New drug duo takes on kidney cancer in major trial

NCT ID NCT03260894

Completed Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested whether combining pembrolizumab (an immunotherapy) with epacadostat (a drug that boosts the immune response) works better than standard drugs (sunitinib or pazopanib) for people with advanced kidney cancer that hasn't been treated before. The study enrolled 129 participants and measured how many saw their tumors shrink. The goal is to find a more effective first-line treatment for this type of cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab plus epacadostat
What this could lead to: If it works, this combination could offer a new first-line treatment option for advanced kidney cancer, potentially improving tumor shrinkage rates.
What could go wrong: This is a completed Phase 3 trial with only 129 participants, so results may not be definitive. The combination may cause side effects and might not outperform existing standard therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 clear cell renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL CELL CARCINOMA (RCC)

Contacts and locations

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Locations

A.O. Cardarelli

Naples, 80131, Italy
Adelaide & Meath Hospital

Dublin, 00024, Ireland
Akershus University Hospital

Lørenskog, 1478, Norway
Akita University Hospital

Akita, 010-8543, Japan
Ankara Numune Education and Research Hospital

Ankara, 06100, Turkey (Türkiye)
Arizona Oncology Associates PC- HOPE

Tucson, Arizona, 85711, United States
Asan Medical Center

Seoul, 05505, South Korea
Atlanta Cancer Care - Conyers

Conyers, Georgia, 30094, United States
Auckland City Hospital

Auckland, Grafton, 1023, New Zealand
Azienda Ospedaliera San Camillo Forlanini

Roma, 00152, Italy
Azienda Ospedaliera-Spedali Civili

Brescia, 25123, Italy
Barts Health NHS Trust - St Bartholomew s Hospital

London, EC1A 7BE, United Kingdom
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi

Adana, 01250, Turkey (Türkiye)
Beatson Institute of Cancer Research

Glasgow, G12 0YN, United Kingdom
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz

Miskolc, 3526, Hungary
CHU Besancon - Hopital Jean Minjoz

Besançon, 25030, France
CHU de Quebec-Universite Laval-Hotel Dieu de Quebec

Québec, Quebec, G1R 2J6, Canada
CHU de Strasbourg - Nouvel Hopital Civil

Strasbourg, 67091, France
CIUSSS de la Mauricie-et-du-Centre-du-Quebec

Trois-Rivières, Quebec, G8Z 3R9, Canada
Cabrini Health

Malvern, Victoria, 3144, Australia
Calvary Mater Newcastle

Waratah, New South Wales, 2298, Australia
Canberra Hospital

Garran, Australian Capital Territory, 2605, Australia
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Clinical Hospital with outpatient Clinic

Moscow, 121359, Russia
Centre Antoine Lacassagne

Nice, Cedex 2, 06189, France
Centre Francois Baclesse

Caen, 14076, France
Centro Avancado de Tratamento Oncologico - CENANTRON -

Belo Horizonte, 30130090, Brazil
Centro de pesquisa Porto Alegre

Porto Alegre, Florianopolis, 90610-000, Brazil
Chang Gung Med Foundation. Kaohsiung Branch

Kaohsiung City, 833, Taiwan
China Medical University Hospital

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital

Hwasun, Jeollanam-do, 58128, South Korea
Clinica Alemana de Osorno

Osorno, Los Lagos Region, 5311089, Chile
Clinique Sainte Anne

Strasbourg, 67000, France
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC

Dnipro, 49102, Ukraine
Dnipropetrovsk Regional Hospital n.a. I.I. Mechnikov

Dnipro, 49005, Ukraine
Ege Universitesi Tıp Fakultesi

Izmir, 35040, Turkey (Türkiye)
Fiona Stanley Hospital

Murdoch, 6150, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Fundacao Pio XII - Hospital de Cancer de Barretos

Barretos, São Paulo, 14784-400, Brazil
Fundacion Arturo Lopez Perez FALP

Santiago, 7500921, Chile
Hacettepe University Medical Faculty

Ankara, 06100, Turkey (Türkiye)
Helios Klinikum Berlin Buch

Berlin, 13125, Germany
Helse Bergen HF Haukeland sykehus

Bergen, 5053, Norway
Hokkaido University Hospital

Sapporo, Hokkaido, 060-8648, Japan
Hopital Europeen Georges Pompidou

Paris, 75015, France
Hopital Prive Toulon Hyeres Sainte Marguerite

Hyères, 83400, France
Hopital Saint Andre

Bordeaux, 33075, France
Hospices Civils de Lyon Centre Hospitalier Lyon Sud

Pierre-Bénite, 69310, France
Hospital Clinico Universitario de Santiago

Santiago de Compostela, 15706, Spain
Hospital Clinico Vina del Mar

Viña del Mar, 2520000, Chile
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Germans Trias i Pujol

Barcelona, 08916, Spain
Hospital Parc Tauli

Sabadell, Barcelona, 08208, Spain
Hospital Sao Jose

São Paulo, São Paulo, 01321-001, Brazil
Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain
Hospital de Clinicas de Porto Alegre

Porto Alegre, 90035-903, Brazil
Hospital del Mar

Barcelona, 08003, Spain
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Institut Gustave Roussy

Villejuif, 94805, France
Instituto Valenciano de Oncologia

Valencia, 46009, Spain
Instituto do Cancer de Sao Paulo - ICESP

São Paulo, São Paulo, 01246-000, Brazil
Istanbul Medeniyet Universitesi Goztepe EAH

Istanbul, 34732, Turkey (Türkiye)
Istanbul Universitesi Onkoloji Enstitusu

Istanbul, 34093, Turkey (Türkiye)
Ivanovo regional oncology dispensary

Ivanovo, 153040, Russia
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet

Szolnok, 5000, Hungary
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Keio University Hospital

Tokyo, 160-8582, Japan
Kindai University Hospital

Sayama, Osaka, 589-8511, Japan
Kingston Health Sciences Centre - KGH Site

Kingston, Ontario, K7L 2V7, Canada
Kyushu University Hospital

Fukuoka, 812-8582, Japan
Leningrad Regional Oncology Dispensary

Saint Petersburg, Leningrad Region, Vsevolozhsky District, 188663, Russia
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
MI Kryviy Rih Center of Dnipropetrovsk Regional Council

Kryvyi Rih, Dnipropetrovsk Oblast, 50048, Ukraine
MI Precarpathian Clinical Oncology Center

Ivano-Frankivsk, 76018, Ukraine
Markusovszky Egyetemi Oktatokorhaz

Szombathely, 9700, Hungary
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical Oncology Ospedale San Donato

Arezzo, 52100, Italy
Medizinische Hochschule Hannover

Hanover, 30625, Germany
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Nagoya University Hospital

Nagoya, Aichi-ken, 466-8560, Japan
Namik Kemal Universitesi Tip Fakultesi

Tekirdağ, 59100, Turkey (Türkiye)
Nara Medical University Hospital

Kashihara, Nara, 634-8522, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70457, Taiwan
National Medical Research Radiology Centre

Moscow, 125284, Russia
National Taiwan University Hospital

Taipei, 10048, Taiwan
New York Oncology Hematology P.C

Albany, New York, 12208, United States
Niigata University Medical & Dental Hospital

Niigata, 951-8520, Japan
Nippon Medical School Hospital

Tokyo, 113-8603, Japan
Northside Hospital

Atlanta, Georgia, 30342, United States
Northwest Georgia Oncology Centers Pc

Marietta, Georgia, 30060, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care

Roanoke, Virginia, 24014, United States
Orszagos Onkologiai Intezet

Budapest, Pest County, 1122, Hungary
Oslo universitetssykehus

Oslo, 0450, Norway
Pinnacle Oncology Hematology

Scottsdale, Arizona, 85258, United States
Policlinico San Matteo

Pavia, 27100, Italy
Pontificia Universidad Catolica de Chile

Santiago, 8320000, Chile
RMI Sumy Regional Clinical Oncology Dispensary

Sumy, 40022, Ukraine
Republican Clinical Oncology Dispensary of Republic of Bashkortostan

Ufa, 450054, Russia
Rush University Medical Center

Chicago, Illinois, 60612, United States
Russian Scientific Center of Roentgenoradiology

Moscow, 117997, Russia
Saitama Medical University International Medical Center

Hidaka, Saitama, 350-1298, Japan
Samsung Medical Center

Seoul, 06351, South Korea
Sapporo Medical University Hospital

Sapporo, Hokkaido, 060-8543, Japan
Scottsdale Healthcare

Scottsdale, Arizona, 85258, United States
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shenandoah Oncology, P.C.

Winchester, Virginia, 22601, United States
Somogy Megyei Kaposi Mor Oktato Korhaz

Kaposvár, 7400, Hungary
Sorlandet sykehus HF

Kristiansand, 4615, Norway
Southeast Nebraska Hematology & Oncology Consultants, P.C.

Lincoln, Nebraska, 68510, United States
St Olavs Hospital

Trondheim, 7030, Norway
Sunnybrook Health Sciences, Odette Cancer Centre

Toronto, Ontario, M4N 3M5, Canada
Sykehuset Oestfold

Grålum, 1714, Norway
Taipei Veterans General Hospital

Taipei, 112, Taiwan
The Christie NHS Foundation Trust

Manchester, MB204BX, United Kingdom
The Royal Marsden Foundation Trust

London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust.

Sutton, Surrey, SM2 5PT, United Kingdom
The West Clinic, P.C.

Germantown, Tennessee, 38138, United States
Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada
Toranomon Hospital

Tokyo, 105-8470, Japan
UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
UC Irvine Comprehensive Cancer Center/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
US Oncology and Research

The Woodlands, Texas, 77380, United States
Universitaetsklinikum Essen

Essen, 45147, Germany
Universitaetsklinikum Frankfurt

Frankfurt am Main, 60590, Germany
Universitaetsklinikum Jena

Jena, 07747, Germany
Universitaetsklinikum Magdeburg. Klinik fuer Urologie

Magdeburg, 39120, Germany
Universitaetsklinikum Tuebingen

Tübingen, 72076, Germany
Universitaetsklinikum der Technischen Universitaet Dresden

Dresden, 01307, Germany
Universitetssykehuset i Nord Norge. Kreftavdelingen

Tromsø, 9019, Norway
University Hospital Waterford

Waterford, X91ER8E, Ireland
University of Tennessee Erlanger Oncology & Hematology

Chattanooga, Tennessee, 37403, United States
Utah Cancer Specialists

Salt Lake City, Utah, 84106, United States
Western General Hospital

Edinburgh, EH4 2XU, United Kingdom
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Willamette Valley Cancer Institute and Research Center

Eugene, Oregon, 97401, United States
Woodlands Medical Specialists, PA

Pensacola, Florida, 32503, United States
Yamaguchi University Hospital

Ube, Yamaguchi, 755-8505, Japan
Zala Megyei Szent Rafael Korhaz

Zalaegerszeg, Pozva, 8900, Hungary

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