Urinary system disorder

This trial is testing an experimental therapy called FKC289 for people with a type of kidney disease called primary membranous nephropathy that has come back or not responded to standard treatment. FKC289 uses the patient's own immune cells, which are modified in the lab to recog…

This trial tests whether combining two drugs—disitamab vedotin and toripalimab—with or without pelvic lymph node removal can help people with muscle-invasive bladder cancer keep their bladder. Participants, who have HER2-positive tumors and decline bladder removal surgery, will r…

This phase 2 trial is testing whether a single infusion of a patient's own genetically modified immune cells, called C-CAR168, can safely and effectively treat lupus nephritis that has not responded to standard therapies. The cells are designed to target and eliminate specific im…

This trial tests whether sending a letter and fact sheet to adults in Manitoba who are at high risk for kidney failure can encourage them to see a kidney specialist. The goal is to catch advanced chronic kidney disease earlier and reduce the number of people who progress to dialy…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This trial tests a new tool called CURTIS, designed to safely remove bladder tumors in one intact piece after they are cut out during surgery. The goal is to see how often the device can successfully retrieve the tumor without breaking it apart, and what the largest tumor size is…

This study offers continued access to tucatinib, an oral targeted therapy, for people with HER2-positive cancers (including breast, cervical, and lung) who were already benefiting from the drug in a previous Pfizer-sponsored trial. The main goal is to monitor long-term safety and…

This trial is testing whether MRI-guided radiation therapy can treat early-stage kidney cancer with fewer side effects than standard CT-based radiation. The study enrolls adults with kidney cancer who are not candidates for surgery or who decline it. Participants receive a single…

This phase 3 trial is testing whether adding the drug obinutuzumab to the standard treatment (mycophenolate mofetil and corticosteroids) can improve outcomes for people with active lupus nephritis, a serious kidney complication of lupus. The study will enroll 70 adults aged 18-65…

This trial is testing a device that delivers heated chemotherapy directly into the bladder for people with non-muscle invasive bladder cancer. The goal is to see if the system is safe and works as intended. Participants will receive the treatment and be monitored for side effects…

This trial tests whether adding a single infusion of zuberitamab to standard steroid therapy can help children aged 1 to 18 with newly diagnosed steroid-sensitive nephrotic syndrome stay relapse-free longer. Participants receive either standard steroids alone or steroids plus zub…

This study tests whether a single dose of tranexamic acid (TXA), a drug that helps blood clot, can reduce blood loss during urethral reconstruction surgery. Forty adults having this surgery will be randomly assigned to receive TXA or standard care. Researchers will compare change…

This trial tests a new type of vascular graft, called STARgraft, for people with end-stage kidney disease who need hemodialysis. The graft is placed in the arm to create a reliable access point for dialysis. The study compares STARgraft to a standard graft to see if it works bett…

This trial tests whether using a wearable cuffless blood pressure monitor to guide treatment can help more hemodialysis patients achieve target blood pressure than standard office-based measurements. Adults on maintenance hemodialysis with high blood pressure will be randomly ass…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests three experimental antibodies—REGN9933, REGN7508, and REGN9533—in people with end-stage kidney disease who are on hemodialysis. The goal is to see if these antibodies can safely reduce blood clot risk during dialysis, potentially offering an alternative to standa…

This study tests whether providing fruits and vegetables along with cooking and nutrition education can improve kidney health in adults with chronic kidney disease. Participants are randomly assigned to receive either fruits and vegetables alone or fruits and vegetables plus a 12…

This trial asks whether an oral medication called daprodustat can match the effectiveness of the injectable drug epoetin alpha in treating anemia linked to chronic kidney disease. Adults with stage 3-5 kidney disease who are not on dialysis and have low hemoglobin levels will rec…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This early-stage trial tests whether giving kidney transplant recipients a special treatment made from their donor's cells, combined with a light-based therapy called photopheresis, can safely reduce the risk of organ rejection. About 24 adults receiving their first kidney transp…

This early-stage trial is testing whether a single infusion of universal STAR-T cells—a type of engineered immune cell that targets both CD19 and BCMA—can safely and effectively treat two autoimmune kidney diseases: IgA nephropathy and primary membranous nephropathy. The study wi…

Acute kidney injury is a frequent and serious complication after cardiac surgery, and effective prevention remains elusive. This study analyzes data from 5,000 adults who had heart surgery with a heart-lung machine to see whether giving the amino acid L-arginine within the first …

This phase III trial is testing whether an experimental drug called elecoglipron can reduce the risk of serious kidney decline, kidney failure, or death in people with chronic kidney disease. About 7,000 adults with the condition, with or without type 2 diabetes, will receive eit…

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be random…

This trial compares two ways of finishing kidney stone removal surgery. In one, a medical glue called Glubran 2 is sprayed into the access tract to seal it, avoiding the need for a drainage tube. In the other, a standard tube is placed. The study aims to see if the glue technique…

This phase 1 trial is evaluating an investigational drug called SI-B036, a bispecific antibody designed to target cancer cells in a unique way. The study will enroll about 30 adults with locally advanced or metastatic urological tumors or other solid tumors. The main goals are to…

This study is testing whether an experimental drug called FXS6837 can safely reduce protein in the urine and help preserve kidney function in people with IgA nephropathy, a disease that can lead to kidney failure. About 60 patients who previously completed a shorter study of FXS6…

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This trial asks whether some people with intermediate-risk bladder cancer can safely skip chemotherapy after having their tumor removed. Doctors will use a urine test before surgery to find patients whose tumors are unlikely to shed detectable signals. These patients will then be…

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

This study tests a new device that combines a camera and suction in one tool for kidney stone removal surgery. About 75 adults with kidney stones between 0.5 and 2.0 cm will undergo the procedure to see if the device safely clears stones and reduces leftover fragments. The goal i…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study compares two surgical methods to repair a short (up to 2 cm) narrowing in the bulbar urethra. One technique removes the scarred section and reconnects healthy ends; the other uses a graft from the lining of the testicle to widen the stricture. 94 men aged 18-50 with no…

This trial compares an experimental oral drug, FXS6837, to the standard infusion eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that causes red blood cells to break apart. About 90 adults who have not previously used complement inhibito…

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kid…

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

This trial tests three 8-week approaches for women with overactive bladder: standard education on pelvic floor exercises, biofeedback-assisted training, and biofeedback combined with tibial nerve stimulation. The goal is to see if adding biofeedback or nerve stimulation provides …

This trial tests whether a newer surgical method called en bloc resection, which removes bladder tumors in one piece, works better than the standard piecemeal approach for people with intermediate- or high-risk non-muscle-invasive bladder cancer. All participants also receive a y…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial compares three ways to remove kidney stones using a scope inserted through the urinary tract. Some patients will have the procedure without a protective sheath, while others will use a flexible sheath, with either low or high laser power. The goal is to see which appro…

This trial is testing whether giving a combination of an experimental immunotherapy (epalolitoworelimab) and a targeted therapy (lenvatinib) before and after surgery can improve outcomes for people with high-risk clear cell kidney cancer. The treatment is given first to shrink th…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This study tests whether elderly patients starting dialysis for kidney failure can receive treatments twice a week instead of the usual three times, without increasing hospitalizations or death. The goal is to see if fewer sessions allow patients to spend more days at home and im…

This pilot trial tests whether restarting renin-angiotensin system inhibitors (RASi) — common blood pressure and kidney-protecting medications — early after acute kidney injury is feasible and well-tolerated. Hospitalized adults who were on RASi before admission and stopped due t…

This phase II trial tests an experimental drug called QLS7305 in people with several kidney diseases driven by overactivation of the complement system, a part of the immune system. The drug is a small interfering RNA (siRNA) designed to reduce production of complement protein C3,…

This phase 1 trial tests an experimental cell therapy called LMY-922 (BAFF CAR-T cells) in people aged 16 to 75 with refractory autoimmune diseases, including rheumatoid arthritis, lupus, dermatomyositis, and systemic sclerosis. The therapy uses donor immune cells engineered to t…

This trial tests whether having clinical dietitians take the lead on nutrition care—rather than waiting for referrals—can help adult medical inpatients at risk of malnutrition. Researchers will compare a dietitian-driven model with usual care on three hospital wards, measuring le…

This trial investigates whether a 12-week supervised exercise program, done during regular hemodialysis sessions, can improve postural problems like hunched back and forward head posture in adults with end-stage renal disease. Participants will be randomly assigned to either the …

This phase 3 trial is testing whether adding an experimental drug called SHR-1501 to the standard BCG therapy can improve outcomes for people with a high-risk form of bladder cancer that has not spread into the muscle wall. Participants must have had all visible tumors removed be…

This trial tests whether an artificial intelligence system can help surgeons better see and remove bladder tumors during a standard procedure called TURBT. The AI analyzes the live video from the surgical camera and highlights suspicious areas and recommended cutting edges on the…

This early-phase trial is testing a new biologic drug, UGN-501, for people whose non-muscle invasive bladder cancer has returned after previous treatment. The drug is given directly into the bladder through a catheter once a week for six weeks, with possible quarterly maintenance…

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibio…

This early-phase trial tests a new treatment called LB-DTK-BKV for people who develop painful bladder bleeding (hemorrhagic cystitis) from BK virus after a stem cell transplant. The treatment uses immune cells from a donor that are trained to attack the virus. About 42 children a…

This phase II trial tests whether obinutuzumab, a B-cell targeting antibody, can alone achieve complete kidney response in people with pure class V lupus nephritis—a form of lupus kidney disease with no approved treatments. Participants receive up to four infusions over seven mon…

This phase 2 trial tests an experimental drug called sacituzumab tirumotecan in people with two rare types of cancer: papillary renal carcinoma and less common forms of bladder cancer. The drug is given by IV every two weeks for up to three years. The main goal is to see how many…

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main g…

This phase 2 trial is testing whether a combination of an antibody-drug conjugate (disitamab vedotin), an immunotherapy (toripalimab), and targeted radiation can improve outcomes for people with high-risk upper tract urothelial carcinoma. Participants receive the drug and immunot…

This trial compares two approaches for people with small, symptom-free kidney stones: immediate surgery versus simply monitoring them over time. Researchers want to know which strategy leads to less disruption in daily life, fewer emergency visits, and better overall well-being. …

This early-stage trial is testing an experimental antibiotic called TUL108 in healthy volunteers to see if it is safe and how the body processes it. The drug is being developed for complicated urinary tract infections (cUTI), which can be difficult to treat with standard antibiot…

This study tests two common methods to treat metabolic acidosis—a condition where blood becomes too acidic—in people on long-term hemodialysis for kidney failure. One group takes oral sodium bicarbonate capsules, while the other gets a higher bicarbonate concentration in their di…

This phase II trial tests a combination of two immunotherapies (ipilimumab and sintilimab) plus a targeted drug (lenvatinib) as a first treatment for people with a rare and aggressive form of kidney cancer called TFE3-rearranged renal cell carcinoma. The study enrolls about 66 pa…

This trial compares two weight-loss approaches—daily calorie restriction versus 5:2 intermittent fasting—in people with small kidney tumors who are being monitored rather than treated immediately. The goal is to see which program helps patients lose more weight and whether that m…

This phase 2 trial tests whether spironolactone, a drug usually used for heart failure and high blood pressure, can help treat anemia in children aged 6–18 who are on hemodialysis. Participants take spironolactone daily for 12 weeks alongside standard care, and researchers measur…

This study tests whether an oral medication that removes lead from the body can slow kidney function decline in people with type 2 diabetes and high lead levels. Participants take dimercaptosuccinic acid (DMSA) capsules for up to 3 months, then are followed for 12 months. The goa…

This study compares two common medications for overactive bladder (OAB): solifenacin, which blocks nerve signals in the bladder, and mirabegron, which helps the bladder muscle relax. Researchers want to see if a person's 'anticholinergic burden'—the combined effect of other medic…

This study tests whether a drug that removes lead from the blood can slow the worsening of kidney function in people with type 2 diabetes who also have higher-than-normal lead levels. Participants receive intravenous infusions of calcium disodium edetate, and their kidney functio…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This trial tests four different breathing strategies during kidney stone surgery to see if reducing kidney motion helps surgeons remove stones more completely and lowers the risk of complications. Eighty adults undergoing the procedure will be randomly assigned to standard ventil…

This early-stage trial tests whether two immune-engaging drugs, blinatumomab and teclistamab, can safely lower blood-group antibodies in people awaiting a living-donor kidney transplant that is not blood-type compatible. The goal is to see if these drugs can prepare the body to a…

This study tests whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can be safely taken by adults with moderate chronic kidney disease. The main goal is to see if it's feasible for participants to take the supplement daily and complete study procedur…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This trial tests whether a prehabilitation program — combining exercise, nutrition advice, and psychological support — can improve fitness and recovery in people with advanced chronic kidney disease awaiting a kidney transplant. Researchers compare an in-person, hospital-based pr…

This study tests whether a supplement called Ketosteril, added to the usual diet, can help people who are starting hemodialysis (a treatment for kidney failure) stay on a less frequent schedule longer. The trial includes 70 adults beginning incremental hemodialysis, where session…

This trial investigates whether adding Naoxintong Capsule, a traditional Chinese medicine made from 16 herbal and animal ingredients, to standard therapy can slow the progression of diabetic nephropathy in people with type 2 diabetes. The study involves 410 participants who will …

This study looks back at the experiences of 35 adults with a rare kidney disease called C3G who received the drug iptacopan through a special early access program in Spain. Researchers will collect information on patient health, lab results, and how the disease responds to treatm…

This trial tests a home-based program of exercise, breathing exercises, nutrition advice, and emotional support for people waiting for a kidney transplant. Participants start the program at least 4 weeks before surgery and continue for 18 weeks after leaving the hospital. The goa…

This early-phase trial tests whether a genetically modified pig kidney combined with thymus tissue can work as a transplant in 4 adults with end-stage kidney disease. The goal is to see if the organ can keep them off dialysis safely for at least 6 months. Participants must be on …

This phase 2 trial is testing whether a combination of two drugs—zanzalintinib (a pill taken daily) and pembrolizumab (given by IV every three weeks)—can shrink advanced kidney tumors before surgery and help prevent the cancer from coming back afterward. The study enrolls people …

This early-stage trial tests a new drug called CT-202 in people with advanced triple-negative breast cancer, colorectal cancer, or bladder cancer that has come back or spread. The drug is a bispecific antibody designed to help the immune system attack cancer cells that have a pro…

This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will …

This phase III trial compares the immunotherapy drug pembrolizumab to active surveillance (no treatment) after kidney cancer surgery in patients with non-clear cell renal cell carcinoma, a less common type of kidney cancer. The goal is to see if pembrolizumab can help the immune …

This study tests a personalized approach for people with muscle-invasive bladder cancer who are scheduled for bladder removal surgery. Before treatment, a small sample of the tumor is used to grow cell clusters in the lab. These clusters are tested against different drugs to find…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This trial tests two BiTE drugs (blinatumomab and teclistamab) in 20 adults with end-stage kidney disease who have very high antibody levels (cPRA ≥90%) and have waited over 5 years for a transplant. The goal is to safely lower these antibodies enough to make a kidney transplant …

This trial tests whether a new flexible and navigable suction ureteral access sheath (FANS) works better than the standard sheath for removing kidney stones smaller than 2 cm in children. Sixty children will be randomly assigned to one of the two devices during a procedure called…

This early-stage trial tests whether a personalized vaccine, made from each patient's unique tumor mutations, can safely boost the effects of the immunotherapy drug pembrolizumab in people with advanced kidney cancer. The vaccine is designed to train the immune system to recogniz…

This study compares two treatments—albumin and fresh frozen plasma—for children with idiopathic nephrotic syndrome who have fluid buildup that doesn't respond to standard diuretics. The goal is to see which approach resolves swelling faster and more safely. Fifty-six children age…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can better manage bone and mineral problems common in people with end-stage kidney disease. Thirty adults on maintenance dialysis will try both the new and standard filters for three months each. R…

This study tests whether adding a single dose of infliximab to a short course of prednisone helps people recover kidney function faster after immunotherapy-related acute kidney injury. Participants receive either the combination or standard prednisone alone. The goal is to see if…

This study tests whether a personalized nursing program can prevent acute kidney injury (AKI) in people with liver cancer who undergo interventional therapy. Researchers first use a prediction model to classify patients into low, moderate, or high risk for AKI. Then, they provide…

This trial tests whether a vacuum-assisted ureteral access sheath (ClearPetra) removes kidney stones more completely than a standard rigid sheath (Navigator) during flexible ureteroscopy. About 156 adults with stones 1-3 cm will be randomly assigned to one sheath. The main goal i…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This trial tests a self-management program that uses education, WhatsApp reminders, and a diary to help hemodialysis patients control weight gain between sessions. The program aims to improve fluid adherence and stabilize blood pressure. Participants are adults on maintenance hem…

This study tests whether combining rituximab with a low dose of mycophenolate mofetil can safely and effectively treat lupus nephritis in children. Lupus nephritis is a serious kidney complication of lupus. The trial enrolls children aged 3 to 18 with active kidney inflammation. …

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This trial compares two sedatives—remimazolam and propofol—given during liver or pancreas surgery to see which better prevents acute kidney injury after the operation. The study includes adults aged 19 to 85 scheduled for elective hepatobiliary-pancreatic surgery. Researchers aim…

This study tests whether a low-carbohydrate, plant-based diet can lower inflammation in people with autosomal dominant polycystic kidney disease (ADPKD). Thirty-six adults will try the special diet and their usual diet in random order, each for 12 weeks. The main goal is to see i…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests whether adding extra bicarbonate and magnesium to the fluid used during dialysis can improve how well the body handles minerals like calcium and phosphate. It involves adults with end-stage kidney disease who have been on dialysis for at least three months. Each …

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This phase 2 trial tests whether a combination of two drugs—enfortumab vedotin (Padcev) and pembrolizumab (Keytruda)—can help people with muscle-invasive bladder cancer avoid bladder removal. About 56 participants will receive the drugs first, and those who respond well may get r…

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes and heart failure, can reduce harmful antibodies and prevent relapses in people with membranous nephropathy, an autoimmune kidney disease. The study enrolls 20 adults who have had a recent rise in anti-PLA2R…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This pilot study tests whether adding a Chinese herbal formula called CKD-1 to standard care can improve kidney function in people with stage 3-4 non-diabetic chronic kidney disease. About 66 adults will be randomly assigned to receive either standard care alone or standard care …

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This pilot study will test whether adding a traditional Chinese herbal formula (DKD-1) to standard care can improve kidney function in people with diabetic kidney disease. Sixty-six adults with type 2 diabetes and moderate-to-severe chronic kidney disease will be randomly assigne…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study looks at whether changing the filter in a kidney dialysis machine more often than usual can lower the chance of new infections in critically ill patients with severe acute kidney injury. About 100 adults in intensive care will be randomly assigned to have their filter …

This study tests whether combining two drugs (trastuzumab rezetecan and camrelizumab) before surgery can improve outcomes for people with a certain type of muscle-invasive bladder cancer (HER2-positive). About 44 adults will receive the treatment to see if it helps eliminate canc…

This Phase 3 trial tests whether BHV-1400 can safely reduce protein in the urine and preserve kidney function in 420 adults with IgA nephropathy. Participants are randomly assigned to receive either the drug or a placebo by injection. The main goal is to see if BHV-1400 lowers pr…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This phase 2 trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, given before surgery to people with muscle-invasive bladder cancer or upper tract urothelial carcinoma. The goal is to see if the drugs can shrink or eliminate the cancer enough that some b…

This study is testing a new device called ARTUS® that acts like an artificial muscle to control urine leakage in women with severe stress urinary incontinence. Six women who have not gotten better with other treatments will get the device implanted and be followed for two years. …

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This study tests a new drug called AK146D1, given alone or with another drug (AK112), in people with advanced urothelial carcinoma (a type of bladder cancer). The goal is to see if the treatment is safe and can shrink tumors. About 132 adults aged 18-75 with measurable tumors and…

This study tests whether giving specific blood pressure drugs based on a patient's circulation type during kidney transplant surgery improves how the body responds to fluids. Researchers will monitor 255 adults and assign drugs like vasopressin or norepinephrine based on real-tim…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This Phase 2 trial tests whether giving two drugs (anlotinib and benmelstobart) before surgery can improve outcomes for people with localized kidney cancer. About 144 participants will either receive the drug combo followed by partial nephrectomy, or surgery alone. The main goal …

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This study looks at people with a very high-risk type of bladder cancer that cannot be fully removed with standard surgery. After initial treatment with immunotherapy and surgery, some patients become tumor-free. The trial then randomly assigns them to either continue immunothera…

This study tests whether adding the cholesterol drug atorvastatin to standard targeted therapy (axitinib) and immunotherapy (toripalimab) can help people with advanced kidney cancer who are not responding well to treatment. The drug combination is guided by lab tests on patient-d…

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This long-term extension study offers continued access to several cancer drugs—including cabozantinib, atezolizumab, and nivolumab—for up to 5,000 patients who benefited from them in earlier Exelixis-sponsored trials. The study focuses on monitoring safety and ongoing clinical be…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether giving two drugs (trastuzumab rezetecan and adebrelimab) before surgery can eliminate or shrink tumors in people with a specific type of muscle-invasive bladder cancer (HER2-positive). About 58 adults will receive the combination, then have their bladder …

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This Phase 2 study will test whether empagliflozin (Jardiance), a drug already used for diabetes, can improve blood vessel health and exercise tolerance in 52 veterans with non-diabetic chronic kidney disease. Participants will take either the drug or a placebo for a period, and …

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests whether a combination of disitamab vedotin (a targeted drug) and toripalimab (an immunotherapy) works better than standard chemotherapy plus immunotherapy for people with HER2-positive muscle-invasive bladder cancer. About 240 participants will receive treatment …

This study tests whether giving a combination of two drugs (a PD-L1 inhibitor called TQB2450 and anlotinib) before surgery can shrink complex kidney tumors enough to allow surgeons to remove only the tumor and save the rest of the kidney. About 33 adults with advanced clear cell …

This study tests whether a 15-month course of Nefecon can prevent proteinuria relapse in 288 adults with IgA nephropathy who have already achieved remission. Participants must have completed prior Nefecon therapy and have stable kidney function. The goal is to see if maintenance …

This study looks at whether giving more protein (1.5-1.7 grams per kilogram per day) to critically ill patients with acute kidney injury who need continuous dialysis can reduce muscle wasting compared to standard protein intake (1.0-1.2 g/kg/d). About 56 adults will be randomly a…

This study tests whether giving a combination of three drugs (pembrolizumab, belzutifan, and lenvatinib) before surgery can shrink kidney tumors in people with localized clear cell renal cell carcinoma. About 150 participants will receive the drugs for 12 weeks before surgery, th…

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests a two-drug treatment (disitamab vedotin plus tislelizumab) for people with a rare, aggressive cancer of the upper urinary tract that has a specific marker (HER2-positive). The goal is to shrink the tumor so that the kidney can be saved, avoiding complete removal.…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study will test whether a supplement made from jaboticaba peel can reduce inflammation, oxidative stress, and gut bacteria imbalances in people with chronic kidney disease. Thirty adults will take either the jaboticaba extract or a placebo for one month. Researchers will mea…

This pilot phase II trial tests whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery is safe and feasible for patients with high-risk clear cell kidney cancer that hasn't spread. Sixteen participants will receive the drugs and then undergo surgery …

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This phase 2 trial tests whether adding a probiotic capsule (MO-03) to the drug zanzalintinib can help treat metastatic kidney cancer that has worsened after immunotherapy. About 34 adults with advanced clear cell renal cell carcinoma will receive both treatments. The goal is to …

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This early-phase study tests a new drug combination (L19IL2 plus ruxolitinib) in people with advanced kidney, pancreatic, or colorectal cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 96 partici…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study looks at people with narrowed kidney arteries and high blood pressure. It uses a special pressure measurement (FFR) to decide who gets a stent and who gets only medication. The goal is to see which approach better protects kidney function and controls blood pressure ov…

This early-stage trial tests a procedure called calcium electroporation for bladder tumors. Doctors inject calcium into the tumor and then apply short electric pulses to destroy cancer cells. The study will include 20 patients who cannot have standard surgery or other treatments.…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This Phase 2 trial tests SLN12140, an experimental drug, in 48 adults with IgA nephropathy whose disease is not well-controlled by standard treatments. Participants receive different doses of SLN12140 or a placebo for 36 weeks, then all can receive the drug for another year. The …

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This study will follow 50 adults with IgA nephropathy who are taking sparsentan. Researchers want to see how the drug affects protein in the urine (albuminuria), a key sign of kidney damage. The study is observational, meaning it just watches what happens in real-world use, witho…

This Phase 1 trial tests a new drug called HLX05-N, which is a biosimilar (a copy) of the cancer drug Erbitux, in 387 people with metastatic colorectal cancer. Participants will receive either HLX05-N or Erbitux (from the US or EU) along with standard chemotherapy. The study aims…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This phase 2 trial tests a combination of two drugs (Benmelstobart and Anlotinib) plus targeted radiation (SBRT) in 29 adults with liver cancer that has spread to a few other spots and no longer responds to first-line treatment. The goal is to see if this triple therapy can slow …

This early-phase study tests a new treatment using specially engineered immune cells (CD19 CAR-γδ T cells) for people with severe autoimmune kidney diseases like lupus nephritis, IgA nephropathy, and membranous nephropathy that haven't responded to standard therapies. About 15 pa…

This phase 3 study tests a new drug called SYS6002 against standard chemotherapy in 406 people with advanced bladder cancer (urothelial carcinoma) that has worsened after platinum chemo and immunotherapy. The main goal is to see if SYS6002 helps people live longer. The study is n…

This study tests a new drug called NM8074 in 12 adults with paroxysmal nocturnal hemoglobinuria (PNH) who are already taking Soliris. PNH is a rare blood disorder where the immune system destroys red blood cells, causing anemia and fatigue. NM8074 is designed to block a different…

This early-stage trial tests a drug called NM8074 in 10 adults with IgA Nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug safely reduces protein in the urine, a sign of kidney damage, after 99 days of treatment. Participants must have a…

This early-phase trial tests a new drug called NM8074 in 18 adults with C3 Glomerulopathy (C3G), a rare kidney disease. The drug is given by IV over several weeks to see if it is safe and can reduce protein in the urine, a sign of kidney damage. Researchers will also check how th…

This study compares two suction-assisted techniques used during minimally invasive kidney stone surgery. The goal is to see which method better clears stones and lowers the risk of infection. About 126 adults with medium-sized kidney stones (2-3 cm) will be randomly assigned to o…

This study tests an experimental drug called FXS6837 in 60 adults with IgA nephropathy, a kidney disease. Participants will receive either the drug or a placebo for about 6 months. The main goal is to see if the drug lowers protein in the urine, a sign of kidney damage.

This phase 2 study tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) and targeted radiation to a standard targeted therapy (fruquintinib) can help people with metastatic colorectal cancer that has spread to a few spots. The trial will enroll 60 adults who …

This early-stage trial tests an experimental imaging agent called 68Ga-NYM096 in 20 adults who have a kidney mass of uncertain nature seen on CT or MRI and are scheduled for surgery. The agent is designed to attach to a protein common on clear cell renal cell carcinoma cells, pot…

This study is testing whether new biomarkers in urine can more accurately diagnose urinary tract infections (UTIs) in two groups where current tests often fail: young children not yet toilet-trained and adults aged 65 and older. In these groups, standard urine tests can be mislea…

This study asks whether levels of uromodulin, a protein in the blood, can indicate the severity of kidney damage in people with lupus nephritis. Researchers will compare uromodulin levels with kidney biopsy results from 90 participants, including those with different classes of l…

This study investigates whether levels of a protein called RNASE1 in the blood can serve as a biomarker for lupus nephritis, a serious kidney complication of systemic lupus erythematosus (SLE). Researchers will compare RNASE1 levels in 128 adults with SLE, some with lupus nephrit…

This trial is testing whether a urine test called ProNephro AKI™ (NGAL) can accurately predict which critically ill adults in the intensive care unit (ICU) will develop moderate to severe acute kidney injury within 48 to 72 hours of admission. The study will enroll 800 adults who…

This trial tests whether a specialized ultrasound catheter, normally used in heart arteries, can be safely threaded into the upper urinary tract to measure how deeply a tumor has invaded the wall. Fifteen adults with upper tract urothelial carcinoma who are already scheduled for …

This study will test an artificial intelligence system that screens for breast, liver, kidney, and bladder cancers using standard CT scans taken for other reasons. Researchers plan to enroll 100,000 participants to see if the AI can catch tumors earlier and help doctors reduce mi…

This trial is testing whether a breath analysis device can detect unique chemical patterns—called volatile organic compounds—that may signal the presence of cancer. Researchers will collect breath samples from 1,000 people with various cancers and 1,000 healthy volunteers, then u…

Lupus nephritis is a serious kidney complication of lupus that can lead to kidney failure. This study investigates whether levels of neutrophil extracellular traps (NETs)—web-like structures released by immune cells—in the blood can predict how well patients respond to therapy. R…

This pilot study is testing whether an artificial intelligence-assisted catheter camera system, called Uro-Cam, can safely and accurately detect bladder cancer. Adults with blood in their urine, abnormal urine cytology, or a history of non-muscle-invasive bladder cancer will unde…

This trial tests whether contrast-enhanced ultrasound (CEUS) using Lumason can detect kidney scarring as accurately as the standard DMSA scan, but without radiation. Children and young adults scheduled for a DMSA scan will receive an additional CEUS exam. If CEUS proves reliable,…

This early-phase study tests a new imaging agent that targets a protein called TROP2, found on many cancer cells. About 40 adults with metastatic bladder, breast, or lung cancer will receive the agent to see where it goes in the body. The goal is to see if this tracer can help do…

This early-phase study tests a new imaging agent called RYZ512 in 10 people with advanced clear cell kidney cancer that has spread. The agent is designed to attach to a protein (CAIX) found on these cancer cells, making them show up on scans. The goal is to see if it is safe and …

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This trial tests three ways to manage urinary symptoms in women aged 65 and older who have frequent urinary tract infections. Some participants receive antibiotics right away, while others get treatment only after a urine test or a lab culture. The goal is to find out which appro…

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. T…

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …

This study tests a wearable device that continuously measures kidney function in ICU patients with acute kidney injury (AKI). The device uses a fluorescent tracer and a chest patch to track GFR in real time. Researchers will compare its accuracy to standard lab tests in 50 adults…

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests an AI tool that analyzes ultrasound images to help doctors decide if a baby with hydronephrosis (kidney swelling) needs surgery. About 322 infants up to 24 months old will take part. Doctors first make a care plan without the AI, then see the AI's prediction and …

This study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.

This trial tests whether a prenatal exercise program that combines Liuzijue qigong with traditional Kegel exercises, guided by a mobile app, can prevent postpartum urinary incontinence and pelvic organ prolapse. Pregnant women in their third trimester will be randomly assigned to…

This trial tests whether a single high dose of nicotinamide (a form of vitamin B3) taken on the morning of heart surgery can reduce the risk of acute kidney injury afterward. The study enrolls 20 adults undergoing coronary bypass or valve surgery with a heart-lung machine who are…

This trial tests whether terbinafine, a common antifungal drug, can prevent acute kidney injury in adults undergoing heart surgery with a heart-lung machine. Participants at high risk of kidney damage will receive terbinafine or a placebo before and after surgery. The study track…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This study tests whether a daily probiotic supplement called Colipral® can prevent repeat bladder infections (cystitis) in menopausal women aged 55–70. Participants take either the probiotic or a placebo for 12 weeks and are monitored for 24 weeks to see if they have fewer infect…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests whether a single dose of the drug disitamab vedotin, given directly into the bladder right after kidney removal surgery, can prevent bladder cancer from coming back. It involves 49 adults with HER2-positive upper tract cancer who are at risk for recurrence. The m…

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective h…

This study looks at newborn boys with posterior urethral valves (PUV), a rare birth defect that raises the risk of serious kidney infections. It compares circumcision alone versus circumcision plus daily antibiotics to see if the surgery alone is enough to prevent these infection…

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This trial tests whether nalfurafine, an oral drug that acts on opioid receptors in the body, can reduce the severe itching that often plagues people with chronic kidney disease who are on hemodialysis. Researchers will compare the drug against a placebo in adults aged 18 to 65 w…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This trial tests whether adding a traditional Chinese herbal decoction, Bushen Huoxue Simiao Formula, to standard care can ease urinary symptoms and improve quality of life for adults recovering from upper urinary tract stone surgery. Participants, aged 18 to 80, will receive eit…

This study tests whether acupuncture laser therapy can reduce neck pain and improve quality of life in people undergoing hemodialysis. Sixty participants will either receive standard care or standard care plus laser therapy three times a week for four weeks. Researchers will meas…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This trial tests whether adding palliative care to standard treatment helps people with advanced chronic kidney disease (stages 4 and 5, including those on dialysis) feel better. Participants are randomly assigned to receive either usual kidney care or usual care plus integrated …

This study tests whether low-intensity shock wave therapy, a non-surgical treatment applied over the lower abdomen, can ease overactive bladder symptoms in women who haven't found relief from standard treatments. Forty women will be randomly assigned to receive either the real th…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This study compares custom-length ureteral stents (based on each person's imaging) to standard one-size-fits-all stents in 128 adults having kidney stone surgery. The goal is to see if the custom stents reduce pain, urinary issues, and other symptoms. Participants will fill out a…

This early-stage study will give 20 bladder cancer patients cannabigerol (CBG) gummies before and after surgery to see if they are safe and tolerable. The goal is to improve quality of life and reduce symptoms during recovery. Researchers will monitor side effects and how well pa…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This study tests whether applying mild electrical pulses (TENS) to the shins can reduce pain and anxiety in people receiving Botox injections into the bladder for overactive bladder. Participants are randomly assigned to receive either active TENS or a sham device during the inje…

This trial tests whether an ultrasound-guided nerve block called QLESP can reduce pain and the need for opioid painkillers after robot-assisted partial nephrectomy for kidney cancer. Adults scheduled for this surgery are randomly assigned to receive either the QLESP block or a st…

This study tests whether adding either dexamethasone (a steroid) or terbutaline (an asthma drug) to standard paracetamol provides better pain relief for people with kidney stones in the emergency room. About 300 adults with severe pain will be randomly assigned to one of the two …

This study investigates whether a simple breathing exercise called the 4-7-8 technique can reduce fatigue and improve sleep in people undergoing hemodialysis for chronic kidney disease. Eighty adult patients are randomly assigned to either practice the breathing exercise twice da…

This study tests whether a 4-7-8 breathing exercise can reduce pain when needles are inserted into the arm for hemodialysis. About 80 adults on dialysis will either learn the breathing technique or receive standard care. The goal is to see if this easy, drug-free method makes the…

This trial compares two approaches for adults with interstitial cystitis, a condition causing long-term bladder pain and frequent urination. All participants receive education and behavioral training, while half also take the antidepressant venlafaxine for 12 weeks. Researchers w…

This study investigates whether adding expiratory muscle strength training (breathing exercises) to standard pelvic floor muscle training can better reduce stress urinary incontinence in women aged 18 to 65. Participants are randomly assigned to either pelvic floor training alone…

This study compares two ways to break up kidney stones using a laser and a suction device. One method turns stones into dust, the other into small fragments. The goal is to see which leaves fewer stone pieces behind after one month. About 86 adults with small kidney stones will t…

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study will test two different pelvic floor exercise techniques in 40 women aged 30-40 with stress urinary incontinence (leaking urine during activities like coughing or exercise). One group will do exercises in gradually harder positions, while the other will use gradually h…

This study investigates whether adding low-intensity shockwave therapy to standard Kegel exercises can better reduce urine leakage in women with stress urinary incontinence. Participants will either do Kegels alone or Kegels plus weekly shockwave sessions for eight weeks. The goa…

This study compares a newer anesthesia drug, fospropofol disodium, with the standard drug propofol for people undergoing ureteroscopy (a procedure to remove kidney stones). About 190 adults will be randomly assigned to receive one of the two drugs during surgery. The main goal is…

This study tests whether stimulating a nerve near the ankle, called percutaneous tibial nerve stimulation (PTNS), can safely treat overactive bladder in children aged 5 to 21. The treatment uses a device called Urgent PC that sends weak electrical signals through a thin needle to…

This study tests whether electroacupuncture (thin needles with mild electrical pulses) can help women with overactive bladder who haven't improved with standard treatments. Thirty-two women will receive either electroacupuncture, a nerve stimulation therapy, or a sham (fake) acup…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study looks at whether intermittent fasting is safe and doable for people with advanced solid tumors who are starting immunotherapy. About 90 participants will be split into three groups: no fasting, eating only during an 8-hour window each day, or fasting every other day. R…

This study will test whether a wearable device that stimulates a nerve in the leg can help women with overactive bladder and frequent nighttime urination. Participants will either use the device plus behavioral therapy or behavioral therapy alone. The goal is to see if the device…

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers …

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study looks at whether a supportive product called Neuridase can help reduce nerve damage (peripheral neuropathy) caused by a combination of two cancer drugs (enfortumab vedotin and pembrolizumab) in people with advanced bladder cancer. About 40 participants will receive sta…

This study will compare two ways to position patients during surgery to remove large kidney stones. One group will lie on their back (supine), the other on their stomach (prone). Researchers want to see which position leads to fewer complications, less pain, and lower costs. The …

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This study compares three approaches to ureteral stenting after kidney stone surgery: no stent, a stent removed after 1 week, and a stent removed after 2 weeks. Researchers will track complications, patient comfort, and recovery in 90 adults with upper urinary tract stones. The g…

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This early study tests a new device that lets dialysis patients use just one needle instead of two for their blood cleaning treatments. The goal is to see if it is safe and works well for people who already have a mature vein connection (fistula). About 20 adults who need dialysi…

This study looks at whether coloring mandalas (circular patterns) can improve mindfulness, mood, and reduce psychological distress in people undergoing hemodialysis for kidney failure. Sixty adults aged 18-50 will be split into two groups: one colors mandalas, the other does free…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This trial will compare two techniques for removing kidney stones larger than 2 cm: a flexible suction sheath (FANS) and direct suction through the scope (DISS). About 100 adults will be randomly assigned to one method. The study will measure surgery time, how completely stones a…

This study tests a new method to deliver botulinum toxin (NT 201) directly into the bladder using the Vibe System for women with overactive bladder. The goal is to reduce daily urine leakage episodes. About 210 women aged 18-80 will participate, and the treatment is compared to a…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether a small, portable nerve stimulation device worn at home can reduce urgent bathroom trips in people with overactive bladder. Sixty adults aged 18 to 65 will either use the device during daily life when they feel urgency or receive standard clinic-based ses…

This study tests whether using virtual reality (VR) during arteriovenous fistula surgery—a procedure for dialysis patients—can lower pain, anxiety, and the need for anesthesia. About 64 adults with end-stage kidney disease will be randomly assigned to receive VR or standard care …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study compares two non-invasive treatments—magnetic field therapy and tibial nerve stimulation—for women with urge urinary incontinence (sudden, strong urges to urinate leading to leaks). Forty women will be randomly assigned to one of the two treatments over six weeks. Rese…

This study compares lidocaine, a numbing drug, to morphine for treating severe kidney stone pain in the emergency room. Researchers will enroll 250 adults whose pain isn't relieved by standard treatment. The goal is to see if lidocaine provides better pain relief at 30 minutes, p…

This study compares two common procedures—RIRS (a scope through the urinary tract) and ESWL (shock waves from outside the body)—to see which removes small kidney stones (up to 1.5 cm) in the lower part of the kidney more effectively. About 66 adults aged 18 to 60 with these stone…

This trial tests whether the drug difelikefalin can reduce severe itching in people with chronic kidney disease who are on hemodialysis. About 106 adults will receive either the drug or a placebo after each dialysis session for 6 weeks. The main goal is to see if itching scores i…

This study compares two new suction-based tools (FANS and CVAC) for removing medium-to-large kidney stones. About 159 adults with stones 8-20 mm will be randomly assigned to one device. The goal is to see which scope clears more stones completely, as shown on CT scans.

This study looks at whether children with chronic kidney disease, especially those on dialysis, have higher levels of PFAS chemicals in their blood. PFAS are found in many everyday products and may interfere with bone development. The study compares PFAS levels in children with k…

This study looks back at adults who had surgery for kidney stones up to 20 mm, comparing those who had a ureteral access sheath placed during the procedure with those who did not. The goal is to see whether using the sheath affects the risk of developing a narrowed ureter or hydr…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study looks back at medical records of critically ill adults who needed emergency dialysis in the emergency department. It compares two methods—standard hemodialysis and a continuous version called CVVHDF—to see how patients fare during their hospital stay. The main focus is…

This study looks at whether eating a high-protein meal changes kidney function in a way that can be measured by a skin sensor. Researchers will give 25 adults an injection of a fluorescent dye and track how quickly it clears from the body before and after the meal. The goal is to…

This observational study tests a new ultrasound-based measure called the Pelvic Floor Fatigue Index (PFFI), which gauges how quickly pelvic floor muscles tire. Researchers will measure PFFI in 75 adults before they undergo ureteroscopy or retrograde intrarenal surgery for kidney …

This study looks at how the experimental drug golcadomide is processed by the body in people with severe kidney impairment or end-stage renal disease compared to those with normal kidney function. The goal is to understand how kidney function affects drug levels and safety after …

This study looks at whether the type of anesthesia used during a common kidney stone procedure affects how much effort the surgeon feels they are putting in. Researchers will observe adults having flexible ureteroscopy and retrograde intrarenal surgery (RIRS), where the anesthesi…

This study looks at whether extra phone calls and text messages can help patients who are likely to miss their urology procedures. About 68 adults at high risk of no-showing will be split into two groups: one gets standard care, the other gets extra reminders. The goal is to see …

This early-stage trial is testing an experimental oral drug called TUL321 in healthy adults to see if it is safe and tolerable. The study will also measure how the drug moves through the body and whether food affects its absorption. TUL321 is being developed as a potential treatm…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This trial is investigating how different levels of kidney function affect the way the body processes a single dose of the antibiotic afabicin. About 60 adults with varying degrees of kidney impairment, from mild to severe, will receive either an oral tablet or an intravenous inf…

This early-stage trial is testing whether hemodialysis—a treatment that filters waste from the blood when kidneys fail—changes how the body processes a combination drug called balcinrenone/dapagliflozin. The study will give a single dose of the drug to about 10 people with kidney…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study tests whether a scoring tool called a nomogram can accurately predict if a patient will be completely stone-free after a minimally invasive kidney stone surgery called flexible ureterorenoscopy. Researchers will compare the nomogram's predictions with actual surgical o…

This study looks at whether a blood-thinning method called citrate anticoagulation is safe and practical for critically ill patients with acute kidney injury who may not process citrate normally. It follows 50 ICU patients who need kidney replacement therapy and are at risk for c…

This study looks at whether two blood markers—DEL-1, an anti-inflammatory protein, and thromboxane A2, a sign of platelet activity—are linked to diabetic nephropathy, a common kidney complication of diabetes. Researchers will measure these markers in 80 adults, including patients…

This study planned to test whether kidneys with small, low-risk tumors could be removed from donors, have the tumor taken out, and then be transplanted into patients with kidney failure. The goal was to increase the number of available donor kidneys. However, the study was withdr…

This pilot study tests whether the experimental drug casdatifan can alter the activity of genes controlled by HIF-2α in people with advanced clear cell kidney cancer that has stopped responding to prior treatments. Participants take casdatifan daily, and researchers analyze tumor…

This registry study follows bladder cancer patients who, after receiving systemic therapy, choose not to undergo bladder removal (cystectomy) or radiotherapy. The goal is to collect data on their outcomes, such as metastasis-free survival, to better understand which patients migh…

This trial is testing whether a connected urine test strip device, called URIKI, can help people with stage 4 or 5 chronic kidney disease monitor their diet from home. Participants will use the device daily for 10 days, logging meals and other health information in a mobile app. …

This study looks at how different levels of kidney function affect the way the body handles an experimental drug called RO7795081. Researchers will give a single oral dose to people with various degrees of kidney impairment and compare them to people with normal kidney function. …

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This study looks at whether the bacteria in your gut and the substances they produce can help predict a serious complication called acute kidney injury (AKI) after heart surgery. Researchers will collect stool and blood samples from about 180 adults before and after their operati…

This observational study investigates whether the ratio of the second to fourth finger length (2D:4D) is associated with urinary stone disease. Researchers will compare finger measurements between adults with kidney or ureteral stones and stone-free controls, all confirmed by CT …

This study examines the most common symptoms of genitourinary syndrome of menopause (GSM) in postmenopausal women and how these symptoms impact quality of life. Researchers will also look at whether using a non-hormonal topical gel called XCM INTIM for at least 8 weeks is linked …

This study looks at the well-being and medical care of people in Korea who had their bladder removed (radical cystectomy) for bladder cancer. Using nationwide insurance records, researchers will track complications, hospital stays, readmissions, and survival up to three years aft…

This study examines how the body processes nemtabrutinib in people with severe kidney impairment compared to healthy volunteers. By measuring drug levels in the blood after a single dose, researchers aim to understand whether kidney function changes how the drug is handled. The r…

This observational study at Sohag University Hospital will look at children from birth to 18 years old who have congenital anomalies of the kidney and urinary tract (CAKUT). Researchers will collect data from medical records and routine follow-ups to describe the types of anomali…

This study looks at whether the biological age of a person's blood vessels, measured before heart surgery, can help predict their risk of acute kidney injury afterward. Researchers will assess vascular aging using noninvasive tests and routine lab results in about 470 adults unde…

Researchers are refining a computer model that estimates the risk of chronic kidney disease progression in adults over 65. Using existing health records from 18,000 patients, the study aims to make the model more accurate and easier for doctors to explain. No new treatments are b…

This study investigates whether psychological well-being and social support influence how well people with diabetic kidney disease manage their own health. Adults with type 2 diabetes and diabetic kidney disease who are not on dialysis will fill out questionnaires about their emo…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

Acute kidney injury is a common and dangerous complication in intensive care, but current tests often detect it too late. This observational study tests whether a pressure gradient in the veins — the difference between the driving force for blood return and the central vein press…

This study looks at how the drug D-2570 moves through the body in people with reduced kidney function compared to those with normal kidneys. About 40 adults aged 18 to 70 will receive a single dose of D-2570. Researchers will measure drug levels in the blood and monitor for side …

This study tests a new tablet version of the experimental drug nurandociguat, which is being developed for chronic kidney disease. Healthy volunteers will receive both the old and new tablets, with and without a high-fat meal, to compare how the drug enters the bloodstream. The g…

This study examines the treatment costs of acute kidney injury (AKI) in patients who undergo cardiac surgery at a UK hospital. By comparing medical records of patients with and without AKI, researchers aim to calculate the financial burden of each stage of kidney injury. The find…

This study investigates whether the triglyceride-glucose (TyG) index, a simple blood-based measure of insulin resistance, can predict early signs of atherosclerosis in people with lupus nephritis. Researchers will measure carotid artery thickness and plaque in 156 adults with lup…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study follows 425 adults with type 2 diabetes and chronic kidney disease who are taking finerenone, a standard medication. Researchers collect blood and urine samples over four months to look for biomarkers that predict whether the drug helps reduce kidney damage. The goal i…

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study follows thousands of people with chronic kidney disease (stages 3 to 5) to understand how the disease progresses and leads to complications. Researchers will collect data from medical records and existing patient groups to build models that could help doctors make bett…

This trial tests an AI-powered teaching platform called iLN, which uses a large language model to help medical students learn about lupus nephritis. Fifty fourth-year medical students are randomly assigned to either use iLN or attend a traditional PowerPoint lecture. The study me…

This observational study looks at whether two urine markers, NGAL and KIM-1, can detect early kidney injury in women undergoing gynecologic laparoscopic surgery. The surgery involves gas inflation and a head-down position that can stress the kidneys. Researchers will compare thes…

This study looks at how the drug vasopressin affects the heart and blood flow in people with septic shock, a life-threatening condition from severe infection. Researchers want to see if different patients respond differently based on their specific heart and blood vessel status. …

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study is creating and testing two new patient-reported tools to measure recurrent urinary tract infection (UTI) symptoms. One is a daily symptom diary for adults, and the other is adapted specifically for people aged 65 and older. About 200 participants with recurrent UTIs w…

This study looks at how different types of dialysis affect heart health, bone metabolism, inflammation, and quality of life in people with end-stage kidney disease. Researchers will compare patients on hemodialysis, continuous ambulatory peritoneal dialysis, and automated periton…

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study compares four surgical techniques for removing bladder stones in patients who have a continent catheterizable urinary reservoir, a surgically created pouch that stores urine. The techniques include using a mini-percussion device through the stoma, a flexible scope thro…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study looks at what changes occur in the kidneys, urine, and blood when people with IgA nephropathy (IgAN) experience loin pain. Researchers will use MRI scans and lab tests to compare findings during a pain episode and when pain-free. The goal is to better understand the ca…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study will test four different water-drinking plans in 20 healthy women to see which one gives the best bladder filling for a pelvic ultrasound. Participants will drink different amounts of water on different days, and researchers will measure bladder volume and comfort. The…

This study measures how much of the antibiotic gepotidacin passes into breast milk after a single 3000 mg dose. Eight healthy lactating women will provide milk and blood samples over 72 hours. The goal is to understand drug exposure for nursing infants, which could guide future u…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This pilot study tests whether a structured discharge summary template and a chat-based educational messaging program can improve care transitions for adults leaving the hospital after acute kidney injury (AKI). Researchers will enroll 160 adults with moderate-to-severe AKI and c…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study will compare two types of tubes (ureteral access sheaths) used during kidney stone surgery to see if one causes less kidney damage. Sixty adults with kidney stones will be randomly assigned to get either the standard tube or a new aspiration-assisted tube. Doctors will…

This study looks at why dialysis patients often have heart problems that are hard to detect. Researchers will use a special heart test during a routine procedure to check for tiny blood vessel issues in 30 adults who have been on dialysis for at least 6 months. The goal is to fin…

This study looks at how changes in blood pressure during the start of anesthesia and throughout surgery may affect the risk of kidney injury after non-cardiac surgery. Researchers will review medical records from 5,000 adults to find patterns. The goal is to better understand how…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study will compare two types of robot-assisted surgery for prostate or kidney cancer: single-port (one small incision) and multi-port (several incisions). Researchers will track 376 adults to see which approach leads to a shorter hospital stay and better recovery. The study …

This study will use millimeter-wave radar to measure how the pelvic floor muscles move in 2,000 women, both healthy and those with stress urinary incontinence. The goal is to create a large database of normal movement patterns and build a standard assessment system. This is an ob…

This study will test a mobile app version of a bladder diary in 40 Portuguese adults with overactive bladder or urinary incontinence. Participants will use the app for one month and then answer questions about how easy it was to use and whether they prefer it over paper diaries. …

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This early-phase trial will test a single dose of the experimental drug GSK4771261 in 30 healthy adults of Chinese, Japanese, and White/European backgrounds. The main goal is to check safety, how the body processes the drug, and whether it causes an immune response. No treatment …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This study follows 30 people with liver cirrhosis and a history of bleeding from high blood pressure in the liver. They will have surgery to remove the spleen and disconnect certain blood vessels. Researchers will track kidney function for two years to see if the surgery helps or…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This early-stage study tests how a new drug called JMKX003142 interacts with other common medications in 112 healthy Chinese adults. The drug is being developed for autosomal dominant polycystic kidney disease (ADPKD). Researchers will measure how the body processes JMKX003142 wh…

This pilot study will test whether a flexible scope inserted into the urinary tract (ureterorenoscopy) under local anesthesia is safe and feasible for monitoring upper tract urothelial cancer in 10 people who have had kidney-sparing surgery. The main goal is to see if the procedu…

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…

This study looks at whether a special CT measurement, called the URSL Predictive Angle, can help doctors know ahead of time if a kidney stone surgery might need to switch to a different method during the procedure. Researchers will review records from 2,200 patients who had this …

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This study will test a special AI program called UroMed AI Doctor, designed to help with urology care. Researchers will compare AI-assisted care to traditional care from a specialist for patients with kidney stones, enlarged prostate, or bladder cancer. The goal is to see if the …

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study looks at whether reading a short educational flyer helps women learn more about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will fill out a quiz before and after reading the pamphlet. The goal is to see if the pamphlet improv…

This study looks at whether men and women on hemodialysis have different dynamic balance, measured by simple tests like standing up and walking. About 155 patients aged 20-60 will participate. No treatment is given—just observation to gather information.

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study looks at how sex hormones from gender-affirming therapy change kidney function. Researchers will measure kidney performance, blood flow, and insulin sensitivity in 60 transgender people before and after one year of hormone treatment. The goal is to understand why men a…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms like swelling, blood in urine, or high blood pressure. Researchers want to learn which kidney diseases are most common and how children respond to initial tr…

This study tests whether a short course of belimumab, a drug used for lupus, can improve detection of immune cells that cause transplant rejection. The goal is to help highly sensitized kidney transplant candidates—people whose immune systems are very picky about donor organs—get…

This study examines two microscopic details in bladder cancer tumors—how deep early cancer cells have invaded and whether small clusters of cells are present at the tumor's edge. Researchers will look at tissue samples from 100 patients to see if these features can predict if the…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults who receive high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk before serio…

This study examines stored tumor samples from 100 bladder cancer patients who had their bladder removed. Researchers will measure the amount of supportive tissue, immune cells, and immune clusters near the tumor. The goal is to see if these features are linked to how long patient…

This study looks at how certain metabolic changes in the body might help predict kidney injury after heart surgery. Researchers will study 540 high-risk patients to find patterns that could warn doctors early. The goal is to improve patient safety and outcomes by catching kidney …

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study aims to find early warning signs of acute kidney injury in children admitted to the intensive care unit. Researchers will monitor 100 children, tracking their medical history, daily fluid intake, urine output, and lab tests. The goal is to identify which risk factors—l…

This study will follow 30 runners in the Western States Endurance Run, a 100-mile race, to see how their kidneys handle the extreme stress. Researchers will use sensitive urine tests to detect early signs of kidney injury and test whether a sodium bicarbonate supplement can help.…

This study looks at whether three proteins in urine—RhoA, NGF, and BDNF—can help doctors diagnose and monitor overactive bladder in children aged 4 to 18 who also have low vitamin D. Researchers will measure these proteins before and after standard behavioral therapy (urotherapy)…

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …