Respiratory system disorder

This study tests whether tuberculosis (TB) treatment can be tailored to each person's risk of a poor outcome. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment course, while higher-risk partic…

This study tests an experimental vaccine called RSVpreF in adults to see if it is safe and triggers a strong immune response against respiratory syncytial virus (RSV). Around 540 adults in India will receive either the vaccine or a placebo. Researchers will monitor for side effec…

This early-stage trial tests a new mRNA COVID-19 booster vaccine made by Bio-Manguinhos/Fiocruz. About 90 healthy adults aged 18-59 will receive one of three doses (25, 50, or 100 micrograms) to check safety and immune response. The study is not yet recruiting and will monitor pa…

This study tests an experimental vaccine from GSK that targets two respiratory viruses: RSV and hMPV. About 1,800 adults aged 18-80 will receive different doses to check safety and immune response. The goal is to see if a single shot can protect against both viruses, which can ca…

This study tests a new vaccine called TdaP2gen in 320 pregnant women in Thailand to see if it safely protects their babies from tetanus, diphtheria, and whooping cough. The vaccine is given during pregnancy, and researchers measure antibody levels in mothers and infants up to 18 …

This study will test a new RSV vaccine in 60 adults aged 20 and older. Researchers want to understand how the vaccine triggers the immune system to create strong antibodies and memory T cells. The goal is to learn how to make RSV vaccines more effective.

This trial investigates a surgical procedure to divide the fissure between lung lobes in people with COPD and emphysema who did not improve after endobronchial valve treatment. The goal is to see if the surgery is safe and feasible, potentially leading to better lung collapse and…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This early-phase trial tests a new therapy for people with advanced small cell lung cancer or similar neuroendocrine cancers that have not responded to prior treatment. The approach involves collecting a patient's own immune cells, modifying them in a lab to recognize a protein c…

This phase 3 trial tests whether adding an experimental drug called izalontamab brengitecan to the standard targeted therapy osimertinib works better than osimertinib alone or with chemotherapy for people with advanced EGFR-mutant non-small cell lung cancer who have not had prior…

This study tests an investigational drug called XTMAB-16 in people with pulmonary sarcoidosis, a condition that causes inflammation and scarring in the lungs. The trial aims to see if the drug can improve lung function (measured by forced vital capacity) and quality of life. Part…

This phase 2 trial tests a combination of two drugs, olomorasib and pembrolizumab, as a first treatment for people with advanced non-small cell lung cancer that has a KRAS G12C mutation and a PD-L1 score between 1% and 49%. The main goal is to see how long patients live without t…

This early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …

This registry will follow 350 COPD patients starting dupilumab (Dupixent) to see how well it works and how safe it is in real life. Researchers will track flare-ups, lung function, and quality of life over 24 months, comparing them to similar patients not on the drug. The goal is…

This study looks at the long-term safety of a drug called admilparant in people with pulmonary fibrosis (lung scarring). About 2,277 adults who finished earlier studies will take the drug and be monitored for side effects. The goal is to see if the drug is safe to use over time, …

This study tests a new combination of three drugs (nivolumab, ipilimumab, and nogapendekin alfa inbakicept) for people with stage IV or recurrent non-small cell lung cancer. The goal is to see if this treatment helps keep the cancer from growing longer than standard two-drug ther…

This phase 2 trial tests whether adding two experimental drugs, imzokitug and pumitamig, to standard chemotherapy helps people with advanced non-small cell lung cancer (NSCLC) who have not had prior treatment. About 160 participants will receive either the three-drug combination …

This large Phase 3 trial is testing a new drug called APG-157, given as a pastille that dissolves in the mouth, for people with advanced head and neck cancer. The study will see if adding APG-157 before and after standard treatments (surgery or chemoradiation) helps keep the canc…

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This study looks at whether adding a home telemonitoring system to standard nighttime breathing support (non-invasive ventilation) can help people with severe COPD and high carbon dioxide levels. About 92 participants will be split into two groups: one using standard home ventila…

This study tests whether recakimab, an injectable drug that lowers cholesterol, can safely reduce high cholesterol caused by the lung cancer medication lorlatinib. The trial enrolls about 29 adults with advanced ALK-positive non-small cell lung cancer who developed high cholester…

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This phase 2 trial tests whether an inhaled form of nintedanib (MNKD-201) is safe and effective for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. About 210 adults with IPF will receive either a low or high dose of the inhaled drug or a plac…

This pilot study tests whether an inhaled drug called cromolyn sodium, already used for asthma, is safe and feasible for people with locally advanced lung cancer. The drug works by calming mast cells, which may play a role in tumor growth and treatment resistance. About 5 to 10 p…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This Phase II trial tests whether a combination of therapeutic plasma exchange (filtering the blood), rituximab (a drug that targets certain immune cells), and intravenous immunoglobulin (IVIg) can slow lung decline in people with progressive idiopathic pulmonary fibrosis (IPF). …

This study tests whether the steroid dexamethasone, when added to standard care, can lower the chance of death within 90 days for people with a serious lung condition called ARDS caused by sepsis. About 1,474 adults on breathing machines will take part. The goal is to see if this…

This trial tests a new method called Longitude-Latitude-Depth (LLD) localization, which uses 3D mapping from a CT scan to guide surgeons to small lung nodules without a needle puncture. It is being compared to the standard CT-guided needle localization in adults with single perip…

This study tests a new combination of three drugs—sorfequiline, pretomanid, and linezolid—in 100 adults with newly diagnosed, drug-sensitive tuberculosis. Participants take the pills daily for 17 weeks. The goal is to see if the combo is safe and can clear the infection faster th…

This study compares two common treatments for moderate obstructive sleep apnea: a custom mouth device that moves the jaw forward (MAD) and a machine that blows air through a mask (CPAP). Researchers want to see how well each treatment improves breathing during sleep and reduces d…

This study tests a medicine called nerandomilast in children aged 2 to 17 with fibrosing interstitial lung disease, a condition where lung tissue becomes scarred and stiff. The goal is to see if the drug is safe and how the body processes it, and to get early signs of whether it …

This study looks at the real-world effectiveness of the RSV vaccine Abrysvo in adults. Researchers will analyze health records from over 290,000 people to compare those who got the vaccine with those who did not. The goal is to see if the vaccine reduces hospitalizations and othe…

This study tests whether a triple-combination inhaler (containing an anti-inflammatory, a long-acting bronchodilator, and another bronchodilator) works better than a standard double-combination inhaler for people whose asthma is not well controlled. About 644 adults with asthma w…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This study looks at the best way to manage high cholesterol caused by the targeted therapy lorlatinib in people with advanced ALK-positive non-small cell lung cancer. Some participants receive standard cholesterol-lowering drugs, while others get a more intensive combination. The…

This early-stage trial tests a new cell therapy called GK01 for people with advanced lung cancer who have not responded to standard treatments. The therapy uses a patient's own immune cells (T cells) that are specially prepared to attack the cancer. The main goal is to check safe…

This clinical trial compares a new three-drug combination (SYHX2011, carboplatin, and enlonstobart) against the standard three-drug regimen (nab-paclitaxel, carboplatin, and tislelizumab) as a first treatment for people with advanced squamous non-small cell lung cancer. The study…

This phase II trial tests a special type of radiation called lattice radiation therapy (LRT) combined with standard chemoimmunotherapy for people with stage III lung cancer that did not shrink enough after initial treatment. The LRT delivers high-dose radiation to specific spots …

This phase 4 trial tests whether combining two oral drugs—ensartinib and anlotinib—can shrink tumors or slow disease in people with ALK-positive non-small cell lung cancer that has become resistant to lorlatinib. About 80 adults with advanced (stage IIIB-IV) cancer will receive t…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This Phase 3 trial tests whether adding the experimental drug SYS6010 to standard immunotherapy can better prevent lung cancer from returning after surgery. About 570 adults with stage II-IIIB non-small cell lung cancer who did not respond well to pre-surgery treatment will be ra…

This study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…

This phase II trial tests two drugs—becotatug vedotin and pucotenlimab—given before surgery to people with advanced hypopharyngeal cancer. The goal is to shrink tumors enough to improve surgical outcomes and possibly preserve the voice box. About 52 participants will receive thre…

This phase 2 trial tests a new drug called AK146D1, given together with other cancer drugs, in 348 people with advanced non-small cell lung cancer that cannot be surgically removed. The study aims to see if the combination is safe and can shrink tumors. Participants will receive …

This phase 2 trial tests the drug trastuzumab deruxtecan (T-DXd) in people with advanced or metastatic non-small cell lung cancer (NSCLC) that has high levels of the HER2 protein. Participants receive T-DXd by IV every three weeks. The study measures how long the cancer stays und…

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD …

This study tests whether a dedicated clinic for COPD flare-ups can reduce the number of future attacks and improve quality of life. About 240 people who recently had a severe COPD attack will be split into two groups: one gets follow-up at the special clinic, the other gets stand…

This phase 3 trial tests whether a daily tablet called florensocatib can reduce the number of lung flare-ups in people with bronchiectasis, a chronic lung condition. About 904 participants aged 12 to 85 will be randomly assigned to receive either the drug or a placebo for up to 7…

This study tests if a monthly injection of Compound Betamethasone (Diprospan) works better than daily prednisone pills for people with early-stage pulmonary sarcoidosis. About 126 participants will receive either the injection or pills for 24 weeks, with lung function tests and s…

This study looks at whether shorter, rifapentine-based treatments for tuberculosis and latent TB are safe and effective in real-world settings in Kazakhstan. It will follow 350 adults, including those with HIV, comparing a 4-month regimen to the standard 6-month one for active TB…

This study tests whether a single injection of dexamethasone works as well as a 5-day course of prednisone pills to prevent asthma patients from returning to the emergency room. About 182 adults with asthma will be randomly assigned to get either the shot or the pills. Researcher…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This study tests a drug called nerandomilast in 466 adults with fibrosing interstitial lung disease (ILD) who are at risk of worsening. Participants take either the drug or a placebo for at least 52 weeks. Doctors measure lung function and use CT scans to see if the drug slows di…

This study tests an inhaled drug called KIT2014 in 36 adults with moderate to severe COPD. Participants will receive either the drug or a placebo daily for 7 days. The main goal is to check safety and how the body handles the drug, with a first look at whether it might help breat…

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This early-phase trial tests a new treatment called ML261 for people with advanced small cell lung cancer or certain neuroendocrine cancers that have not responded to standard treatments. ML261 is made from a patient's own immune cells, which are modified in a lab to better recog…

This phase 3 trial tests a new daily pill, GFH375, against standard chemotherapy (docetaxel) in 300 people with advanced KRAS G12D lung cancer that has worsened after prior treatments. The drug is designed to block the specific cancer-driving mutation. Participants are randomly a…

This phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…

This phase II trial tests a new approach for advanced non-small cell lung cancer that hasn't responded to standard treatments. It combines photoimmunotherapy (ASP-1929), a light-activated drug that targets cancer cells, with cemiplimab, an immunotherapy that boosts the immune sys…

This phase 3 trial tests whether a personalized radiation plan, which expands the treatment area based on each patient's tumor margins, can control nasopharyngeal cancer as well as the standard approach. The study includes 568 adults with newly diagnosed, non-metastatic disease. …

This Phase 2 trial is testing a drug called firmonertinib for people with a specific type of advanced lung cancer (EGFR-mutated non-small cell lung cancer). The study uses a blood test (ctDNA) to decide if treatment should be adjusted over time. About 154 participants will receiv…

This trial tests an experimental daily pill, VS-7375, for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12D. Participants must have already tried chemotherapy and an immunotherapy drug. The study looks at whether the drug can shri…

This study tests whether a structured remote clinic using video calls can reduce the number of severe asthma attacks in adults who have just been discharged from the hospital after an asthma flare-up. 220 participants will be randomly assigned to either two remote pulmonology vis…

This phase 3 study tests whether an inhaled medication called HSK39004 can improve lung function in people with moderate to severe chronic obstructive pulmonary disease (COPD). Participants receive either the drug or a placebo twice daily for 24 weeks. The main goal is to measure…

This study tests whether a personalized mobile app that gives temperature-related health warnings and safety tips can reduce acute exacerbations (sudden worsening of symptoms) in people with chronic obstructive pulmonary disease (COPD). About 240 participants will either receive …

This early-phase study tests an inhaled mRNA immunotherapy for adults with advanced lung cancer or solid tumors that have spread to the lungs. The treatment is given as a dry powder through an inhaler. The main goal is to check safety and find the best dose, with 60 participants …

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study tests whether adding melatonin to standard magnesium sulfate treatment improves recovery in full-term newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by oxygen deprivation at birth. Eighty babies will be split into two groups: one gets magnes…

This study tests if pirfenidone, a drug used for lung scarring, can safely slow scar buildup in the windpipe of people with idiopathic subglottic stenosis (iSGS). About 40 adults will receive either pirfenidone or a placebo for one year, alongside their usual steroid injections. …

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This study tests a new drug (BL-M14D1) combined with an approved immunotherapy (atezolizumab) in 36 adults with extensive-stage small cell lung cancer that has no standard treatment. The goal is to see if the combination can shrink tumors and control the disease. Participants mus…

This trial investigates whether the sequence of endurance and strength exercises during pulmonary rehabilitation affects muscle strength in people with moderate to severe COPD. Participants are randomly assigned to do either strength training before endurance work or the reverse.…

This early-phase study tests an oral drug called SNH-118110 in 240 adults with advanced solid tumors that have a specific genetic change (RET). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants must have tried other treatm…

This study tests whether adding a new drug called BL-B01D1 to the standard targeted therapy osimertinib can improve outcomes for people with a specific type of lung cancer (EGFR-mutated non-small cell lung cancer) that can be removed with surgery. About 90 participants will recei…

This study tests whether a 3-day course of amoxicillin works as well as a 5-day course for children aged 3 months to 5 years with uncomplicated pneumonia. The goal is to see if shorter treatment can reduce side effects, lower costs, and fight antibiotic resistance. About 250 chil…

This trial tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) to standard chemotherapy before chemoradiation can improve outcomes for people with advanced nasopharyngeal cancer. About 60 adults with non-metastatic, EBV-positive nasopharyngeal carc…

This early-phase trial tests an experimental drug called CLSP-5282 in up to 140 adults with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific genetic change called KRas G12V. The drug is given by IV infusion. The main goals are to check safe…

This study tests a new inhaled drug called HRS-9821 in people with moderate to severe COPD. About 90 participants will receive either the drug or a placebo for 28 days. The main goal is to see if the drug improves lung function, measured by how much air they can exhale in one sec…

This study tests a new drug combination (SYS6010 plus enlonstobart) against the usual immunotherapy with chemotherapy for people with a type of advanced lung cancer that has a specific marker (PD-L1 positive). About 500 adults aged 18-75 who have not had prior treatment for their…

This study tests a new drug called HS-20122 in combination with other cancer medicines for people with advanced non-small cell lung cancer. The trial includes three different drug combinations depending on the patient's tumor type. The main goals are to check safety, find the bes…

This study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This Phase 2 trial tests whether adding two drugs (benmelstobart and anlotinib) to standard chemotherapy before chemoradiation helps people with stage III lung cancer that cannot be removed by surgery. 152 participants will be randomly assigned to receive either the new induction…

This study tests whether adding DHA/ARA supplements to the milk of extremely premature babies (born at 28 weeks or earlier) during their first two weeks of life can reduce the severity of bronchopulmonary dysplasia, a chronic lung disease. About 150 babies will be randomly assign…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study tests whether the drug divarasib can prevent lung cancer from coming back in people with a specific gene mutation (KRAS G12C) who have already had surgery and chemotherapy. About 400 adults with stage II-III non-small cell lung cancer will be randomly assigned to recei…

This Phase 2 trial tests whether adding the antihistamine diphenhydramine to the immunotherapy drug toripalimab and standard chemotherapy helps shrink tumors more effectively in people with operable non-small cell lung cancer. About 120 participants will receive either the combin…

This early-stage trial tests R-3750, a live biotherapeutic product, in 20 adults with late-stage acute respiratory distress syndrome (ARDS). The main goal is to see if it is safe and tolerable, while also checking for signs of improved lung function and less need for a ventilator…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This Phase 2 trial tests whether adding lurbinectedin to paclitaxel works better than paclitaxel alone for people with advanced small cell lung cancer that has returned after first treatment. About 69 adults will be randomly assigned to one of two groups. The study measures how m…

This study tests whether adding a new drug (BL-B01D1) to the standard pill osimertinib can help people with a certain type of Stage III lung cancer stay cancer-free longer. Participants must have an EGFR gene mutation and have already completed chemotherapy and radiation without …

This study tests a combination of two drugs, QL1706 and anlotinib, for people with advanced small cell lung cancer who have already tried at least two prior treatments. The goal is to see if the combination helps control the cancer and extends survival. About 120 adults aged 18 t…

This study tests whether giving a Pfizer-BioNTech COVID-19 mRNA vaccine before standard immunotherapy (pembrolizumab) and chemotherapy can improve outcomes for people with stage 4 non-small cell lung cancer. Researchers will enroll 500 adults to see if the vaccine helps the immun…

This phase 2 trial tests whether combining two drugs, lomustine and anlotinib, can shrink tumors or slow disease in people with extensive-stage small cell lung cancer that has not responded to at least two prior treatments. About 46 participants will receive the drug combination …

This phase 2 trial tests whether combining SX-682 (a drug that blocks certain immune-suppressing proteins) with atezolizumab (an immunotherapy) can shrink tumors in people with advanced non-small cell lung cancer that has worsened after chemotherapy and immunotherapy. About 32 ad…

This study follows 200 adults with severe chronic sinusitis and nasal polyps who are starting tezepelumab as part of their routine care. Researchers will track changes in symptoms and quality of life over up to two years using patient questionnaires. The goal is to see how well t…

This Phase 2 trial tests whether giving a combination of amivantamab and either lazertinib or chemotherapy before surgery can shrink or stop the growth of EGFR-mutated non-small cell lung cancer. About 68 people with stage II-IIIB lung cancer that can be surgically removed will p…

This study tests a new inhaled powder called TQC3927 for people with chronic obstructive pulmonary disease (COPD). The goal is to see if different doses can improve lung function and are safe over a short treatment period. About 90 adults aged 40 to 75 with COPD will take part. T…

This trial tests whether an intelligent breathing exercise device helps people recover lung function after surgery for non-small cell lung cancer. Participants use the device for breathing exercises twice daily for 30 days after surgery, while a comparison group receives standard…

This study tests the long-term safety and effectiveness of an experimental inhaler called HSK39004 in 300 adults aged 40 to 80 with moderate-to-severe COPD. Participants will use the inhaler twice daily for 52 weeks. The main goal is to monitor side effects and see how well the t…

This study is testing two remote programs—a chatbot app called QuitBot and a text messaging service—to help American Indian and Alaska Native adults quit smoking. About 772 participants will be randomly assigned to one of the programs. The goal is to see which approach works bett…

This study will test whether a nutrition supplement with different forms of certain nutrients works better than standard supplements for adults with cystic fibrosis. Sixty participants will take the supplement for six weeks, and researchers will measure nutrient levels in their b…

This pilot study tests whether an inhaled drug called AER101 can reduce glycolysis—the process cancer cells use to break down sugar for energy—in early-stage non-small cell lung cancer. Participants inhale the drug three times daily for two weeks before their scheduled surgery. T…

This study tests a new drug (GV20-0251) combined with an immunotherapy (anti-PD-1) in people with advanced solid tumors that have not responded to or cannot tolerate standard treatments. About 227 adults with various cancers, including lung, breast, and colorectal, will participa…

This study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive di…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This study tests whether adding tarlatamab to durvalumab after standard chemotherapy and radiation can delay cancer return and extend life in people with limited-stage small cell lung cancer. Tarlatamab works by helping immune cells recognize and attack cancer cells. About 430 pa…

This early-stage trial tests a nasal spray for adults with chronic sinusitis (without polyps). The spray contains stem cell exosomes to heal the nose lining, an antibiotic to kill bacteria, and an enzyme to break up thick mucus. 108 participants will use the spray twice daily for…

This phase III trial will enroll 854 Hispanic adults who smoke and want to quit. Participants will use the iCanQuit smartphone app, which teaches skills to manage cravings and prevent relapse. Half will also receive nicotine replacement therapy (gum, patch, or lozenge) to ease wi…

This phase 2 trial tests two different immunotherapy drug combinations (durvalumab with monalizumab or oleclumab) followed by personalized radiation for people with advanced non-small cell lung cancer that has a high PD-L1 score. The goal is to see which combination works better …

This phase 2 trial tests whether the drug becotatug vedotin can prevent cancer from returning in 140 patients with high-risk nasopharyngeal carcinoma who have completed standard chemo-radiation. Participants are randomly assigned to receive the drug or standard care. The main goa…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This Phase II trial tests a combination of two drugs, trastuzumab rezetecan and ivonescimab, in 30 people with advanced non-small cell lung cancer that has HER2 gene abnormalities. The goal is to see if the combo can control the cancer and delay progression. Participants must hav…

This study tests a new treatment plan for people with HPV-positive oropharyngeal cancer (a type of throat cancer linked to HPV). The plan combines an immune-boosting drug (nogapendekin alfa inbakicept), a vaccine targeting HPV, chemotherapy, and a lower dose of radiation. The goa…

This study tests two treatment plans for people with lung cancer that has spread to the brain but is not causing major symptoms. One group gets focused radiation to all brain tumors first, then a new immunotherapy drug (ivonescimab) plus chemotherapy. The other group gets the imm…

This study tests whether an Ayurvedic treatment that targets digestion and gut health can reduce allergy symptoms and immune markers in people with allergic rhinitis (hay fever). 104 adults aged 18-40 with confirmed allergies will receive either the Ayurvedic treatment plus stand…

This Phase 3 trial will test whether a new drug called BL-M14D1 combined with atezolizumab works better than the current standard treatment for people with extensive-stage small cell lung cancer who have not had prior therapy. About 550 adults will be randomly assigned to receive…

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This early-phase study tests two drugs together—navlimetostat and pumitamig—in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP-deficient). The main goal is to find a safe dose and see if the combination helps shrink tumors. About 17 adults…

This study tests whether a traditional Chinese herbal formula, Xuanbai Shengmai Decoction, can improve survival in adults with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in the ICU. About 308 participants will receive either the herbal decoctio…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests a new combination of two drugs (becotatug vedotin and pucotenlimab), with or without radiation, as a first treatment for people with advanced non-small cell lung cancer that has a specific protein (EGFR) on its surface. About 39 participants will receive the drug…

This study compares two smartphone apps designed to help people stop smoking. One app uses a therapy that focuses on mood and behavior, while the other uses standard quitting advice. About 1,800 adult smokers who want to quit in the next month will use one of the apps for 30 days…

This phase 2 trial tests whether adding intermittent hypoxic training (IHT) – short sessions of breathing low-oxygen air – to standard chemo-immunotherapy can improve outcomes for people with stage II-IIIA lung squamous cell carcinoma. About 60 participants will receive either st…

This early-stage trial tests a new oral drug called AQUA07, alone or with another drug (lorlatinib), in about 102 people with ALK-positive non-small cell lung cancer that has spread or cannot be removed. The main goals are to check safety, find the right dose, and see how the bod…

This study tests whether taking only a few lymph node samples (selective sampling) works as well as removing all nearby lymph nodes (systematic dissection) in people with stage IIA-IIIB non-small cell lung cancer. All participants will first receive chemotherapy combined with imm…

This early-stage study tests a new tablet, LT-010391, in people with advanced solid tumors (lung, colon, or pancreatic cancer) that have a specific genetic change called KRAS G12D. The main goals are to check safety and find the right dose. About 198 participants who have tried o…

This study compares two types of tonsil surgery for adults with obstructive sleep apnea and enlarged tonsils. One surgery removes the tonsils completely, while the other removes only part of them. The goal is to see if the less invasive approach works just as well at improving br…

This study looks at whether taking the drug stapokibart for 4 weeks before sinus surgery helps adults with chronic nasal polyps more than surgery alone. About 48 participants will receive either the drug or a placebo before their operation and be followed for nearly a year. The g…

This phase II trial is testing whether the targeted therapy firmonertinib, taken as a pill for 8 to 16 weeks before surgery, can shrink tumors in people with stage II-IIIB EGFR-mutated lung adenocarcinoma. About 60 participants will receive the drug and then undergo surgery to re…

This phase 2 trial tests a new drug called SKB571 combined with other cancer medicines in 150 people with non-small cell lung cancer. The goal is to see if the combination can shrink tumors and control the disease. Participants will receive the drugs by injection or mouth, and re…

This study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…

This study tests a new method for setting ventilators during abdominal surgery to prevent postoperative respiratory failure. The approach adjusts settings based on 'mechanical power,' a measure that combines several ventilator parameters. The trial will enroll 490 adults having a…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This phase II trial tests an immunotherapy drug called SHR-1701 combined with chemotherapy and radiation for people with unresectable stage III non-small cell lung cancer. The study will enroll 84 participants and compare giving SHR-1701 before or after standard chemoradiation. T…

This study tests whether keeping very preterm babies on CPAP (a breathing machine) until 34 weeks after conception, instead of switching to a nasal cannula, reduces their risk of bronchopulmonary dysplasia (a chronic lung disease) or death. About 860 infants born before 29 weeks …

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This early-stage trial tests a new drug, AK138D1, alone or with another drug (ivonescimab) in people with advanced non-small cell lung cancer. The goal is to see if the treatment is safe and shrinks tumors. About 265 adults aged 18-75 with stage IIIB/IV cancer will take part.

This study tests an experimental drug called DXC006 combined with either an immunotherapy drug (toripalimab) or standard chemotherapy (carboplatin or cisplatin) in 200 people with small cell lung cancer. The goal is to find the safest dose and see if the combination shrinks tumor…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

This early-phase study tests a new cancer vaccine (EVM14) combined with an immunotherapy drug (ivonescimab) in 13 people with advanced squamous non-small cell lung cancer that has not been treated before. The main goals are to check safety and find the right dose, while also look…

This early-phase trial will test a combination of a Chinese herbal formula (Yiqi Huoxue Jiedu) and bacteriophages (viruses that target bacteria) in 250 people with severe pneumonia caused by drug-resistant bacteria. The goal is to see if this combo can clear the infection faster …

This study tests whether adding a special type of radiation (SF-SBRT) to the usual combination of immunotherapy (toripalimab) and chemotherapy helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 200 participants will be rand…

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This study tests a new drug combination (IBI3005) in about 282 adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to check safety and see if the treatment shrinks tumors. Participants will be closely monitored for side effects a…

This study tests a new drug called SCTB41 combined with the chemotherapy docetaxel in 90 people with advanced non-small cell lung cancer that has worsened after prior treatment. The goal is to see if the combination is safe and works better than docetaxel alone. Participants will…

This study tests whether taking a low dose of the antibiotic azithromycin every day for a year can reduce the number of serious lung infection flare-ups in adults with non-CF bronchiectasis. About 500 participants will receive either azithromycin or a placebo pill, added to their…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This Phase 2 trial tests whether combining lurbinectedin (Zepzelca) with durvalumab (Imfinzi) as maintenance therapy can delay cancer growth in people with extensive-stage small-cell lung cancer whose disease has not worsened after initial chemotherapy plus durvalumab. About 50 p…

This study tests whether a shorter, 5-month combination of TB drugs works as well as the standard 6-month treatment for people with both HIV and drug-susceptible tuberculosis. It involves 148 participants with very weak immune systems (CD4 count under 100). The goal is to see if …

This study looks at whether adding a mix of nutritional supplements (spirulina, bifidobacterium, fish oil, grape seed, blueberry, and ganoderma spore oil) to standard steroid treatment can help people with severe lung inflammation caused by cancer immunotherapy. About 60 adults w…

This study tests whether a special anti-regurgitation formula, made from extensively hydrolysed casein, is safe and well-tolerated in infants with cow's milk protein allergy (CMPA). About 55 babies aged 1 to 9 months will take part. The formula is given in a controlled food chall…

This early-stage trial tests MP101, a mix of two viruses that attack bacteria (phages), in 18 adults with Pseudomonas aeruginosa pneumonia. Participants receive a single dose of MP101 or a placebo alongside standard antibiotics. The main goal is to check safety and how the body h…

This study tests whether arranging a telehealth appointment with an asthma specialist before patients leave the emergency room increases follow-up care. Forty adults who come to the ER for an asthma attack will either get a scheduled telehealth visit or usual care. The goal is to…

This study tests a new drug called ALK202 combined with other medicines for people with advanced non-small cell lung cancer. The trial will include 252 participants and aims to see if the combinations are safe and can shrink tumors. It is divided into two phases: first to find th…

This Phase 3 trial tests a new drug called HRS-7058 against other KRAS G12C inhibitors in 450 adults with advanced or metastatic non-small cell lung cancer that has a specific KRAS G12C mutation and has stopped responding to standard treatments. The study compares how well HRS-70…

This study tests whether giving sintilimab (an immunotherapy drug) together with chemotherapy can shrink advanced stage IIIC lung cancer enough to allow surgery. About 33 adults with previously untreated, unresectable non-small cell lung cancer will receive four cycles of the com…

This early-stage study tests a new drug called JL19001 in people with advanced solid tumors or a type of lymphoma that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. About 14 participants will receive the drug as a sh…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This early-phase study is testing a combination of two experimental drugs, Ris-Rez and ivonescimab, in about 184 adults with advanced solid tumors that have spread. The main goals are to find a safe dose, understand side effects, and see if the combo can shrink tumors. It's a fir…

This study tests whether precisely targeted radiation (SBRT) can stop or slow the growth of a few resistant spots in metastatic lung cancer patients who are already on targeted therapy (TKI). About 60 adults with EGFR or ALK mutations will receive radiation to those spots, and do…

This study tests a nerve-monitoring device that alerts surgeons when a child's vocal cord nerve is at risk during throat, chest, or heart surgery. About 90 children under 18 will be randomly assigned to standard care or standard care plus the monitor. After surgery, doctors will …

This study tests an experimental tablet called SYH2059 in 156 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing harder. Participants will receive either the drug or a placebo to see if it can slow the decline in lung function. The…

This study tests a new approach for lung cancer patients who are at high risk of incomplete tumor freezing during cryoablation. Before the freezing procedure, doctors will block small blood vessels near the tumor using a temporary, absorbable material. The goal is to make the fre…

This study tests whether a non-invasive ventilator (a mask that helps you breathe at night) can lower hemoglobin levels in people with high-altitude polycythemia, a condition where the blood becomes too thick due to low oxygen. About 70 adults living at high altitudes will either…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

This early-phase trial tests whether inhaling tiny particles from stem cells (exosomes) can help heal lung inflammation caused by immunotherapy drugs. The study involves 40 adults with cancer who have persistent lung problems despite standard steroid treatment. Participants will …

This study tests an oral chemotherapy (paclitaxel) combined with immunotherapy given before surgery in patients aged 70-85 with non-small cell lung cancer. The goal is to see if this approach can shrink tumors enough to improve surgery outcomes and long-term survival. About 75 pa…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This early-stage trial tests a new tablet called HW241045 in 102 healthy volunteers to see if it is safe and how the body processes it. The drug is being developed for idiopathic pulmonary fibrosis, a lung-scarring disease. The study is randomized, double-blind, and placebo-contr…

This early-stage study tests a new treatment called DCTY1102 for people with advanced cancers (like pancreatic, colorectal, or lung cancer) that have a specific genetic change (KRAS/NRAS G12D mutation) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own …

This pilot study will test whether flushing the chest tube with saline alone can treat complicated pleural infections (fluid buildup around the lungs). If saline doesn't work, patients will receive stronger clot-busting drugs (fibrinolytics) or surgery. The study will track how l…

This early-phase trial tests a new type of cell therapy called TCR1188-ABC for people with certain advanced cancers (pancreatic, colorectal, lung, or bile duct) that have a specific KRAS G12V mutation. The treatment involves taking a patient's own immune cells, engineering them t…

This early-stage trial tests a new drug called JH021 in 60 people with advanced solid tumors that have stopped responding to standard treatments. JH021 is a special antibody that targets two cancer-related proteins, EGFR and cMET, to potentially slow or stop tumor growth. The mai…

This Phase 3 trial tests whether adding an experimental drug called SYS6010 to the standard treatment osimertinib can help people with a specific type of advanced lung cancer (EGFR-mutant NSCLC) live longer without their cancer getting worse. About 680 participants will be random…

This Phase III trial will compare proton beam radiotherapy with standard photon radiotherapy in 504 patients with non-metastatic nasopharyngeal carcinoma. The goal is to see if proton therapy reduces toxic side effects and improves survival. Participants will be randomly assigned…

This study tests a new combination of two drugs, AMT116 and ivosimab, in people with advanced non-small cell lung cancer that cannot be removed by surgery. The goal is to find the safest dose and see if the combination shrinks tumors. About 118 adults aged 18 to 75 will take part…

This study tests a new treatment for people with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. It combines low-dose radiation to the chest with an immunotherapy drug (adebrelimab) and chemotherapy, followed by maintenance immunotherapy for up to t…

This Phase 2 trial tests whether NRICM102, a Traditional Chinese Medicine, can help adults with community-acquired pneumonia reach clinical stability faster when added to standard antibiotic therapy. About 150 hospitalized participants will take either NRICM102 or a placebo for 7…

This study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs an…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This trial investigates whether a femtosecond laser combined with an artificial intelligence model can diagnose lung cancer from fresh tissue samples as accurately as the standard frozen section method. About 294 adults scheduled for lung surgery will have their tumor specimens e…

This early-phase study tests a new imaging agent that targets a protein called TROP2, found on many cancer cells. About 40 adults with metastatic bladder, breast, or lung cancer will receive the agent to see where it goes in the body. The goal is to see if this tracer can help do…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study tests an artificial intelligence (AI) prototype designed to quickly evaluate tissue samples taken during a bronchoscopy, a procedure used to diagnose lung cancer. The AI analyzes microscope images of the samples to determine if they are adequate for diagnosis and wheth…

This trial tests a new dual-function semirigid thoracoscope against the standard rigid thoracoscope for diagnosing pleural disease (fluid buildup around the lungs). The new device is designed to be easier to maneuver and potentially less painful while still obtaining large tissue…

This early-phase trial will test a new radioactive tracer called [68Ga]Ga-PentixaFor in 15 people with metastatic small cell lung cancer. The goal is to see if this PET-CT scan can find tumors as well as the standard FDG PET-CT scan, both at diagnosis and when the disease gets wo…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study is testing whether a blood test that looks for genetic changes (ctDNA) can help detect lung cancer early in people who have suspicious lung nodules found on CT scans. Researchers will collect blood samples from 200 participants in Hong Kong and Vietnam at the start and…

This study looks at whether certain blood inflammation markers can help doctors tell the difference between harmless, precancerous, and cancerous vocal cord growths. Researchers will check medical records of 250 adults who have been diagnosed with a vocal cord lesion. The goal is…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will collect cough sounds, breath sounds, and symptom questionnaires from 1,400 children with respiratory symptoms like cough or fever. Researchers will use this data to build a computer model that can help diagnose conditions like asthma and pneumonia. The goal is to …

This study aims to see if a simple blood test can find HPV-related oropharyngeal cancer early in men aged 50 and older who have no symptoms. Researchers will check blood for two markers of HPV and then follow up with those who test positive to find and treat any tumors. If succes…

This study will enroll 2,250 adults with a family history of lung cancer to see if an AI model called Sybil can accurately predict future lung cancer from chest CT scans. Participants will provide previously taken CT images, and the AI will analyze them to estimate risk. The goal…

This study tests whether a lung ultrasound score can help doctors decide faster when to give surfactant—a medicine that helps babies' lungs work—to preterm infants with respiratory distress. Researchers will include 100 babies born between 27 and 34 weeks who need breathing suppo…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

This study tests whether a special combination of supplements (sodium nucleinate, magnesium, vitamin B6, and high-dose vitamin D) can prevent respiratory infections like colds and flu better than standard multivitamins. Two hundred healthy male military recruits in Kazakhstan wil…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study tests whether home-based breathing exercises and stationary bike workouts can improve lung health in 200 current and former smokers aged 50 and older. Participants will use a handheld breathing device and a stationary bike for 12 weeks. The goal is to see if these exer…

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This pilot study tests a digital program called Reaching Calm, designed to prevent anxiety in pregnant women at higher risk. The program sends text messages and provides web-based exercises to help women cope. Researchers will check if it's easy to use and if it reduces anxiety s…

This large trial will study whether flu and pneumonia vaccines can reduce serious flare-ups and medical costs in people aged 45-80 with COPD. About 7,000 participants will be split into four groups: flu vaccine, pneumonia vaccine, both, or no vaccine. Researchers will track lung …

This study tests a WeChat mini-program that sends heat warnings to parents and teachers of 200 fourth-graders in Beijing. When temperatures reach risky levels, the program shares health tips and alerts. The goal is to see if this helps children stay physically healthy and think c…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This pilot study will test a 10-session virtual group program called Parents and Babies, designed to prevent postpartum depression in LGBTQ+ parents. The program teaches coping skills based on cognitive-behavioral therapy. Researchers will enroll 16 LGBTQ+ individuals who are pre…

This study tests a vaccine called SurVaxM in 80 current or former heavy smokers at high risk for lung cancer. The vaccine trains the immune system to recognize and attack cells that produce a protein called survivin, which is common in cancer cells. The goal is to see if the vacc…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This study tests a mobile app called e-Perinatal designed to prevent depression and anxiety during and after pregnancy. The app offers personalized tips, mental health tracking, and a support button. Researchers will enroll 3,000 pregnant women across primary care centers in Spai…

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This phase 3 trial will give a single dose of the dTpa vaccine (Boostrix) to 95 healthy Japanese pregnant women between 27 and 37 weeks of pregnancy. The goal is to see if the vaccine triggers strong immunity in the mothers and passes protective antibodies to their babies at birt…

This study looks at whether elastic-band resistance training, with or without breathing exercises, can improve lung function and physical abilities in older adults with mild breathing problems. Seventy-five people aged 60 to 85 will be randomly assigned to one of three groups: re…

This study tests whether adding a muscle relaxant (rocuronium) to standard painkiller (fentanyl) helps doctors place breathing tubes in newborns on the first try, without causing dangerous drops in oxygen or heart rate. About 102 premature or sick babies in a Brazilian NICU will …

This trial compares standard radiation therapy with a new method that specifically avoids damaging small airways in the lungs. The goal is to see if this airway-sparing approach helps patients with stage III non-small cell lung cancer retain better breathing function after treatm…

This study tests whether an injection called stapokibart can reduce nasal allergy symptoms like runny nose, congestion, sneezing, and itching in adolescents aged 12 to 17 with seasonal allergic rhinitis (hay fever). Participants receive either stapokibart or a placebo alongside t…

This study will compare two types of nerve blocks for pain relief after shoulder surgery. One is a standard block that can sometimes weaken breathing; the other is a newer block that may avoid that side effect. 120 adults having shoulder arthroscopy will be randomly assigned to o…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This trial compares early versus delayed acupuncture to reduce dry mouth caused by chemoradiation in head and neck cancer patients. Participants receive acupuncture either during chemoradiation or after, and their dry mouth symptoms are tracked for a year. The goal is to find the…

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This pilot study tests whether using bright light therapy for an hour each morning, delivered through an iPad app, is tolerable for people with advanced melanoma or non-small cell lung cancer who are about to start immunotherapy. The idea is that synchronizing the body's internal…

This study tests whether an extended-release form of nalbuphine, a pain medication, can safely reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. About 306 adults with IPF and a cough lasting at least 8 weeks will receive either t…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study tests whether a ketogenic diet (low carb, high fat) is better than a standard diet at preserving muscle function in older adults hospitalized with pneumonia. Researchers will enroll 30 patients aged 55 and older and measure handgrip strength and diet adherence. The goa…

This early-stage trial tests whether the drug ponsegromab can help adults with advanced non-small cell lung cancer who are losing muscle mass (cachexia). About 80 participants will receive either ponsegromab or a placebo. The study measures changes in muscle size and physical fun…

This study tests whether a 12-week remote group rehabilitation program, done via video calls and a smartphone app, can help COPD patients living in remote areas start and stick with rehab. It compares this approach to standard in-person rehab. The goal is to see if the remote opt…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests a new device that uses muscle signals from the face and neck to recognize silent speech and turn it into voice. It is for adults who have lost their voice due to laryngectomy or severe voice problems. The goal is to see if the device can accurately identify words…

This study tests whether adding a blood flow restriction cuff to aerobic exercise helps people with emphysema or COPD build muscle and improve daily function. Sixty participants will either do standard aerobic exercise or the same exercise with the cuff. The goal is to see if thi…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study checks if a new propellant (HFA-152a) in asthma inhalers is as safe as the current one (HFA-134a). About 110 adults with asthma will use both types of inhalers and be monitored for side effects. The goal is to make sure the new propellant is safe for everyday use.

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether adding exercise sessions and asthma education to usual care helps children aged 10-17 manage their asthma better. 60 participants will be randomly placed into one of three groups: usual care only, education only, or exercise plus education. The goal is to…

This study looks at whether intermittent fasting is safe and doable for people with advanced solid tumors who are starting immunotherapy. About 90 participants will be split into three groups: no fasting, eating only during an 8-hour window each day, or fasting every other day. R…

This study tests a program called LiveWell, which teaches emotional coping skills to people with metastatic lung cancer who are feeling anxious or depressed. About 80 participants will either take the program or receive usual care. The goal is to see if the program is practical, …

This study tests a smart breathing exercise device for people recovering from lung cancer surgery. About 200 adults will either use the device for 30 days after surgery or receive standard care. The goal is to see if the device improves lung function, reduces shortness of breath,…

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study compares two exercise approaches—short 'exercise snacks' spread throughout the day versus traditional aerobic exercise—in adults with moderate to severe obstructive sleep apnea. Researchers will measure sleep quality, daytime sleepiness, and physical function over 8 we…

This study tests a home-based app for lung cancer patients on combination drug therapy. The app helps patients track symptoms, get personalized advice, and receive nurse support during treatment breaks. Researchers will see if it reduces symptom burden and improves quality of lif…

This study tests whether a smartphone reminder app can help lung cancer patients stay physically active during radiation therapy. About 32 adults with lung cancer will use the app or standard care, and their daily step counts will be compared. The goal is to see if simple digital…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study tests whether a virtual reality (VR) program that guides slow, controlled breathing and arm exercises can help people with interstitial lung disease (ILD) manage symptoms like breathlessness and fatigue. Participants will either use a VR headset or follow printed instr…

This study tests whether a decision-making tool can help veterans with sleep apnea choose and stick with a treatment that works for them. About 128 veterans will be randomly assigned to receive either a brief education program or the same program plus a personalized tool. The goa…

This study tests whether a treadmill workout that combines walking downhill (eccentric) and uphill (concentric) is better than standard uphill walking for people with mild to moderate COPD. Forty participants will do 12 exercise sessions over 4 weeks. Researchers will measure leg…

This study tests whether wearing a special LED vest for 20 minutes twice a week can improve lung function and exercise ability in children aged 6 to 17 with mild to moderate asthma. The vest uses light to reduce inflammation without heat. Half the children will get the active ves…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This phase 2 trial tests the safety of stapokibart injection in 15 teenagers aged 12-17 with seasonal allergic rhinitis (hay fever). Participants receive the drug alongside their usual allergy treatments. The study focuses on side effects and how the body processes the drug, not …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study tests whether electrical stimulation of the muscles used to breathe in (inspiratory) versus out (expiratory) can help patients on mechanical ventilators wean off the machine faster. The trial will include 48 adults aged 45-65 who have been on a ventilator for at least …

This study tests a small device called the Serene Sleep Palatal Implant, placed in the soft palate to reduce snoring and mild-to-moderate obstructive sleep apnea. About 26 adults will be split into two groups based on their condition. The main goal is to check safety, like whethe…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study tests whether caffeine can improve breathing in newborns with meconium aspiration syndrome, a condition where babies inhale their first stool into their lungs. Twenty babies who still need oxygen support at 10-14 days old will receive either caffeine or a placebo. Rese…

This study tests whether acupuncture can help people with mild-to-moderate chronic asthma breathe better and feel less anxious or depressed. 180 adults will be randomly assigned to real acupuncture, fake acupuncture, or usual care. The main goal is to see if real acupuncture impr…

This study tests whether combining a virtual reality forest experience with mindfulness practice can help reduce anxiety and depression in pregnant women. One hundred women between 20 and 24 weeks of pregnancy will either use VR forest sessions plus mindfulness or standard mindfu…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study looks at whether changing body position and doing special breathing exercises can help prevent lung issues like pneumonia after heart surgery. About 124 adults having planned heart surgery will be split into four groups: one getting usual care, one doing only breathing…

This pilot study tests a program called COPE (Creating Opportunities for Personal Empowerment) in 40 women with stage I-III breast cancer who are starting their first treatment. Participants will either receive the 7-week COPE sessions plus standard care, or standard care alone. …

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study tests whether a culturally tailored text-message program can help Spanish-speaking Hispanic adults with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. Fifty adults will receive automated texts that offer support, troubleshoo…

This study tests whether a supervised exercise and education program (pulmonary rehabilitation) can help people with long-term lung diseases like COPD, asthma, and post-TB lung damage in Nigeria, South Africa, and Cameroon. Researchers will enroll 90 patients to see if the progra…

This study looks at whether replacing gas stoves with portable electric hot plates and toaster ovens can improve indoor air quality and asthma control. About 20 adults with poorly controlled asthma who cook with gas at least three times a week will participate. Researchers will m…

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests if Dymista nasal spray safely eases allergy symptoms like sneezing, stuffy nose, and itchy eyes in Chinese teenagers aged 12 to 17. About 100 participants will use the spray twice daily for two weeks. The goal is to see if symptoms improve, not to cure allergies.

This study compares two tonsil surgery methods in adults: full removal (extracapsular) and partial removal (intracapsular). The goal is to see if partial surgery allows a shorter sick leave and less need for opioid painkillers, while still being as effective at relieving tonsilli…

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests a new program called ADAPT, which is a type of talk therapy for lung cancer patients and their spouses. The goal is to help both partners feel less afraid of the cancer coming back. About 72 couples will try the program during chemotherapy or radiation and answer…

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests a child-friendly breathing exercise program for children aged 6-18 recovering from severe pneumonia. The program is designed to be fun and engaging, aiming to improve recovery and make caregivers happier with the care. Researchers will compare kids who do the exe…

This study tests four different nebulized solutions (various salt concentrations and distilled water) to see which works best for clearing mucus from the airways of pneumonia patients. Eighty adults with pneumonia who need help coughing up phlegm will receive the treatment four t…

This study tests whether giving children aged 5-17 with severe asthma attacks early breathing support (called BPAP) in the emergency room is practical and safe. About 36 children will either get standard asthma care alone or standard care plus BPAP. The goal is to see if this app…

This study tests a new nasal spray called PL-14 Allergy Blocker in about 120 adults with seasonal allergies. Unlike regular allergy sprays, PL-14 is drug-free and works by forming a gel-like barrier in the nose to block allergens. The study compares it to a simple saline spray ov…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This small pilot study will test two common blood pressure medicines—nicardipine and sodium nitroprusside—in 12 patients with acute respiratory failure and high blood pressure. Researchers will use a special imaging technique called electrical impedance tomography to see how thes…

This study reviews medical records of 250 people with advanced or metastatic non-small cell lung cancer that has a specific change in the EGFR gene. Researchers want to learn about patients' backgrounds, the treatments they receive, and how well those treatments work. The goal is…

This phase 1 trial tests a new investigational drug, SCB0020160, for the first time in humans. Healthy adult men aged 18 to 65 receive either the drug or a placebo to evaluate safety, tolerability, and how the drug moves through the body. The study also looks at whether food affe…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study compares two ways to rebuild the nose after partial or total loss: surgery using skin flaps, or a custom-made prosthetic nose (epithesis). Researchers will ask people who had either treatment at least one year ago to fill out a questionnaire about how their nose looks …

This study looks at how two sedative drugs, dexmedetomidine and remifentanil, affect breathing effort in patients with acute hypoxemic respiratory failure who are receiving high-flow nasal oxygen. Researchers will measure changes in inspiratory effort and symptoms like shortness …

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study looks at health records of babies born in Scotland to see if those whose mothers received the RSV vaccine (ABRYSVO) during pregnancy have fewer hospital visits for RSV. No new participants are enrolled; researchers will analyze existing data. The goal is to understand …

This study measures how children ages 7 to 15 with normal hearing understand speech in realistic noisy environments, like a school cafeteria or playground. Using a 360-degree sound system, researchers play sentences in different background noises to see how well kids repeat them.…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…

This study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…

This study tests whether using a blood flow restriction (BFR) device during exercise can increase muscle fatigue in people with COPD, potentially making rehab more effective. Forty participants will do one session of resistance or cycling exercise with and without BFR. The goal i…

This study will compare how quickly and how much THC enters the blood when people vape THC liquids versus smoking cannabis. Forty healthy adults who already use both products will try each method in a random order. Researchers will measure THC levels, side effects, and puffing be…

This study will enroll 1,500 current or former smokers aged 50-80 to see if an artificial intelligence (AI) model can help doctors better detect lung nodules and predict cancer spread. Participants will undergo CT scans, and the AI's results will be compared to standard radiologi…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study tests whether adding special air quality sensors and software to hospital ventilation systems can lower the number of respiratory infections among healthcare workers. About 850 Mayo Clinic staff will report symptoms and provide self-swabs when sick. The goal is to see …

This study uses blood tests (liquid biopsies) to track how small cell lung cancer changes during chemotherapy and immunotherapy. Researchers will analyze DNA from blood samples taken before, during, and after treatment in 50 patients. The goal is to understand why some cancers be…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

This study looks at how lying on your left side, right side, or back affects lung function in adults with acute respiratory distress syndrome (ARDS) after abdominal surgery. Researchers will use a special imaging technique called electrical impedance tomography to measure how wel…

This study will screen 477 current or former smokers in Brazil for lung cancer using CT scans. It aims to see how often the scans give false alarms (false positives) in a region where lung infections are common. The goal is to improve screening accuracy and reduce unnecessary fol…

This study looks at 88 ICU patients who are ready to try breathing on their own after being on a ventilator. Some patients will be taken off the ventilator completely (T-piece test), while others will breathe with a little machine help (PS-ZEEP test). The goal is to see which tes…

This study aims to develop a blood test that measures B regulatory cells, which may indicate whether allergen immunotherapy (allergy shots) is successfully reducing allergic reactions. Researchers will study 80 adults with pollen or venom allergies who are starting routine allerg…

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most e…

This study will enroll 200 children with cystic fibrosis (100 Hispanic, 100 non-Hispanic white) to measure indoor and outdoor air pollution and see how it relates to lung function, inflammation, and airway bacteria. Researchers hope to understand why Hispanic children often have …

This observational study will use bedside ultrasound to measure the diaphragm—the main breathing muscle—in 120 adults with liver cirrhosis and compare them to healthy volunteers. Researchers want to see if cirrhosis weakens the diaphragm and if removing fluid from the belly impro…

This observational study will look at how often very low birth weight babies in Canadian NICUs get ventilator-associated pneumonia (VAP) and how these infections are treated. Researchers will compare different hospitals' approaches to diagnosis and care, with the goal of creating…

This study will use lung ultrasound to check how different surgical positions (lying on back, stomach, side, or in lithotomy) affect lung collapse after general anesthesia. Researchers will enroll 100 adults having planned surgery. The goal is to see if some positions are better …

This study explores whether a hair follicle or cheek swab can accurately measure a person's internal body clock (circadian rhythm) in patients with advanced lung cancer receiving immunotherapy. Researchers will use a new tool called TimeTeller to analyze gene activity from these …

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study tests a new way to see where an immunotherapy drug goes in the lungs of people with stage III lung cancer. Twenty participants will receive a small dose of a fluorescent version of the drug durvalumab, then have a special camera bronchoscopy to spot the drug in tumors …

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study involves 3,400 people with advanced non-small cell lung cancer to see if a new test for a protein called TROP2 works consistently across different laboratories. The goal is to ensure that doctors can reliably use this test to guide treatment decisions. Participants pro…

This study uses a special eye scan (OCT angiography) to look at blood vessel development in the retinas of children born very prematurely (at or before 28 weeks) compared to those born full-term. The goal is to see if premature birth and related lung problems affect eye blood ves…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study will collect data from 624 patients in respiratory intermediate care units (RICUs) across Catalonia to build a model that predicts 30-day survival. Researchers will also test an artificial intelligence approach and create a quick app for doctors. The goal is to better …

This study looks at how to get all pediatric clinics and hospitals in the Basque Health Service to use a proven care plan for children with asthma attacks. About 4,680 children will be involved. The goal is to see which strategies work best to make sure every child gets the right…

This study will enroll over 3,200 adults in Delhi and surrounding areas to understand how air pollution, especially fine particles (PM2.5), combines with other factors like smoking and genetics to increase lung cancer risk. Researchers will also look for biomarkers and identify g…

This pilot study will test whether using ultrasound during common office procedures for voice and swallowing problems is helpful and practical. Researchers will enroll 200 adults with conditions like chronic cough, vocal cord issues, or swallowing difficulties. They will measure …

This study will develop an artificial intelligence model that uses a patient's series of CT scans over time to predict whether a lung nodule will grow or become cancerous. Researchers will analyze scans from nearly 5,000 people to train the AI to recognize different growth patter…

This observational study looks at adults with non-small cell lung cancer that has spread to the brain. Researchers want to see if getting radiation and immunotherapy 30 days apart or closer together changes how long the brain tumors stay stable and how long patients live. Partici…

This study looks at how different ventilator pressure settings affect breathing and heart function in people with COPD undergoing lung surgery. Forty-eight patients will each try three short pressure settings in random order. The goal is to find which setting keeps the lungs open…

This study tests a decision-making support program based on restorative justice principles, designed specifically for Black adults who are at high risk for lung cancer. The goal is to see if this approach increases understanding, trust, and willingness to get screened. Forty-five…

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study compares a new visual bronchial blocker (with a tiny camera) to the standard blind method for placing a breathing tube during lung surgery. About 652 adults having lung, esophagus, or chest surgery will take part. The goal is to see if the camera-guided tool improves f…

This study follows 45 adults with alpha-1 antitrypsin deficiency (a genetic condition that can cause liver damage) to learn how the disease progresses. Researchers will analyze stored blood and liver tissue samples to find biomarkers and understand the molecular pathways involved…

This pilot study tests whether a simple tip sheet can help ICU doctors have better conversations with families of patients on breathing machines, especially families from different racial backgrounds. About 106 doctors and their patients' families will take part. The goal is to s…

This study looks at whether a standard step-by-step plan can help adults on high-flow oxygen therapy stop it more quickly and safely. About 2,000 patients across 8 hospitals will be involved. The goal is to see if the plan leads to more patients successfully coming off oxygen wit…

This study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study looks at how often ICU patients silently inhale food or liquid into their lungs after a breathing tube is removed, without showing obvious signs like coughing. Researchers will compare a routine bedside swallowing test with a more detailed camera test to see if the bed…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study tests whether using a special ventilator monitor to track lung volume during one-lung surgery, combined with lung-opening maneuvers, can prevent lung collapse after surgery. 44 adults having lung surgery will be randomly assigned to either standard care or the monitori…

This study looks at how much pembrolizumab (an immunotherapy drug) remains in the blood after treatment ends and whether that affects how well chemotherapy works later. Researchers will follow 110 people with non-small cell lung cancer or head and neck cancer who have stopped pem…

This study looks at whether a new method of interpreting fetal heart rate recordings (cardiotocography) can better identify when a baby is not getting enough oxygen during labor. Researchers will review data from 1,000 full-term pregnancies, combining past records and new enrollm…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study looks at two different methods doctors use to re-inflate a lung after it has been collapsed during surgery. About 350 people having lung surgery will take part. The goal is to see which method leads to fewer lung problems like pneumonia or collapsed air sacs in the wee…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will observe how many eligible infants in Czechia receive nirsevimab, a monoclonal antibody that helps prevent RSV, during their first RSV season. Researchers will survey parents of about 250 infants born between April 2025 and March 2027 to understand immunization rat…

This study will track 427 adults with interstitial lung disease (ILD) who need a bronchoscopy as part of their care. Researchers want to see how often complications happen within 30 days after the procedure. The goal is to better understand the risks so doctors can make safer cho…

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study looks at whether inhaling nitric oxide can improve how well the lungs exchange oxygen during exercise in people with mild to moderate COPD. Researchers will measure lung blood vessel function and breathing efficiency in 80 participants (40 with COPD and 40 healthy volu…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study looks at a specific type of lung cancer called lung adenocarcinoma and how it can spread through tiny air spaces in the lungs. Researchers will collect tumor and healthy tissue samples from 140 patients to find genetic markers that might predict this spread. The goal i…

This study looks at whether getting immunotherapy infusions in the morning versus the afternoon changes outcomes for people with advanced lung cancer or head and neck cancer. About 238 participants will be randomly assigned to morning or afternoon infusions. Researchers will trac…

This study tests whether personalized patient navigation can help more American Indian and Alaska Native people in Washington state get screened for lung cancer. About 237 adults aged 50-77 who smoke or recently quit will be enrolled. The goal is to see if tailored support helps …

This study will collect blood samples from 25 people with small cell lung cancer who are being treated with the drug tarlatamab. Researchers will analyze the samples to learn more about how the drug works, who might benefit most, and how to predict side effects like cytokine rele…

This study looks at how a gas called nitric oxide, given through a mask or nasal tubes, changes the way air and blood flow match in the lungs of people with ARDS (a serious lung injury). Researchers will use a special imaging technique (EIT) to see these changes right away. The g…

This early-stage study will give 8 healthy Chinese men a single dose of the experimental lung cancer drug zorifertinib, which has been tagged with a tiny amount of radioactivity. By collecting blood, urine, and stool samples over two weeks, researchers will track exactly how the …

This early-phase trial will test a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. The goal is to see if the imaging agent can safely tell the difference between tum…

This study tests whether a team-based care strategy for bubble continuous positive airway pressure (bCPAP) is feasible for children with severe pneumonia in Pakistan. Researchers will enroll 95 children and their caregivers to see if a larger trial is possible. The focus is on wh…

This study looks at medical records of 3,000 adults with lung cancer to see if the stage at diagnosis is shifting to earlier, more curable stages. Researchers will track how often cancer is found through screening programs, chest X-rays, or heart scans. No new treatments or tests…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study looks at whether ventilating only one lung during heart-lung bypass surgery can reduce fluid buildup and lung damage in high-risk patients. Forty-five older adults having major elective heart surgery will take part. The goal is to see if this approach leads to better l…

This study tests whether a specially designed educational toolkit, called the Lung Toolkit, can improve knowledge about lung cancer and screening among American Indian and Alaskan Native adults aged 50 to 80 who smoke cigarettes. The toolkit includes a website with resources and …

This study will observe how healthy lungs work by using two non-invasive tests: a special MRI that shows lung ventilation and a breathing test that measures airway resistance. Twenty healthy adults will participate to help researchers understand the relationship between these mea…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study will use artificial intelligence to analyze data from over 31,000 tuberculosis patients. The goal is to create a system that helps doctors decide which patients can be cured with a short treatment course and which need longer therapy. The AI will be tested to see if it…

This study checks if a Turkish version of a questionnaire called S3-NIV is reliable and accurate for people with chronic breathing failure who use a home breathing machine. Researchers will ask 120 stable patients to fill out the questionnaire to see how well it measures their di…

This study looks at how people diagnosed with tuberculosis (TB) in rural and coastal areas of Southwest England experience stigma. Researchers will interview 20 patients to understand how stigma affects their lives and access to care. The goal is to develop better ways to support…

This study looks at whether a new strategy to detect and refer pregnant and postpartum women with depression or anxiety to mental health services works well in routine care. About 3000 women will take part. The goal is to see if early help is feasible and acceptable, and to test …

This study will check if a quick ultrasound measurement of the skin-to-epiglottis distance in the neck can help predict when placing a breathing tube will be difficult. Researchers will measure this distance in 300 adult patients before surgery and compare it to standard airway c…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This observational study will look at how body composition (fat and muscle) relates to breathing endurance and exercise capacity in 100 adults with obesity and a restrictive breathing pattern. Participants will undergo tests like spirometry, body fat measurement, and a six-minute…

This study looks at two different methods for setting the pressure on a breathing machine (ventilator) in people with a serious lung condition called ARDS. The goal is to see which method improves oxygen levels better over 24 hours. About 52 adults with moderate to severe ARDS wi…

This study aims to see how nicotine changes eye movements in people who use e-cigarettes. Researchers will measure things like how fast eyes move and how well they follow objects, along with blood nicotine levels and self-reported feelings. The goal is to find a more objective wa…

This study aims to find out how much dental interns in Egypt know about pediatric obstructive sleep apnea, a common but often missed sleep disorder in children. Researchers will survey 350 interns using a questionnaire to assess their knowledge, attitudes, and practices. The goal…

This study will compare two common anesthesia methods—inhaled gas versus intravenous drugs—to see which one causes less lung injury after major surgery in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to one of the two groups. Resea…

This study watches how well the drug repotrectinib works and what side effects it causes in Korean patients with a specific type of lung cancer or solid tumors that have certain gene changes. About 10 patients will be followed for up to 12 months during their normal treatment. Th…

This study compares a new electromagnetic navigation system to standard CT scans for guiding surgeons to small lung nodules during surgery. About 400 adults with nodules up to 2 cm will be randomly assigned to one method. The goal is to see which approach helps surgeons find and …

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study will look back at medical records of 300 people with advanced non-small cell lung cancer (NSCLC) whose disease got worse after first-line immunotherapy. Researchers want to see which second-line treatments were used and how well they worked in real-world practice. The …

This study looks at whether people with peripheral vascular disease (narrowed leg arteries) might also be at high risk for lung cancer because of shared smoking history. Researchers will check if these patients qualify for lung cancer screening and refer them for a low-dose CT sc…

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study explores whether a technique called LIBS, which maps chemical elements in lung tissue, can help doctors identify possible environmental or workplace causes of chronic lung diseases. Researchers will analyze stored biopsy samples from 70 adult patients using LIBS and an…

This study will test a new wearable device that monitors your body's internal clock (circadian rhythm) by tracking signals like heart rate and movement. Researchers will compare the device's readings to standard saliva tests in 30 adults who are either healthy, have sleep apnea, …

This study looks at how different ways of measuring height affect ventilator settings and lung injury risk in people with acute respiratory distress syndrome (ARDS). Researchers will measure 39 patients' heights using five methods (stadiometer, visual estimation, tape, laser, and…

This study tests a new computer system that helps pharmacists provide better care for people with COPD, a serious lung disease. The system guides pharmacists to check symptoms, adjust medications, and create action plans. About 25 pharmacy staff and their COPD patients will use t…

This observational study will follow about 2,000 patients in China who have early-stage lung cancer with a specific gene mutation (EGFR) and have received targeted therapy pills (EGFR-TKIs) after surgery. Researchers will track how long patients live and how long they stay cancer…

This study tests whether a special headset (extended reality) can help surgeons plan the removal of cancer-affected lymph nodes in the neck for people with lung cancer. Ten patients will have their PET and CT scans combined into a 3D model that the surgeon views just before surge…

This study looks at how adults with lung nodules that might be cancer make decisions about their care before a final diagnosis. Researchers will use questionnaires to measure patients' confidence, doubts, and satisfaction with their choices. The goal is to find out what factors h…

This study tests a program called HOLA that teaches oncologists special communication skills to build better relationships with their Latino patients who have advanced cancer. Researchers will compare how strong the bond is between doctors who take the training and those who don'…

This study will observe 300 adults scheduled for a lung biopsy (EBUS-TBNA) to see if the size of their windpipe, measured by ultrasound before the procedure, can predict dangerous drops in oxygen levels. The procedure is done under sedation, and low oxygen is a known risk. The go…

This study looks at whether being at a moderate altitude (like 4,000 meters) can hurt your ability to remember to do things later, called prospective memory. Fifty healthy adults will take memory tests while breathing low-oxygen air or normal air in a chamber. Researchers also wa…