Simple test could slash use of Last-Resort antibiotics for UTIs

NCT ID NCT07675018

Not yet recruiting Diagnosis Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. Those whose test is negative will receive a standard third-generation cephalosporin instead of stronger drugs like carbapenems. The goal is to see if this approach reduces the number of days patients are treated with broad-spectrum antibiotics without compromising recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Detection of integrons (diagnostic test)
What this could lead to: If successful, this test could help doctors avoid using strong, broad-spectrum antibiotics for many urinary tract infections, reducing the risk of antibiotic resistance.
What could go wrong: This is a relatively small, early-stage trial. The test may not accurately predict resistance in all cases, and the approach may not work for all patients or settings.

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Conditions

The condition(s) this trial relates to.

bacterial urinary tract infection urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIBACTERIAL AGENTS BIOMARKERS DRUG RESISTANCE, MICROBIAL URINARY TRACT INFECTIONS (UTI'S)

Contacts and locations

Locations

CHRU Tours, Hôpital Trousseau

Chambray-lès-Tours, 37170, France
CHU de Reims

Reims, 51100, France
Grenoble university hospital

La Tronche, 38700, France
Groupe Hospitalier Universitaire Bichat-Claude Bernard - APHP

Paris, 75018, France
Hopital lariboisière

Paris, 75010, France
Hôpital Saint Louis - APHP

Paris, 75010, France
Limoges university hospital

Limoges, 87042, France

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