New antibody drug shows promise for kidney disease
NCT ID NCT05065970
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tested a drug called felzartamab in 54 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The drug targets immune cells to reduce protein leakage in urine, a sign of kidney damage. The study compared felzartamab to a placebo to see if it safely lowers protein levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Felzartamab (a monoclonal antibody that targets CD38 on immune cells)
What this could lead to
If successful, this could point toward a new treatment to control IgA nephropathy and reduce kidney damage.
What could go wrong
This is an early Phase 2 trial with only 54 participants, so results may not hold up in larger studies. The drug may cause side effects or fail to improve kidney function long-term.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ajou University Hospital
Suwon, Gyeonggido, 16499, South Korea
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Amicis Research Center, Vacaville
Vacaville, California, 95687, United States
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CHU Sart Tilman Hospital
Liège, 4000, Belgium
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Clinical Centre of Vojvodina
Novi Sad, Vojvodina, 21000, Serbia
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Clinical Hospital Centar Zvezdara
Belgrade, Serbia
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Clinical Hospital Center Bezanijska Kosa
Belgrade, 11080, Serbia
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Communal Nonprofit Enterprise "Kyiv City Center of Nephrology and Dialysis"
Kyiv, Ukraine
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Core Research Group
Milton, Queensland, 4064, Australia
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Diagnostic- Consultative Center Convex EOOD
Sofia, Sofia-Grad, 1680, Bulgaria
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Eticka komise Fakultni nemocnice Olomouc
Olomouc, Olomouc Region, 775 20, Czechia
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FOMAT Medical Research - FOMAT - HyperCore - PPDS
Oxnard, California, 93030, United States
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Fakultni nemocnice Kralovske Vinohrady Hospital
Prague, Praha, Hlavní Mesto, 10034, Czechia
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Far Eastern Memorial Hospital
Taipei, 220, Taiwan
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Fukushima Medical University Hospital
Fukushima, Hukusima, 960-1295, Japan
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Fundacio Puigvert
Badalona, 8025, Spain
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General Hospital Krusevac
Kruševac, 37000, Serbia
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Hokkaido University Hospital
Sapporo, Hokkaidô, 060-8648, Japan
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Hospital Clinic de Barcelona
Barcelona, 8036, Spain
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Hospital Ruber Juan Bravo (Grupo Quironsalud)
Madrid, Spain
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Hospital Universitari Arnau de Vilanova
Lleida, 25198, Spain
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Hospital Universitari de Girona Dr Josep Trueta
Girona, Spain
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Hospital Universitario Germans Trias i Pujol
Badalona, 8916, Spain
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Hospital Universitario Vall d'Hebron - PPDS
Barcelona, 8035, Spain
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Hospital del Mar
Barcelona, 8003, Spain
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Hospital of the University of Occupational and Environmental Health, Japan
Kitakyushu-Shi, Hukuoka, 807-8556, Japan
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Imelda VZW
Bonheiden, Antwerpen, Belgium
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JCHO Sendai Hospital
Sendai, Miyagi, 981-3205, Japan
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JSC Evex Hospitals
Tbilisi, 121, Georgia
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Japanese Red Cross Ashikaga Hospital
Ashikaga-Shi, Tochigi, 326-0843, Japan
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Juntendo University Hospital
Bunkyō-Ku, Tokyo, 113-8431, Japan
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Konkuk University Medical Center
Seoul, Seoul Teugbyeolsi, 5030, South Korea
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Kurume University Hospital
Kurume-Shi, Hukuoka, 830-0011, Japan
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L. Managadze National Center of Urology LTD
Tbilisi, 144, Georgia
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Mayo Clinic Hospital - Methodist Campus
Rochester, Minnesota, 55902, United States
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MedResearch INC
El Paso, Texas, 79935, United States
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Medical Center Hera EOOD, Montana
Montana, 3400, Bulgaria
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Medical Center Hipokrat- N EOOD
Plovdiv, 4000, Bulgaria
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Municipal Non-profit Enterprise Ternopil Regional Clinical Hospital of Ternopil Regional Council
Ternopil, Ternopil Oblast, 46002, Ukraine
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Municipal Nonprofit Enterprise Zaporizhzhia Regional Clinical Hospital Zaporizhzhia Regional Council
Zaporizhzhia, 69600, Ukraine
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National Hospital Organization Chibahigashi National Hospital
Chiba, Chiba, 260-0801, Japan
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Nemocnice AGEL Novy Jicin a.s
Nový Jicín, Moravian-Silesian Region, 741 01, Czechia
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Osaka University Hospital
Suita-Shi, Ôsaka, 565-0871, Japan
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Regionaal Ziekenhuis Jan Yperman VZW
Ieper, Belgium
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Seoul National University Bundang Hospital
Seongnam, Gyeonggido, 13620, South Korea
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St Frances Cabrini Medical Center and Cancer Institute
Santo Tomas, Batangas, 4234, Philippines
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State Institution Institute of Nephrology of NAMS of Ukraine
Kyiv, Ukraine
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Sunshine Hospital - Australia
Saint Albans, Victoria, Australia
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Taichung Veterans General Hospital
Taichung, 407, Taiwan
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Taipei Medical University Shuang Ho Hospital
New Taipei City, 23561, Taiwan
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Tbilisi State Medical University's and Ingorokva's University Clinic of High Medical Technologies
Tbilisi, 144, Georgia
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The Catholic University of Korea, Uijeongbu St. Mary's Hospital
Uijeongbu-si, South Korea
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UZ Leuven Hospital
Leuven, Vlaams Brabant, 3000, Belgium
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University Clinical Center Nis
Niš, 18000, Serbia
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University Malaya Medical Centre
Pantai, Malaysia
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University Multiprofile Hospital for Active Treatment
Stara Zagora, Bulgaria
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Universitätsklinikum Essen
Essen, North Rhine-Westphalia, 45122, Germany
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, Germany
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Vseobecna Fakultni Nemocnice V Praze
Prague, Praha, Hlavní Mesto, 128 08, Czechia