New drugs aim to slow muscle decline in duchenne muscular dystrophy

NCT ID NCT07682129

Not yet recruiting Disease control Sponsor: Entrada Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study tests two experimental drugs, ENTR-601-44 and ENTR-601-45, in people with Duchenne muscular dystrophy (DMD) who have already taken part in earlier studies. The goal is to see if long-term use is safe and tolerable, and whether it can help maintain muscle function. Participants receive regular intravenous infusions and undergo tests like blood work, physical exams, and muscle biopsies. The study also tracks changes in walking speed and other physical abilities over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ENTR-601-44 and ENTR-601-45 (intravenous infusions)
What this could lead to: If successful, this could show that long-term treatment with these drugs is safe and may help preserve muscle function in people with Duchenne muscular dystrophy.
What could go wrong: This is an early-phase extension study, so it is small and not designed to prove effectiveness. The drugs may cause side effects or not work as hoped.

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Conditions

The condition(s) this trial relates to.

Duchenne muscular dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUCHENNE MUSCULAR DYSTROPHY (DMD)

Contacts and locations

Locations

Alder Hey Children's NHS Foundation Trust

Liverpool, L122AP, United Kingdom
Centre Hospitalier Régional de la Citadelle

Liège, 4000, Belgium
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore

Roma, 00168, Italy
Fondazione Serena Onlus - Centro Clinico NeMO Milano

Milan, 20162, Italy
Freeman Hospital

Newcastle upon Tyne, NE1 3BZ, United Kingdom
Great Ormond Street Hospital for Children

London, WC1N 3JH, United Kingdom
Hospital Sant Joan de Deu

Barcelona, 08950, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
Leeds General Infirmary

Leeds, LS1 3EX, United Kingdom
Leids Universitair Medisch Centrum

Leiden, 2333 ZA, Netherlands
Ospedale Pediatrico Bambino Gesu

Rome, 00165, Italy
Oxford University Hospitals NHS Foundation Trust

Oxford, OX3 9DU, United Kingdom
Royal Manchester Children's Hospital

Manchester, M13 9WL, United Kingdom
Stichting Radboud Universitair Medisch Centrum

Nijmegen, 6525 GA, Netherlands
UZ Leuven

Leuven, 3000, Belgium
University Hospital Gent

Ghent, 9000, Belgium

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