Urinary system disorder

This study explores whether adding high-intensity interval training (HIIT) to standard immunotherapy (nivolumab plus ipilimumab) helps patients with advanced kidney cancer. Thirty participants are randomly assigned to either a supervised exercise program or usual care. Researcher…

This study tests whether a personalized nursing program can prevent acute kidney injury (AKI) in people with liver cancer who undergo interventional therapy. Researchers first use a prediction model to classify patients into low, moderate, or high risk for AKI. Then, they provide…

This trial tests whether a vacuum-assisted ureteral access sheath (ClearPetra) removes kidney stones more completely than a standard rigid sheath (Navigator) during flexible ureteroscopy. About 156 adults with stones 1-3 cm will be randomly assigned to one sheath. The main goal i…

This study tests a drug called exaluren in 24 people aged 12 and older with Alport syndrome caused by specific genetic errors. The drug is given as a daily shot for 32 weeks. Half the group starts exaluren right away, while the other half gets a placebo first and then switches to…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This trial tests a self-management program that uses education, WhatsApp reminders, and a diary to help hemodialysis patients control weight gain between sessions. The program aims to improve fluid adherence and stabilize blood pressure. Participants are adults on maintenance hem…

This early study is testing a new approach for people whose bladders have become small and scarred, causing frequent urination and discomfort. Doctors will take a small sample of the patient's own bladder cells, grow them in a lab on a special scaffold to create a 'neo-bladder' p…

This study looks back at the experiences of 35 adults with a rare kidney disease called C3G who received the drug iptacopan through a special early access program in Spain. Researchers will collect information on patient health, lab results, and how the disease responds to treatm…

This study tests whether combining rituximab with a low dose of mycophenolate mofetil can safely and effectively treat lupus nephritis in children. Lupus nephritis is a serious kidney complication of lupus. The trial enrolls children aged 3 to 18 with active kidney inflammation. …

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This trial compares two sedatives—remimazolam and propofol—given during liver or pancreas surgery to see which better prevents acute kidney injury after the operation. The study includes adults aged 19 to 85 scheduled for elective hepatobiliary-pancreatic surgery. Researchers aim…

This study tests whether a low-carbohydrate, plant-based diet can lower inflammation in people with autosomal dominant polycystic kidney disease (ADPKD). Thirty-six adults will try the special diet and their usual diet in random order, each for 12 weeks. The main goal is to see i…

This phase 3 trial tests the drug atrasentan in 28 children aged 2 to 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The study measures whether atrasentan reduces protein in the urine, a sign of kidney damage, over 36 weeks. All participants receive th…

This phase 2 trial tests whether giving focused radiation (SBRT) along with immunotherapy drugs (cemiplimab, with or without fianlimab) before bladder removal can safely shrink muscle-invasive bladder tumors. The study enrolls 44 patients who cannot or choose not to take standard…

This study compares two surgical methods to repair a short (up to 2 cm) narrowing in the bulbar urethra. One technique removes the scarred section and reconnects healthy ends; the other uses a graft from the lining of the testicle to widen the stricture. 94 men aged 18-50 with no…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This early-stage trial tests a new treatment called P-CD19CD20-ALLO1, a type of CAR-T cell therapy, for people with severe lupus that hasn't improved with standard treatments. The study will enroll 162 participants and aims to check if the therapy is safe and tolerable. It also l…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether adding extra bicarbonate and magnesium to the fluid used during dialysis can improve how well the body handles minerals like calcium and phosphate. It involves adults with end-stage kidney disease who have been on dialysis for at least three months. Each …

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This study tests whether giving focused radiation or surgery to all visible tumors (both the original kidney tumor and its metastases) can allow people with advanced kidney cancer to stop all cancer treatments for at least a year. Participants must have stable or partially improv…

This phase 2 trial tests whether a combination of two drugs—enfortumab vedotin (Padcev) and pembrolizumab (Keytruda)—can help people with muscle-invasive bladder cancer avoid bladder removal. About 56 participants will receive the drugs first, and those who respond well may get r…

This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will …

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes and heart failure, can reduce harmful antibodies and prevent relapses in people with membranous nephropathy, an autoimmune kidney disease. The study enrolls 20 adults who have had a recent rise in anti-PLA2R…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study looks at whether using ureteral stents (small tubes) after bladder cancer surgery leads to more or fewer problems than not using them. About 190 adults having their bladder removed will be randomly assigned to get stents or not. The main goal is to see who ends up back…

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This early-phase trial tests whether adding radiation therapy or bladder removal surgery can safely eliminate remaining cancer in patients with advanced bladder cancer who have already responded to a drug combination. The study enrolls 12 adults with muscle-invasive bladder cance…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This pilot study tests whether adding a Chinese herbal formula called CKD-1 to standard care can improve kidney function in people with stage 3-4 non-diabetic chronic kidney disease. About 66 adults will be randomly assigned to receive either standard care alone or standard care …

This study tests whether adding TAVNEOS to standard treatment helps control ear, nose, and throat symptoms in people with granulomatosis with polyangiitis (GPA). About 30 adults with active ENT disease will receive either TAVNEOS or a placebo for 52 weeks. The goal is to see if m…

This study tests whether giving children an amino acid infusion during and after heart surgery can lower their risk of acute kidney injury and reduce time on a ventilator. About 30 children at high risk will receive either the amino acid or a placebo for up to 72 hours. The goal …

This pilot study will test whether adding a traditional Chinese herbal formula (DKD-1) to standard care can improve kidney function in people with diabetic kidney disease. Sixty-six adults with type 2 diabetes and moderate-to-severe chronic kidney disease will be randomly assigne…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This early-phase trial tests a new treatment called LB-DTK-BKV for people who develop painful bladder bleeding (hemorrhagic cystitis) from BK virus after a stem cell transplant. The treatment uses immune cells from a donor that are trained to attack the virus. About 42 children a…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study looks at whether changing the filter in a kidney dialysis machine more often than usual can lower the chance of new infections in critically ill patients with severe acute kidney injury. About 100 adults in intensive care will be randomly assigned to have their filter …

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study tests whether combining two drugs (trastuzumab rezetecan and camrelizumab) before surgery can improve outcomes for people with a certain type of muscle-invasive bladder cancer (HER2-positive). About 44 adults will receive the treatment to see if it helps eliminate canc…

This Phase 3 trial tests whether BHV-1400 can safely reduce protein in the urine and preserve kidney function in 420 adults with IgA nephropathy. Participants are randomly assigned to receive either the drug or a placebo by injection. The main goal is to see if BHV-1400 lowers pr…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This phase 2 trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, given before surgery to people with muscle-invasive bladder cancer or upper tract urothelial carcinoma. The goal is to see if the drugs can shrink or eliminate the cancer enough that some b…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This early-stage study tests a new drug called N-3C01, given alone or with an immunotherapy, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the right dose, and see if the combination shrinks tumors. About 114 a…

This study is testing a new device called ARTUS® that acts like an artificial muscle to control urine leakage in women with severe stress urinary incontinence. Six women who have not gotten better with other treatments will get the device implanted and be followed for two years. …

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

This study tests a new drug called AK146D1, given alone or with another drug (AK112), in people with advanced urothelial carcinoma (a type of bladder cancer). The goal is to see if the treatment is safe and can shrink tumors. About 132 adults aged 18-75 with measurable tumors and…

This early-stage trial tests a new drug called ATO-101 for a type of bladder cancer that hasn't responded to standard treatments. The drug delivers a short-range radioactive particle directly into the bladder to kill cancer cells while sparing healthy tissue. About 24 patients wi…

This study tests whether giving specific blood pressure drugs based on a patient's circulation type during kidney transplant surgery improves how the body responds to fluids. Researchers will monitor 255 adults and assign drugs like vasopressin or norepinephrine based on real-tim…

This early-phase trial is testing whether adding sitagliptin, a diabetes drug, to the immunotherapy pembrolizumab is safe and can help people with advanced kidney cancer or melanoma whose cancer has stopped responding to standard treatment. The study will first find the safest do…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This Phase 2 trial tests whether giving two drugs (anlotinib and benmelstobart) before surgery can improve outcomes for people with localized kidney cancer. About 144 participants will either receive the drug combo followed by partial nephrectomy, or surgery alone. The main goal …

This early-stage trial will test the safety and tolerability of a new drug, cevostamab, in 46 people with systemic lupus erythematosus, some of whom also have active lupus nephritis. The drug is given intravenously, and researchers will monitor side effects and how the drug moves…

This study tests a new medicine called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage.

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This study looks at people with a very high-risk type of bladder cancer that cannot be fully removed with standard surgery. After initial treatment with immunotherapy and surgery, some patients become tumor-free. The trial then randomly assigns them to either continue immunothera…

This study tests whether adding the cholesterol drug atorvastatin to standard targeted therapy (axitinib) and immunotherapy (toripalimab) can help people with advanced kidney cancer who are not responding well to treatment. The drug combination is guided by lab tests on patient-d…

This study tests whether a drug called Angiotensin II works better than the usual treatment (norepinephrine) for people with septic shock, a life-threatening condition where blood pressure drops dangerously. About 78 adults with septic shock will receive either Angiotensin II or …

This Phase 3 trial is testing whether a combination of an experimental drug (SHR-1501) plus the standard immunotherapy BCG works better than chemotherapy for people with a type of bladder cancer (papillary-only NMIBC) that no longer responds to BCG alone. The study plans to enrol…

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This long-term extension study offers continued access to several cancer drugs—including cabozantinib, atezolizumab, and nivolumab—for up to 5,000 patients who benefited from them in earlier Exelixis-sponsored trials. The study focuses on monitoring safety and ongoing clinical be…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether giving two drugs (trastuzumab rezetecan and adebrelimab) before surgery can eliminate or shrink tumors in people with a specific type of muscle-invasive bladder cancer (HER2-positive). About 58 adults will receive the combination, then have their bladder …

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This Phase 2 study will test whether empagliflozin (Jardiance), a drug already used for diabetes, can improve blood vessel health and exercise tolerance in 52 veterans with non-diabetic chronic kidney disease. Participants will take either the drug or a placebo for a period, and …

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests whether altering gut bacteria can restore the effectiveness of immunotherapy in people with advanced kidney cancer. About 33 adults will receive a bowel cleanse, a live bacterial supplement, and then a combination of immunotherapy drugs. The goal is to see if thi…

This study tests an experimental drug called STL303 for people with IgA nephropathy, a kidney disease. About 15 adults will receive either STL303 or a placebo to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Possible side effects include na…

This study tests whether a combination of disitamab vedotin (a targeted drug) and toripalimab (an immunotherapy) works better than standard chemotherapy plus immunotherapy for people with HER2-positive muscle-invasive bladder cancer. About 240 participants will receive treatment …

This study tests two approaches to prevent kidney stones from coming back in people who have had them before. One approach uses a daily pill called empagliflozin (a diabetes drug) and the other gives personalized diet advice based on urine tests. The trial will involve 400 adults…

This study tests whether giving a combination of two drugs (a PD-L1 inhibitor called TQB2450 and anlotinib) before surgery can shrink complex kidney tumors enough to allow surgeons to remove only the tumor and save the rest of the kidney. About 33 adults with advanced clear cell …

This study tests whether a 15-month course of Nefecon can prevent proteinuria relapse in 288 adults with IgA nephropathy who have already achieved remission. Participants must have completed prior Nefecon therapy and have stable kidney function. The goal is to see if maintenance …

This early-stage study tests a new drug called JL19001 in people with advanced solid tumors or a type of lymphoma that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. About 14 participants will receive the drug as a sh…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This study looks at whether giving more protein (1.5-1.7 grams per kilogram per day) to critically ill patients with acute kidney injury who need continuous dialysis can reduce muscle wasting compared to standard protein intake (1.0-1.2 g/kg/d). About 56 adults will be randomly a…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study tests whether giving a combination of three drugs (pembrolizumab, belzutifan, and lenvatinib) before surgery can shrink kidney tumors in people with localized clear cell renal cell carcinoma. About 150 participants will receive the drugs for 12 weeks before surgery, th…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study tests a drug called sparsentan to reduce high levels of protein in the urine (proteinuria) caused by certain cancer treatments. About 20 adults with cancer who are taking VEGF inhibitors and have developed proteinuria will receive sparsentan for 8 weeks. The goal is to…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests an experimental daily pill called zanzalintinib in 44 adults with advanced bladder cancer that has continued to grow after previous treatments. The goal is to see if the drug can shrink tumors or slow the cancer's progression. Participants will take the pill once…

This early-stage trial tests a new drug, REGN15505, alone or with other drugs, in adults with advanced prostate or kidney cancer that has spread. The goal is to help the immune system attack cancer cells. About 265 participants will be enrolled to check safety, side effects, and …

This study tests a two-drug treatment (disitamab vedotin plus tislelizumab) for people with a rare, aggressive cancer of the upper urinary tract that has a specific marker (HER2-positive). The goal is to shrink the tumor so that the kidney can be saved, avoiding complete removal.…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study will test whether a supplement made from jaboticaba peel can reduce inflammation, oxidative stress, and gut bacteria imbalances in people with chronic kidney disease. Thirty adults will take either the jaboticaba extract or a placebo for one month. Researchers will mea…

This pilot phase II trial tests whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery is safe and feasible for patients with high-risk clear cell kidney cancer that hasn't spread. Sixteen participants will receive the drugs and then undergo surgery …

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This study tests the long-term safety of HRS-5965 capsules in 380 adults with primary IgA nephropathy, a kidney disease. Participants will take the drug and be monitored for side effects, as well as changes in urine protein and kidney function. The goal is to see if HRS-5965 can …

This phase 2 trial tests whether adding a probiotic capsule (MO-03) to the drug zanzalintinib can help treat metastatic kidney cancer that has worsened after immunotherapy. About 34 adults with advanced clear cell renal cell carcinoma will receive both treatments. The goal is to …

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests whether using a special ultrasound technique (mVExUS) to guide how much fluid is removed during dialysis can improve outcomes for critically ill patients with acute kidney injury. 126 adults in the ICU will be randomly assigned to either standard care or the ultr…

This study tests whether a new drug called AIC263029 is safe and can lower BK virus levels in kidney transplant recipients. About 24 adults who had a kidney transplant within the past year and have a first-time BK virus infection will receive weekly injections for 4 weeks. Resear…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This early-phase trial is testing a new treatment called LNK001 for people with advanced or metastatic clear cell renal cell carcinoma (a type of kidney cancer) that has not responded to standard treatments. LNK001 is a type of immunotherapy where a patient's own immune cells are…

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study tests a treatment called HIVEC, which delivers heated chemotherapy directly into the bladder. It is for people with a type of bladder cancer that has not responded to standard therapy and who cannot have their bladder removed. The goal is to see if this approach is saf…

This trial tests a new type of vascular graft, called STARgraft, for people with end-stage kidney disease who need hemodialysis. The graft is placed in the arm to create a reliable access point for dialysis. The study compares STARgraft to a standard graft to see if it works bett…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This early-phase study tests a new drug combination (L19IL2 plus ruxolitinib) in people with advanced kidney, pancreatic, or colorectal cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 96 partici…

This phase 2 trial tests a new drug called zanzalintinib, taken as a pill, combined with a bone-strengthening agent for people with advanced kidney cancer that has spread to the bones. The study enrolls 20 participants whose cancer has worsened after 1–3 prior treatments, includi…

This study tests whether bempedoic acid, a drug already approved for high cholesterol, can safely slow the progression of autosomal dominant polycystic kidney disease (ADPKD). About 120 adults with rapidly progressing ADPKD will receive either the drug or a placebo for two years.…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study looks at people with narrowed kidney arteries and high blood pressure. It uses a special pressure measurement (FFR) to decide who gets a stent and who gets only medication. The goal is to see which approach better protects kidney function and controls blood pressure ov…

This early-stage trial tests a procedure called calcium electroporation for bladder tumors. Doctors inject calcium into the tumor and then apply short electric pulses to destroy cancer cells. The study will include 20 patients who cannot have standard surgery or other treatments.…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This pilot study tests whether using a cap containing chlorhexidine on dialysis catheters can reduce infections compared to standard caps. Sixty adults with kidney failure who need dialysis through a central line will be randomly assigned to one of the two caps. The main goal is …

This Phase 2 trial tests SLN12140, an experimental drug, in 48 adults with IgA nephropathy whose disease is not well-controlled by standard treatments. Participants receive different doses of SLN12140 or a placebo for 36 weeks, then all can receive the drug for another year. The …

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with fluid buildup because standard treatments remove it too quickly, causing heart and brain damage. The device is worn at home for a few hours after…

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study will follow 50 adults with IgA nephropathy who are taking sparsentan. Researchers want to see how the drug affects protein in the urine (albuminuria), a key sign of kidney damage. The study is observational, meaning it just watches what happens in real-world use, witho…

This study tests a kidney-sparing approach for people with high-risk upper tract urothelial carcinoma, a cancer in the kidney or ureter. Instead of removing the whole kidney, participants get endoscopic surgery, targeted radiotherapy, and two drugs (disitamab vedotin and toripali…

This Phase 1 trial tests a new drug called HLX05-N, which is a biosimilar (a copy) of the cancer drug Erbitux, in 387 people with metastatic colorectal cancer. Participants will receive either HLX05-N or Erbitux (from the US or EU) along with standard chemotherapy. The study aims…

This study compares two treatments for stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). One group gets a shot of platelet-rich plasma (PRP) made from their own blood, while the other gets a standard surgical sling. The trial will enroll 42 women an…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This early-stage trial tests a new drug called CT-202 in people with advanced triple-negative breast cancer, colorectal cancer, or bladder cancer that has come back or spread. The drug is a bispecific antibody designed to help the immune system attack cancer cells that have a pro…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

This phase 2 trial tests a combination of two drugs (Benmelstobart and Anlotinib) plus targeted radiation (SBRT) in 29 adults with liver cancer that has spread to a few other spots and no longer responds to first-line treatment. The goal is to see if this triple therapy can slow …

This Phase 1 trial tests whether HLX18, a biosimilar of the cancer drug OPDIVO, works similarly in people with esophageal, melanoma, or bladder cancer after their tumors have been surgically removed. About 174 participants will receive either HLX18 or OPDIVO to compare how the dr…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This early-phase study tests a new treatment using specially engineered immune cells (CD19 CAR-γδ T cells) for people with severe autoimmune kidney diseases like lupus nephritis, IgA nephropathy, and membranous nephropathy that haven't responded to standard therapies. About 15 pa…

This phase 3 study tests a new drug called SYS6002 against standard chemotherapy in 406 people with advanced bladder cancer (urothelial carcinoma) that has worsened after platinum chemo and immunotherapy. The main goal is to see if SYS6002 helps people live longer. The study is n…

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This early-stage trial tests a daily capsule called NDI-5001 in 24 adult men with a rare inherited kidney condition (X-linked congenital nephrogenic diabetes insipidus) that causes extreme thirst and frequent urination. The study's main goal is to check the drug's safety and how …

This study tests a new drug called NM8074 in 12 adults with paroxysmal nocturnal hemoglobinuria (PNH) who are already taking Soliris. PNH is a rare blood disorder where the immune system destroys red blood cells, causing anemia and fatigue. NM8074 is designed to block a different…

This early-stage trial tests a drug called NM8074 in 10 adults with IgA Nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug safely reduces protein in the urine, a sign of kidney damage, after 99 days of treatment. Participants must have a…

This early-phase trial tests a new drug called NM8074 in 18 adults with C3 Glomerulopathy (C3G), a rare kidney disease. The drug is given by IV over several weeks to see if it is safe and can reduce protein in the urine, a sign of kidney damage. Researchers will also check how th…

This study compares two suction-assisted techniques used during minimally invasive kidney stone surgery. The goal is to see which method better clears stones and lowers the risk of infection. About 126 adults with medium-sized kidney stones (2-3 cm) will be randomly assigned to o…

This study gives ongoing access to benralizumab (Fasenra) for people with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a prior benralizumab trial and still benefit from the drug. About 230 participants will receiv…

This study will test whether using wipes with a special antibacterial solution (chlorhexidine gluconate) before surgery can reduce bacteria on the skin better than standard cleaning. It involves 40 men with urethral stricture who are scheduled for reconstructive surgery. Research…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study tests whether adding a 5-day fasting-mimicking diet (low-calorie, low-protein) to the usual combination of toripalimab (an immunotherapy) and axitinib (a targeted drug) can help people with advanced kidney cancer. The trial will enroll 43 adults who have not had prior …

This study tests an extended-release vitamin D capsule (CTAP101) in 40 children aged 8 to 17 with stage 3 or 4 chronic kidney disease, secondary hyperparathyroidism, and low vitamin D. Participants take one capsule daily at bedtime for 8 weeks. The goal is to see how the body pro…

This study tests an experimental drug called FXS6837 in 60 adults with IgA nephropathy, a kidney disease. Participants will receive either the drug or a placebo for about 6 months. The main goal is to see if the drug lowers protein in the urine, a sign of kidney damage.

This early study tests a new cell therapy called UCL70805F in 21 people with advanced clear cell kidney cancer that has not responded to standard treatments. The therapy uses immune cells designed to target a protein called CD70 on cancer cells. The main goals are to check safety…

This phase 2 study tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) and targeted radiation to a standard targeted therapy (fruquintinib) can help people with metastatic colorectal cancer that has spread to a few spots. The trial will enroll 60 adults who …

This study tests whether a single dose of tranexamic acid (TXA), a drug that helps blood clot, can reduce blood loss during urethral reconstruction surgery. Forty adults having this surgery will be randomly assigned to receive TXA or standard care. Researchers will compare change…

This early-stage trial tests a lab-grown penile tissue made from a man's own cells to repair severe, irreversible damage to the penis. Ten men aged 18-60 who have failed standard treatments will receive the implant. The main goal is to check safety, not effectiveness.

This study tests whether an investigational drug called HTD1801 can slow the worsening of kidney disease in adults who have both type 2 diabetes and chronic kidney disease. About 75 participants will take either HTD1801 or a placebo twice daily for 12 weeks. Researchers will meas…

This study tests a new drug called WGI-0301 combined with the immunotherapy nivolumab in people with advanced liver or kidney cancer. The goal is to see if the combination is safe and can shrink tumors. About 230 adults aged 18 to 75 will take part, and the study does not use a p…

This study tests a new treatment for people with a rare cancer of the upper urinary tract (UTUC) that has spread beyond the kidney. Participants must have had surgery and cannot take standard chemo due to health reasons. They will receive either a targeted drug (disitamab vedotin…

This study tests if temporarily restricting blood flow to an arm (called ischemic preconditioning) before kidney cancer surgery can reduce kidney damage. About 174 adults having partial nephrectomy will be randomly assigned to receive this technique or standard care. The goal is …

This lab study tests whether chitosan nanoparticles—made from shrimp shells—can break down the sticky biofilms that protect E. coli bacteria in urinary tract infections. Researchers will collect bacteria from 60 patients and treat them with chitosan alone or with the antibiotic c…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests whether regularly measuring the amount of mycophenolate mofetil in the blood helps more people with lupus kidney disease achieve kidney remission. One hundred adults with active lupus nephritis will be split into two groups: one gets standard dosing, the other ge…

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This phase 2 trial will test a combination of precise radiation (SBRT) and two drugs—anlotinib (which cuts off tumor blood supply) and bemarituzumab (which boosts the immune system)—in 27 people with advanced kidney cancer that cannot be surgically removed. The main goal is to se…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This early-stage trial tests whether treating a donor kidney with a drug called SYN002 before transplant can safely reduce the risk of passing cytomegalovirus (CMV) to the recipient. About 12 adults waiting for a kidney transplant will receive a treated organ. The main goal is to…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests a new way to guide fluid treatment in patients with septic shock (a severe infection causing low blood pressure). The goal is to see if using a non-invasive arm cuff to measure blood flow pressure can help doctors give the right amount of fluids to prevent acute …

This study tests whether a combination of a controlled diet, structured exercise, and a symbiotic supplement can reduce inflammation and harmful gut toxins in young people with early chronic kidney disease (stages 1-3). Two hundred participants will receive either the multimodal …

This study tests whether adding a probiotic (Clostridium butyricum) to a combination of targeted therapy (Disitamab Vedotin) and immunotherapy (Toripalimab) can help preserve the bladder in people with muscle-invasive bladder cancer who cannot take the chemotherapy drug cisplatin…

This early-stage trial tests a new drug called JL19001, given alone or with standard BCG therapy, in 18 people with high-risk non-muscle invasive bladder cancer. The main goals are to check safety, find the right dose, and see how the body handles the drug. It's a first step to s…

This study watches 226 adults with small kidney tumors (stage T1a) who get radiofrequency ablation, a treatment that uses heat to destroy cancer cells. Researchers will track how well the procedure works and any side effects. No extra treatments or tests are given—just normal car…

This Phase 2 trial tests an experimental drug called HS-10542 in 90 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either a high dose, low dose, or placebo for a set period. The main goal is to see if the drug reduces prot…

This Phase 3 trial tests NDV-01, a sustained-release combination of two chemotherapy drugs (gemcitabine and docetaxel), given directly into the bladder. It aims to prevent cancer from coming back in people with non-muscle invasive bladder cancer, including those who have not resp…

This study tests whether L-methionine, a natural amino acid, can make urine more acidic in people who form calcium phosphate kidney stones. These stones tend to form in alkaline urine, and current medications can sometimes make the problem worse. Fifteen participants will follow …

This study tests a new treatment called HS-10566, a gel that delivers the chemotherapy drug gemcitabine directly into the bladder. It is for people with high-risk non-muscle-invasive bladder cancer who cannot or choose not to have their bladder removed. The trial will check if th…

This study compares a new tool called the CVAC system, used with a special scope, to standard treatments for removing kidney stones. About 1,000 adults who need stone removal will be randomly assigned to either the new method or usual care. The main goal is to see if the new appr…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can help people with advanced kidney cancer (clear cell type) whose cancer returned after prior immunotherapy. About 108 adults will receive the combination to see if it shrinks tumors or delays cancer gr…

This study tests a Traditional Chinese Medicine (TCM) herbal formula, Jiajian Yishen Xiaozheng Qufeng Granules, combined with AI-driven diagnostics to treat diabetic nephropathy (kidney disease from type 2 diabetes). About 198 adults with mild-to-moderate kidney damage will recei…

This study tests whether the drug avelumab can help keep metastatic urothelial carcinoma (a type of bladder cancer) from growing after patients have already received two lines of chemotherapy. About 144 adults whose cancer has not worsened after second-line chemo will receive ave…

This early-phase trial tests a new type of immunotherapy called CD70 CAR T cells in people with lymphoma, myeloma, and certain solid tumors (like kidney cancer and sarcomas) that have come back or not responded to standard treatments. The immune cells are modified in the lab to r…

This early-stage study tests whether injecting human umbilical cord stem cells can prevent narrowing of the arm vein used for dialysis in people with end-stage diabetic kidney disease. About 54 participants will receive the stem cell treatment after fistula surgery. The goal is t…

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. T…

This early-phase study tests a new imaging agent called RYZ512 in 10 people with advanced clear cell kidney cancer that has spread. The agent is designed to attach to a protein (CAIX) found on these cancer cells, making them show up on scans. The goal is to see if it is safe and …

This early-phase study tests a new imaging agent that targets a protein called TROP2, found on many cancer cells. About 40 adults with metastatic bladder, breast, or lung cancer will receive the agent to see where it goes in the body. The goal is to see if this tracer can help do…

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …

This study tests a wearable device that continuously measures kidney function in ICU patients with acute kidney injury (AKI). The device uses a fluorescent tracer and a chest patch to track GFR in real time. Researchers will compare its accuracy to standard lab tests in 50 adults…

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study will test an artificial intelligence system that screens for breast, liver, kidney, and bladder cancers using standard CT scans taken for other reasons. Researchers plan to enroll 100,000 participants to see if the AI can catch tumors earlier and help doctors reduce mi…

This study tests if a very thin, single-use camera can be used in a doctor's office to look for cancer in the upper urinary tract, instead of doing it in an operating room under general anesthesia. Ten adults with known or suspected upper tract urothelial carcinoma will undergo t…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests an AI tool that analyzes ultrasound images to help doctors decide if a baby with hydronephrosis (kidney swelling) needs surgery. About 322 infants up to 24 months old will take part. Doctors first make a care plan without the AI, then see the AI's prediction and …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.

This study looks at whether measuring anti-alpha-actinin antibodies in the blood can help identify active lupus nephritis (kidney inflammation) in people with lupus. Researchers will compare antibody levels with findings from standard kidney biopsies in 96 adults. If the blood te…

This study looks at whether a blood test for a substance called copeptin can help doctors diagnose and classify bedwetting in children aged 5-18. Currently, diagnosis relies on a detailed urine diary, which is inconvenient and error-prone. The researchers will compare copeptin le…

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test can detect cancer mutations and track change…

This study will test whether a kidney ultrasound and a urine test can predict acute kidney injury in people with sepsis. Researchers will measure kidney blood flow and specific urine markers in 130 adults shortly after sepsis diagnosis. The goal is to see if these tests can spot …

This study tests whether a special PET scan using a drug called 89Zr-girentuximab can detect kidney cancer that remains or comes back after initial treatment. Ten adults with clear cell renal cell carcinoma will receive the drug and then have a PET scan. Some will also have a sec…

This study looks at whether measuring a hormone called irisin in the blood can help find diabetic kidney disease early and track how it gets worse. Researchers will compare irisin levels in 200 adults with type 2 diabetes to healthy people. The goal is to see if irisin can be a s…

This study is testing a new blood test called PROSTest to see if it can accurately detect prostate cancer in men with high PSA levels. Researchers will compare the test results with standard prostate biopsy findings in 1,500 men. If the test works well, it could help many men avo…

This study tests whether a simple blood test called the Systemic Immune Inflammation Index (SII) can help diagnose and predict acute kidney injury (AKI) in people with liver cirrhosis. AKI is a common and serious complication in cirrhosis, but current tests are often unreliable. …

This study tests whether a daily probiotic supplement called Colipral® can prevent repeat bladder infections (cystitis) in menopausal women aged 55–70. Participants take either the probiotic or a placebo for 12 weeks and are monitored for 24 weeks to see if they have fewer infect…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests whether a single dose of the drug disitamab vedotin, given directly into the bladder right after kidney removal surgery, can prevent bladder cancer from coming back. It involves 49 adults with HER2-positive upper tract cancer who are at risk for recurrence. The m…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This study tests if giving a simple amino acid infusion during heart surgery can prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adults before and after surgery. Half will receive standard care, and the other …

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective h…

This study looks at newborn boys with posterior urethral valves (PUV), a rare birth defect that raises the risk of serious kidney infections. It compares circumcision alone versus circumcision plus daily antibiotics to see if the surgery alone is enough to prevent these infection…

This study tests whether electroacupuncture can prevent recurrent lower urinary tract infections in women. Over 300 participants will receive either real or sham electroacupuncture for 6 months, tracking infection episodes and antibiotic use. The goal is to see if this needle-bas…

This study looks at whether giving women a single dose of antibiotics right before a clinic-based urethral bulking procedure (for stress incontinence) can lower their chance of getting a urinary tract infection afterward. About 150 women will be split into two groups: one gets th…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can prevent postoperative delirium in elderly patients undergoing urological surgery. Researchers will apply TMS to the left frontal lobe during anesthesia and monit…

This study tests whether adding core muscle exercises to standard pelvic floor training can better reduce urinary incontinence. Fifty adults with stress or mixed incontinence will do 12 weeks of exercises, either standard or with core co-activation. Researchers will measure sympt…

This study compares two ways to break up kidney stones using a laser and a suction device. One method turns stones into dust, the other into small fragments. The goal is to see which leaves fewer stone pieces behind after one month. About 86 adults with small kidney stones will t…

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This study tests a new at-home device called the Floora Pelvic Rehabilitation Vaginal Dilator in 10 women with interstitial cystitis (painful bladder syndrome) and high-tone pelvic floor dysfunction. Participants use the device three times a week for 12 weeks, combining heat and …

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study will test two different pelvic floor exercise techniques in 40 women aged 30-40 with stress urinary incontinence (leaking urine during activities like coughing or exercise). One group will do exercises in gradually harder positions, while the other will use gradually h…

This study investigates whether adding low-intensity shockwave therapy to standard Kegel exercises can better reduce urine leakage in women with stress urinary incontinence. Participants will either do Kegels alone or Kegels plus weekly shockwave sessions for eight weeks. The goa…

This study tests whether giving patients a standing prescription for antibiotics to use at the first sign of a UTI after Botox for overactive bladder reduces unplanned healthcare visits. 260 women scheduled for Botox will either get the self-start prescription or follow standard …

This study compares a newer anesthesia drug, fospropofol disodium, with the standard drug propofol for people undergoing ureteroscopy (a procedure to remove kidney stones). About 190 adults will be randomly assigned to receive one of the two drugs during surgery. The main goal is…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether stimulating a nerve near the ankle, called percutaneous tibial nerve stimulation (PTNS), can safely treat overactive bladder in children aged 5 to 21. The treatment uses a device called Urgent PC that sends weak electrical signals through a thin needle to…

This study tests whether a new intravenous drug, Anrikefon, can improve sleep quality better than a standard oral medication (nalfurafine) in people with chronic kidney disease who suffer from severe itching and are on hemodialysis. Fifty adults will receive either Anrikefon inje…

This study tests whether electroacupuncture (thin needles with mild electrical pulses) can help women with overactive bladder who haven't improved with standard treatments. Thirty-two women will receive either electroacupuncture, a nerve stimulation therapy, or a sham (fake) acup…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests whether doing simple handgrip exercises at home for 8 weeks can lower blood pressure in people with chronic kidney disease (CKD). Researchers will measure changes in resting blood pressure, blood vessel function, and stiffness. The study involves 50 adults aged 4…

This study looks at whether intermittent fasting is safe and doable for people with advanced solid tumors who are starting immunotherapy. About 90 participants will be split into three groups: no fasting, eating only during an 8-hour window each day, or fasting every other day. R…

This study will test whether a wearable device that stimulates a nerve in the leg can help women with overactive bladder and frequent nighttime urination. Participants will either use the device plus behavioral therapy or behavioral therapy alone. The goal is to see if the device…

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers …

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study looks at whether a supportive product called Neuridase can help reduce nerve damage (peripheral neuropathy) caused by a combination of two cancer drugs (enfortumab vedotin and pembrolizumab) in people with advanced bladder cancer. About 40 participants will receive sta…

This study will compare two ways to position patients during surgery to remove large kidney stones. One group will lie on their back (supine), the other on their stomach (prone). Researchers want to see which position leads to fewer complications, less pain, and lower costs. The …

This pilot study tests a 16-week physical activity and power training program for up to 30 older Veterans with advanced chronic kidney disease. The main goal is to see if the program is doable and well-tolerated. Participants will be pre-frail or have difficulty walking, and the …

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This study compares three approaches to ureteral stenting after kidney stone surgery: no stent, a stent removed after 1 week, and a stent removed after 2 weeks. Researchers will track complications, patient comfort, and recovery in 90 adults with upper urinary tract stones. The g…

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This study tests whether adding either dexamethasone (a steroid) or terbutaline (an asthma drug) to standard paracetamol provides better pain relief for people with kidney stones in the emergency room. About 300 adults with severe pain will be randomly assigned to one of the two …

This early study tests a new device that lets dialysis patients use just one needle instead of two for their blood cleaning treatments. The goal is to see if it is safe and works well for people who already have a mature vein connection (fistula). About 20 adults who need dialysi…

This pilot study will test whether a short eye-exercise program done during dialysis sessions can improve physical function, balance, and fear of falling in people with kidney failure. Thirty adults on maintenance hemodialysis will be randomly assigned to do the exercises or rece…

This study looks at whether coloring mandalas (circular patterns) can improve mindfulness, mood, and reduce psychological distress in people undergoing hemodialysis for kidney failure. Sixty adults aged 18-50 will be split into two groups: one colors mandalas, the other does free…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This study tests whether acupuncture laser therapy can reduce neck pain and improve quality of life in people undergoing hemodialysis. Sixty participants will either receive standard care or standard care plus laser therapy three times a week for four weeks. Researchers will meas…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This early-stage study will give 20 bladder cancer patients cannabigerol (CBG) gummies before and after surgery to see if they are safe and tolerable. The goal is to improve quality of life and reduce symptoms during recovery. Researchers will monitor side effects and how well pa…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study compares custom-length ureteral stents (based on each person's imaging) to standard one-size-fits-all stents in 128 adults having kidney stone surgery. The goal is to see if the custom stents reduce pain, urinary issues, and other symptoms. Participants will fill out a…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This trial will compare two techniques for removing kidney stones larger than 2 cm: a flexible suction sheath (FANS) and direct suction through the scope (DISS). About 100 adults will be randomly assigned to one method. The study will measure surgery time, how completely stones a…

This study tests a device called Tensi+ that uses mild electrical pulses to a nerve in the ankle to treat overactive bladder symptoms like sudden urges and frequent bathroom trips. About 60 adults with these symptoms will use the device at home for 12 weeks. The goal is to see if…

This study tests a new method to deliver botulinum toxin (NT 201) directly into the bladder using the Vibe System for women with overactive bladder. The goal is to reduce daily urine leakage episodes. About 210 women aged 18-80 will participate, and the treatment is compared to a…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether a small, portable nerve stimulation device worn at home can reduce urgent bathroom trips in people with overactive bladder. Sixty adults aged 18 to 65 will either use the device during daily life when they feel urgency or receive standard clinic-based ses…

This study tests whether using virtual reality (VR) during arteriovenous fistula surgery—a procedure for dialysis patients—can lower pain, anxiety, and the need for anesthesia. About 64 adults with end-stage kidney disease will be randomly assigned to receive VR or standard care …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This study compares two non-invasive treatments—magnetic field therapy and tibial nerve stimulation—for women with urge urinary incontinence (sudden, strong urges to urinate leading to leaks). Forty women will be randomly assigned to one of the two treatments over six weeks. Rese…

This study compares lidocaine, a numbing drug, to morphine for treating severe kidney stone pain in the emergency room. Researchers will enroll 250 adults whose pain isn't relieved by standard treatment. The goal is to see if lidocaine provides better pain relief at 30 minutes, p…

This study compares two common procedures—RIRS (a scope through the urinary tract) and ESWL (shock waves from outside the body)—to see which removes small kidney stones (up to 1.5 cm) in the lower part of the kidney more effectively. About 66 adults aged 18 to 60 with these stone…

This trial tests whether the drug difelikefalin can reduce severe itching in people with chronic kidney disease who are on hemodialysis. About 106 adults will receive either the drug or a placebo after each dialysis session for 6 weeks. The main goal is to see if itching scores i…

This study tests whether a special teaching method called Pecha Kucha can help people on hemodialysis better follow their fluid and diet restrictions. The method uses a fast, visual slideshow to make information easier to remember. 70 patients will be split into two groups: one g…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This study tests whether doing progressive relaxation exercises at times matched to each patient's natural circadian rhythm can help manage symptoms, improve sleep quality, increase comfort, and boost mental well-being in people receiving hemodialysis. Researchers will enroll 75 …

This study compares two new suction-based tools (FANS and CVAC) for removing medium-to-large kidney stones. About 159 adults with stones 8-20 mm will be randomly assigned to one device. The goal is to see which scope clears more stones completely, as shown on CT scans.

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This study will compare two types of lasers used to break up kidney stones during a procedure called ureteroscopy. About 70 adults with a single kidney stone or multiple stones totaling 7-20 mm will be randomly assigned to receive either a pulsed Thulium:YAG laser or a pulse-modu…

This study tests whether a nurse-led program of laptop-based education, phone reminders, and a booklet can help people on hemodialysis better follow their diet and fluid restrictions, be more active, and improve their quality of life. About 112 adults who have been on dialysis fo…

This study tests whether adding pulsed electromagnetic field (PEMF) therapy to standard bladder instillations of heparin and bupivacaine can better reduce chronic pelvic pain in women with interstitial cystitis/bladder pain syndrome. Twenty female adults who already receive bladd…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

This study tests whether an erector spinae plane block, a type of nerve block, can reduce pain and the need for opioid painkillers after percutaneous nephrolithotomy, a surgery to remove large kidney stones. Sixty adults scheduled for this surgery will receive either the block pl…

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests a device called VTone that uses gentle electrical pulses inside the vagina to strengthen muscles and reduce stress urinary incontinence (leaking when coughing, sneezing, or exercising). Fifteen women will receive 8 weekly treatments and be followed for 3 months. …

This study compares a new ureteral access sheath with built-in suction (FANS) to the standard sheath used during kidney stone removal surgery. The goal is to see if the suction device helps clear more stone fragments and reduces infections. About 134 adults with kidney stones wil…

This study tests whether using virtual reality (VR) during pelvic floor exercises helps women who leak urine after childbirth. Fifty women, ages 22-35, who had a vaginal delivery 3-6 months ago will be randomly assigned to standard training or VR-enhanced training. The goal is to…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study compares four surgical techniques for removing bladder stones in patients who have a continent catheterizable urinary reservoir, a surgically created pouch that stores urine. The techniques include using a mini-percussion device through the stoma, a flexible scope thro…

This study planned to test whether kidneys with small, low-risk tumors could be removed from donors, have the tumor taken out, and then be transplanted into patients with kidney failure. The goal was to increase the number of available donor kidneys. However, the study was withdr…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing only the lower body) for a type of kidney stone surgery called retrograde intrarenal surgery. Researchers will look at how well the stones are removed, pain levels, and patient satisfactio…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

This study will observe 128 critically ill patients with acute kidney injury who need dialysis to remove excess fluid. Researchers want to understand why some patients become unstable during fluid removal. They will monitor heart function, blood flow, and other signs before and d…

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study looks at what changes occur in the kidneys, urine, and blood when people with IgA nephropathy (IgAN) experience loin pain. Researchers will use MRI scans and lab tests to compare findings during a pain episode and when pain-free. The goal is to better understand the ca…

This study will enroll 200 adults aged 60 or older who are scheduled for major surgery for urologic cancer. Researchers want to see if an artificial intelligence analysis of a standard heart test (ECG) taken before surgery can predict whether a patient will suffer heart injury or…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study will test four different water-drinking plans in 20 healthy women to see which one gives the best bladder filling for a pelvic ultrasound. Participants will drink different amounts of water on different days, and researchers will measure bladder volume and comfort. The…

This study measures how much of the antibiotic gepotidacin passes into breast milk after a single 3000 mg dose. Eight healthy lactating women will provide milk and blood samples over 72 hours. The goal is to understand drug exposure for nursing infants, which could guide future u…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study looks at whether extra phone calls and text messages can help patients who are likely to miss their urology procedures. About 68 adults at high risk of no-showing will be split into two groups: one gets standard care, the other gets extra reminders. The goal is to see …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This pilot study tests whether a structured discharge summary template and a chat-based educational messaging program can improve care transitions for adults leaving the hospital after acute kidney injury (AKI). Researchers will enroll 160 adults with moderate-to-severe AKI and c…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This study will collect information from 100,000 critically ill patients worldwide who receive continuous renal replacement therapy (CRRT), a type of kidney dialysis, in intensive care units. Researchers want to understand how CRRT is used and how it affects patient survival and …

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study will compare two types of tubes (ureteral access sheaths) used during kidney stone surgery to see if one causes less kidney damage. Sixty adults with kidney stones will be randomly assigned to get either the standard tube or a new aspiration-assisted tube. Doctors will…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

This study looks at how a specific gene change (AGXT) affects oxalate production in people who have had calcium oxalate kidney stones. Four participants will eat a low-oxalate diet for five days and then receive an intravenous dose of glycolate. Researchers will measure oxalate l…

This study will look at how people with chronic kidney disease use a digital app called MyRenalCare. Researchers want to see if the app helps improve health, lowers hospital visits, and reduces costs and environmental impact. About 1,000 adults under kidney care will be included.

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study looks at why dialysis patients often have heart problems that are hard to detect. Researchers will use a special heart test during a routine procedure to check for tiny blood vessel issues in 30 adults who have been on dialysis for at least 6 months. The goal is to fin…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study looks at how changes in blood pressure during the start of anesthesia and throughout surgery may affect the risk of kidney injury after non-cardiac surgery. Researchers will review medical records from 5,000 adults to find patterns. The goal is to better understand how…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study will compare two types of robot-assisted surgery for prostate or kidney cancer: single-port (one small incision) and multi-port (several incisions). Researchers will track 376 adults to see which approach leads to a shorter hospital stay and better recovery. The study …

This study will use millimeter-wave radar to measure how the pelvic floor muscles move in 2,000 women, both healthy and those with stress urinary incontinence. The goal is to create a large database of normal movement patterns and build a standard assessment system. This is an ob…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study will test a mobile app version of a bladder diary in 40 Portuguese adults with overactive bladder or urinary incontinence. Participants will use the app for one month and then answer questions about how easy it was to use and whether they prefer it over paper diaries. …

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets (low phosphorus then high phosphorus, or vice versa) for 19 days …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This early-phase trial will test a single dose of the experimental drug GSK4771261 in 30 healthy adults of Chinese, Japanese, and White/European backgrounds. The main goal is to check safety, how the body processes the drug, and whether it causes an immune response. No treatment …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This study follows 30 people with liver cirrhosis and a history of bleeding from high blood pressure in the liver. They will have surgery to remove the spleen and disconnect certain blood vessels. Researchers will track kidney function for two years to see if the surgery helps or…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tests whether an electronic health record alert can help primary care doctors refer patients with blood and protein in their urine to a kidney specialist. About 1,200 adults with these high-risk signs will be included. The goal is to see if the alert improves referral …

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This early-stage study tests how a new drug called JMKX003142 interacts with other common medications in 112 healthy Chinese adults. The drug is being developed for autosomal dominant polycystic kidney disease (ADPKD). Researchers will measure how the body processes JMKX003142 wh…

This pilot study will test whether a flexible scope inserted into the urinary tract (ureterorenoscopy) under local anesthesia is safe and feasible for monitoring upper tract urothelial cancer in 10 people who have had kidney-sparing surgery. The main goal is to see if the procedu…

This study will test whether using a special ultrasound technique called VeXUS to guide fluid treatment can help protect kidney function in 100 ICU patients with acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and lasting kidney damage. Th…

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…

This study looks at whether a special CT measurement, called the URSL Predictive Angle, can help doctors know ahead of time if a kidney stone surgery might need to switch to a different method during the procedure. Researchers will review records from 2,200 patients who had this …

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This early-stage study looks at how a single dose of VC005 tablets is processed in people with kidney impairment compared to those with normal kidney function. Researchers will measure drug levels in the blood and check safety. The goal is to understand if kidney problems affect …

This study will test a special AI program called UroMed AI Doctor, designed to help with urology care. Researchers will compare AI-assisted care to traditional care from a specialist for patients with kidney stones, enlarged prostate, or bladder cancer. The goal is to see if the …

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study looks at whether reading a short educational flyer helps women learn more about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will fill out a quiz before and after reading the pamphlet. The goal is to see if the pamphlet improv…

This study looks at whether men and women on hemodialysis have different dynamic balance, measured by simple tests like standing up and walking. About 155 patients aged 20-60 will participate. No treatment is given—just observation to gather information.

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study looks at how sex hormones from gender-affirming therapy change kidney function. Researchers will measure kidney performance, blood flow, and insulin sensitivity in 60 transgender people before and after one year of hormone treatment. The goal is to understand why men a…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms like swelling, blood in urine, or high blood pressure. Researchers want to learn which kidney diseases are most common and how children respond to initial tr…

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults, both those with a history of calcium oxalate kidney stones and healthy volunteers. Researchers will measure levels of citrate, pH, calcium, and calcium oxa…

This study will observe how safe and effective the antibiotic Zavicefta is when used in everyday medical practice in Japan. It includes 59 patients with sepsis (a severe blood infection) or reduced kidney function who are receiving Zavicefta for the first time. Researchers will t…

This study tests whether a short course of belimumab, a drug used for lupus, can improve detection of immune cells that cause transplant rejection. The goal is to help highly sensitized kidney transplant candidates—people whose immune systems are very picky about donor organs—get…

This study examines two microscopic details in bladder cancer tumors—how deep early cancer cells have invaded and whether small clusters of cells are present at the tumor's edge. Researchers will look at tissue samples from 100 patients to see if these features can predict if the…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults who receive high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk before serio…

This study examines stored tumor samples from 100 bladder cancer patients who had their bladder removed. Researchers will measure the amount of supportive tissue, immune cells, and immune clusters near the tumor. The goal is to see if these features are linked to how long patient…

This study looks at how certain metabolic changes in the body might help predict kidney injury after heart surgery. Researchers will study 540 high-risk patients to find patterns that could warn doctors early. The goal is to improve patient safety and outcomes by catching kidney …

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study will follow 300 adults and children with kidney failure who use a specific type of catheter for peritoneal dialysis. Researchers will track infections, complications, and how well the catheter works over time. The goal is to see if these catheters are safe and effectiv…

This study aims to find early warning signs of acute kidney injury in children admitted to the intensive care unit. Researchers will monitor 100 children, tracking their medical history, daily fluid intake, urine output, and lab tests. The goal is to identify which risk factors—l…

This pilot study tests a patient navigation program for people who visited the ER for kidney stones and are at risk of missing their follow-up urology appointment. About 31 participants will get a trained navigator who helps with scheduling, transportation, and other barriers for…

This study will follow 30 runners in the Western States Endurance Run, a 100-mile race, to see how their kidneys handle the extreme stress. Researchers will use sensitive urine tests to detect early signs of kidney injury and test whether a sodium bicarbonate supplement can help.…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study looks at whether three proteins in urine—RhoA, NGF, and BDNF—can help doctors diagnose and monitor overactive bladder in children aged 4 to 18 who also have low vitamin D. Researchers will measure these proteins before and after standard behavioral therapy (urotherapy)…

This study tracks 120 adults having heart surgery to see if continuous monitoring of blood pressure and brain oxygen levels can predict problems like confusion, memory loss, or kidney injury afterward. Researchers will measure how long and how severely these levels drop during su…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This study will follow 300 people with non-spreading bladder cancer who receive high-dose radiation therapy (with or without a chemotherapy booster). Researchers want to see how long patients live, how often the cancer returns in the bladder or elsewhere, and what side effects oc…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This study looks at whether eating a high-protein meal changes kidney function in a way that can be measured by a skin sensor. Researchers will give 25 adults an injection of a fluorescent dye and track how quickly it clears from the body before and after the meal. The goal is to…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study tests whether shorter or standard-length dialysis sessions using expanded hemodialysis can remove waste products from the blood as well as a more intensive technique called high-volume hemodiafiltration. Fifteen adults with end-stage kidney disease will try three diffe…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will develop a computer model that uses machine learning to predict a patient's risk of developing acute kidney disease after heart surgery. Researchers will collect data from 820 adults undergoing certain heart procedures to build and test the model. The goal is to cr…

This study will observe 80 adults with IgA nephropathy who are prescribed iptacopan or atrasentan as part of their routine care. Researchers will collect data on patient profiles, treatment patterns, and clinical outcomes over 24 months. The goal is to understand how these drugs …

This study looks at how acute kidney injury (AKI) impacts the process of removing a breathing tube (weaning) in critically ill adults in the ICU. Researchers will track 85 patients to see if AKI makes weaning harder, slower, or more risky. The goal is to learn whether kidney prob…

This study will follow 225 adults with end-stage kidney disease who are on regular dialysis. Researchers want to see if missing a dialysis session raises the risk of heart problems like heart attack or stroke within the next 72 hours. Participants will have heart tests after a mi…

This study will follow 290 Mexican adults with advanced chronic kidney disease who are on dialysis (hemodialysis or peritoneal dialysis). Researchers will track how many patients die, how often they are hospitalized, and how many infections they get. The goal is to better underst…

This pilot study will test whether a potassium-containing salt substitute is safe for people with end-stage kidney disease on hemodialysis. Twenty participants will use the salt substitute for 16 days and regular table salt for 16 days, with a break in between. Researchers will m…

This early-stage study checks whether a single dose of JMKX003142 affects the heart's electrical activity in 24 healthy Chinese adults. Participants will be randomly assigned to receive the drug or a placebo. The goal is to see if the drug causes any changes in heart rhythm, not …

This phase 1 trial will enroll 8 healthy Chinese men to study how the experimental drug JMKX003142 is absorbed, broken down, and eliminated from the body. Participants will receive the drug in both pill and IV forms, some with a radioactive tracer. The study aims to measure the d…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…

This study will translate and test a questionnaire called USIQ, which measures how severe urinary urgency is and how it affects daily life, for Turkish-speaking women with overactive bladder. Researchers will enroll 130 women and compare their answers on the USIQ with other stand…