AI-Designed drug targets scarred lungs in major trial

NCT ID NCT07687459

Not yet recruiting Disease control Sponsor: InSilico Medicine Hong Kong Limited Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether the oral drug rentosertib (INS018_055) can slow lung function decline in adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. About 320 participants will receive either rentosertib or a placebo daily for 52 weeks. The main goal is to measure changes in forced vital capacity, a key indicator of lung health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rentosertib (INS018_055)
What this could lead to: If successful, rentosertib could slow lung function decline in people with idiopathic pulmonary fibrosis, offering a new treatment option for this serious disease.
What could go wrong: This is a phase 3 trial, but results may not show benefit over placebo. The drug could have side effects, and its long-term safety is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Affiliated Hangzhou First People's Hospital,School of Medicine, Westlake University

Hangzhou, Zhejiang, China
Anhui Chest Hospital

Hefei, Anhui, China
Anhui Provincial Hospital

Hefei, Anhui, China
Beijing Chaoyang Hospital, Capital Medical University

Beijing, Beijing Municipality, China
Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China
Fuzhou University Affiliated Provincial Hospital

Fuzhou, Fujian, China
Hainan General Hospital

Haikou, Hainan, China
Hebei Medical University Third Hospital

Shijiazhuang, Hebei, China
Henan Provincial People's Hospital

Zhengzhou, Henan, China
Introduction of the First Affiliated Hospital of Shandong First Medical University

Jinan, Shandong, China
Jiangxi Provincial People' Hospital

Nanchang, Jiangxi, China
Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China
Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China
Nanyang First People's Hospital

Nanyang, Henan, China
Ningbo Medical Center Lihuili Hospital

Ningbo, Zhejiang, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, China
Qilu Hospital of Shandong University

Jinan, Shandong, China
Renmin Hospital of Wuhan University

Wuhan, Hubei, China
Shanghai Pulmonary Hospital Affiliated to Tongji University

Shanghai, Shanghai Municipality, China
Shanxi Bethune Hospital

Taiyuan, Shanxi, China
Shengjing Hospital of China Medical University

Shenyang, Liaoning, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Chengdu, Sichuan, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
The First Affiliated Hospital of Xi'an Medical College

Xi'an, Shaanxi, China
The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China
The First Hospital of Jiaxing

Jiaxing, Zhejiang, China
The First People Hospital of Yunnan Province

Kunming, Yunnan, China
The People's Hospital of Anyang City

Anyang, Henan, China
The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China
The Second Affiliated Hospital of Xiamen Medical College

Xiamen, Fujian, China
The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China
The Second Hospital of Jilin University

Changchun, Jilin, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, China
The Xiangya Hospital of Central South University

Changsha, Hunan, China
Tianjin Chest Hospital

Tianjin, Tianjin Municipality, China
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China
West China Hospital, Sichuan University

Chengdu, Sichuan, China
Yichang Central People's Hospital

Yichang, Hubei, China
Yuncheng Central Hospital

Yuncheng, Shanxi, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.