Could circumcision replace antibiotics for preventing kidney infections in newborns with PUV?

NCT ID NCT07527442

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at newborn boys with posterior urethral valves (PUV), a rare birth defect that raises the risk of serious kidney infections. It compares circumcision alone versus circumcision plus daily antibiotics to see if the surgery alone is enough to prevent these infections. About 72 boys will be followed for two years to track infection rates and kidney health.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • APHM

    Marseille, France

  • APHP Hôpital Armand Trousseau

    Paris, 75012, France

  • APHP Hôpital Necker

    Paris, 75015, France

  • APHP Hôpital Robert Debré

    Paris, 75019, France

  • CHU de Besançon

    Besançon, France

  • CHU de Bordeaux

    Bordeaux, France

  • CHU de Limoges

    Limoges, France

  • CHU de Montpellier

    Montpellier, France

  • CHU de Nantes

    Nantes, France

  • CHU de Reims

    Reims, France

  • CHU de Rennes

    Rennes, France

  • CHU de Toulouse

    Toulouse, France

  • CHU de la Réunion

    Saint-Denis, 97400, France

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Other studies related to the condition(s) this trial covers.