One shot, two viruses? new mRNA vaccine targets RSV and hMPV

NCT ID NCT07764237

Not yet recruiting ⭐️ VACCINE ⭐️ Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This early-stage trial tests an experimental mRNA vaccine called mRNA-1365 in healthy adults aged 60 and older. The vaccine is designed to trigger immunity against two respiratory viruses—RSV and hMPV—which can cause severe illness in older people. Researchers will evaluate the vaccine's safety and how well it stimulates the immune system, comparing it with other vaccine formulations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA-1365 (Profile 2), an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV.
What this could lead to: If successful, this vaccine could offer broad protection against two common respiratory viruses in older adults, reducing severe illness and hospitalizations.
What could go wrong: This is an early-phase trial focused on safety and immune response, not proof of effectiveness. The vaccine may cause side effects or fail to generate strong immunity.

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Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUMAN METAPNEUOMOVIRUS (HMPV) RESPIRATORY SYNCYTIAL VIRUS (RSV)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Diex Recherche Quebec

Québec, Quebec, G1V 4T3, Canada
Diex Recherche Victoraville

Victoriaville, Quebec, G6P 3Z8, Canada
Guys and St. Thomas Hospital, NHS

London, SE1 7EH, United Kingdom
MAC Clinical Research

Manchester, Greater Manchester, M13 9NQ, United Kingdom
Norfolk and Norwich University Hospital, NHS

Norwich, Norfolk, NR4 7UQ, United Kingdom
Royal Free Hospital, NHS

London, NW3 2QG, United Kingdom
Royal Victoria Infirmary, NHS

Newcastle, NE1 4LP, United Kingdom
Southampton General Hospital, NHS

Southampton, Hampshire, SO16 6YD, United Kingdom
St. George University Hospital, NHS

London, SW17 0RE, United Kingdom
University Hospital Birmingham, NHS

Birmingham, West Midlands, B15 2TH, United Kingdom

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