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A simple vein pressure reading may warn of kidney failure days earlier

NCT ID NCT07722325

Knowledge-focused Sponsor: Sichuan Academy of Medical Sciences Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

Acute kidney injury is a common and dangerous complication in intensive care, but current tests often detect it too late. This observational study tests whether a pressure gradient in the veins — the difference between the driving force for blood return and the central vein pressure — can predict kidney injury earlier. Researchers will measure this gradient in 180 ICU patients who are at risk but have not yet developed kidney injury, and track whether it correlates with later kidney damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the venous return pressure gradient proves reliable, it could give doctors a simple, earlier way to predict acute kidney injury in ICU patients.
What could go wrong
This is an observational study, not a treatment trial, so it cannot show cause and effect. The measurement method is specialized and may not be widely available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult ICU patients (age ≥18 years) at risk for acute kidney injury, with central venous and radial arterial catheters in place for hemodynamic monitoring, no AKI at ICU admission per KDIGO criteria, and complete data available for calculation of venous return pressure gradient (Pmsf-CVP) within 48 hours of admission.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years 2. Admitted to the intensive care unit (ICU) within 48 hours 3. Central venous catheter in place for continuous central venous pressure (CVP) monitoring 4. Radial artery catheter in place for hemodynamic monitoring including mean systemic filling pressure (Pmsf) 5. No acute kidney injury (AKI) at ICU admission according to KDIGO criteria Exclusion Criteria: 1. Maintenance hemodialysis or continuous renal replacement therapy (CRRT) prior to ICU admission 2. Previous kidney transplantation 3. Pregnancy 4. Extracorporeal membrane oxygenation (ECMO) support at ICU admission 5. Incomplete core hemodynamic data precluding calculation of venous return pressure gradient (Pmsf-CVP) or AKI assessment

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI - acute kidney injury

How to take part

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  1. The official record

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