New study tests simple trick to stop pain after nerve blocks wear off
NCT ID NCT07666009
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving scheduled morphine alongside patient-controlled pain relief can prevent the intense 'rebound pain' that often occurs when a nerve block wears off after orthopaedic surgery. About 100 adults having arm or leg surgery will be randomly assigned to receive either standard patient-controlled morphine or patient-controlled morphine plus fixed-dose slow-release morphine every 12 hours. The main goal is to see if the scheduled doses reduce the worst pain experienced in the first 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- morphine
- What this could lead to
- If it works, this could provide a simple way to prevent severe pain after nerve blocks wear off, reducing the need for extra painkillers.
- What could go wrong
- This is a small, early-stage trial with only 100 participants, so results may not apply to everyone. Adding scheduled morphine may increase side effects like nausea or drowsiness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHUV, Centre Hospitalier Vaudois
Lausanne, Canton of Vaud, 1000, Switzerland
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