Can skipping opioids during surgery improve recovery?
NCT ID NCT07739641
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial asks whether avoiding opioids during general anesthesia can improve recovery quality in women undergoing laparoscopic hysterectomy. It compares an opioid-free approach using dexmedetomidine and ketamine with a standard fentanyl-based anesthesia. The study tracks postoperative pain, nausea and vomiting, and the need for rescue pain medication. Participants are women aged 40-65 scheduled for elective laparoscopic hysterectomy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Opioid-free anesthesia using dexmedetomidine and ketamine, compared to fentanyl-based anesthesia
- What this could lead to
- If opioid-free anesthesia works well, it could offer a way to reduce postoperative nausea and vomiting while managing pain effectively, improving recovery after hysterectomy.
- What could go wrong
- This is a small trial, and results may not apply to all patients. Opioid-free anesthesia might not control pain as well as opioids, and the drugs used have their own side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ain Shams
Cairo, Abbasia, 00202, Egypt
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