Urinary system disorder

This study tested two DNA vaccines designed to prevent hemorrhagic fever with renal syndrome caused by Hantaan and Puumala viruses. A total of 132 healthy adults received up to four doses of vaccine using a needle-free jet injector. The main goal was to see if the vaccines trigge…

This trial tests whether adding specially formulated low-protein foods (FLAVIS products) to a standard low-protein diet helps people with chronic kidney disease (stages 3a-5) better control their protein intake. Participants will be randomly assigned to either a low-protein diet …

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This trial compares three common procedures—mini-PNL, RIRS, and SWL—for treating medium-sized (10-20 mm), dense (over 1000 HU) kidney stones located outside the lower pole. Researchers aim to see which method offers the best stone-free rate, fewest complications, lowest cost, and…

This trial compares two procedures for treating hard, medium-sized kidney stones (10-20 mm) that are not in the lower pole of the kidney. One is mini-PNL, a minimally invasive surgery, and the other is SWL, which uses shock waves to break up stones. The study will randomly assign…

This trial tests whether taking oral sodium bicarbonate to correct metabolic acidosis can slow the buildup of calcium in the blood vessels of people on long-term hemodialysis. The study will include 40 adults who have been on dialysis for over six months and have low bicarbonate …

This trial tests whether a common kidney stone procedure called retrograde intrarenal surgery (RIRS) can be performed safely and effectively without using X-ray guidance. Instead, surgeons rely on direct visualization through a tiny camera. The goal is to reduce radiation exposur…

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 partic…

This study tested whether giving a diuretic (furosemide) during flexible ureteroscopy for medium-sized kidney stones (up to 30 mm) reduces leftover stone fragments. 2000 adults were randomly assigned to receive furosemide or standard care. Stone-free status was checked with a CT …

This trial tests whether spironolactone, a pill already used to protect the heart in other patients, can reduce heart failure and heart-related deaths in people on dialysis. Participants take either spironolactone or a placebo daily. The study aims to see if this treatment is bot…

This phase 2 trial is testing whether colchicine, a drug used for gout, can safely reduce inflammation and potentially lower heart injury in people with advanced chronic kidney disease or on dialysis. Participants take colchicine daily for 16 weeks, starting at a low dose and the…

This trial compares two ways to treat kidney stones in people whose kidneys are shaped or positioned abnormally from birth. One method, retrograde intrarenal surgery (RIRS), uses a thin scope passed through the urinary tract to break up stones with a laser. The other, shockwave l…

This pilot study tested whether a multicultural anti-inflammatory diet is practical and acceptable for racial/ethnic minorities with chronic kidney disease (CKD). Researchers enrolled 18 adults with stage 3 CKD in the Bronx, providing dietary counseling tailored to each person's …

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This phase II trial is testing whether combining the targeted drug ixazomib with two chemotherapy drugs (gemcitabine and doxorubicin) can shrink tumors or stop them from growing in patients with a rare and aggressive kidney cancer called renal medullary carcinoma. The study enrol…

This trial tests whether obinutuzumab, a next-generation antibody, can help people with membranous nephropathy—a kidney disease that causes protein leakage and swelling—who haven't responded well to the standard drug rituximab or who can't take it due to allergic reactions. About…

This trial tests whether lanthanum carbonate, a drug typically used to bind phosphate, can also reduce oxalate levels in urine. People with secondary hyperoxaluria and a history of kidney stones take the drug with meals for 28 days, with the dose increasing after two weeks. The g…

This trial tests two different concentrations of citrate solution used to prevent blood clotting during continuous kidney replacement therapy in critically ill patients with acute kidney injury. The goal is to see which concentration leads to fewer metabolic complications, such a…

This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see …

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This trial tests an experimental oral drug called EVER001 in people with primary membranous nephropathy, a kidney disease where the immune system damages the kidney's filtering units, causing protein to leak into urine. The study aims to see if EVER001 can reduce proteinuria and …

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study looks at the best time to add the drug vasopressin for people with septic shock—a life-threatening drop in blood pressure from infection. About 2,050 adults will be treated using either an earlier or later threshold for starting vasopressin. The goal is to see which ap…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This trial tests whether giving a single dose of cyclosporine A to deceased organ donors before their kidneys are removed can reduce the chance of delayed graft function in recipients. Delayed graft function means the kidney does not start working right away, often requiring dial…

This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as …

This trial tests whether a combination of everolimus and low-dose tacrolimus is better than the standard tacrolimus plus mycophenolate mofetil at preventing serious long-term complications in children who have had a heart transplant. The study will follow 211 participants from 25…

This trial is testing whether adding an experimental drug called HBI-8000 to the immunotherapy nivolumab can safely control advanced melanoma, kidney cancer, and non-small cell lung cancer. The study enrolls adults whose cancers have not responded to prior treatments. Researchers…

This pilot study is testing whether a rapid, timed sequence of different drugs can improve outcomes for people with advanced or inoperable clear cell kidney cancer. Participants first receive cabozantinib, then a combination of two immunotherapies (ipilimumab and nivolumab), foll…

This trial tests whether febuxostat, a drug that lowers uric acid, can slow the progression of chronic kidney disease and reduce thickening of the carotid artery wall. Adults with moderate-to-severe kidney disease and high uric acid levels will take febuxostat or standard care fo…

This trial tests whether a structured nurse-led education program can improve how hemodialysis patients approach diet therapy, self-care, and chronic disease self-management. Sixty adults on maintenance hemodialysis are randomly assigned to either the eight-session program or usu…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial investigates whether daily pumpkin seed oil supplements can reduce inflammation, oxidative stress, and unhealthy blood fats in people undergoing hemodialysis. Researchers will compare a group taking the oil with a group that does not, measuring markers like interleukin…

This trial compares two immunosuppressive regimens in CMV-positive kidney transplant recipients. One group receives everolimus with a reduced dose of cyclosporine A, while the other gets standard mycophenolic acid with full-dose cyclosporine. The goal is to see whether the everol…

This trial tests an experimental drug called HRS-5965 in people with primary IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug can reduce protein leakage in the urine, a sign of kidney damage. About 123 adults with confirmed IgA nep…

This trial tests whether a belatacept-based immunosuppressive regimen, combined with either alemtuzumab or rabbit antithymocyte globulin (rATG) and early steroid withdrawal, can reduce the risk of graft loss, death, or poor kidney function after a kidney transplant. The study com…

This trial tests a modified surgical approach for removing bladder tumors that are 3 centimeters or larger. The technique first removes the outer part of the tumor in pieces, then removes the base in one piece. The goal is to see if this method leads to complete tumor removal and…

This trial investigates whether drinking fig leaf tea twice a day for 8 weeks, along with a low-glycemic diet, can help protect kidney function in adults with type 2 diabetes and stage 2 chronic kidney disease. Researchers will measure changes in blood sugar, cholesterol, and kid…

This study looked at whether a high-protein drink with added curcumin (a compound from turmeric) could lower inflammation and oxidative stress in adults on hemodialysis for advanced kidney disease. 39 participants were randomly assigned to receive either the curcumin drink or a p…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. About 900 participants took part. The goal was to s…

This study investigates whether taking vitamin E supplements, at 200 mg or 400 mg per day, can reduce calcium oxalate crystals in people with kidney stones. Participants continue their usual medications while adding vitamin E. The goal is to see if this antioxidant can help manag…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This trial evaluates the Bitrack robotic system, designed to assist surgeons during laparoscopic kidney removal (partial or total) and prostate removal. The study includes 15 adults scheduled for these surgeries. The goal is to check if the robot works safely and effectively, as …

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This trial tests an experimental drug called enfortumab vedotin, which is designed to seek out and destroy cancer cells that have a specific protein called Nectin-4 on their surface. The study includes people with metastatic urothelial cancer (a type of bladder cancer) and other …

This study tests whether starting haemodialysis with fewer sessions per week (twice instead of the standard three times) can help preserve patients' remaining natural kidney function. New dialysis patients who still have some kidney function are randomly assigned to either standa…

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This study tests whether the drug tolvaptan can safely bring sodium and water levels back to normal in people with low blood sodium (hyponatremia). Participants take a daily tablet or a placebo for a set period. The trial focuses on patients whose hyponatremia is due to excess bo…

This phase 2 trial tests felzartamab (MOR202), an antibody that targets CD38 on plasma cells, in people with membranous nephropathy who did not improve with rituximab or similar therapies. The goal is to reduce protein leakage in urine and achieve remission of nephrotic syndrome.…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This early-stage trial tests an experimental antibody called JS004, which targets a protein on immune cells called BTLA, to see if it can help the immune system fight advanced solid tumors like melanoma, kidney cancer, and bladder cancer. The study includes JS004 alone or combine…

This study tests whether eating a special kidney-friendly meal during hemodialysis affects how well the treatment works and how tired patients feel. Adults on maintenance dialysis will receive the meal during one period and no food during another, acting as their own control. Res…

This phase 2 trial tests an experimental drug called LDP, an anti-PD-L1 monoclonal antibody that helps the immune system attack cancer cells. It enrolls adults with muscle-invasive bladder cancer, non-clear cell kidney cancer, or advanced penile cancer. Participants receive LDP i…

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This phase II trial tests the drug lenalidomide (CC-5013) in people with advanced or inoperable kidney cancer. Lenalidomide works by cutting off blood flow to tumors, which may stop or slow their growth. The study aims to see how many patients respond to treatment and what side e…

This phase 2 trial is testing a new drug called cadonilimab (AK104), either alone or combined with axitinib, as a first treatment for advanced or metastatic kidney cancer. The study includes two parts: one testing different doses of cadonilimab alone in various kidney cancer type…

This study tests whether a 3-month nurse-led program can reduce frailty and improve self-management in people undergoing peritoneal dialysis. The program includes personalized assessments, education, exercise training, and social support. Researchers compare this program to stand…

This trial compares two surgical techniques for removing kidney stones that are 2 to 4 centimeters in size. The newer method, called suction mini-PCNL, uses a smaller tube and suction to remove stone fragments, while the standard method uses a larger tube. The goal is to see if t…

This study looked at two drugs, mirabegron and oxybutynin, in 52 children over age 3 who had surgery for posterior urethral valves. The goal was to see which drug better improves bladder and kidney function and reduces urinary tract infections. Researchers also checked safety by …

This study tested whether adding balcinrenone to the standard drug dapagliflozin helps people with chronic kidney disease more than dapagliflozin alone. 324 adults with kidney disease and protein in their urine took either a combination pill or dapagliflozin alone for 12 weeks. R…

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced urinary tract cancer live longer. 506 patients with cancer that had spread or could not be removed by surgery took part. The study compar…

This study looks at whether a new method of measuring parathyroid hormone (PTH) can help doctors better manage calcium and phosphate levels in people on hemodialysis. About 80 patients with end-stage kidney disease will be randomly assigned to have their PTH measured either with …

This large phase 3 trial tested whether taking sorafenib or sunitinib after kidney cancer surgery could prevent the cancer from coming back. Nearly 2000 patients participated. Unfortunately, neither drug improved disease-free survival compared to a placebo, and they caused side e…

This completed Phase 4 trial tested two drugs—dapagliflozin and spironolactone—alone and together in 12 adults with Alport syndrome, a genetic kidney disease. The goal was to see if these drugs could lower protein levels in urine, a key sign of kidney damage. Participants took ea…

This early-phase study tested whether stem cells taken from a patient's own urine (called KDSTEM Inj.) are safe for people with chronic kidney disease. Six participants received low or high doses of the cells through an IV. The main goal was to check for side effects, while also …

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested a combination of two experimental treatments for people with advanced kidney cancer that cannot be removed by surgery. The first is Pexa-Vec, a modified virus designed to infect and destroy cancer cells while also boosting the immune system. The second is cemipl…

This pilot study tested whether adding the anti-inflammatory drug celecoxib (Celebrex) to standard chemotherapy before bladder cancer surgery is safe and affects tumor genes. 22 people with muscle-invasive bladder cancer took part. The goal was to see how the treatment changed ca…

This study evaluates the long-term safety and effectiveness of Advantage® strips, a type of surgical tape, for treating stress urinary incontinence in women. Researchers are reviewing the medical records of 500 women who received the strip between 2012 and 2015, with an average f…

This study tested a new drug called BION-1301 in 103 healthy volunteers and adults with IgA nephropathy, a kidney disease. The main goal was to check the drug's safety and how the body processes it. Researchers measured side effects, blood pressure, and kidney function over time.

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study compares two dialysis filters, SOLACEA-H and HYDROLINK-NVU, to see if SOLACEA-H can allow dialysis sessions with less or no blood thinner (heparin). The trial involves 20 adults who have been on dialysis for at least 3 months and are medically stable. Each participant …

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study tested a new drug called XH-S003 in 25 adults with IgA nephropathy, a kidney disease. The goal was to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage, after 90 days. Participants had to have a kidney biopsy confirming the disease. T…

This study tested whether face-to-face nutrition education about potassium could help people on maintenance hemodialysis control their potassium levels. Fifty adult patients with high potassium took part. The goal was to reduce complications and improve quality of life.

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This study looked at whether giving kidney transplant patients a lower dose of the drug cyclosporine could protect their kidney function over time. 208 patients who were at least one year post-transplant and on stable medications took part. The goal was to balance preventing orga…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study tested whether transplanting healthy gut bacteria (washed microbiota transplantation) could help people who get frequent urinary tract infections (UTIs). Thirty adults with recurrent UTIs received the treatment through a tube into the gut. Researchers tracked how many …

This study looked at 120 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special method called sodium profiling dialysis to standard dialysis to see if it helped keep blood pressure stable and reduced fluid buildup in the lun…

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study looked at how well the Ellipsys Vascular Access System works for creating arteriovenous (AV) fistulas in people with end-stage kidney disease who need dialysis. A total of 142 patients were followed for 12 months to see how long the access stayed open and how safe the …

This study tested whether a probiotic supplement could change gut bacteria and reduce harmful antibodies that damage kidneys in IgA nephropathy. 18 adults with the disease took probiotics for 3 months. Researchers measured changes in antibody levels and kidney function to see if …

This study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …

This study tested a plant-based tablet called PH3 in 100 adults with diabetic nephropathy (kidney damage from diabetes). The goal was to see if PH3 can safely reduce protein in the urine, a sign of kidney stress, over 24 weeks. Researchers also looked at the best dose to use in f…

This study tested eculizumab in 25 adults with PNH in China who had not previously taken complement inhibitors. Participants received infusions over 62 weeks. The main goal was to see if the drug reduced LDH levels, a marker of disease activity. Results showed a decrease in LDH, …

This study tested a new drug called sacituzumab govitecan against standard treatments in 711 people with advanced bladder cancer that had spread or couldn't be removed. The goal was to see if the new drug helped people live longer. Participants received either the new drug or a t…

This study tested whether finerenone, a drug that blocks a hormone involved in kidney damage, can reduce protein in urine and slow kidney function decline. One hundred adults with non-diabetic glomerulonephritis took either finerenone or a placebo for 9 months, on top of their us…

This study tested whether a smart app called Weiyin Health could improve follow-up care for 223 adults on peritoneal dialysis for kidney failure. One group used the app for reminders, AI questions, and risk alerts, while the other got standard care via WeChat and phone calls. The…

This study tested a tailored lifestyle counseling program for 120 adults with early-stage chronic kidney disease (CKD). Participants received personalized advice based on their readiness to change, focusing on diet, exercise, and kidney health knowledge. The goal was to see if th…

This study tested a new drug called HSK39297 in 87 adults with IgA nephropathy, a kidney disease. The goal was to see if the drug could lower protein levels in urine, a sign of kidney damage, compared to a placebo. Participants took the drug or placebo for up to 24 weeks, and res…

This study tested a new drug called XTX202 in 95 people with advanced solid tumors that had not responded to standard treatments. The goal was to check safety, find the right dose, and see if the drug could shrink tumors. The trial is now complete.

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This phase 3 trial compared a combination of two immunotherapy drugs (nivolumab and ipilimumab) against the standard drug sunitinib in over 1,000 people with untreated advanced or metastatic kidney cancer. The study measured how well the tumors shrank, how long patients lived wit…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study tested a new way to treat muscle-invasive bladder cancer by tailoring therapy based on each patient's tumor genetics. After initial chemotherapy, patients with a good response could avoid bladder removal and instead opt for active monitoring or less invasive treatments…

This early-stage trial tested a drug called belzutifan in 29 people with advanced clear cell kidney cancer that had worsened after other treatments. The main goal was to check safety and find the right dose. Participants took belzutifan pills daily, and researchers monitored side…

This Phase 3 trial tested whether combining pembrolizumab (an immunotherapy) with epacadostat (a drug that boosts the immune response) works better than standard drugs (sunitinib or pazopanib) for people with advanced kidney cancer that hasn't been treated before. The study enrol…

This study tests a new drug called SHR6508 in 303 adults on hemodialysis who have secondary hyperparathyroidism, a condition where parathyroid hormone levels get too high. The drug is given as an injection to help control these hormone levels and related minerals like calcium and…

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

This study tested whether a daily supplement called Avmacol Extra Strength, which contains sulforaphane from broccoli seeds, can slow kidney disease progression in people with stage 3 or 4 chronic kidney disease. The trial enrolled 96 adults and compared the supplement to a place…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This study tested a special stent called MEMOKATH 051 in 13 adults with long-term ureter blockages who usually need a standard double J stent. The goal was to see how long the new stent lasts and how well it is tolerated over 3 years. Participants had the new stent placed during …

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This study tested whether giving tranexamic acid, a drug that helps blood clot, through a vein and in surgical fluid can reduce bleeding during kidney stone removal. 90 adults with large kidney stones were randomly assigned to receive the drug or a placebo. The goal was to see if…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study compared two types of surgery to remove the bladder in people with bladder cancer: one done with a robot and one done as open surgery. About 339 patients took part across multiple hospitals. The main goal was to see which approach let patients spend more days at home a…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This early study tested an experimental drug called OMS906 (zaltenibart) in 15 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease where red blood cells break apart. The main goal was to check safety and how the body handles the drug. Researchers also look…

This study tested a new way to monitor kidney oxygen levels during liver surgery to try to prevent acute kidney injury (AKI). 80 adults having liver surgery were randomly assigned to either standard care or extra monitoring that triggered a step-by-step treatment plan if oxygen l…

This study tested whether adding an immunotherapy drug (nivolumab) to a targeted therapy (tivozanib) helps people with advanced kidney cancer live longer without their cancer growing. The trial included 343 adults whose cancer had worsened after one or two prior treatments, inclu…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This study followed 120 adults with paroxysmal nocturnal hemoglobinuria (PNH) who switched from the older drug eculizumab to the newer ravulizumab. Researchers measured changes in a blood marker called LDH to see if the new drug controlled red blood cell breakdown just as well or…

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel hardening took part. Each person used a standard fluid for 12 months and a citrate fluid for anoth…

This study tested an experimental drug, ziltivekimab, in 36 adults with advanced chronic kidney disease (not on dialysis) to see if it can safely reduce inflammation and related heart risks. Participants received either a low dose, a high dose, or a placebo injection every 4 week…

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney …

This trial tested a combination of two drugs—axitinib (a standard kidney cancer drug) and seleniomethionine (a form of selenium)—in 45 adults with advanced clear cell renal cell carcinoma that had spread. The goal was to find the safest dose and see if the combination could shrin…

This study tested a device called Break Wave™ that uses focused ultrasound waves to break kidney stones into tiny pieces that can pass naturally. 64 adults with upper urinary tract stones (4-10 mm) received the treatment. The goal was to see if the device is safe and effective at…

This early-phase study tested a new drug, HBM1020, in 17 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The drug was given by IV every three weeks. Because this is a Phase 1 trial, i…

This early-phase trial tested the safety of a new drug called VIS649 in 51 healthy volunteers. VIS649 is an antibody that blocks a protein called APRIL, which is thought to play a role in IgA nephropathy, a kidney disease. The study gave single doses of the drug or a placebo and …

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This phase 3 trial tested a drug called imlifidase in 64 highly sensitized kidney transplant patients who had almost no chance of finding a compatible donor. The drug breaks down harmful antibodies, allowing a transplant from a donor that would normally be rejected. The study mea…

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at whether a 12-week program of exercise, a protein-controlled diet, and education could improve health in people with early-stage kidney disease (stages G1 and G2). Fifteen participants completed the program. Researchers measured changes in cholesterol, muscle …

This study tested a new tool called the CVAC System, a steerable catheter that helps remove kidney stones during a procedure called ureteroscopy. Thirty adults with kidney stones took part. The main goal was to see how safe the device is and how well it clears stones, measured by…

This Phase 2 trial tested a drug called felzartamab in 54 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The drug targets immune cells to reduce protein leakage in urine, a sign of kidney damage. The study compared felzartamab to a placebo to see i…

This study looked at whether taking a prebiotic fiber (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 patients were randomly assig…

This study tested whether a 6-month program of plant-based diet, home exercise, medication management, and behavioral counseling could improve physical function in 42 adults with stage 3-4 chronic kidney disease. Participants were randomly assigned to the lifestyle program or usu…

This study tested a new treatment for people with advanced clear cell kidney cancer that had spread and stopped responding to standard therapies. Six adults received four injections of a radioactive drug (177Lu-PSMA-1) that targets cancer cells. The goal was to check safety and s…

This study tested a new drug called VIS649 in 155 adults with IgA nephropathy, a kidney disease. The goal was to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo, and researchers monitored sid…

This study tested whether baricitinib, a drug used for arthritis, can safely reduce high protein levels in the urine of African American adults with a specific genetic form of kidney disease (APOL1). Eight participants took the drug to see if it lowered their urine protein and pr…

This phase 2 study tested a drug called pegcetacoplan in 13 kidney transplant patients whose original kidney disease (C3G or IC-MPGN) had come back. The goal was to see if the drug could reduce signs of disease activity in the kidney. The study was small and early-stage, so resul…

This Phase 3 trial tested whether sparsentan, a drug that blocks two pathways involved in kidney damage, can better protect kidney function than the standard treatment irbesartan in people with focal segmental glomerulosclerosis (FSGS). The study enrolled 371 adults and children …

This study tested whether methylene blue, a dye that affects blood vessel function, can prevent dangerous drops in blood pressure during kidney dialysis. It involved 261 critically ill adults with acute kidney injury who needed dialysis. The goal was to see if the treatment could…

This early-phase study tested two immunotherapy drugs (spartalizumab and canakinumab) given before surgery to 17 people with localized clear cell kidney cancer. The main goal was to see if this approach was safe and did not delay surgery. The study also looked at how the drugs af…

This study tests whether taking a daily alpha lipoic acid supplement can reduce the return of cystine kidney stones in people with cystinuria. Half of the 50 participants will take 1200 mg of the supplement daily for three years, and the other half will take a placebo. The main g…

This phase 2 trial tested the drug sunitinib in 21 patients with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors by blocking blood flow and cell growth. Researchers measured how many patients had a response after two treatment…

This study tested whether taking probiotics or synbiotics (probiotics plus fiber) for 6 months could improve health in 60 adults with kidney failure on dialysis. Researchers measured changes in blood toxins, heart health, quality of life, and thinking ability. The goal was to see…

This study tested a special dialysis fluid called icodextrin in 439 adults with chronic kidney failure who use peritoneal dialysis at home. The goal was to see if it works better than standard glucose solutions for overnight exchanges and to check for side effects. Researchers tr…

This study compared two surgical techniques for removing early-stage bladder tumors: a new laser method (holmium laser en-bloc resection) and the standard approach (conventional transurethral resection). 100 adults with suspected non-muscle-invasive bladder cancer were randomly a…

This phase 1 trial tested a new treatment called urinary microbiota transplantation (UMT) for people with cystitis glandularis, a chronic bladder condition often linked to pelvic lipomatosis. The treatment involves placing processed donor urine bacteria into the bladder. After on…

This study tested a new type of urinary catheter coated with copper nanoparticles to see if it could lower the risk of urinary tract infections in hospitalized adults. 256 patients who needed a catheter for a long time took part. The goal was to compare this new catheter to stand…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This Phase 3 trial tested whether lanreotide, a drug that blocks certain growth hormones, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Participants received ei…

This early-phase trial tested the safety of combining two drugs—L-NMMA and pembrolizumab (Keytruda)—in 12 adults with various advanced cancers. Pembrolizumab helps the immune system recognize cancer cells, while L-NMMA may remove a chemical barrier that blocks immune attack. The …

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested whether levocetirizine, an allergy medication, can reduce protein leakage in the urine of people with diabetic kidney disease. The trial enrolled 60 adults aged 40-65 with type 2 diabetes and early kidney damage. Researchers measured changes in albuminuria to se…

This completed Phase 4 trial tested the drug atorvastatin (Lipitor) in 100 children aged 8-18 with steroid-sensitive nephrotic syndrome and high cholesterol. The goal was to see if the drug safely lowers cholesterol to healthy levels within 3 to 6 months. The study compared atorv…

This study looked at the long-term safety of pegunigalsidase alfa, an enzyme replacement therapy, in 97 adults with Fabry disease. Participants received the drug intravenously every two weeks for up to several years. The main goal was to track side effects and see how well the dr…

This study is testing whether a new urine analysis device, the Sysmex UF-5000, can accurately measure inflammation markers in healthy men. The goal is to establish a baseline for what's normal, which could help develop a quick, non-invasive test for urethritis, a common infection…

This study tests whether a non-invasive light-based monitor, called near-infrared spectroscopy (NIRS), can detect kidney injury early in newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. The monitor measures oxygen levels in the kidneys and b…

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This study tests whether a non-invasive ultrasound measurement called the renal resistive index (RRI) can predict if acute kidney injury (AKI) will progress to a severe stage in intensive care unit (ICU) patients. Researchers will measure RRI in 120 adults with early-stage AKI wi…

This study tests whether a furosemide stress test can predict if acute kidney injury will get worse in ICU patients. Researchers will give furosemide to 140 patients and measure urine output over 2 hours. The goal is to see if the test can identify who will need dialysis, helping…

This study tested whether an electronic stethoscope can help doctors detect narrowing (stenosis) of the arteriovenous fistula in hemodialysis patients. Researchers collected sound recordings from 30 adults on long-term dialysis over 3 months. The goal was to see if the device cou…

This completed study tested whether a special type of MRI (multiparametric MRI) can accurately tell the difference between benign and malignant small kidney tumors. About 387 adults with small solid kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal was to s…

This early-phase trial tested a radioactive tracer called Tc-99m-Tilmanocept to see if it can help doctors detect diabetic kidney disease using SPECT/CT scans. The study involved 57 adults with suspected diabetic kidney disease. The goal was to measure how the tracer behaves in t…

This study tests a new MRI method to see if the bladder lining is leaky in people with Interstitial Cystitis (IC), a chronic bladder pain condition. Participants receive a single MRI after contrast dyes are placed into the bladder through a catheter. The goal is to distinguish be…

This study tests whether a quick urine measurement after a single dose of furosemide (a water pill) can predict which ICU patients with low albumin levels will develop severe acute kidney injury. Researchers will compare this test to blood biomarkers to see which is more accurate…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study looked at whether functional MRI can accurately measure kidney function in children with pyelo-ureteral junction syndrome, a common urinary blockage. Researchers compared MRI results to the standard scintigraphy scan in 270 children aged 0-17. The goal was to see if MR…

This study tested whether an ultra-low-dose CT scan, combined with a deep-learning AI reconstruction, can accurately detect urinary tract stones. 62 adults with known or suspected kidney stones received both a standard low-dose CT and an additional ultra-low-dose scan (less than …

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether the Nephrocheck™ device can predict if early acute kidney injury will reverse within 72 hours in patients with septic shock. Researchers enrolled 184 adults in the ICU and measured the device's accuracy. The goal is to help doctors decide who might recov…

This study tested whether analyzing urine with a special light technique (spectroscopy) can accurately detect bladder cancer. Researchers collected urine samples from 899 people undergoing cystoscopy. The goal was to see if the light patterns could tell apart those with cancer fr…

This study tested whether a special type of MRI, called perfusion MRI, can help doctors find and diagnose kidney tumors more accurately. 75 people with kidney cancer or suspected kidney tumors took part. The goal was to see if this imaging method could predict tumor type and how …

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study tested how well a special MRI scan (called multiparametric MRI) can tell if bladder cancer has grown into the muscle layer of the bladder. Researchers used a scoring system called VI-RADS to interpret the scans. The study included 60 people with bladder masses who were…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part across multiple hospitals. Researchers measured how well the questionnaire predicted kidney prob…

This study looked at whether a special light-based monitor (near-infrared spectroscopy) placed on the skin can help predict kidney injury after heart surgery. Researchers measured oxygen levels in the kidneys of 113 adults during surgery and checked if low levels were linked to l…

This study tested whether a simple breath test can predict if cancer patients will respond to immunotherapy drugs. Researchers used an electronic nose device to analyze breath samples from 190 patients with lung, melanoma, kidney, bladder, or head and neck cancers. The goal is to…

This study looked at whether a urine test called Cxbladder can accurately detect bladder cancer in 682 people who had blood in their urine. The test's results were compared to the standard method, a camera exam of the bladder (cystoscopy). The goal was to see if the urine test co…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study tested whether taking a specific probiotic (Lactobacillus crispatus M247) along with another probiotic blend could help prevent repeat urinary tract infections (UTIs) in women. 84 women with a history of frequent UTIs took either the probiotic combo or a standard probi…

This trial is testing whether an oral probiotic supplement, MetProrenes, can safely reduce the risk of kidney stones in adults who have had recurrent stone-related colicky pain. About 14 participants will take the supplement twice a day, and researchers will measure changes in pa…

This trial tests whether screening for chronic kidney disease (CKD) in trusted community settings, like churches, can identify people with early kidney damage who don't yet have symptoms. Participants are adults aged 18-70 without known kidney disease who attend community health …

This study looks at whether giving L-Arginine soon after heart surgery that uses a heart-lung machine can lower the chance of acute kidney injury. It will follow over 5,000 adults in the intensive care unit after their operation. The goal is to see if this simple amino acid might…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the pas…

This study tested whether adding tactile (touch) feedback to pelvic floor muscle training helps prevent stress urinary incontinence in pregnant women. 141 women in their third trimester were assigned to routine education, standard pelvic floor exercises, or exercises with hands-o…

This study tested whether a program to help people drink more water could prevent kidney stones from coming back. Over 1,600 adults and children who had a kidney stone in the past used a smart water bottle to track their intake, with some getting financial rewards for meeting the…

This study tested whether D-mannose, a natural sugar, can prevent urinary tract infections (UTIs) in people who need a catheter for a long time. Nineteen participants with recurrent UTIs were followed to see if D-mannose reduced the number of infections needing treatment. The goa…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested whether pentoxifylline, a drug that improves blood flow, can prevent kidney damage caused by contrast dye used in medical imaging. The trial included 70 adults with chronic kidney disease who were in the intensive care unit and needed contrast dye. Researchers m…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This trial tests whether pelvic floor muscle exercises, progressive muscle relaxation, or a combination of both can improve comfort in women with stress urinary incontinence—a condition causing urine leakage during activities like coughing or laughing. Women aged 45-55 with this …

This trial tests whether virtual reality exercise games or electrical muscle stimulation can reduce shoulder pain and improve movement in people with chronic kidney disease who are on dialysis. Participants will receive one of the two therapies several times a week for eight week…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This trial tests whether a physical therapy technique called Muscle Energy Technique (MET) can reduce restless legs syndrome in people with end-stage kidney disease who are on hemodialysis. Participants receive either routine dialysis care or the same care plus MET during their d…

This study tested whether giving patients a mobile app with educational information before kidney stone surgery could reduce their anxiety, fear, pain, and time in the hospital. 68 adults scheduled for surgery were randomly assigned to either receive the app or standard care. Res…

This trial tests whether a nerve block called the erector spinae plane block can better control pain during extracorporeal shock wave lithotripsy (ESWL), a common procedure to break up kidney stones. Sixty adults with 2-3 cm kidney stones will receive either the nerve block or a …

This trial investigates whether high-intensity magnetic stimulation, combined with pelvic floor muscle training, can reduce urge urinary incontinence in postmenopausal women aged 50 to 55. Participants receive either magnetic stimulation plus Kegel exercises or Kegel exercises al…

This trial tests whether adding electromyographic (EMG) biofeedback to pelvic floor muscle training can improve bladder control in women with wet overactive bladder. Participants receive either bladder training alone or bladder training plus 24 supervised biofeedback sessions ove…

This trial tests whether a guided exercise program done during hospital hemodialysis sessions can improve physical capacity and quality of life in adults with chronic kidney disease. Participants will perform strength and balance exercises for their arms and legs while receiving …

This trial tests whether a sacral neuromodulation device programmed to cycle on and off (8 hours on, 16 hours off) works as well as continuous stimulation for women with overactive bladder. Participants who have already had a successful trial of the device will be randomly assign…

This study compares two types of exercise programs for married women receiving long-term hemodialysis for kidney failure. One group exercises during dialysis sessions, while another follows a home-based routine. The goal is to see if either approach improves quality of life, self…

This pilot study tested an optimized dialysis technique using a special membrane and biofeedback software to see if it helps kidney failure patients recover faster after treatment. 18 patients on standard dialysis who took at least 4 hours to recover were observed. The study meas…

This study compares a new handle design for the Uresta pessary to the current one in women with stress urinary incontinence. Participants who already use the Uresta will try both handle designs and fill out questionnaires rating their experience. The goal is to see if the new han…

This study tests whether wearing virtual reality glasses and watching a calming nature video during hemodialysis can help lower anxiety and keep vital signs stable. Researchers are enrolling 56 adults who are receiving dialysis for the first time. Half will watch a 4K nature vide…

This study tests whether an ultrasound-guided nerve block (erector spinae plane block) can reduce pain and the need for morphine after percutaneous nephrolithotomy, a surgery to remove large kidney stones. Fifty-six adults undergoing elective surgery will be randomly assigned to …

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This study investigates whether acupuncture can relieve symptoms and improve quality of life in women diagnosed with treatment-resistant interstitial cystitis/bladder pain syndrome. Participants receive eight sessions of acupuncture over four weeks at specific points on the body.…

This study tested whether listening to music and applying acupressure before needle insertion can reduce pain in dialysis patients. 72 participants were split into four groups: music plus acupressure, acupressure alone, music alone, or standard care. Pain was measured during thre…

This study tests whether a non-invasive device that sends mild electrical pulses to nerves in the neck can reduce restless legs syndrome in people undergoing dialysis. Thirty-six adults aged 40-50 will receive either real or sham stimulation three times a week for four weeks. Res…

This study looked at two different strengths of the numbing medicine bupivacaine used in a nerve block for pain after kidney stone surgery. Sixty adults having the surgery received either a 0.25% or 0.375% concentration. Researchers measured their pain levels, how much extra pain…

This study tested whether briefly stopping a patient's breathing during kidney stone laser surgery could make stone removal more efficient by reducing kidney movement. 150 adults with kidney stones were randomly assigned to normal breathing, low-volume breathing, or a short breat…

This study tested whether listening to live or recorded music during dialysis can reduce pain, itch, anxiety, and depression. 102 adults on dialysis took part. They had one week of normal dialysis for baseline data, then a week with live music, then a week with recorded music. Re…

This study tested whether a structured education program could help people on dialysis manage chronic itch and improve their quality of life. 104 adults with kidney failure and itch took part, receiving either two educational sessions or standard care. The program focused on unde…

This study tested whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Thirty-six adults on dialysis for at least six months were split into an exercise group and a usual-care group. …

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a device that uses ultrasound to help guide needles into the blood vessels of people with end-stage kidney disease who need dialysis. Ten adults with an arteriovenous fistula or graft took part. The main goal was to see if the device could help place needles suc…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study compared two ways to remove kidney stones smaller than 20 mm: shock wave lithotripsy (ESWL) and ultra-mini surgery (PCNL). 138 adults aged 20-60 with a single stone in the kidney pelvis took part. The main goals were to see which method cleared stones better and which …

This study looked at 40 infants under 1 year old having kidney surgery. They received a pain block with either bupivacaine alone or bupivacaine plus ketamine. The goal was to see if adding ketamine reduces pain and the need for extra pain medicine after surgery.

This study tested whether teaching children aged 9-12 how to manage their time during haemodialysis can reduce their anxiety and fear. Twenty children were split into two groups: one received the training, the other got usual care. Researchers measured anxiety and fear levels bef…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested three different fluids used during shock wave treatment for kidney stones: plain water, normal saline, and saltier water. The goal was to see which fluid breaks stones best with the least pain and skin problems. 294 adults with kidney stones took part.

This completed early-phase trial tested whether low-intensity shockwave therapy (Li-ESWT) can ease symptoms of radiation cystitis, a painful bladder condition from pelvic radiation. Twenty-five adults who had radiation at least six months prior were enrolled. The study compared s…

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study looked at 131 people having surgery for kidney stones. Some were already taking mirabegron for overactive bladder, which relaxes the ureter. Researchers wanted to see if this helped surgeons insert a tube more easily and caused less injury. The idea is that a relaxed u…

This study compared two surgeries—PCNL and RIRS—for removing kidney stones that are 1-2 cm in size. Researchers wanted to see if the stone's location in the kidney affects which surgery works best. 110 adults took part, and the main goal was to see how many people were stone-free…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study compared two FDA-approved lasers used to break up kidney stones during surgery: the newer SOLTIVE Thulium Fiber Laser and the standard Ho:YAG laser. About 100 adults with a single stone smaller than 2 cm took part. Researchers measured how well each laser cleared stone…

This study tested whether using a 3D model of a patient's kidney before surgery could shorten the time needed for robotic-assisted partial nephrectomy (removing a kidney tumor). 370 adults with small kidney tumors took part. The goal was to see if better planning with 3D imaging …

This study tested whether a 16-week program of cycling during dialysis sessions could improve heart function in 30 adults with kidney failure and early signs of heart stiffness. Participants first received standard care for 16 weeks, then added supervised cycling during dialysis …

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study looked at two methods for removing kidney stones: laser dusting (breaking stones into tiny pieces that pass naturally) and basket extraction (using a small wire basket to remove fragments). Researchers compared how well each method cleared stones, how much pain patient…

This study tested a smartphone app designed to help women with urinary incontinence reduce leakage episodes and improve quality of life. About 194 women used the app or received standard care for 12 weeks. The goal was to see if the app could cut incontinence episodes in half.

This study tested whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the main goal was to see if the fistula diameter increased. The approach is sim…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This study tested a modified Single-J ureteric stent designed to cause less discomfort than the standard Double-J stent after kidney stone surgery. 28 adults who already had a stent placed before surgery received the modified stent during their procedure. Researchers compared sym…

This early-phase trial tested whether a nutritional supplement called Impact Advanced Recovery® could help men recover better after bladder cancer surgery. Thirty men took the drink before and after their operation. The goal was to see if it reduced surgical complications, infect…

This study looked at whether two drugs, mirabegron and montelukast, are safe and helpful for people with liver cirrhosis who also have overactive bladder and asthma. 78 participants took part over 3 months. Researchers tracked bladder symptoms, breathing issues, and side effects …

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study looked at 184 women with stress urinary incontinence who had a single-incision sling surgery. Researchers compared two sling insertion angles—one acute and one standard—to see which led to better cure rates and quality of life at 6 months. The goal is to find the best …

This study follows adults receiving maintenance hemodialysis for end-stage kidney disease to develop a model that predicts the risk of dying from cardiovascular disease. Researchers will track routine lab results, including how often blood phosphate levels stay in a target range,…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

This study looks back at 250 patients who had surgery to widen a narrowed urethra using a graft from the inside of the cheek. The goal is to identify factors that predict whether the narrowing will return. Researchers will review medical records from the past 10 years, focusing o…

This study looks at thousands of Chinese adults aged 60 and older to understand how kidney function changes with age. Researchers are examining a range of blood and urine markers to see which ones best predict kidney failure, heart problems, and death. They are also testing diffe…

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This study looks at whether antimuscarinic drugs used for overactive bladder (OAB) affect how long ejaculation lasts and the time before a man can ejaculate again. Researchers will follow men aged 20 to 50 who are prescribed tolterodine or propiverine for OAB. Participants fill o…

This study investigates the link between gut bacteria and diabetic kidney disease, a common complication of type 2 diabetes. Researchers will analyze blood, urine, and stool samples from 556 adults with the condition to look for bacterial and metabolic markers. The goal is to und…

This study reviews medical records of 360 Japanese patients with advanced bladder cancer who received avelumab as a maintenance treatment after initial chemotherapy. The goal is to understand patient characteristics, treatment patterns, and outcomes like survival and tumor respon…

This study asks whether a person's ABO/Rh blood type is linked to how well their diabetic kidney disease responds to standard treatment. Researchers will follow 161 adults with type 2 diabetes and kidney disease for one year, measuring kidney function and protein in the urine at …

This study looks at how IgA nephropathy, a kidney disease, is actually treated in the United States. By analyzing medical records from thousands of patients, researchers aim to understand which therapies are used, in what order, and for how long. The goal is to see how current tr…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study looks at why women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) develop kinesiophobia—a fear of movement. Researchers will survey 112 women to measure their fear of movement, physical activity levels, incontinence severity, an…

This study aimed to develop and test two new questionnaires for people with recurrent urinary tract infections (UTIs). The Recurrent UTI Symptom Scale measures symptom severity, while the Recurrent UTI Impact Questionnaire looks at how the condition affects daily life, work, and …

This study follows adults who had a severe form of acute kidney injury (AKI) during a hospital stay. Researchers will use non-invasive tests to measure body composition and kidney size, and review medication plans. Participants will also be contacted by phone at 90 days and 12 mo…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing only the lower body) for a type of kidney stone surgery called retrograde intrarenal surgery. Researchers will look at how well the stones are removed, pain levels, and patient satisfactio…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study looks back at medical records of adults who were sent home from the emergency department to receive hospital-level care for common infections like pneumonia, urinary tract infections, or skin infections. The goal is to understand why some of these patients end up needi…

This study follows 112 critically ill patients with pre-existing kidney disease who receive one or two doses of contrast dye for imaging. Researchers track kidney function, including acute injury and long-term decline, over six months. The goal is to understand how repeated contr…

This study explores whether high-resolution multiparametric MRI can create detailed maps of kidney tumors before they are surgically removed. Researchers compare the MRI images with microscopic analysis of the tumor tissue to see how well the scan reveals the tumor's internal str…

This study explores whether a special type of PET/CT scan, using a radioactive tracer called 18F-FDG, can accurately measure disease activity in people with granulomatosis with polyangiitis (GPA), a rare condition that causes inflammation of blood vessels. Researchers will compar…

This study looks at how robotic surgery for prostate, bladder, or kidney cancer affects patients' finances. Researchers will ask 120 people who had surgery in the last year to fill out questionnaires about their medical costs, travel expenses, and support needs. The goal is to un…

This study looks at immune cell patterns in people with three types of nephrotic syndrome—membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. Researchers aim to see if certain immune cells can serve as biomarkers to track how well a patient res…

This study developed and tested HistoMX, an automated platform that analyzes gene activity in kidney transplant biopsy samples. Researchers used over 2,400 archived biopsies from adult kidney transplant recipients to see if the platform could accurately identify different types o…

This study investigates whether the amount of urine left in the bladder after urination (post-void residual) influences the return or worsening of non-muscle invasive bladder cancer. Researchers will follow 500 patients who have had surgery to remove bladder tumors, measuring res…

This study aims to create and validate a questionnaire that measures how people with chronic kidney failure experience each hemodialysis session. Researchers want to capture physical, emotional, and relational factors that affect the quality of the session. The tool could help he…

This study follows 211 people with IgA nephropathy who previously took a 6-9 month course of the steroid methylprednisolone in the TESTING trial. Researchers want to see if the steroid helped prevent end-stage kidney disease (needing dialysis or a transplant) over the long term. …

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study looks at why a specific type of dialysis called haemodiafiltration (HDF) improves survival when higher fluid volumes are used. Researchers think it may be because larger waste molecules are removed more effectively and blood pressure stays more stable. They will measur…

This study investigates how moderate and severe kidney impairment affects the way the body processes a single dose of the drug BI 764198. Researchers compare people with kidney disease to healthy volunteers with normal kidney function. The goal is to understand how kidney functio…

This study examines whether common blood test results — such as markers of inflammation and nutrition — can help predict which patients are at higher risk of complications or death after surgery for acute aortic dissection. Researchers will review medical records from about 127 p…

This study tests a program designed to increase living donor kidney transplants among Hispanic patients with end-stage renal disease. The program provides Spanish-language education and outreach by bicultural health workers. Researchers will compare transplant rates between Hispa…

This study tests whether advanced ultrasound techniques (2D and 3D speckle-tracking echocardiography) can detect early signs of heart muscle dysfunction in children aged 4 to 18 with end-stage kidney disease who have been on dialysis for at least a year. Researchers aim to see if…

This study investigates how flavored carbonated drinks change saliva flow, composition, and taste perception compared to plain water, carbonated water, or non-carbonated drinks. Healthy adults aged 18-45 who regularly drink carbonated beverages will provide saliva samples after t…

This study examines how the sleep aid YZJ-1139 behaves in people with severe kidney impairment compared to those with normal kidney function. Sixteen adults will receive a single 20 mg dose, and researchers will measure drug levels in the blood and urine, as well as any side effe…

This study uses a dye called iohexol to measure how well the kidneys are working in patients leaving the intensive care unit after acute kidney failure. The goal is to find out how many patients still have reduced kidney function even though their standard blood tests look normal…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This study looked at 516 patients who had surgery for a torn aorta (aortic dissection). Researchers checked if a high ankle-brachial index (a simple test of blood flow in the legs) before surgery was linked to kidney problems afterward. The goal was to see if this test could help…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This study looked at how eating high or low amounts of oxalate (a natural compound in many foods) affects urine crystals and immune cells in healthy adults. Fourteen participants followed two controlled diets to see if oxalate changes crystal formation and immune function. The go…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study looked at the IgA antibodies in 80 people — 40 with IgA nephropathy (a kidney disease) and 40 healthy volunteers. Researchers took one blood sample from each person to analyze the IgA repertoire. The goal was to understand why IgA deposits form in the kidneys, which co…

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This completed study examined whether a specific variation in the VEGF gene (rs699947) is linked to a higher risk of developing kidney cancer in people who have received a kidney transplant. Researchers analyzed DNA from 272 transplant patients, some of whom had kidney cancer. Th…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This completed study looked at red and white blood cells in people with a rare blood disorder called PNH who also have bone marrow failure. Over 5,500 participants aged 10 and older with aplastic anemia or related conditions provided blood samples. The goal was simply to learn mo…

This study tested a prediction tool (nomogram) to see if it could forecast how patients with metastatic clear cell renal cell carcinoma respond to the targeted therapy sunitinib. Researchers looked at 45 patients who had their kidney removed and were treated with sunitinib as the…

This study looked at 398 adults who needed a temporary dialysis catheter, comparing those who got it in the emergency department versus those who got it in the dialysis unit. Researchers tracked infections and blood clots in the catheter for 10 days after placement. The goal is t…

This study follows people over 75 with advanced chronic kidney disease to better understand their health and treatment paths. Researchers want to create a tool that predicts which patients are at high risk of dying soon after starting dialysis. The goal is to help patients, famil…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at 155 critically ill patients on ventilators to see if the difference between carbon dioxide in their breath and blood could predict acute kidney injury. Researchers measured this gap over the first 24 hours in the ICU. The goal was to find a simple, early warn…

This study looked at whether three proteins (E-cadherin, β-catenin, and SOX4) can help predict if non-muscle invasive bladder cancer will return or get worse after surgery. Researchers examined tissue samples from 30 patients who had bladder tumor removal. The goal was to see if …

This completed study looked at antibiotic resistance in bacteria causing urinary tract infections (UTIs) in Uganda. Researchers compared resistance patterns in patients who sought care at community drug shops versus hospitals. By studying 890 participants, they aim to understand …

This study looks at whether gastric bypass surgery can protect the kidneys of people who are severely obese and have chronic kidney disease. Researchers measured kidney function before and one year after surgery in 14 patients. The goal is to see if the surgery improves the balan…

This completed study compared two devices used to place a breathing tube during kidney stone surgery: a videolaryngoscope and a VideoLMA. Researchers measured how long each took and how often they worked on the first try. The trial involved 100 adults and aimed to find which devi…

This study aims to create and test a new mathematical formula that estimates how much sodium (salt) people on peritoneal dialysis consume. The researchers will enroll 30 adults who have been on peritoneal dialysis for at least three months and have no remaining kidney function. I…

This study aimed to create lab models of a rare and aggressive cancer of the upper urinary tract. Researchers took tumor samples from 20 patients and tried to grow them in mice and on chicken egg membranes. The goal was to develop tools to test new treatments for this cancer, whi…

This study analyzes data from 748 patients who had their bladder removed due to bladder cancer. The goal is to find factors that can predict whether cancer has spread to the ureter, the tube that carries urine from the kidney to the bladder. By identifying these factors, doctors …

This study followed 623 adults in France with advanced kidney cancer who were starting treatment with the immunotherapy drugs nivolumab (with or without ipilimumab) for the first time. Unlike a clinical trial, this was an observational study that simply tracked what happened in e…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at 174 adults in the intensive care unit (ICU) to find out how often acute kidney injury happens and what factors make it more likely. Researchers tracked patients who stayed in the ICU for at least 48 hours, excluding those with kidney problems at the start. Th…

This study tested whether doing a second surgery soon after the first helps manage high-risk non-muscle invasive bladder cancer. 70 patients who had an initial tumor removal got an early second look procedure. The goal was to see if any cancer remained and what factors affected t…

This completed study looked at 170 adults who needed emergency hemodialysis for acute kidney injury. Researchers measured three blood markers (Activin A, Nostrin, and Angiopoetin-2) before dialysis to see if they could predict whether the kidneys would recover or if the patient w…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at whether a four-week program of gentle mobilization exercises could improve balance in orchestra musicians, who often stand or sit in awkward positions for long periods. Twenty-three musicians were split into groups that did the exercises once or twice a week.…

This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an e…

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This study looked at two tools to help people with chronic kidney disease (CKD) stay healthier. One tool gave doctors a registry to track patients, and the other offered phone coaching from a health coach. The goal was to see if these approaches could lower blood pressure and imp…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This study looked at how two types of exercise affect bone health in people with chronic kidney disease. Sixty patients did either treadmill walking or resistance training for 6 months. Researchers measured bone turnover markers and bone density before and after the program to se…

This study looked at 166 older adults (65+) on hemodialysis to compare three types of vascular access: fistulas, grafts, and catheters. The goal was to see which option leads to fewer complications and better quality of life. Researchers tracked how many procedures were needed to…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This completed study looked at why people with IgA nephropathy (a kidney disease) often experience memory and attention problems. Researchers used powerful 7-Tesla MRI scanners to examine the brains of 100 patients and 100 healthy volunteers, along with analyzing their gut bacter…

This study looked at 1416 very sick adults in the ICU to see how well different stages of acute kidney injury (AKI) match the kidneys' actual ability to filter waste. Researchers used a urine test to measure kidney function and compared two common ways to diagnose AKI: one based …

This study looked at pressure inside the kidney during surgery to remove kidney stones. Twenty-one adults had the procedure with either a suction or a non-suction tube. The goal was to see which method keeps pressure lower, which could make surgery safer and help clear more stone…

This study developed an AI model to predict how well bladder cancer responds to treatment before surgery. Researchers used data from 469 patients, including medical images and genetic information, to train the AI. The goal is to help doctors choose the best treatment plan for eac…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the risk of emergency visits, hospital stays, or death within 30 days in older adults with chronic kidney disease. Researchers analyzed health records from over…

This completed study looked at 211 people with sepsis, some of whom also had acute kidney injury. Researchers measured specific microRNAs and other markers in the blood to understand how kidney damage happens. The goal was to find new targets for diagnosis or treatment, not to te…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study looked at whether placing a ureteral stent after ureteroscopy for kidney stones reduces complications. 103 adults with small kidney stones were randomly assigned to get a stent or not. Researchers tracked ER visits, unplanned doctor visits, and hospitalizations to see …

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at 50,000 living kidney donors in Canada to see if they are more likely to develop kidney stones years after donating, compared to similar people who never donated. Researchers used health records from 1992 to 2024 to track surgeries or hospital visits for kidne…

This study tested a new method to measure bladder fullness using heart signals. Researchers placed sticky patches (electrodes) on the body to record the heart's electrical activity during a standard bladder test. The goal was to develop a computer algorithm that could estimate bl…

This study looked at information from about 70,000 adults receiving hemodialysis around the world to find out how many have IgA nephropathy (a type of kidney disease) and how it affects their health. Researchers compared patients with IgA nephropathy to other dialysis patients to…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This study tested a home education program called Explore Transplant@Home for nearly 1,000 patients with chronic kidney disease. The program mailed videos, postcards, and texts to teach about kidney transplant options, especially from living donors. The goal was to see if this ap…

This study tested a new device called EchoMark LP, which is implanted near a surgically created blood vessel connection (fistula) used for dialysis. The device works with a special ultrasound system (EchoSure) to measure blood flow, depth, and diameter of the fistula. The trial i…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at how lifestyle factors like obesity and muscle loss affect kidney cancer risk and survival after kidney removal. Researchers collected blood, tissue, and questionnaire data from 161 patients over up to 5 years. The goal was to understand how to personalize tre…

This study looked at whether giving antibiotics before a kidney drainage procedure (called percutaneous nephrostomy) prevents urinary tract infections in cancer patients whose urinary tract is blocked by a tumor. Researchers reviewed records of 320 cancer patients who had the pro…

This completed research study collected and stored tumor tissue, blood, and urine samples from 8,000 children and young adults with kidney tumors. The goal was to help scientists study DNA changes and find biomarkers that could improve understanding of these cancers. No treatment…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study tested whether an AI tool that predicts the risk of kidney transplant failure within one year can improve conversations between patients, their families, and doctors. 76 adults with a functioning kidney transplant but declining kidney function took part. The goal was t…

This study looked at 58 adults on hemodialysis to understand how the mix of bacteria in their gut relates to waste products in their blood. Researchers measured different types of gut bacteria and chemicals they produce, like short-chain fatty acids and uremic toxins. The goal wa…

This study looked at 210 adults who had kidney stone surgery (RIRS) to see if placing a stent before the procedure helped clear stones completely and reduced the need for a second surgery. Researchers compared how long the stent was left in before surgery. The goal is to find the…

This pilot study tested whether a single dose of oral estrogen-progestin can raise oxytocin levels in people with arginine vasopressin deficiency (AVD), a rare condition that also causes low oxytocin. Researchers compared 28 adults—some with AVD and some healthy—to see if oxytoci…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study tested whether telemedicine could help people in rural Nigeria get urology care faster. 220 adults were split into two groups: one had a standard in-person consultation, the other a virtual consultation with a urologist. Researchers measured how long it took to see a s…

This study tested whether implanting tiny gold markers near spinal tumors helps deliver radiation more accurately. Researchers also checked if giving slightly more radiation to the nearby esophagus is safe, which might improve tumor control. The study involved 41 adults with vari…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study looked at nearly 30,000 older adults (65+) having non-cardiac surgery to see if levels of homocysteine, a natural amino acid, could predict serious complications like kidney injury or death. Researchers measured homocysteine before and after surgery. The goal was to se…

This study looked at 61 adults with kidney stones to see if stone size and density could predict how much laser energy is needed during a procedure called thulium fiber laser lithotripsy. Researchers used CT scans before surgery to measure stone volume and density, then tracked t…

This study looked at 100 critically ill adults with severe kidney failure who were receiving continuous kidney replacement therapy. Researchers used a special ultrasound technique to check for fluid buildup in the body, which can harm organs. The goal was to see how common fluid …

This study looked at whether a software program called Carevive could help patients with advanced kidney cancer track side effects from their oral targeted therapy or immunotherapy. 21 patients used the software to report symptoms and received self-care tips. The goal was to see …

This study looked at 150 adults with sepsis in the ICU to see if low magnesium levels are connected to blood clotting problems. Researchers measured magnesium and clotting markers at admission and tracked outcomes like DIC and survival. The goal was to understand if magnesium cou…

This study looked at whether starting dialysis at a specific time, based on a new mathematical formula, could help people with end-stage kidney disease live longer. 388 patients were randomly assigned to start dialysis either at an 'optimal' or 'late' time. Researchers tracked de…

This completed study from Aarhus University looked at how the urea cycle works in 10 people with end-stage kidney disease on dialysis. Participants received a 3-hour alanine infusion, and researchers measured urea production before and after dialysis. The goal was to understand u…

This study compared two common sedation drugs, propofol and dexmedetomidine, in 65 older adults undergoing a less invasive heart valve replacement called TAVR. The goal was to see which drug leads to better kidney function, less confusion, and fewer complications after the proced…

This study looked at 200 adults having kidney stone surgery to see if lying on their back versus their belly changes the risk of lung problems after surgery. Researchers measured lung 'mechanical power' during surgery and tracked complications. The goal is to find the safest posi…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used the AI tool, the other did not. The goal was to see if AI could improve readability and save time,…

This study looks at people who carry one copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Some carriers develop kidney stones, while others do not. Researchers will compare their urine oxalate levels and lifestyle factors to find out what triggers symp…

This study looked at whether adding hands-on simulation training to standard classroom teaching helps nurses cause fewer problems when inserting needles into the arm access (arteriovenous fistula) of dialysis patients. About 9600 adults on chronic hemodialysis took part. The goal…

This completed study asked 140 people—including patients with chronic kidney disease, their families, healthcare professionals, and researchers—to identify the most important outcomes for self-managing the condition before dialysis is needed. Through multiple survey rounds, parti…

This study looked at 120 men who had HoLEP surgery for an enlarged prostate. Researchers wanted to see if bowel problems before surgery made recovery harder. Patients filled out questionnaires about bowel and urinary symptoms before and after surgery. The goal was to learn how bo…

This study looked at how a 10 km run and a 1.5 km swim affect kidney function in 40 healthy, active adults. Researchers used sensitive urine tests to detect subtle kidney changes that standard blood tests might miss. The goal was to better understand temporary kidney stress from …

This completed Phase 2 study investigated how the drugs dapagliflozin and balcinrenone, alone or together, affect the body's handling of water and salts in people over 50 with stage 3 chronic kidney disease. Over 28 days, 103 participants took daily pills to measure changes in ur…

This study followed over 3,400 people with autosomal dominant polycystic kidney disease (ADPKD) to learn how the disease progresses. Researchers measured kidney size, symptoms, quality of life, and healthcare costs. The goal was to identify factors that predict faster disease pro…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3BC) in 24 patients who were facing bladder removal surgery. The tool provides personalized information, videos, and summaries to help patients talk with their doctors and prepare for rec…

This study looked at 308 people with myelodysplastic syndromes (MDS) who had a stem cell transplant. Researchers identified each patient's unique genetic mutations and then monitored those mutations in blood and bone marrow samples after transplant. The goal was to see if rising …

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This study looked at 174 older adults (ages 65-80) having lumbar fusion surgery to see whether using sodium acetate Ringer's solution or sodium lactate Ringer's solution during the operation better protects the kidneys. Researchers measured early kidney injury markers in urine an…

This study looked at 135 people with advanced lung cancer, lymphoma, or other tumors treated with immunotherapy drugs called checkpoint inhibitors. Researchers collected blood and tumor samples over time to measure immune cells and molecules that might predict whether the treatme…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study looked at 395 adults on long-term dialysis to find out how often their blood pressure drops dangerously during treatment and what makes it more likely. Researchers collected information on patients' health history, medications, and dialysis settings. The goal is to hel…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This study looked at whether information from national health insurance cards—like past antibiotic use and hospital stays—can predict if a person's urinary tract infection will be resistant to common antibiotics. Researchers analyzed data from over 1,100 patients with community-a…

This study looked at how often acute kidney injury happens in people with liver cirrhosis, and what factors might increase the risk. Researchers at Sohag University Hospital followed 180 adult patients with cirrhosis, excluding those with pre-existing kidney disease or other majo…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This pilot study tested a shared decision-making tool called the Donor Offer Plan (DOP) for people on the kidney transplant waiting list. 100 participants reviewed an online education module and discussed their donor preferences with a transplant nurse. The goal was to see if thi…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study looked at whether special ultrasound measurements of the urethra can predict how severe a woman's stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) will be. Researchers measured the length and angle of the urethra in 50 adult women. The…