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Simple breathing device may speed recovery from a deadly sickle cell complication

NCT ID NCT07703566

Not yet recruiting Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This trial investigates whether continuous positive airway pressure (CPAP) can help adults with sickle cell disease recover faster from acute chest syndrome, a serious lung complication. Participants who need extra oxygen are randomly assigned to receive either standard oxygen alone or oxygen plus CPAP for at least 6 hours a day. The study measures how quickly symptoms like fever, chest pain, and low oxygen levels resolve.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Continuous positive airway pressure (CPAP), a non-invasive breathing support device that delivers a steady stream of air to keep the airways open
What this could lead to
If effective, CPAP could become a standard, low-cost treatment to speed recovery from acute chest syndrome and reduce the need for intensive care in sickle cell disease.
What could go wrong
This is a relatively small trial, and earlier studies of other breathing support methods have not shown clear benefits. CPAP may not improve outcomes or could be poorly tolerated by some patients.

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Conditions

The condition(s) this trial relates to.

acute chest syndrome sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CHEST SYNDROME (ACS) SICKLE CELL DISEASE (SCD) SICKLE CELL DISEASE (SCD) PATIENT HOSPITALISED FOR ACUTE CHEST SYNDROME (ACS) REQUIRING SUPPLEMENTAL OXYGEN

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.