studies -Round Rock Site Number : 8400038

Round Rock, Texas, 78681, United States
Be Well Clinical Studies Site Number : 8400036

Lincoln, Nebraska, 68516, United States
CVS Health - Peoria Site Number : 8400042

Peoria, Arizona, 85381, United States
CVS Health - Phoenix Site Number : 8400041

Phoenix, Arizona, 85019, United States
CVS Health - Thousand Oaks Site Number : 8400043

Thousand Oaks, California, 91361, United States
Cenexel Research Centers of America Site Number : 8400024

Hollywood, Florida, 33024, United States
Centricity Research - Georgia Site Number : 8400009

Rincon, Georgia, 31326, United States
Coastal Carolina Research Center Site Number : 8400015

North Charleston, South Carolina, 29405, United States
DM Clinical Research - Chicago Site Number : 8400027

River Forest, Illinois, 60305, United States
DM Clinical Research - CyFair Site Number : 8400025

Houston, Texas, 77065, United States
IMA Clinical Research-San Antonio Site Number : 8400039

San Antonio, Texas, 78229, United States
Investigational Site Number : 0360001

Southport, 4215, Australia
Investigational Site Number : 0360002

Camberwell, Victoria, 3124, Australia
Investigational Site Number : 0360003

Botany, New South Wales, 2019, Australia
Investigational Site Number : 6300001

San Juan, 00909, Puerto Rico
Investigational Site Number : 6300002

San Juan, 00918, Puerto Rico
Investigational Site Number : 6300003

Guayama, 000784, Puerto Rico
Investigational Site Number : 6300004

Carolina, 984, Puerto Rico
Investigational Site Number : 6300005

Guaynabo, 00968, Puerto Rico
Lynn Institute of Norman Site Number : 8400023

Norman, Oklahoma, 73072, United States
Martin Diagnostic Clinic Site Number : 8400026

Tomball, Texas, 77375, United States
Optimal Research Alabama Site Number : 8400032

Huntsville, Alabama, 35802, United States
Peninsula Research Associates Site Number : 8400013

Rolling Hills Estates, California, 90274, United States
Suncoast Research Associates, LLC Site Number : 8400003

Miami, Florida, 33173, United States
Velocity Clinical Research - Providence Site Number : 8400006

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research - San Diego - ERN - PPDS Site Number : 8400010

La Mesa, California, 91942, United States
Velocity Clinical Research Site Number : 8400017

Cleveland, Ohio, 44122, United States
Velocity Clinical Research Site Number : 8400018

West Jordan, Utah, 84088-8865, United States
Velocity Clinical Research Site Number : 8400019

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research, Medford Site Number : 8400014

Medford, Oregon, 97504, United States

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