New combo shows promise in kidney cancer fight

NCT ID NCT03260894

First seen May 22, 2026 · Last updated May 22, 2026

Summary

This study tested whether adding epacadostat to the immunotherapy drug pembrolizumab works better than standard treatments (sunitinib or pazopanib) for people with advanced kidney cancer that has spread. The trial included 129 patients who had not received prior therapy. Researchers measured how many patients' tumors shrank or disappeared and tracked side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. Cardarelli

    Naples, 80131, Italy

  • Adelaide & Meath Hospital

    Dublin, 00024, Ireland

  • Akershus University Hospital

    Lørenskog, 1478, Norway

  • Akita University Hospital

    Akita, 010-8543, Japan

  • Ankara Numune Education and Research Hospital

    Ankara, 06100, Turkey (Türkiye)

  • Arizona Oncology Associates PC- HOPE

    Tucson, Arizona, 85711, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Atlanta Cancer Care - Conyers

    Conyers, Georgia, 30094, United States

  • Auckland City Hospital

    Auckland, Grafton, 1023, New Zealand

  • Azienda Ospedaliera San Camillo Forlanini

    Roma, 00152, Italy

  • Azienda Ospedaliera-Spedali Civili

    Brescia, 25123, Italy

  • Barts Health NHS Trust - St Bartholomew s Hospital

    London, EC1A 7BE, United Kingdom

  • Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi

    Adana, 01250, Turkey (Türkiye)

  • Beatson Institute of Cancer Research

    Glasgow, G12 0YN, United Kingdom

  • Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz

    Miskolc, 3526, Hungary

  • CHU Besancon - Hopital Jean Minjoz

    Besançon, 25030, France

  • CHU de Quebec-Universite Laval-Hotel Dieu de Quebec

    Québec, Quebec, G1R 2J6, Canada

  • CHU de Strasbourg - Nouvel Hopital Civil

    Strasbourg, 67091, France

  • CIUSSS de la Mauricie-et-du-Centre-du-Quebec

    Trois-Rivières, Quebec, G8Z 3R9, Canada

  • Cabrini Health

    Malvern, Victoria, 3144, Australia

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605, Australia

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Central Clinical Hospital with outpatient Clinic

    Moscow, 121359, Russia

  • Centre Antoine Lacassagne

    Nice, Cedex 2, 06189, France

  • Centre Francois Baclesse

    Caen, 14076, France

  • Centro Avancado de Tratamento Oncologico - CENANTRON -

    Belo Horizonte, 30130090, Brazil

  • Centro de pesquisa Porto Alegre

    Porto Alegre, Florianopolis, 90610-000, Brazil

  • Chang Gung Med Foundation. Kaohsiung Branch

    Kaohsiung City, 833, Taiwan

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Chonnam National University Hwasun Hospital

    Hwasun, Jeollanam-do, 58128, South Korea

  • Clinica Alemana de Osorno

    Osorno, Los Lagos Region, 5311089, Chile

  • Clinique Sainte Anne

    Strasbourg, 67000, France

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC

    Dnipro, 49102, Ukraine

  • Dnipropetrovsk Regional Hospital n.a. I.I. Mechnikov

    Dnipro, 49005, Ukraine

  • Ege Universitesi Tıp Fakultesi

    Izmir, 35040, Turkey (Türkiye)

  • Fiona Stanley Hospital

    Murdoch, 6150, Australia

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Fundacao Pio XII - Hospital de Cancer de Barretos

    Barretos, São Paulo, 14784-400, Brazil

  • Fundacion Arturo Lopez Perez FALP

    Santiago, 7500921, Chile

  • Hacettepe University Medical Faculty

    Ankara, 06100, Turkey (Türkiye)

  • Helios Klinikum Berlin Buch

    Berlin, 13125, Germany

  • Helse Bergen HF Haukeland sykehus

    Bergen, 5053, Norway

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648, Japan

  • Hopital Europeen Georges Pompidou

    Paris, 75015, France

  • Hopital Prive Toulon Hyeres Sainte Marguerite

    Hyères, 83400, France

  • Hopital Saint Andre

    Bordeaux, 33075, France

  • Hospices Civils de Lyon Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69310, France

  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, 15706, Spain

  • Hospital Clinico Vina del Mar

    Viña del Mar, 2520000, Chile

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007, Spain

  • Hospital Germans Trias i Pujol

    Barcelona, 08916, Spain

  • Hospital Parc Tauli

    Sabadell, Barcelona, 08208, Spain

  • Hospital Sao Jose

    São Paulo, São Paulo, 01321-001, Brazil

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050, Spain

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, 90035-903, Brazil

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Instituto Valenciano de Oncologia

    Valencia, 46009, Spain

  • Instituto do Cancer de Sao Paulo - ICESP

    São Paulo, São Paulo, 01246-000, Brazil

  • Istanbul Medeniyet Universitesi Goztepe EAH

    Istanbul, 34732, Turkey (Türkiye)

  • Istanbul Universitesi Onkoloji Enstitusu

    Istanbul, 34093, Turkey (Türkiye)

  • Ivanovo regional oncology dispensary

    Ivanovo, 153040, Russia

  • Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet

    Szolnok, 5000, Hungary

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Keio University Hospital

    Tokyo, 160-8582, Japan

  • Kindai University Hospital

    Sayama, Osaka, 589-8511, Japan

  • Kingston Health Sciences Centre - KGH Site

    Kingston, Ontario, K7L 2V7, Canada

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Leningrad Regional Oncology Dispensary

    Saint Petersburg, Leningrad Region, Vsevolozhsky District, 188663, Russia

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • MI Kryviy Rih Center of Dnipropetrovsk Regional Council

    Kryvyi Rih, Dnipropetrovsk Oblast, 50048, Ukraine

  • MI Precarpathian Clinical Oncology Center

    Ivano-Frankivsk, 76018, Ukraine

  • Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700, Hungary

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical Oncology Ospedale San Donato

    Arezzo, 52100, Italy

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • Namik Kemal Universitesi Tip Fakultesi

    Tekirdağ, 59100, Turkey (Türkiye)

  • Nara Medical University Hospital

    Kashihara, Nara, 634-8522, Japan

  • National Cancer Center Hospital East

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital

    Tainan, 70457, Taiwan

  • National Medical Research Radiology Centre

    Moscow, 125284, Russia

  • National Taiwan University Hospital

    Taipei, 10048, Taiwan

  • New York Oncology Hematology P.C

    Albany, New York, 12208, United States

  • Niigata University Medical & Dental Hospital

    Niigata, 951-8520, Japan

  • Nippon Medical School Hospital

    Tokyo, 113-8603, Japan

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Northwest Georgia Oncology Centers Pc

    Marietta, Georgia, 30060, United States

  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care

    Roanoke, Virginia, 24014, United States

  • Orszagos Onkologiai Intezet

    Budapest, Pest County, 1122, Hungary

  • Oslo universitetssykehus

    Oslo, 0450, Norway

  • Pinnacle Oncology Hematology

    Scottsdale, Arizona, 85258, United States

  • Policlinico San Matteo

    Pavia, 27100, Italy

  • Pontificia Universidad Catolica de Chile

    Santiago, 8320000, Chile

  • RMI Sumy Regional Clinical Oncology Dispensary

    Sumy, 40022, Ukraine

  • Republican Clinical Oncology Dispensary of Republic of Bashkortostan

    Ufa, 450054, Russia

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Russian Scientific Center of Roentgenoradiology

    Moscow, 117997, Russia

  • Saitama Medical University International Medical Center

    Hidaka, Saitama, 350-1298, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sapporo Medical University Hospital

    Sapporo, Hokkaido, 060-8543, Japan

  • Scottsdale Healthcare

    Scottsdale, Arizona, 85258, United States

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shenandoah Oncology, P.C.

    Winchester, Virginia, 22601, United States

  • Somogy Megyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400, Hungary

  • Sorlandet sykehus HF

    Kristiansand, 4615, Norway

  • Southeast Nebraska Hematology & Oncology Consultants, P.C.

    Lincoln, Nebraska, 68510, United States

  • St Olavs Hospital

    Trondheim, 7030, Norway

  • Sunnybrook Health Sciences, Odette Cancer Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Sykehuset Oestfold

    Grålum, 1714, Norway

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The Christie NHS Foundation Trust

    Manchester, MB204BX, United Kingdom

  • The Royal Marsden Foundation Trust

    London, SW3 6JJ, United Kingdom

  • The Royal Marsden NHS Foundation Trust.

    Sutton, Surrey, SM2 5PT, United Kingdom

  • The West Clinic, P.C.

    Germantown, Tennessee, 38138, United States

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N 4N2, Canada

  • Toranomon Hospital

    Tokyo, 105-8470, Japan

  • UC Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • UC Irvine Comprehensive Cancer Center/Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • US Oncology and Research

    The Woodlands, Texas, 77380, United States

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590, Germany

  • Universitaetsklinikum Jena

    Jena, 07747, Germany

  • Universitaetsklinikum Magdeburg. Klinik fuer Urologie

    Magdeburg, 39120, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076, Germany

  • Universitaetsklinikum der Technischen Universitaet Dresden

    Dresden, 01307, Germany

  • Universitetssykehuset i Nord Norge. Kreftavdelingen

    Tromsø, 9019, Norway

  • University Hospital Waterford

    Waterford, X91ER8E, Ireland

  • University of Tennessee Erlanger Oncology & Hematology

    Chattanooga, Tennessee, 37403, United States

  • Utah Cancer Specialists

    Salt Lake City, Utah, 84106, United States

  • Western General Hospital

    Edinburgh, EH4 2XU, United Kingdom

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Willamette Valley Cancer Institute and Research Center

    Eugene, Oregon, 97401, United States

  • Woodlands Medical Specialists, PA

    Pensacola, Florida, 32503, United States

  • Yamaguchi University Hospital

    Ube, Yamaguchi, 755-8505, Japan

  • Zala Megyei Szent Rafael Korhaz

    Zalaegerszeg, Pozva, 8900, Hungary

Conditions

Explore the condition pages connected to this study.