Nervous system disorder

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This phase 2 trial tests whether ENERGI-F705 tablets, taken twice daily alongside standard Parkinson's medications, can improve motor function and safety in people aged 40–75 with idiopathic Parkinson's disease. Participants are randomly assigned to receive a high dose, low dose,…

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This early-stage study tests whether an injection of the drug topotecan into the eye can safely prevent retinal detachment from coming back in people with a condition called proliferative vitreoretinopathy (PVR). About 50 adults having retinal detachment surgery will either recei…

This trial investigates whether faricimab, an eye injection, can help people with chronic central serous chorioretinopathy (CSCR), a condition where fluid builds up under the retina and can cause vision loss. The study includes 50 adults with persistent fluid for at least three m…

This study tests whether combining a gentle electrical brain stimulation (called FNS) with sling-based exercises can help people who have paralysis on one side after a stroke. The trial will enroll 54 adults aged 18-70 who had a stroke within the last 6 months. Participants will …

This Phase 3 trial tests whether vatiquinone can slow the progression of Friedreich's ataxia, a rare genetic disorder that damages the nervous system and impairs movement. About 120 adults with moderate symptoms will take the drug for 24 months. Researchers will measure changes i…

This study tests whether brain imaging and clinical data can help select the best treatment for people with depression that hasn't improved with standard therapies. Participants receive either repetitive transcranial magnetic stimulation (rTMS) or ketamine, and researchers check …

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This phase 3 trial tests whether viloxazine extended-release capsules, taken once daily, can safely reduce ADHD symptoms in Korean children and adolescents aged 6 to 17. Participants receive either the drug or a placebo for 8 weeks, with doses adjusted based on response. The stud…

This study tests a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare condition that leads to severe vision loss from a young age. The treatment is given as a single injection under the retina in the worse…

This study tests whether treating enlarged stomach veins (gastric varices) early with a procedure called retrograde transvenous obliteration (RTO) can prevent dangerous bleeding. 68 adults with cirrhosis and gastric varices will be randomly assigned to either RTO or standard care…

This study tests two experimental drugs, ENTR-601-44 and ENTR-601-45, in people with Duchenne muscular dystrophy (DMD) who have already taken part in earlier studies. The goal is to see if long-term use is safe and tolerable, and whether it can help maintain muscle function. Part…

This study tests a combination of three drugs—tislelizumab, bevacizumab, and capecitabine—in people with advanced solid tumors. The trial focuses on two challenging groups: those whose cancers have stopped responding to immunotherapy and those with tumors that have spread to the …

This trial investigates whether a surgical procedure that connects lymph vessels in the neck to veins, combined with the standard drug donepezil, can slow cognitive decline in people with moderate Alzheimer's disease. The surgery aims to improve drainage of waste from the brain, …

This phase 2 trial tests whether ublituximab, an immune-modulating drug, can reduce symptoms in people with treatment-resistant schizophrenia. Participants receive the drug by IV infusion, and researchers measure changes in symptom scores over time. The goal is to see if targetin…

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This study compares activating a cochlear implant on the day of surgery versus the usual two-week wait. About 100 adults receiving a cochlear implant will be randomly assigned to one of the two groups. Researchers will track how quickly the implant settings stabilize, hearing imp…

This study tests a fun, game-based training program that teaches children with cerebral palsy how to breathe better and improve their posture. The program includes exercises like blowing out candles and floating boats, along with visual and audio cues. Researchers want to see if …

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This study tests a new treatment called BCB-276 for children and young adults with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. BCB-276 is made from a patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The tr…

This trial compares three sedatives—propofol, midazolam, and dexmedetomidine—for controlling pressure inside the skull after urgent brain surgery for moderate-to-severe traumatic brain injury. Adults who have had surgery within 24 hours of injury will receive one of the three dru…

This trial tests whether using a balloon guide catheter along with a filter can better protect the brain during carotid artery stenting. People with narrowed neck arteries (carotid stenosis) who need stenting are randomly assigned to get either the balloon-plus-filter combo or a …

This study tests whether an investigational drug called HF1K16, when combined with the approved drug bevacizumab, can help people with recurrent or progressive glioma—a type of brain tumor. The trial enrolls about 30 adults whose tumors have returned or worsened after prior treat…

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified in a lab to better recognize and attack tumor cells. The main goals are to see if t…

This trial tests a personalized vaccine called YS247 for people with recurrent glioblastoma, an aggressive brain cancer. The vaccine is made from each patient's own immune cells and designed to target unique markers on their tumor. The study aims to see if the vaccine is safe and…

This study tests whether a daily dose of tricaprilin, a type of fat that may provide energy to brain cells, can improve memory, thinking, and daily function in people with mild-to-moderate Alzheimer's disease. About 535 participants will receive either tricaprilin or a placebo fo…

This early-phase study tests a new combination of two different immune cells—NK cells and CAR-T cells—for children and young adults with neuroblastoma or osteosarcoma that has returned or not responded to standard treatments. The NK cells are designed to help the CAR-T cells work…

This phase 3 trial tests whether NPI-001, taken twice daily for 24 months, can slow the loss of light-sensing cells in the eyes of adults with Usher syndrome, a genetic condition that causes both hearing and vision loss. About 80 participants will receive either the drug or a pla…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This phase 3 study evaluates the safety of HS-10506, an experimental insomnia medication, in 600 Chinese adults aged 18 to 64 with insomnia disorder. Researchers track side effects, serious adverse events, and specific safety concerns over both short and long-term use. The goal i…

This study tests a smartphone-based digital training program designed to improve working memory in people with schizophrenia or related disorders. Participants use the app to practice cognitive exercises, and researchers measure changes in memory and mental health. The goal is to…

This study investigates whether a program of functional progressive resistance training—exercises like sit-to-stand, step-ups, and stair climbing with gradually increasing resistance—can improve bone mineral density and balance in children with cerebral palsy. The trial includes …

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This study tests an experimental drug called empasiprubart in people with a specific type of generalized myasthenia gravis (gMG) who have AChR antibodies. The goal is to see if the drug is safe and can improve symptoms like muscle weakness that affect daily activities. Participan…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This study tests a single injection of TRCN-1023 into the spinal fluid of adults with ALS. The goal is to see if it is safe and shows early signs of slowing the disease over 24 weeks. Participants are randomly assigned to receive the drug or a placebo, and neither they nor their …

This study tests whether high-intensity breathing exercises can improve respiratory muscle strength, lung function, fatigue, and quality of life in people with multiple sclerosis (MS). Participants are randomly assigned to high-intensity interval breathing training, low-intensity…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests a computer-based practice method to help people with aphasia—a language disorder often caused by stroke—retrieve words more easily. Participants practice naming pictures with or without cues and receive feedback, repeating items until they meet a learning goal. T…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This pilot study tests a deep brain stimulation device that sends electrical pulses to two brain areas (STN and CM) to reduce seizures in adults with drug-resistant motor epilepsy. Ten participants will have the device implanted and will be monitored for changes in seizure freque…

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

This study tests a drug called Angiotensin II for patients who develop dangerously low blood pressure after heart bypass surgery. About 329 adults will receive the drug along with standard treatments, and their outcomes will be compared to similar patients from the past. The goal…

This study tests a new, faster method to deliver the drug AB-1005 into the brain of people with advanced Parkinson's disease. The goal is to see if the new approach can consistently reach the target area while being safer and quicker. 18 participants will be enrolled to assess th…

This phase III trial tests whether giving tranexamic acid continuously for 24 hours after hip surgery can reduce blood loss in non-ambulatory children with cerebral palsy. About 52 children aged 4 to 16 will be randomly assigned to receive either the drug or a placebo. The goal i…

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This study compares five FDA-approved drugs—rituximab, ravulizumab, inebilizumab, satralizumab, and eculizumab—to see which best prevents relapses in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition that can cause vision loss and paralysis. …

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The…

This trial tests whether giving blood pressure medication inside a mobile stroke unit—a special ambulance with a CT scanner—can improve outcomes for people having a brain bleed. About 706 adults with high blood pressure and a recent stroke will be randomly assigned to either the …

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This early-stage trial tests whether using focused ultrasound with microbubbles can temporarily open the blood-brain barrier, allowing the immunotherapy drug nivolumab to reach brain tumors more effectively. It includes 30 children and young adults with relapsed diffuse midline g…

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

This study tests a program that combines executive function training (like planning and problem-solving) with cognitive behavioral social skills training for adults aged 60 and older who have schizophrenia or schizoaffective disorder. Participants attend 42 sessions that teach pr…

This study tests the drug ublituximab in children aged 10 to 18 with relapsing multiple sclerosis (MS). It compares ublituximab to another drug, fingolimod, to see which better controls relapses. The trial involves 240 participants and will also monitor long-term safety and effec…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study tests a drug called ravulizumab in 20 Chinese adults with generalized myasthenia gravis, a condition that causes severe muscle weakness. The drug is given through a vein and works by blocking a part of the immune system to reduce symptoms. Researchers will measure how …

This phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a single daily polypill (combining blood pressure, cholesterol, and anti-clotting drugs) can help recent stroke survivors in Ghana avoid future strokes or heart attacks. About 500 participants will take the polypill or receive usual care for 24 months. Th…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This study tests whether adding mental health screening and family planning counseling to routine baby check-ups helps new mothers. About 920 migrant, refugee, and underserved women in Jordan will take part. They will be screened for postpartum depression, receive support or refe…

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will co…

This study tests a single intravenous dose of an experimental drug called CGB3002 in healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. This is a first step toward possibly developing a treatment for Alzheimer's disease.

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which appr…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

This early study tests a new cell therapy called QH101 for people with solid tumors that have spread to the brain, spinal cord, or surrounding membranes. The therapy uses specially engineered immune cells designed to better recognize and attack cancer cells. The main goals are to…

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This study tests a high-density flexible brain sensor (ECoG) used during surgery to help surgeons precisely remove the area causing seizures. It includes 85 people aged 3-60 with drug-resistant focal epilepsy. The goal is to see if this tool leads to better seizure control after …

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study tests a new nasal spray treatment for frontotemporal dementia (FTD), a brain disease that changes personality and language. The spray contains tiny particles from umbilical cord stem cells that may protect brain cells and reduce harmful protein buildup. About 33 adults…

This study investigates whether upper extremity exercise training delivered via tele-rehabilitation (synchronous or asynchronous) can improve motor symptoms, hand dexterity, and daily living activities in people with Parkinson's disease. Participants will receive either remote or…

This study tests a drug called ravulizumab in about 19 Chinese adults with a rare autoimmune disease called NMOSD. The goal is to see if it can reduce the number of disease attacks (relapses) and slow disability. Participants must have had at least one attack in the past year and…

This phase 2 trial compares the drug quetiapine with interpersonal and social rhythm therapy (IPSRT) in 216 people with bipolar II disorder who have disrupted daily rhythms. Participants will be randomly assigned to one of the two treatments for 12 weeks. Researchers will measure…

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study will follow 5,000 adults with carotid artery disease who receive a treatment called TCAR using the ENROUTE system. The goal is to see how safe and effective the device is in real-world settings, especially for groups not well-studied before. Researchers will track majo…

This study tests whether a fluorescent dye called 5-ALA can help surgeons see and remove abnormal brain tissue in people with drug-resistant epilepsy caused by focal cortical dysplasia (FCD). FCD lesions are often hard to distinguish from healthy brain during surgery, making comp…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This study tests whether a stellate ganglion block (a nerve block injection) can improve neurological outcomes in people who have had a bleeding stroke from a ruptured aneurysm. The procedure is done before surgery to reduce brain artery spasms and improve blood flow. Researchers…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This trial tests a single injection of a gene therapy called ZVS101e for people with Bietti crystalline dystrophy, a rare inherited eye disease that leads to progressive vision loss. The therapy uses a harmless virus to deliver a working copy of the CYP4V2 gene to cells in the ey…

This early-stage trial tests two oral drugs, IN10018 and dalpiciclib, in 24 adults with progressive meningiomas (brain tumors that keep growing despite treatment). The main goal is to check safety and find the best dose. Researchers will also see if the combination can shrink tum…

This study looks at whether giving focused radiation before surgery (neoadjuvant) or after surgery (adjuvant) works better to keep brain metastases from coming back. About 68 adults with 1 to 12 brain tumors will be randomly assigned to one of the two groups. Doctors will track t…

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests whether adding 20 minutes of moderate-to-high intensity aerobic exercise before constraint-induced movement therapy helps stroke survivors walk better. Fifty adults who had a stroke at least 6 months ago will take part in a 4-week intensive program, followed by a…

This phase 3 trial tests whether claseprubart (DNTH103) can improve symptoms of generalized myasthenia gravis, a condition causing muscle weakness. About 195 adults with a specific antibody type are randomly assigned to receive the drug or a placebo. The main goal is to see if th…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This phase III trial compares a new type of MRI, called CEST MRI, to standard MRI for guiding surgery in 60 patients with newly diagnosed glioblastoma. The CEST MRI may detect tumor tissue that standard MRI misses, allowing surgeons to remove more of the cancer. The study will me…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This early study tests a small, wireless brain implant designed to help people with severe speech problems communicate by thought. Four adults with conditions like locked-in syndrome or ALS will get the implant and learn to control it. The main goal is to see if the device is saf…

This study tests a drug called salanersen in babies with spinal muscular atrophy (SMA) who have already received gene therapy. The drug aims to help the body make more SMN protein, which is needed for muscle function. About 42 babies with two copies of the SMN2 gene will be rando…

This study tests an experimental drug called BMS-986504 in people with a rare cancer called malignant peripheral nerve sheath tumor (MPNST) that cannot be removed by surgery. Only people whose tumors are missing a gene called MTAP can join. The drug is taken daily by mouth, and t…

This study tests a computer program called PRIMUS that helps neurologists choose treatments for people with relapsing-remitting multiple sclerosis (MS). The tool uses data from past patients to predict how the disease might progress under different therapies. Doctors in some clin…

This study tests whether semaglutide (a GLP-1 drug used for weight loss) is safe for adolescents and young adults with Duchenne muscular dystrophy (DMD) who are also overweight or obese. The main concern is that the drug might reduce muscle mass, which is already weak in DMD. Par…

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This trial investigates whether giving a thyroid hormone (levothyroxine) to very small preterm infants with mildly low thyroid function can improve their physical growth and brain development by age two. The study includes infants born weighing under 1500 grams who are small for …

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests a new wireless, noninvasive device called the Rhaeos Shunt Monitoring System (RSMS) that sticks to the skin to detect fluid flow in brain shunts used for hydrocephalus. About 85 children and adults with working shunts will have their shunt flow measured with both…

This study tests whether a type of PET scan that tracks amino acids can accurately tell apart radiation necrosis (dead tissue from treatment) from tumor regrowth in people who have had radiation for brain metastases. About 80 patients who already received this PET scan will have …

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study tests whether a new type of PET scan (18F-MFBG) can detect neuroblastoma tumors as accurately as the current standard scan (123I-MIBG). About 84 children and adults with newly diagnosed, high-risk neuroblastoma will receive both scans to compare results. If the new sca…

This study tests whether a special 4D-flow MRI can accurately measure blood flow and pressure in the liver without needing an invasive catheter. Researchers will enroll 60 adults with cirrhosis and compare MRI results to the standard pressure test. If it works, this could make di…

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …

This study will test a device called Delphi-MD that uses magnetic pulses and brain wave recordings to diagnose traumatic brain injury (TBI). Researchers will compare results from 215 people with TBI to healthy controls, looking for patterns that could help identify and assess bra…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study explores whether a painless ultrasound technique, called shear wave elastography, can detect early signs of muscle weakness in critically ill patients on breathing machines. About 98 adults will have their nerves scanned on days 1, 4, and 7 in the ICU. The goal is to s…

This study tests whether an artificial intelligence (AI) system can help eye doctors identify urgent retinal conditions—like retinal detachment or bleeding—more accurately from wide-field eye images. Eight ophthalmologists will review images with and without AI assistance to see …

This study explores whether a PET/MR scan using a radioactive tracer called 18F-Florbetaben can detect amyloid deposits—abnormal protein clumps that can damage organs—in people with certain blood disorders. Participants receive a single injection of the tracer followed by a whole…

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

This study tests whether a digital program that combines cognitive behavioral therapy for insomnia with circadian rhythm coaching can prevent depressive symptoms from worsening in college students aged 18-24 who have trouble falling asleep and tend to be night owls. Participants …

This study tests whether a special combination of supplements (sodium nucleinate, magnesium, vitamin B6, and high-dose vitamin D) can prevent respiratory infections like colds and flu better than standard multivitamins. Two hundred healthy male military recruits in Kazakhstan wil…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study tests whether light therapy (photobiomodulation) can prevent mouth sores in children receiving chemotherapy. Fifty children aged 0-30 will receive daily light treatments during hospital stays and at home. Researchers will check if the therapy is easy to use and accepta…

This study tests whether giving a single IV dose of lidocaine before a C-section can prevent headaches caused when doctors press on the belly to deliver the baby. About 680 women having planned C-sections under spinal anesthesia will be randomly assigned to receive lidocaine or a…

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This study tests whether giving a mild electrical brain stimulation (tDCS) before, during, or after physical therapy helps stroke patients recover arm movement faster. Sixty hospitalized stroke survivors will receive three daily tDCS sessions, with only one being real and the oth…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study investigates whether major ozone autohemotherapy — a procedure where a small amount of blood is mixed with ozone and returned to the body — can improve pain, fatigue, sleep, and muscle health in women with fibromyalgia. Sixty participants will receive either exercise a…

This trial investigates whether photobiomodulation (low-level laser light) can reduce early nerve damage caused by chemotherapy. About 98 cancer patients with early signs of peripheral neuropathy will receive either light therapy or a placebo. The goal is to see if this non-invas…

This study tests whether taking a daily capsule of decaffeinated green tea extract can reduce nerve pain in people who have had cancer treatment. The trial enrolls 20 adults with stable pain who are not currently undergoing cancer therapy. Participants receive either the green te…

This study tests whether a virtual reality (VR) session the day before gallbladder surgery can lower patients' anxiety and uncertainty about general anesthesia. Two hundred adults who have never had anesthesia will either watch a VR video showing the operating room and anesthesia…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This study tests whether a 15-20 minute virtual reality (VR) relaxation session can reduce anxiety in adolescents aged 12 to 18 during a primary care visit. Participants use the Healthy Mind® VR platform to explore calming environments like beaches or mountains while doing guided…

This study investigates whether a type of noninvasive brain stimulation called continuous theta-burst stimulation (cTBS) can reduce symptoms of cervical dystonia, a condition that causes involuntary muscle contractions in the neck and head. Participants receive either real or sha…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This pilot study will test whether a high-fat, low-carbohydrate ketogenic diet can reduce symptoms of bipolar disorder when added to standard treatments. The study will enroll 100 adults in rural Alabama and measure changes in mania severity. The goal is to see if a dietary appro…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Parti…

This study tests whether a device that sends magnetic pulses to a specific brain area (dorsomedial prefrontal cortex) can safely reduce obsessive-compulsive behaviors in adults aged 22 and older. Participants receive either real or sham stimulation over six visits. The main goal …

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study tests a brief mindfulness-based lifestyle program for caregivers of people with neurodegenerative disorders like Alzheimer's or Parkinson's. Many caregivers are not physically active, raising their risk for heart disease. The program combines in-person group sessions w…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This study tests whether an artificial intelligence (AI) and computer vision system can help people with fibromyalgia perform effective exercise at home. Participants use a smartphone or tablet app that watches their movements and gives real-time feedback, with or without added r…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study will test whether a 4-week daily music therapy app can reduce chronic pain and improve quality of life in 25 youth with sickle cell disease. Participants will either use the app or receive standard educational materials. Researchers will also look at changes in immune …

This study tests whether a daily capsule containing lotus seed and rice germ extract, called ZenRest™, can improve sleep quality in menopausal women aged 40 to 65 who have mild-to-moderate sleep problems. Participants take either the supplement or a placebo for six weeks, and sle…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests a personalized music program for people who wear hearing aids but are unhappy with how music sounds. Researchers will create a custom frequency profile for each participant and add it to their hearing aids as a dedicated music setting. The trial includes 66 adult…

This study tests whether watching a short educational video before surgery can lower anxiety in adults having elective procedures. Participants are randomly assigned to receive the video via a QR code they scan on their own phone, via a tablet provided in the waiting area, or to …

This study tests whether a structured, midwife-led review of the childbirth experience can improve mental health in new mothers and fathers. The intervention involves a 45-60 minute session where parents discuss their birth story, receive emotional support, and get clarifications…

This study compares sound therapy, cognitive behavioral therapy (CBT), and their combination to help people with chronic tinnitus (ringing in the ears). Sixty adults aged 18-65 with stable health will be randomly assigned to one of three groups for six weeks. The goal is to see w…

This Phase 3 study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce irritability in children and adolescents aged 5 to 17 with autism spectrum disorder. About 176 participants will receive either the drug combo or a placebo for 8 weeks. The main goal…

This study tests whether a new medication, KarXT + KarX-EC, can reduce irritability in children and teens (ages 5 to 17) with autism. About 176 participants will receive either the drug or a placebo. The main goal is to see if the drug improves irritability scores after 8 weeks.

This study tests whether a short mindfulness exercise, followed by questions that help patients reflect on their experience, can reduce pain and anxiety after knee or hip replacement surgery. Adults who have had a joint replacement will receive a guided breathing exercise via tex…

This study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests whether adding short mindfulness sessions (5-10 minutes) before physical therapy can reduce anxiety, depression, and body image concerns in people with non-flaccid facial paralysis. Twenty-four adults with conditions like Bell's palsy or Ramsay Hunt syndrome will…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study compares two drugs, lumateperone and cariprazine, when added to a mood stabilizer for people with bipolar I depression. Researchers will track changes in depression symptoms over 8 weeks using standard rating scales. The goal is to see which drug works better and has f…

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This study tests whether special attention exercises can improve focus and quality of life in people who have had a stroke. 46 participants will do either attention training or standard rehab for 4 weeks. Researchers will measure changes in attention and daily functioning.

This study tests whether a wearable device called cueStim can shorten the duration of freezing of gait—a sudden inability to move—in people with Parkinson's disease. About 60 participants, aged 60 to 90, will wear the device for four weeks during daily life and be assigned to one…

This study tests whether a set of four gentle osteopathic manual techniques can reduce stress and anxiety in young adults aged 18 to 35. Thirty participants will either receive the real techniques or a placebo simulation, and researchers will measure changes in heart rate variabi…

This study tests whether a smartphone app called Bodhi AIM can help youth aged 13–20 who are on probation or in related legal programs improve their psychological wellbeing and reduce distress. Participants use the app for one month, following daily guided meditations. The trial …

This study tests a program to help adult patients sleep better in the intensive care unit (ICU) after surgery. The program includes sleep education, earplugs and eye masks, reducing noise and light at night, and grouping nursing tasks to avoid waking patients. Researchers will co…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This study investigates whether playing 3D motion-sensing games (using Kinect and Google Cardboard) can improve motor control, thinking skills, and quality of life in people with mild to moderate Alzheimer's disease. Participants play specially designed games for 30 minutes a day…

This trial compares three treatments for idiopathic trigeminal neuralgia, a condition causing severe facial pain. One group gets standard carbamazepine alone, another adds the antiviral acyclovir, and the third adds the anti-inflammatory celecoxib. The goal is to see which combin…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN). CIPN causes numbness, tingling, pain, and movement problems. The study compa…

This study tests whether giving patients a printed opioid prescription instead of sending it directly to the pharmacy can reduce opioid use after total hip replacement. About 100 adults will be randomly assigned to receive either the standard pain regimen with automatic pharmacy …

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study tests a speech therapy called DTTC-Connect for children aged 3 to 12 with childhood apraxia of speech, a disorder that makes it hard to say words clearly. The therapy focuses on helping children move from saying single words to speaking in phrases. Sixty-eight children…

This study will test a mobile app designed to help people with schizophrenia or those at high risk for psychosis recognize and change biased thinking patterns. One hundred participants will use the app and report on their mood and negative symptoms. The goal is to see if this sim…

This pilot study tests whether eye movement training can help people who lost part of their vision after a stroke. Twenty participants will either use an eye-tracking machine in the clinic or do reading exercises at home. Researchers will measure changes in eye movements and read…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

This pilot study will test whether oral ketamine can control pain as well as oxycodone in emergency department patients who need extra pain medication. Sixty adults with certain types of pain will be randomly assigned to receive either drug. Researchers will measure changes in pa…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests a 3D-printed 'oxygen support cage' placed over the patient's head during cataract surgery. The cage lifts surgical drapes off the face, which may reduce feelings of suffocation and anxiety. Researchers will measure changes in blood pressure, heart rate, breathing…

This study will test whether a gentle, non-invasive brain stimulation technique called tDCS can improve verbal fluency, thinking, and motor control in people with Parkinson's disease. Twenty participants aged 50-90 with Parkinson's and a verbal fluency deficit will receive the st…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study tests whether a simple online computer game can help children with brain tumors think faster. 300 kids will do 15 minutes of cognitive training, 5 times a week for 8 weeks. Researchers will check if the training is easy to do at home and if it actually improves process…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can reduce negative symptoms (like lack of emotion or motivation) and cognitive problems in people with schizophrenia. 62 participants will receive either real or sham sti…

This study compares three different walking training programs for people recovering from a stroke. Twenty participants will be randomly assigned to moderate-intensity walking, high-intensity walking, or high step-count walking during their inpatient rehab. The goal is to see whic…

This study tests whether a structured program of touch, temperature, vibration, and movement exercises can improve sensation and hand function in people with diabetic peripheral neuropathy. Fifty-nine adults with stable diabetes will be randomly assigned to either the active trai…

This study tests a headset called HALO Clarity™ that sends mild electrical currents to the brain to help people with moderate-to-severe insomnia sleep better. 160 adults will use either the active device or a sham (fake) device at home for 4 weeks, then be followed for another 4 …

This study tests a home-based eye movement therapy (optokinetic stimulation) for people with spatial neglect after a stroke. Spatial neglect makes it hard to pay attention to one side of the world, often leading to falls. The therapy involves watching moving dots on a computer sc…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests BraveBot, a computer program that talks with young people (ages 12-22) through their phone or computer while they do exposure therapy homework for anxiety or OCD. BraveBot does not replace the therapist but offers real-time coaching and encouragement during assig…

This study compares two types of nerve blocks—quadro-iliac plane block and supra-inguinal fascia iliaca compartment block—for pain after total hip replacement. Sixty adults scheduled for hip surgery will receive one of the blocks along with spinal anesthesia. Researchers will mea…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study will test whether a structured aquatic therapy program can improve balance in children aged 5 to 12 with spastic diplegic cerebral palsy. Fifty participants will be split into two groups: one receiving water-based therapy and the other continuing standard land-based ph…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive flexibility—the ability to adapt thinking—in people with major depression. 105 participants will receive either active stimulation to two brain areas, active stimulation to one a…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This study tests whether pelvic floor down training—gentle breathing and relaxation exercises—can reduce tailbone pain in new mothers. Fifty-two women, 6 months to 1 year after childbirth, will practice these exercises daily. Researchers will measure pain and daily function befor…

This study tests whether giving scheduled morphine alongside patient-controlled pain relief can prevent the intense 'rebound pain' that often occurs when a nerve block wears off after orthopaedic surgery. About 100 adults having arm or leg surgery will be randomly assigned to rec…

This study looks at whether plyometric (jumping) exercises on the less affected leg can improve strength, movement control, and balance in children aged 6-10 with hemiplegic cerebral palsy. Forty children will either get standard physical therapy alone or standard therapy plus pl…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study compares two ways to manage pain after open inguinal hernia repair: an ultrasound-guided nerve block (TFPB) versus surgical wound infiltration with local anesthetic. About 104 adults will be randomly assigned to one method. The goal is to see which reduces opioid use a…

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study tests whether a 12-week program combining individual physiotherapy, group movement-awareness sessions, and group psychotherapy can improve physical function, reduce fatigue, and enhance quality of life in 45 adults with multiple sclerosis. Each participant serves as th…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placeb…

This study tests a special helmet that shines near-infrared light on the brain (called transcranial photobiomodulation) in 40 people with Lewy body dementia. Participants use the helmet twice daily for 6 months. Researchers will check thinking skills, symptoms, and quality of lif…

This pilot study tests an 8-week group program designed to improve life balance for parents of preschool children. The program includes group sessions, personal goal setting, and phone check-ins. Researchers will measure changes in life balance, parenting stress, and mental healt…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study compares two types of nerve blocks used to manage pain after total hip replacement. Sixty adults having hip replacement will receive either a quadro-iliac plane block or a PENG block combined with a lateral femoral cutaneous nerve block. Researchers will measure pain s…

Many Asian Americans with depression also suffer from physical symptoms like pain or fatigue, but no proven treatment addresses both together. This study will test whether combining a stress management program with Qigong/Tai Chi movements is practical and acceptable for 70 adult…

This study tests whether a digital mental health platform called NAVO:J can help teens feel better. About 250 students will use the app in weekly group sessions at school for 17 weeks. Researchers will measure changes in depression, anxiety, stress, and resilience to see if the p…

This study tests whether a structured debriefing session within 24 hours after a difficult birth can reduce post-traumatic stress and improve the birth experience. About 142 women who had an unexpected or adverse event during labor will be split into two groups: one gets usual ca…

This study tests whether a numbing injection called a superficial parasternal intercostal plane block (SPIPB) can widen the internal thoracic artery, making it easier for surgeons to harvest during coronary artery bypass grafting (CABG). The trial involves 50 adults aged 22 to 65…

This phase 3 trial tests whether a cannabis extract called VER-01 can reduce leg pain in people with chronic nerve root compression (sciatica-like pain) who haven't gotten enough relief from standard painkillers. About 810 participants will receive either VER-01 or a placebo for …

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete 20-30 minute weekly sessions. Researchers will measure changes in symptoms and goal-directed behavior before and after the prog…

This study tests whether TECAR therapy, a device that uses radiofrequency energy to heat tissues, can reduce pain and improve hand function in people with carpal tunnel syndrome after a burn. Fifty-two adults aged 20 to 40 with mild to moderate carpal tunnel and a history of uppe…

This study tests whether giving scheduled morphine doses alongside on-demand pain relief can prevent the severe 'rebound pain' that often occurs when a nerve block wears off after orthopedic surgery. One hundred adults having arm or leg surgery will be randomly assigned to receiv…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests a self-guided digital psychology app, called Manage My Pain, along with weekly email reminders, for people with fibromyalgia or chronic pelvic pain who are on a waitlist for specialized pain care. The goal is to see if this approach is feasible and acceptable, an…

This study tests whether a mobile app that trains specific brain waves can improve working memory in adults with schizophrenia or schizoaffective disorder. Thirty participants will use the app at home twice a week for 12 weeks. Half get real neurofeedback, half get a placebo vers…

This study tests whether low-energy shockwave therapy can improve facial nerve function in people with chronic Bell's palsy. Forty-two adults aged 45 to 55 will receive the treatment on specific points along the facial nerve. The goal is to reduce facial muscle weakness and impro…

This study tests whether giving family members of ICU patients a QR code that links to an educational video can improve their understanding of the ICU and reduce their anxiety. Participants are randomly assigned to receive either standard verbal information or the same informatio…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study looks at whether giving a nerve block (serratus anterior plane block) before or after mastectomy surgery leads to better recovery and less pain. Eighty women having a mastectomy will be randomly assigned to receive the block either before the surgeon makes the first cu…

This small study tests whether wearing a rigid leg cast (from thigh to ankle) during treadmill training can safely improve how children with cerebral palsy walk. Six children aged 7 to 14 will take part in a 4-week walking program. Researchers will use motion cameras and muscle s…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

This clinical trial will compare Sahrmann exercises and McGill exercises in 42 adults with non-specific low back pain. Participants will be randomly assigned to one of the two exercise programs, alongside standard physical therapy. The study aims to see which approach better redu…

This study investigates whether matrix rhythm therapy, a device that delivers gentle vibrations to the hand and arm, can reduce symptom severity and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Participants receive either active or sham therapy tw…

This study tests whether 8 weekly group sessions of Acceptance and Commitment Therapy (ACT), led by a nurse, can help people with schizophrenia improve social thinking, emotion control, and mental flexibility. 64 participants will be split into two groups: one gets ACT plus usual…

This study investigates whether sleeping on a gently rocking bed can improve sleep quality and memory in people undergoing neurorehabilitation after conditions like stroke, traumatic brain injury, or inflammatory diseases of the central nervous system. Participants will sleep on …

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests a new device called the EpiFaith™ Syringe, which gives a clear visual signal when a doctor reaches the right spot for an epidural pain injection. Currently, doctors rely on feel alone, which can lead to multiple needle sticks or mistakes. The study will compare t…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This study tests whether short virtual reality nature sessions can lower stress for people admitted to an acute psychiatric ward. 120 adult patients will either receive standard care or add 10-15 minute VR nature experiences every other day. Researchers will measure changes in pe…

This study tests whether a special ultrasound-guided nerve block can lower the amount of strong painkillers (opioids) needed after breast reduction surgery. About 80 women will be randomly assigned to receive either standard pain treatment alone or standard treatment plus the ner…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This trial tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce inattention in adults with ADHD. Forty adults with ADHD will receive either real or fake tDCS for five days in a row. Researchers will meas…

This study tests whether a non-invasive device that gently stimulates a nerve on the forehead (external trigeminal nerve stimulation, or eTNS) can immediately improve walking and other movement problems in people with Parkinson's disease. Thirty participants will each try two dif…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study will test whether a wearable device called Apollo Neuro is practical and acceptable for autistic children aged 6 to 14 who hurt themselves. The device delivers low-intensity vibrations through the skin. For about a month, 18 children will wear it at least 3 hours a day…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study will test whether Reiki therapy, a gentle hands-on energy technique, can improve recovery, comfort, and mood in women who have had a cesarean section. Eighty new mothers will receive three Reiki sessions on days 1, 2, and 7 after birth, in addition to standard care. Re…

This study tests whether an 8-session training program based on Acceptance and Commitment Therapy (ACT) can help caregivers of schizophrenia patients feel less burdened, express emotions more healthily, and become more psychologically flexible. About 60 caregivers will be randoml…

This study tests whether combining a painless brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with balance exercises can improve walking and balance in people with Parkinson's disease. Twenty participants aged 40-80 will receive the combined…

This study tests whether a daily supplement of sulforaphane, a compound found in broccoli sprouts, can improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. Sixty participants aged 12 to 45 who are stable on antipsychotic medicati…

This study tests a physiotherapy program that combines neck muscle exercises with a gentle nerve stimulation technique (transcutaneous vagus nerve stimulation) in 50 adults with migraine. The goal is to see if this approach can reduce pain, improve daily function, and boost quali…

This study tests if a combination of manual therapy and nerve stimulation can relieve symptoms of moderate carpal tunnel syndrome as well as surgery recovery does. About 150 adults aged 30-50 with confirmed moderate carpal tunnel will be split into two groups: one gets the non-su…

This study tests a special acupuncture technique called 'Nine Pharyngeal Acupoints' to help stroke patients who have trouble swallowing. The goal is to see if it improves their ability to eat and drink safely. Researchers will use muscle activity tests and video X-rays to measure…

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure tota…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study tests a new type of physical therapy called NICE rehabilitation for people who have had a stroke and have weakness on one side. The therapy uses a computer to show patients how to activate specific muscles, helping them regain arm movement. Researchers will measure cha…

This study looks at whether adding the drug bupropion (Wellbutrin) to standard hormone therapy can help women with early-stage breast cancer who have lost interest in sex. About 100 women will be randomly assigned to receive either their usual hormone therapy alone or with buprop…

This study compares two vaginal treatments—estrogen and DHEA—for relieving menopause symptoms like vaginal dryness, discomfort, and painful intercourse. About 324 women aged 40-90 will use one of the treatments and report changes in symptoms and sexual health. The goal is to help…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

This study tests whether giving caregivers hands-on practice plus a video to review at home improves their knowledge, skills, and stress levels when caring for a patient with a feeding tube (PEG). About 54 caregivers will be randomly assigned to either the video-enhanced training…

This study tests two simple, no-cost methods to reduce pain and fear in children aged 6-12 during blood draws: rhythmic skin tapping by a nurse just above the needle site, and the child humming an 'mmmm' sound. Both techniques are based on the idea that touch and vibration can pa…

This study tests a new device that uses muscle signals from the face and neck to recognize silent speech and turn it into voice. It is for adults who have lost their voice due to laryngectomy or severe voice problems. The goal is to see if the device can accurately identify words…

This study looks at whether posture and tongue position affect how children pronounce Hebrew sounds. Researchers will test if adding muscle-strengthening exercises to regular speech therapy helps kids learn correct pronunciation faster. About 80 children with and without speech i…

This study tests whether listening to ASMR or white noise before bed can improve sleep quality for adults recovering from elective lower leg surgery. Participants are randomly assigned to listen to a 30-minute ASMR recording, white noise, or receive routine care. Sleep quality is…

This study compares two therapies for children aged 4-8 with monochannel sensory processing disorder, where the brain relies on one sense at a time. One group will do exercises in a therapy pool, while the other uses a sensory room. Researchers will measure changes in sensory int…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This study tests whether a virtual reality (VR) tour of the hospital and operating room can help children aged 3 to 12 feel less anxious and scared before elective surgery. Half of the 56 children will use a VR program called NixiKit, while the other half will receive the usual p…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests whether watching movements in person (live) or on video helps children with spastic diplegia improve their balance and walking. About 45 children aged 4 to 7 with mild spasticity will participate. The goal is to see which method works better for improving stabili…

This study tests whether a quick, gentle push on the lower back (called lumbar spinal manipulation) can improve balance and lower fall risk in people who have had a chronic stroke. Fifty-two participants will receive both the real manipulation and a placebo version at different t…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether a cochlear implant placed just outside the inner ear, near the round window, can safely reduce severe tinnitus that has not responded to standard treatments. Six adults with long-term, high-impact tinnitus will receive the implant in a two-step procedure.…

This study aims to reduce unwanted loneliness and improve the daily experience of family caregivers for people with Alzheimer's disease. Researchers will test a combination of music therapy and health education with 50 caregivers. The goal is to see if these activities can help c…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests whether a device that delivers high-intensity focused electromagnetic pulses can strengthen core muscles and improve balance in people with multiple sclerosis. Sixty participants will either receive the electromagnetic therapy plus balance exercises, or balance e…

This study will test whether a 24-week Tai Chi program can reduce chronic pain, improve thinking and mobility, and lower fall risk in older adults (65+) who have pain in multiple body areas and are at risk for falls. 266 participants will be randomly assigned to Tai Chi or light …

This study tests whether 5 days of accelerated transcranial magnetic stimulation (TMS) can quickly reduce depression symptoms. 264 adults with major depressive disorder will receive either real or sham stimulation, along with brain scans and mood tracking. The goal is to see if t…

This study tests an oral ketamine capsule (KET-AD) designed to be abuse-deterrent in adults with treatment-resistant bipolar depression. About 160 participants will receive either KET-AD or a placebo, taken three times a week for up to 7 weeks, alongside their usual treatment. Th…

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study tests whether a non-electric, hand-held temple massager—used daily for 4 weeks with a special lotion and optional lavender aromatherapy—can lower stress, improve emotional wellbeing, sleep quality, and overall quality of life in women aged 35 to 65. Participants use th…

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This trial investigates whether doing enjoyable, meaningful activities—like cooking, gardening, or painting—can improve thinking skills and daily function in older adults with Parkinson's disease who have mild to moderate memory or thinking problems. Participants are randomly ass…

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study aims to find unique biological and clinical markers for a specific genetic form of Parkinson's disease linked to the LRRK2 gene. Researchers will compare 10 people with LRRK2-related Parkinson's to 10 people with sporadic Parkinson's using blood tests, brain MRI scans,…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study investigates how stimulating the vagus nerve through the ear affects stomach function and brain activity in people with Parkinson's disease. Participants receive non-invasive electrical stimulation via a device placed on the ear, and researchers measure stomach respons…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study interviews bereaved parents and oncologists to understand how they discussed uncertainty during a child's cancer treatment. The goal is to find better ways for doctors and families to communicate about what the future may hold. Participants include parents whose child …

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study surveys 1,000 adults with Restless Legs Syndrome (RLS) to find out how often pain is part of their symptoms and how it affects their daily lives. Participants fill out an online questionnaire about their medical history, sleep, pain, and quality of life. The goal is to…

This study investigates why severe traumatic brain injury (sTBI) often leads to additional brain damage. Researchers think changes in the gut and immune system may play a key role. They will analyze blood, stool, and other samples from 40 adults with sTBI, as well as from trauma …

This study investigates whether balance problems explain why fatigue leads to a greater fear of falling in people with multiple sclerosis (MS). Researchers will assess fatigue, balance, and fear of falling in 40 adults with MS who can walk independently or with a device. The goal…

This study investigates sexual and urinary problems in people with generalized myasthenia gravis, an autoimmune disease that causes muscle weakness. While visible symptoms like droopy eyelids are well-known, issues like sexual dysfunction and bladder problems are often ignored. R…

This study looks at whether people who better understand the risks and steps of their upcoming lung procedure (endobronchial ultrasound) need less propofol, a sedative. Researchers will ask participants questions about what they understood from the consent process and measure the…

This study compares two ways to rebuild the nose after partial or total loss: surgery using skin flaps, or a custom-made prosthetic nose (epithesis). Researchers will ask people who had either treatment at least one year ago to fill out a questionnaire about how their nose looks …

This study investigates whether auditory and cognitive training can help adults with cochlear implants understand speech better. Researchers will enroll 100 experienced implant users and randomly assign them to different training programs. The goal is to see if these intervention…

This early study tests whether asciminib, a drug already approved for leukemia, can get into brain tumors in children and young adults (ages 6-25) with recurrent brain tumors. Some participants will also get sildenafil to see if it helps the drug enter the tumor. The main goal is…

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study looks at whether university students who exercise regularly have better cognitive awareness, body awareness, and sleep quality compared to those who are sedentary. Researchers will survey 140 students aged 18-25, grouping them by their physical activity levels. No drug…

This study follows adults waiting for a liver transplant to see how their sleep quality changes from before surgery to six months after. Researchers use questionnaires to measure sleep, anxiety, and other factors. The goal is to understand what influences sleep problems in these …

This study will recruit 100 sexual partners of people diagnosed with gonorrhea. Researchers will take an extra throat swab to analyze all the bacteria and their genes using a technique called metagenomics. The goal is to find hidden infections, antibiotic resistance, and see how …

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and the…

This study will follow 60 children with SLC6A1-NDD, a rare genetic condition causing seizures, developmental delays, and autism. Researchers will track symptoms like seizure frequency and development over time to better understand the disease. The goal is to gather information th…

This study will see if setting up vision centers in rural South Asian communities helps more people get the eye care they need. Researchers will compare communities that get a vision center right away with those that wait. They will check if more people get glasses and if their e…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study adapts the Pain and Smoking Inventory (PSI) for Turkish-speaking adults who have chronic pain and smoke daily. Researchers will test whether the translated version is reliable and accurate by comparing it with other measures of pain and nicotine dependence. The goal is…

This study looks at how emotional childhood maltreatment (like verbal abuse or neglect) affects social skills, brain structure, and inflammation in people with bipolar disorder. Researchers will compare 80 people with bipolar disorder and 80 healthy controls, using brain scans, b…

This study investigates whether deep brain stimulation (DBS) of the subthalamic nucleus alters inflammation in people with Parkinson's disease. Researchers will measure inflammatory and neurodegenerative markers in the blood of 90 participants before and after DBS surgery, compar…

This early-stage trial in 18 healthy adults compares a new octreotide tablet (T25) with an existing capsule (MYCAPSSA) to see how much drug gets into the blood. It also checks whether a high-fat meal changes absorption of the tablet. Participants take single doses under fasting o…

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

This study tests a mobile health program called FANS-EI that aims to support caregivers of young autistic children in staying engaged with early interventions. Researchers will measure caregiver comfort, participation, and sense of support. The study involves 28 caregiver-child p…

This study translates and tests a 9-question scale called BITEC, which measures what people with chronic pain expect from their treatment. Researchers will enroll 250 adults in Turkey who have had pain for at least three months. Participants fill out surveys about their pain, exp…

This study will use artificial intelligence and video analysis to assess how well children with cerebral palsy can walk and move. Researchers will collect data from 200 children aged 4 to 18 who can walk with or without help. The goal is to see if AI can accurately predict mobili…

This observational study aims to understand why individuals perceive colours and visual rivalry differently. Researchers will test 128 adults using computer-based tasks to measure colour perception and binocular rivalry (when each eye sees a different image). They will also explo…

This study will use ultrasound to measure the thickness and movement of breathing muscles between the ribs in 65 stroke patients. Researchers will compare the affected and unaffected sides and see how these measurements relate to breathing strength, movement, balance, and quality…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This study investigates why some chronic stroke survivors with slow walking speed improve after high-intensity interval training (HIIT) while others do not. Participants will undergo 12 weeks of supervised cycling sessions, along with MRI brain scans and walking tests before and …

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This observational study will compare dental caries (tooth decay) experiences and quality of life between visually impaired and sighted children aged 6 to 14. Researchers will use a special questionnaire to measure how cavities affect daily life, and will also count decayed, miss…

This study tests whether a wearable sensor (Syde device) can reliably measure arm and hand function in boys with Duchenne muscular dystrophy who can no longer walk. Current tests are done in clinics and may miss small changes. The goal is to see if home-based digital monitoring i…

This observational study will follow 200 women aged 45 to 60 to understand how muscle strength, bone density, body composition, physical activity, sleep, mood, and menopause symptoms relate to overall functional health. Participants will undergo simple strength tests, bone scans,…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This observational study will follow 30 multiple myeloma patients receiving a standard CAR-T therapy called cilta-cel. Researchers will collect blood, bone marrow, and other samples to find biomarkers linked to rare toxicities like nerve damage, blood issues, and gut problems. Th…

This study follows 100 new nurses over time, using non-invasive sleep monitors and questionnaires to track sleep quality, stress, and burnout. Researchers will use AI to see if sleep data can predict which nurses are at risk of burnout or leaving their jobs. No treatments are giv…

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study will measure how different types of transcranial magnetic stimulation (TMS) change brain activity in 250 military veterans with major depressive disorder. Researchers hope to use this information to develop more personalized brain stimulation treatments. Participants w…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study will measure certain proteins in the blood of people who have had a brain hemorrhage (bleeding in the brain) and compare them to healthy volunteers. The goal is to see if these proteins are linked to inflammation after the bleed. No drugs or treatments are being tested…

This study will test two advanced DNA sequencing methods—long-read sequencing and optical genome mapping—to find hidden genetic causes of neurogenetic diseases. Researchers will analyze skin biopsy samples from 304 people aged 6 to 60 who have or may have these conditions. The go…

This study compares a new type of brain scan—watching movie clips during functional MRI (fMRI)—to standard task-based fMRI for mapping language areas in people with brain tumors (gliomas). The goal is to see if the simpler movie-watching method works as well or better for helping…

This trial aims to see if educational videos or audio messages can improve parents' knowledge and practices about retinopathy of prematurity (ROP) screening. About 99 parents of premature infants in Karachi will receive either a video, audio, or standard pamphlet. Their understan…

This study will follow 40 older adults (age 60+) with severe hearing loss who have or will receive a cochlear implant. Researchers want to see if the implant improves social interaction and thinking skills. Participants will fill out questionnaires, wear a small audio recorder fo…

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study examines tumor samples from 100 people diagnosed with primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL), a rare cancer that starts in the brain or spine. Researchers will use advanced genetic and molecular techniques to identify patterns in the …

This study collects a wide range of information from stroke survivors and healthy volunteers, including genetic data, brain scans, electrical brain activity, and thinking and memory tests. The goal is to build a model that can predict which stroke survivors are most likely to dev…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

This study will look at how balance, arm movement, and body awareness are related in 53 people who had a stroke at least 6 months ago. Participants will complete tests like standing on a special platform, reaching tasks, and questionnaires. The goal is to understand these connect…

This study will observe 30 children with type I or type II spinal muscle atrophy who are taking risdiplam. Researchers will track motor function improvements over 24 months using standard tests. The goal is to see how well the drug works in everyday medical practice.

This study compares how well teens with autism spectrum disorder (ASD) drive compared to neurotypical teens. Researchers will use a driving simulator and a real road test to measure errors, visual attention, and anxiety. The goal is to understand differences in driving performanc…

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study looks at how common heart problems are in children with ADHD. Researchers will compare 50 children with ADHD who take medication to 50 healthy children. They will use ECG and echocardiograms to check for heart issues.

This study will test whether using results from a sensory integration assessment can improve counseling for children aged 3-12 with neurodevelopmental problems like sensory sensitivity or coordination difficulties. Researchers will measure changes in sensory processing and daily …

This study explores whether tracking eye movements and arm motions during virtual reality driving tasks can help identify early signs of mild cognitive impairment (MCI) in older adults. Researchers will enroll 192 participants, including healthy young adults, healthy older adults…

This study will implant deep brain stimulation devices in 10 adults with severe, treatment-resistant OCD to record brain activity during approach and avoidance tasks. Researchers will compare clinic-based and at-home recordings to find neural markers of OCD symptoms. The goal is …

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study aims to develop new methods to help veterans with vision loss caused by age-related macular degeneration. About 20 veterans aged 50 and older with reduced vision will take part. Researchers will measure how well they recognize objects and how their brains respond befor…

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

This study will compare how young adults, older adults, and stroke survivors sense small electrical pulses on their skin. Researchers will measure the smallest changes in pulse frequency, strength, and timing that people can detect. The goal is to gather basic information to impr…

This study follows 50 adults with migraines who have had or plan to have a procedure called middle meningeal artery embolization as part of their regular care. Researchers will look at how headache frequency, severity, medication use, and quality of life change over 12 months. Th…

This study will analyze the complete DNA of 1,500 people in Manitoba—some with schizophrenia and some without—to find genetic differences linked to the illness. Researchers will also look at how genes affect medication response and side effects. The goal is to better understand s…

This study looks at whether a tumor's DNA repair status (MMR) changes how well the presence of cancer cells in lymph vessels predicts spread to lymph nodes in stomach cancer. Researchers will review medical records of 3,000 patients who had surgery. The goal is to improve risk as…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study will test the long-standing theory that depression is caused by low serotonin levels in the brain. Researchers will give a single dose of fenfluramine (a drug that releases serotonin) to 46 people—half with depression and half healthy—and use PET brain scans to measure…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study looks at whether a painless ultrasound scan of the sciatic nerve and a blood test for a specific protein can help detect diabetic peripheral neuropathy (nerve damage) earlier than current methods. Researchers will measure nerve size and blood flow in 120 people with ty…

This study tests whether a simple, non-invasive brain test (EEG) can predict which of two common ADHD medications—methylphenidate or amphetamines—works best for a child. About 220 children aged 7-11 with ADHD will try both medicines in a random order over 7 weeks. The goal is to …

This study looks at how the tiny organisms in the gut (the microbiome) are connected to brain development and daily skills in children with autism. Researchers will collect stool samples and measure movement, thinking, and behavior in 600 children aged 3 to 12. The goal is to bet…

This study looks at how dopamine levels affect the ability to keep a steady beat in people with early-stage Parkinson's disease. 34 participants will do simple tapping tasks both on their usual levodopa medication and after skipping it for 12 hours. The goal is to understand whet…

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This study tracks how the experimental drug AZD1390 moves through and leaves the body after a single dose. It involves about 8 adults with advanced solid tumors who are not currently on active cancer treatment. By using a tiny radioactive label, researchers can measure the drug i…

This study explores whether a noninvasive technique called transcranial electrical stimulation can reduce pain and improve quality of life in people with fibromyalgia. Participants receive daily sessions of mild electrical pulses to the scalp over four weeks, targeting different …