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Gene therapy breakthrough targets kidney disease in High-Risk patients

NCT ID NCT07182227

Recruiting now Disease control Sponsor: Purespring Therapeutics Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests a new gene therapy, PS-002, for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The therapy aims to control the disease in people who are at high risk of getting worse despite current treatments. Participants receive a single dose and are monitored for up to 5 years to check safety and how well it works.

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Conditions

The condition(s) this trial relates to.

autoimmune disease glomerulonephritis IgA glomerulonephritis immune system disorder kidney disorder nephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOGLOBULIN A (IGA) NEPHROPATHY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Cardiff and Vale University Health Board

    NOT_YET_RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • Leicester General Hospital

    NOT_YET_RECRUITING

    Leicester, Leicestershire, LE5 4PW, United Kingdom

  • Manchester University NHS Foundation Trust

    RECRUITING

    Manchester, Greater Manchester, M13 9WL, United Kingdom

  • Nottingham University Hospitals NHS Trust

    RECRUITING

    Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

  • Royal Infirmary of Edinburgh Clinical Research Facility

    RECRUITING

    Edinburgh, EH16 4SA, United Kingdom

  • Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust

    RECRUITING

    Manchester, Greater Manchester, M13 9WL, United Kingdom

  • Southmead Hospital

    RECRUITING

    Bristol, BS10 5NB, United Kingdom

  • The Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • The Royal London Hospital

    RECRUITING

    London, E1 1FR, United Kingdom

  • University of Miami Hospital

    RECRUITING

    Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.