Experimental drug duo aims to boost immune attack on tough cancers
NCT ID NCT07707895
First seen Jul 16, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This study tests a combination of two experimental drugs, obrixtamig and ZL-1310, designed to help the immune system fight cancer. It is for adults with advanced small cell lung cancer or other neuroendocrine cancers. The trial has two parts: the first finds a safe dose of the two-drug combo, and the second adds a third drug (a checkpoint inhibitor) to see if the combination is tolerable and can stop cancer growth. Participants receive the drugs as infusions and are monitored for up to two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of two experimental drugs: obrixtamig and ZL-1310, sometimes with atezolizumab
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced neuroendocrine cancers, potentially slowing tumor growth.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the benefits and risks are not yet well understood. The combination may cause significant side effects or may not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC Locatie VUMC
Amsterdam, 1081HV, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CTR Leon Berard
Lyon, 69373, France
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Charité - Universitätsmedizin Berlin
Berlin, 13354, Germany
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Chris Obrien Lifehouse
Camperdown, New South Wales, 2050, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Freeman Hospital
Newcastle upon Tyne, NE7 7DN, United Kingdom
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Guy's Hospital
London, SE1 9RT, United Kingdom
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HOP Timone
Marseille, 13385, France
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Hokkaido Cancer Center
Hokkaido, Sapporo, 003-0804, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinico De Valencia (INCLIVA)
Valencia, 46010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Duran i Reynals
L'Hospitalet Del Llobregat, 08908, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Institut Gustave Roussy
Villejuif, 94800, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kansai Medical University Hospital
Osaka, Hirakata, 573-1191, Japan
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Lower Silesian Oncology Centre
Wroclaw, 53439, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Robert Bosch Gesellschaft für medizinische Forschung mbH
Stuttgart, 70376, Germany
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Shanghai Chest Hospital
Shanghai, 200030, China
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Shanghai Pulmonary Hospital
Shanghai, 200433, China
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Shizuoka Cancer Center
Shizuoka, Sunto-gun, 411-8777, Japan
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St. Marianna University Hospital
Kanagawa, Kawasaki, 216-8511, Japan
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Szpital Specjalistyczny W Brzozowie Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza
Brzozów, 36-200, Poland
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The Affiliated Cancer Hospital, Guangxi Medical University
Nanning, 530021, China
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Universitair Ziekenhuis Antwerpen
Edegem, 2650, Belgium
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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University of Kentucky Medical Center
Lexington, Kentucky, 40536, United States
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131, Germany
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
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