Urinary system disorder

This early-phase trial is testing a therapy called anti-CD70 CAR-T cells in people with advanced kidney cancer that has not responded to standard treatments. The approach involves taking a patient's own immune cells, engineering them in a lab to recognize a protein called CD70 on…

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This phase 3 trial asks whether removing the bladder right away is as effective as giving chemotherapy first, for patients with muscle-invasive bladder cancer who have no visible tumor left after a thorough biopsy. About 236 adults will be randomly assigned to either surgery alon…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study tracks 132 people with PNH who are taking Fabhalta to see how safe it is and what side effects occur. Researchers will monitor infections and check for serious red blood cell breakdown if the drug is stopped. The goal is to better understand the drug's risks in everyda…

This phase 2 trial is testing whether a traditional Chinese medicine called Lishitonglin Formula can improve non-severe urinary tract infections and lower urinary tract symptoms in men with urethral stricture before they undergo surgery. Participants will take either the herbal f…

This early-phase study tests two drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in 100 adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination can help the immune system fight cancer better…

This phase 3 trial tests sefaxersen, a drug that targets a part of the immune system, in 428 people with IgA nephropathy at high risk of kidney decline. Participants receive either sefaxersen or a placebo as a shot under the skin. The main goal is to see if the drug reduces prote…

This phase 2 trial tests whether adding evolocumab (a cholesterol-lowering drug) to nivolumab (an immunotherapy) can help control metastatic kidney cancer that has not responded to prior treatments. Only 10 participants are enrolled, and the main goal is to check safety and side …

This study tests whether taking a probiotic (a 'good' bacteria) can help women who get frequent urinary tract infections (UTIs). About 90 women with a history of repeat UTIs will take either a probiotic or a placebo (a dummy pill) for 6 months. The goal is to see if the probiotic…

This phase 2 trial tests a combination of three drugs—pemetrexed, etrumadenant, and zimberelimab—in 10 people with advanced bladder cancer that has a specific genetic change (MTAP deficiency) and has already been treated with immunotherapy. The goal is to see if the combo is safe…

This trial is testing whether specially grown T cells from cord blood can help prevent or treat infections caused by common viruses (CMV, EBV, BKV, and adenovirus) in people who have had a cord blood transplant. The study aims to find the safest and most effective dose of these v…

This early-stage trial tests a personalized treatment for people with metastatic solid cancers that have KRAS mutations. Doctors take a patient's own white blood cells, genetically modify them to recognize and attack KRAS-mutated cancer cells, and return them to the patient along…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This study tests if adding another drug (belzutifan or quavonlimab) to a standard two-drug treatment can help people with advanced clear cell kidney cancer live longer or stop their cancer from growing. About 1,650 adults who have not had prior treatment for advanced disease will…

This study looks at whether using ureteral stents (small tubes) after bladder cancer surgery leads to more or fewer problems than not using them. About 190 adults having their bladder removed will be randomly assigned to get stents or not. The main goal is to see who ends up back…

This study tests whether adding entinostat to high-dose aldesleukin (interleukin-2) can help shrink tumors in people with metastatic kidney cancer. About 47 adults with clear cell renal cell carcinoma that has spread will receive both drugs. The goal is to find the safest dose an…

This study compares two medical sling devices used to treat stress urinary incontinence in women. About 300 women will receive either a single-incision sling or a standard transobturator sling. Researchers will check how well each device stops urine leakage during a cough test an…

This early-stage study is testing a new drug, AB801, alone or with other treatments, in about 91 people with advanced cancers (like lung, colon, or breast cancer) that have not responded to standard therapies. The main goal is to check the drug's safety and find the best dose for…

This phase 3 trial is testing whether adding the immunotherapy drug durvalumab to standard BCG treatment can safely control high-risk non-muscle-invasive bladder cancer. About 100 adults who have never received BCG before will get both treatments for up to a year. The main goal i…

This study tests whether a newer drug, benralizumab, works as well as the current standard, mepolizumab, for people with a rare disease called EGPA that inflames blood vessels. About 140 adults with active EGPA will receive either drug for a year, along with their usual steroids.…

This early-stage trial tests a personalized cell therapy called ADP-A2M4CD8 in people with certain cancers that have a specific marker (MAGE-A4). The therapy uses a patient's own immune cells, modified to better attack tumors, and is given alone or with standard immunotherapy dru…

This study is testing a new, recharge-free nerve stimulator (Axonics SNM system) in 144 adults with overactive bladder or fecal incontinence. The device is implanted to stimulate sacral nerves and improve control. Researchers will measure quality of life and symptom changes over …

This trial compares removing a urinary catheter on day 3 versus day 6 after a living donor kidney transplant. The goal is to see if earlier removal reduces urinary tract infections within 30 days without causing more complications like urine leaks. The study involves 172 adult ki…

This trial tests whether rituximab, an infusion drug that calms certain immune cells, can help people with idiopathic membranous nephropathy and nephrotic syndrome. Participants receive either rituximab or a placebo, and the study tracks how many achieve a significant reduction i…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 85 adults with advanced kidney cancer that could not be removed by surgery. The goal was to see if stopping nivolumab early in those who responded well, or adding ipilimumab in those who did not, could better…

This early-stage study tests a new oral drug, FX-909, alone or with another drug (pembrolizumab) in people with advanced solid tumors, including a type of bladder cancer. The main goals are to check safety and find the best dose. About 120 adults will take part, taking daily pill…

This study is tracking 238 adults who are already scheduled to have a procedure for kidney stones or an enlarged prostate (BPH) using Boston Scientific devices. The main goal is to see how often serious side effects happen with these tools in real-world use. Researchers will also…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study tests an experimental drug called VX-407 in 24 adults with autosomal dominant polycystic kidney disease (ADPKD) who have specific changes in the PKD1 gene. The goal is to see if the drug can slow kidney growth and is safe. Participants take VX-407 tablets by mouth and …

This study tests whether a standardized approach to prescribing opioid pain medication after percutaneous nephrolithotomy (PCNL), a surgery to remove kidney stones, can reduce the number of unused painkillers patients take home. Researchers will compare the usual prescribing habi…

This trial investigates whether combining two drugs—BCG and gemcitabine—can safely and effectively treat a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC) that has come back after previous BCG treatment. Participants receive BCG directly into the bladder …

This phase II trial is testing whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug gemcitabine can help patients with a type of bladder cancer that does not respond to the usual BCG treatment. The study involves 161 participants and looks at how many pati…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This study tests whether combining newer immunotherapy drugs with a standard targeted therapy (axitinib) can safely control advanced kidney cancer. About 199 adults with untreated, advanced clear-cell renal cell carcinoma will receive one of three drug combinations. The main goal…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This phase 3 trial tests whether the drug pazopanib can delay or prevent kidney cancer from coming back in patients who have had all visible tumors removed by surgery. 129 adults with clear cell kidney cancer that had spread are randomly assigned to take either pazopanib or a pla…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study looks at the long-term safety and tolerability of iptacopan in adults with paroxysmal nocturnal hemoglobinuria (PNH) who have already completed earlier phase 2 or 3 studies with the drug. About 208 participants will continue taking iptacopan and be monitored for side e…

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with bladder cancer that has spread to nearby lymph nodes. About 60 participants will receive either chemo alone or chemo plus durvalumab, followed by maintenance durvalumab fo…

This phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) to the immunotherapy drug nivolumab can prevent high-risk bladder cancer from coming back after surgery. About 62 participants will receive either the combination or nivolumab alone. The st…

This early-phase trial is testing a new drug called enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. A…

This early-phase study tested a new drug called UGN-201 in 10 people with bladder cancer who were scheduled to have their bladder removed. The main goal was to check the drug's safety and see if it caused any serious side effects or surgery delays. Researchers also looked for sig…

This trial tests whether sodium butyrate, a short-chain fatty acid, can reduce protein in the urine and slow kidney function decline in people with IgA nephropathy, a kidney disease. Participants receive either sodium butyrate or a placebo for 12 weeks, then switch after a washou…

This early-stage trial is testing a new drug called belzupacap sarotalocan (AU-011) for people with non-muscle-invasive bladder cancer. The drug is injected directly into the tumor, sometimes with a laser. The main goal is to see if this approach is safe and feasible. About 55 pa…

This trial tests whether sildenafil, a drug that improves blood flow and muscle strength, can help postmenopausal women with stress or mixed urinary incontinence. The idea is that sildenafil may reduce pelvic floor muscle atrophy, improving symptoms. Participants take sildenafil …

This study tests whether the drug ubamatamab, alone or with cemiplimab, can help control rare cancers like renal medullary carcinoma and epithelioid sarcoma. About 40 adults with advanced or metastatic disease will receive the treatment to check safety and effectiveness. The goal…

This study tests if the drug enfortumab vedotin can safely and effectively shrink or eliminate high-grade urothelial carcinoma in the upper urinary tract before standard surgery. It includes 24 people who cannot take or choose not to take the chemotherapy drug cisplatin. The main…

This Phase 2 trial is testing whether combining two drugs, durvalumab (an immunotherapy) and olaparib (a targeted therapy), can help people with advanced bladder cancer who are not healthy enough for standard platinum chemotherapy. About 154 participants will receive either the d…

This study tests a new medicine, crovalimab, for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease that destroys red blood cells. It involves healthy volunteers and people with PNH to check safety and how well the drug works. The goal is to control the disease, not …

This early-stage trial tests a new treatment called P-CD19CD20-ALLO1, a type of CAR-T cell therapy, for people with severe lupus that hasn't improved with standard treatments. The study will enroll 162 participants and aims to check if the therapy is safe and tolerable. It also l…

This study tests whether adding the targeted therapy cabozantinib to standard immunotherapy (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer. About 1,175 adults with kidney cancer that has spread will receive either the usual treatment or the usual …

This study tests whether adding the drug eribulin to standard chemotherapy can help people with advanced bladder cancer live longer. It is for patients whose cancer has spread and no longer responds to immunotherapy. About 184 participants will receive either the new combination …

This trial tests a new antibody called acasunlimab, alone or with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The study has two parts: first to find safe doses, then to see how well those doses work. About 429 participa…

This Phase 3 trial tests whether the immunotherapy drug pembrolizumab (Keytruda) can help prevent bladder cancer from returning after surgery. About 739 patients with muscle-invasive or locally advanced urothelial cancer are randomly assigned to receive pembrolizumab or just be o…

This phase II trial tests whether adding cabozantinib to the immunotherapy drug nivolumab can prevent mucosal melanoma from returning after surgery. About 101 patients with resected mucosal melanoma will receive either nivolumab alone or nivolumab plus cabozantinib. The study aim…

This phase II trial tests whether adding the immunotherapy drug atezolizumab to the standard drug cabozantinib helps people with advanced papillary kidney cancer live longer without their disease getting worse. About 200 participants will receive either cabozantinib alone or cabo…

This study tests a new surgical technique that uses a piece of foreskin (from circumcision) to repair complex ureteral strictures—narrowing of the tube that carries urine from the kidney to the bladder. The trial will enroll 50 men who cannot be treated with standard surgery. The…

This trial tests whether a procedure called renal denervation can safely lower blood pressure in people with chronic kidney disease (stage 3) whose hypertension is not controlled by medication. The procedure uses ultrasound energy to calm overactive nerves in the kidney that may …

This Phase III trial tests whether adding the immunotherapy drug atezolizumab to standard chemoradiotherapy helps people with muscle-invasive bladder cancer that hasn't spread. About 475 participants receive either chemoradiotherapy alone or with atezolizumab. The main goal is to…

This large global trial is testing whether two experimental drugs—volrustomig (an immunotherapy) and casdatifan (a pill)—work better than the current standard immunotherapy combination for people with advanced clear cell kidney cancer. About 1,100 participants who have not had pr…

This phase 2 trial tests a one-time treatment called CC-97540, made from a patient's own immune cells engineered to target and calm the overactive immune system in lupus. The study enrolls 89 adults with active lupus (including kidney inflammation) who have not responded well to …

This study is testing experimental combinations of drugs for people with advanced kidney cancer (clear cell type) that has gotten worse after initial treatment. The goal is to see if these combinations are safe and can shrink tumors. About 370 participants will be enrolled in thi…

This study tests an experimental drug called GSK4771261 for safety and how the body processes it. Part A involves healthy volunteers, and Part B includes people with autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that causes kidney cysts and can lead to…

This study tests a new robotic surgery technique for kidney cancer that avoids clamping blood vessels and using stitches to close the kidney. The goal is to preserve as much kidney function as possible and reduce the risk of long-term kidney disease. About 59 adults with small ki…

This phase 3 trial is testing whether a combination of the experimental drug XL092 and the immunotherapy nivolumab can help people with advanced non-clear cell kidney cancer live longer without their disease worsening. Participants have not received prior treatment for their adva…

This trial compares two surgical techniques—percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS)—for removing kidney stones up to 3 cm in people who have only one functioning kidney. The goal is to see which approach clears more stones with fewer complicat…

This UCLA study is testing whether the Autoimmune Protocol (AIP) diet — which avoids dairy, grains, and sugar — can reduce protein levels in the urine of people with IgA nephropathy, a kidney disease that can lead to kidney failure. Thirty adults aged 18 to 65 with active disease…

This study tracks the safety of avacopan, a medication for ANCA-associated vasculitis, an autoimmune disease that causes blood vessel inflammation. Researchers will compare side effects like liver injury, heart problems, serious infections, and cancer in people taking avacopan ve…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This phase 2 trial is testing whether adding stereotactic body radiation therapy (SBRT) to high-dose Interleukin-2 (IL-2) can improve response rates in people with metastatic renal cell carcinoma. All participants receive IL-2, and half also get two doses of SBRT to a few tumor s…

This early-stage trial is testing an experimental drug called belzutifan in people with advanced solid tumors that have not responded to standard treatments. Belzutifan works by blocking a protein (HIF-2α) that tumors use to survive in low-oxygen conditions. The main goal is to f…

This study compares two treatments for stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). One group gets a shot of platelet-rich plasma (PRP) made from their own blood, while the other gets a standard surgical sling. The trial will enroll 42 women an…

This clinical trial tests an experimental drug called SAL0120 in people with chronic kidney disease (CKD). The study aims to see if different doses of SAL0120 can reduce protein in the urine, a key marker of kidney damage. Participants are randomly assigned to receive either SAL0…

This study tests whether combining a targeted drug called disitamab vedotin with BCG therapy can improve outcomes for people with HER2-positive high-risk non-muscle invasive bladder cancer. The drug is given intravenously every three weeks, while BCG is delivered directly into th…

This study tests an immunotherapy drug called camrelizumab, given directly into the bladder, for people with high-risk non-muscle invasive bladder cancer that did not respond to BCG treatment. The goal is to find a safe dose and see if it can prevent cancer from coming back or ge…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study tests whether oral lactoferrin, a protein found in milk, can improve anemia and bone health in adults with end-stage kidney disease on dialysis. Participants receive either lactoferrin, IV iron, or both for three months, alongside their usual anemia medication. The goa…

This study tests a treatment plan for people with muscle-invasive bladder cancer who want to avoid bladder removal. Participants receive chemotherapy plus an immunotherapy drug called tislelizumab, followed by a tailored course of radiation therapy. The goal is to see if this com…

This study investigates whether the acidity of a person's urine influences how effectively shock wave lithotripsy (ESWL) can break up a single kidney stone smaller than 2 cm. Researchers will measure urine pH before treatment and track whether the stone is completely cleared. If …

This trial is for people with advanced cancers who have already responded well to 6 months of standard immunotherapy. It compares continuing the same drugs at the usual frequency versus giving them every 3 months. The goal is to see if the reduced schedule can prevent cancer prog…

This early-stage trial is testing a new peptide vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab (Keytruda) in 30 adults with high-risk non-muscle invasive bladder cancer that did not respond to or could not tolerate standard BCG therapy. The vaccine is de…

This study tests the long-term safety of an experimental drug called OMS906 in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Participants receive OMS906 as an intravenous infusion every 8 weeks. The goal is to see if this dosing schedule is safe an…

This phase 1/2 trial tests the immunotherapy drug durvalumab alone or combined with other treatments (BCG, radiation, or chemotherapy) in 55 people with non-muscle invasive bladder cancer. The goal is to find safe doses and see if these combinations can eliminate cancer and preve…

This Phase 3 trial tested sibeprenlimab, a drug given as a shot under the skin, in 530 adults with IgA nephropathy, a kidney disease. The study compared the drug to a placebo to see if it could reduce protein in the urine and protect kidney function over time. Participants were a…

This trial tests whether lab-grown miniature tumors, called organoids, can help choose the best chemotherapy for people with intermediate-risk bladder cancer. Tumor samples are taken during surgery and grown in the lab. After testing several drugs on the organoids, the most effec…

This study tests whether adding terlipressin to standard care helps maintain stable blood pressure during kidney transplant surgery. Researchers will compare two groups of 150 adults: one receiving terlipressin plus dobutamine, the other dobutamine alone. The main goal is to see …

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder for people with non-muscle invasive bladder cancer. The goal is to see if this treatment can control or eliminate tumors, especially for those who cannot get stand…

This study tests a drug called sacituzumab govitecan (Trodelvy) in Japanese patients with advanced solid tumors, including certain breast and bladder cancers. The trial has two phases: first, to find the safest dose, and second, to see how well the drug shrinks tumors. Participan…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This phase 3 trial is testing a new treatment called cretostimogene grenadenorepvec for people with a type of bladder cancer (non-muscle invasive) that did not improve after standard BCG therapy. The treatment uses a modified virus to target and destroy cancer cells. About 190 pa…

This phase 2 trial tests whether daratumumab, a drug used for multiple myeloma, can help people with active lupus nephritis—a serious kidney complication of lupus. The study enrolls adults with confirmed lupus and active kidney inflammation. Participants receive daratumumab injec…

This study compares two treatments for adults with overactive bladder that hasn't improved with standard medications. One group receives a single injection of Botox into the bladder, while the other gets three weekly instillations of Platelet-Rich Plasma (PRP) made from their own…

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy helps people with advanced bladder cancer that has not been treated before. Participants have a type of bladder cancer that has spread or cannot be removed by surgery and shows a protein c…

This phase 2 trial investigates whether intravenous ribavirin (Virazole) can reduce deaths in adults with hemorrhagic fever with renal syndrome (HFRS), a severe viral illness that can cause kidney failure. The study enrolls military-affiliated personnel with probable or suspected…

This trial tests a combination of two drugs—anlotinib (a pill that blocks blood vessel growth to tumors) and sintilimab (an IV immunotherapy that helps the immune system attack cancer cells)—as a first treatment for people with advanced non-clear cell renal cell carcinoma, a rare…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study tests whether a structured health coaching program can help people on maintenance hemodialysis better manage their own health. Participants receive one-on-one coaching during dialysis sessions plus follow-up support through a messaging app. The goal is to improve self-…

This phase 2 trial tests whether dapagliflozin, a drug already used for diabetes and chronic kidney disease, can slow kidney damage in people with lupus nephritis. Lupus nephritis is a serious complication of lupus that causes kidney inflammation and can lead to chronic kidney di…

This study tests a drug called belantamab mafodotin in people with multiple myeloma that has come back or stopped responding to treatment, and who also have kidney problems—from mild impairment to end-stage disease requiring dialysis. The drug is an antibody-drug conjugate that t…

This trial tests whether dapagliflozin (Farxiga), a drug originally developed for diabetes, can protect kidney function in people who have received a heart transplant. Kidney failure is a common and serious complication after heart transplant. The study involves 430 participants …

This phase 3 trial tests whether adding two immunotherapy drugs—pembrolizumab and enfortumab vedotin—before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. The study includes patients who cannot take o…

This study tests a robotic-assisted surgery tool to remove bladder lesions. About 30 adults with small bladder tumors will undergo the procedure. The goal is to see if the robot helps remove the tumor in one piece with healthy tissue around it, which may improve diagnosis and red…

This Phase 3 trial tests a lab-grown blood vessel (ATEV) against the standard surgically created fistula in 121 women with end-stage kidney disease who need dialysis. The goal is to see if the ATEV allows more days without a catheter and reduces infections over 12 months. If succ…

This study monitors about 200 adults with paroxysmal nocturnal hemoglobinuria (PNH) who are already taking iptacopan (Fabhalta). Researchers will use registry data to count infections caused by certain bacteria. The goal is to better understand the real-world safety of this medic…

This trial tests an experimental drug called TRK-950 in combination with several standard anti-cancer treatments for people with advanced solid tumors, including colorectal, bladder, ovarian, and other cancers. The main goal is to find safe doses and understand side effects. Part…

This study compares two types of dialysis in 64 adults with end-stage kidney disease. One group gets standard hemodialysis, the other gets hemodiafiltration, which uses both diffusion and convection to remove waste. The main goal is to see if hemodiafiltration leads to less weigh…

This early-phase study tests a new treatment called NKX019 for people with lupus, an autoimmune disease. NKX019 uses specially engineered immune cells to target and calm overactive B cells. The main goal is to check safety in about 6 participants, while also looking for signs tha…

This study looks at the long-term safety and effects of atacicept in people with IgA nephropathy, a kidney disease. Participants have already completed a previous trial with atacicept. Researchers will monitor side effects and measure kidney function over time to see if the drug …

This study offers continued access to the cancer drug avelumab (and sometimes other drugs) for people with advanced cancers like lung, ovarian, or bladder cancer who are already seeing benefits from a previous Pfizer-sponsored trial. About 77 participants will be followed for saf…

This study is testing the long-term safety and effectiveness of an experimental drug called XH-S003 in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that can cause fatigue, blood clots, and other serious problems. About 26 people who have already ta…

This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this…

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This phase 2 trial is testing whether adding precise, high-dose radiation (SBRT) to standard immunotherapy (ipilimumab and nivolumab) can help people with metastatic kidney cancer live longer without their disease getting worse. About 66 participants with intermediate or poor-ris…

This study tests a new treatment called CHT105 for people with lupus nephritis that hasn't responded to standard therapies. CHT105 uses specially engineered immune cells from healthy donors to target and destroy the faulty immune cells causing kidney damage. Fourteen adults will …

This was a planned early-stage trial to test whether anti-CD19 CAR-T cells could safely help children with multi-drug resistant nephrotic syndrome, a serious kidney condition. The study was withdrawn before any patients were enrolled, so no data on safety or effectiveness were co…

This trial aimed to test whether anti-CD19 CAR-T cells could safely and effectively treat children with refractory ANCA-associated vasculitis, a rare autoimmune disease. The study was withdrawn before enrolling any participants, so no results are available. It was designed for ch…

This study follows 100 men who have had prostate surgery and still struggle with stress urinary incontinence (leaking urine when coughing or moving). They receive an adjustable implant called REMEEX to help control leakage. Researchers will track how well it works, side effects, …

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study looks at how well a combination of two drugs (enfortumab vedotin and pembrolizumab) works as a first treatment for people with advanced upper tract urothelial carcinoma, a rare cancer of the urinary tract. Researchers will track 50 patients in France to see how many re…

This early-stage trial tests whether the drug dexmedetomidine can reduce acute kidney injury in 78 adults undergoing ascending aortic surgery with a heart-lung machine. Half receive the drug, half get a placebo. The goal is to see if the drug's anti-inflammatory effects help prev…

This phase II trial is testing a combination of two drugs—sEphB4-HSA and pembrolizumab (Keytruda)—in 70 people with advanced bladder or prostate cancers that have not responded to standard treatments. The goal is to see if the combo is safe and can shrink tumors. Participants rec…

This study tests whether giving two drugs—nivolumab (immunotherapy) and cabozantinib (targeted therapy)—before removing the kidney can make all visible cancer disappear in people with advanced kidney cancer that has spread. About 38 adults with metastatic renal cell carcinoma wil…

This study tests whether using highly focused radiation (SBRT) on a limited number of growing cancer spots can help control the disease in patients with metastatic breast or genito-urinary cancers. Instead of switching to a new drug when some tumors start growing, doctors will ta…

This phase 3 trial tests whether the drug atrasentan can slow kidney function loss in people with IgA nephropathy, a disease that can lead to kidney failure. About 404 participants receive either atrasentan or a placebo, along with standard care. The main goal is to see if atrase…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This early-phase study tests a personalized cell therapy for people with certain cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, or sarcoma) whose tumors have a specific marker called MAGE-A4. The treatment involves taking a patient's own immune cells, …

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study follows 60 men with an enlarged prostate who already used the Butterfly device for a year. Researchers will track safety and symptom relief for up to 5 years. The goal is to see if the device remains effective and safe over the long term.

This study compares two types of surgery to create dialysis access in older adults (60+) with end-stage kidney disease. One method connects a vein directly to an artery (fistula), the other uses a synthetic tube (graft). The goal is to see which leads to fewer infections and more…

This study tests a drug called vonsetamig in 43 people with chronic kidney disease who are on dialysis and have very high levels of anti-HLA antibodies, making it nearly impossible to find a matching kidney donor. The drug aims to safely lower these antibodies so that a kidney tr…

This phase 2 study tests the drug atrasentan in 103 adults with various kidney diseases that cause protein leakage, including IgA nephropathy and FSGS. Participants take a daily tablet to see if it reduces protein in urine, a sign of kidney damage. The goal is to find a new way t…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This phase 3 study tests whether a combination of two drugs, enfortumab vedotin and pembrolizumab, works better than standard chemotherapy for people with advanced urothelial cancer that has spread. About 886 participants who have not had prior treatment for their advanced cancer…

This study tests whether a two-drug combination can help the immune system attack ovarian cancer that has returned after standard treatments. The drugs are E7777, which removes certain immune cells that block the body's defenses, and pembrolizumab, which reactivates cancer-fighti…

This study tests a new drug called obinutuzumab in 100 children aged 1-18 with refractory nephrotic syndrome, a kidney condition causing swelling and protein loss. The drug targets immune cells to reduce disease flares and dependence on steroids and other medications. Researchers…

This study tests a new medicine, NS-229, in 45 adults with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA), which causes inflammation in blood vessels. The goal is to see if NS-229 can help patients achieve remission while lowering their daily steroid d…

This phase 3 study tests whether combining two drugs (savolitinib and durvalumab) works better than the standard drug sunitinib for people with a rare, advanced kidney cancer called papillary renal cell carcinoma that has a specific genetic change (MET-driven). About 148 adults w…

This study tests a combination of two drugs, cadonilimab and lenvatinib, in 28 adults with advanced clear cell kidney cancer that worsened after initial immunotherapy. The goal is to see if the combo can shrink tumors or slow disease progression. Participants receive treatment un…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This study aimed to see if adding ANKTIVA to standard BCG treatment works better than BCG alone for people with a high-grade type of bladder cancer that hasn't spread into the muscle. It was designed for adults with papillary tumors who had not received BCG before or had limited …

This study is testing whether eating Brazil nuts can reduce inflammation and oxidative stress in people with chronic kidney disease. Fifty patients will take Brazil nut supplements for six months while researchers measure changes in blood and gut bacteria. It is a small, early-st…

This phase 3 trial tests whether adding belzutifan to standard pembrolizumab after kidney cancer surgery can delay or prevent the cancer from coming back. About 1800 participants with clear cell renal cell carcinoma are randomly assigned to receive either belzutifan plus pembroli…

This study looks at whether a combination of nurse health coaching, doctor training, and subsidies for a kidney-protecting drug can help slow the worsening of chronic kidney disease. About 724 adults with moderate-to-severe kidney disease in Singapore will be randomly assigned to…

This phase 3 trial compares the experimental drug belzutifan to the standard drug everolimus in 755 people with advanced kidney cancer that has worsened after prior treatments. The goal is to see if belzutifan can better delay cancer growth and improve survival. Participants take…

This study looks at whether taking cinnamon supplements for three months can lower inflammation and improve gut health in people with chronic kidney disease. Thirty patients will take either cinnamon capsules or a placebo. Researchers will measure markers of inflammation and oxid…

This study tests a combination of two drugs (fruquintinib and serplulimab) as the first treatment for people with a rare type of kidney cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors or slow the disease. About 39 adults will t…

This study tests whether adding an SGLT2 inhibitor to standard ARB therapy better reduces protein in the urine (a sign of kidney damage) in diabetic patients without high blood pressure. Sixty adults aged 30-60 with diabetes and microalbuminuria will receive either ARBs alone or …

This study tests a new drug called SKB264 in people with advanced solid tumors that have not responded to standard therapies. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The trial includes over 1,400 participants with various …

This study tests whether a lower dose of the steroid prednisone can treat relapses of nephrotic syndrome in children as effectively as the standard dose. Fifty children aged 1 to 18 with active relapses will be randomly assigned to either the reduced-dose or standard-dose regimen…

This study tests whether combining radiation therapy with immunotherapy drugs (durvalumab with or without tremelimumab) can help people with advanced bladder cancer who cannot or will not have chemotherapy. The trial includes 13 participants with cancer that has spread or cannot …

This study tests a drug called UGN-102 for people with a low-grade type of bladder cancer that hasn't spread into the muscle. The drug is given directly into the bladder to destroy tumors without surgery. The main goal is to see if the cancer disappears completely after 3 months.…

This study looks at the long-term safety of a drug called sibeprenlimab for people with IgA nephropathy, a kidney disease. About 600 adults who completed earlier trials of this drug will continue receiving it for up to 2 more years. Researchers will track side effects and measure…

This early-stage trial tests a new drug called VSA012 in about 50 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that destroys red blood cells. The study includes people who have not used complement inhibitors before or who still have low hemoglobin …

This phase III trial tests whether an immune-enhancing nutritional supplement, taken before and after bladder cancer removal surgery, can reduce post-operative complications and infections. About 203 participants are randomly assigned to receive either the supplement or a placebo…

This phase 3 trial compares a combination of two drugs, belzutifan and lenvatinib, against the standard drug cabozantinib in 747 people with advanced kidney cancer that has worsened after initial treatment. The goal is to see if the combo can better slow cancer growth or improve …

This early-phase study tests whether a single infusion of special immune cells (regulatory dendritic cells) from the kidney donor can help the recipient's body accept the new kidney with fewer side effects. 14 first-time kidney transplant recipients will receive the cells one wee…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assi…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests whether empagliflozin, a drug used for diabetes, is safe and tolerable for people with autosomal dominant polycystic kidney disease (ADPKD). About 50 adults with moderate kidney function will receive either the drug or a placebo for 12 months. Researchers will mo…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy can help people with muscle-invasive bladder cancer live longer without their cancer returning or spreading. About 520 participants who are eligible for non-surgical treatment will …

This study compares two surgical procedures for stress urinary incontinence (leaking urine when coughing, sneezing, or lifting). One uses a mesh tape (transvaginal tape), the other tightens the urethral ligaments without mesh. Researchers will follow 200 women for one year to see…

This early-phase study tests a new gene therapy for people with advanced clear cell kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better attack cancer, and return them to the body. The main goals are to check safety and see if tumors shr…

This study tests a new device called STARgraft-3, a tube used for dialysis in people with end-stage kidney disease. The goal is to see if it stays open longer and resists infection better than standard grafts. About 21 adults will be followed for up to a year to check how well th…

This study tests a drug called tezepelumab in 42 adults with EGPA, a rare disease that causes inflammation in blood vessels and can damage organs. The goal is to see if the drug helps patients reach remission, meaning no active disease and low steroid use. Participants receive ei…

This study looked at 70 men with an enlarged prostate and overactive bladder symptoms. Some received a Botox injection into the prostate during surgery, while others took standard medication after surgery. The Botox group showed better symptom scores at 12 weeks, suggesting a pot…

This study tests a drug called ceralasertib, alone or with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, and endometrial cancers. The goal is to see if these combinations can shrink tumors by blocking enzymes that help cancer grow.…

This Phase 3 trial tests sparsentan, a new drug, against irbesartan (a standard treatment) in 406 adults with IgA nephropathy, a kidney disease. The goal is to see if sparsentan better protects kidney function over about 2 years. Participants must have significant protein in thei…

This study tests a minimally invasive procedure that blocks blood flow to kidney angiomyolipomas (non-cancerous tumors). The goal is to shrink the tumors and stop bleeding while preserving kidney function. Researchers will follow 50 patients for one year to check safety and effec…

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with locally advanced kidney cancer that hasn't spread to other organs. About 18 participants will receive the combination for 12 weeks before their operation. The go…

This study aimed to see if a special blood filter (Seraph 100) could reduce BK virus levels in kidney transplant patients with high viral loads. It planned to enroll adults with a BK virus level of 10,000 IU/mL or higher who already had dialysis access. However, the trial was wit…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This study tests whether giving estrogen through a vein during kidney transplant surgery can reduce damage to the new kidney. It includes 30 women who need dialysis and are getting a kidney from a deceased donor. The goal is to see if estrogen helps the kidney work better right a…

This study follows 9 people with Fanconi Anemia who already received a gene therapy that adds a working FANCA gene to their blood stem cells. Researchers will check their health and blood counts for 15 years to see if the treatment remains safe and keeps working. No new treatment…

This phase 2 trial is testing a daily pill called belzutifan in 50 people with VHL disease who have kidney cancer. The goal is to see if the drug can shrink tumors. Researchers are also monitoring how long any tumor shrinkage lasts and checking for side effects.

This registry follows 750 patients with small kidney tumors who are not good candidates for surgery. They receive either cryotherapy (freezing) or radiofrequency ablation (heating) to destroy the tumor. Researchers will track survival, kidney function, and complications over time…

This study tests whether ambrisentan, a drug approved for lung blood pressure, can help patients with hepatorenal syndrome—a serious kidney problem that can occur in advanced liver cirrhosis. About 54 hospitalized adults will receive either ambrisentan or the standard drug terlip…

This study tests a drug called atacicept given once a month to people with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if monthly dosing lowers harmful antibodies and reduces protein in the urine, which are signs of kidney damage. About 9…

Some people waiting for a kidney transplant have immune systems that reject most donors, leading to years of waiting. This study tests whether two drugs—carfilzomib (used for multiple myeloma) and belatacept (an immune-suppressing drug)—can reduce that sensitivity. About 21 parti…

This phase 2 trial is testing whether the immunotherapy drug Keytruda (pembrolizumab) can help people with muscle-invasive bladder cancer avoid having their bladder removed. About 46 participants will receive two cycles of Keytruda, then doctors will check if the cancer has compl…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study tests a device called SUI-100 for women aged 22-70 with mild-to-moderate stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 130 participants will be randomly assigned to receive either the real device or a sham (fake) treatment. T…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study looks at adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) for people with advanced or metastatic bladder cancer that cannot be removed by surgery. Researchers want to see if giving the drugs in a different order—chemothera…

This study tests two immunotherapy drugs (nivolumab with or without urelumab) given before bladder removal surgery in 15 patients with muscle-invasive bladder cancer who cannot or refuse standard chemotherapy. The goal is to see if adding urelumab boosts the immune response again…

This study tests whether starting immunotherapy earlier—based on a blood test that finds tumor DNA—can control bladder cancer that may have spread after the bladder is removed. About 154 adults whose cancer has returned or is at high risk of spreading will receive the treatment. …

This study tests a new two-drug combination (cadonilimab plus axitinib) as a first treatment for people with advanced or spread kidney cancer of rare types. About 37 participants will receive the drugs until their disease gets worse or side effects become too severe. The goal is …

This phase II trial tests the immunotherapy drug pembrolizumab in 39 people with advanced adrenocortical carcinoma that cannot be removed by surgery. The study aims to see if the drug can shrink or control the cancer. Participants receive pembrolizumab and are monitored for tumor…

This study compares two types of sling surgery for stress urinary incontinence (leaking urine with cough or sneeze) in women who are also having surgery for pelvic organ prolapse. One sling uses a single incision, the other uses two incisions. The trial will enroll 180 women and …

This study tested a treatment called CG0070, a virus designed to attack cancer cells, in people with high-grade non-muscle invasive bladder cancer. Participants had already tried standard therapy (BCG) without success and chose not to have their bladder removed. The goal was to s…

This study tests the long-term safety and effectiveness of pegcetacoplan in 100 people with two rare kidney diseases, C3 glomerulopathy and IC-MPGN. Participants previously completed a one-year trial and saw benefit from the drug. The goal is to see if pegcetacoplan can keep redu…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This early study tests a new artificial urinary sphincter device in 6 men with stress incontinence. The device is implanted to help control urine leakage. Researchers will check how many devices are successfully activated and how many need to be removed or revised within 6 months…

This study tests a new artificial urinary sphincter device in 6 women with stress incontinence (leaking urine during activity). The goal is to see if the device is safe and works well. Researchers will check how many devices need to be removed or fixed, and if pad weight tests sh…

This study looks at whether drinking nitrate-rich beetroot juice every day for three months can improve blood vessel health, movement, and thinking in people with chronic kidney disease. About 92 participants with moderate kidney disease will receive either the active beetroot ju…

This study compares two treatments for a rare type of urinary tract cancer. One group gets chemotherapy before surgery, the other has surgery alone. The goal is to see if chemo helps shrink the tumor and improve long-term outcomes. About 120 adults with high-risk, non-spread canc…

This phase III trial is testing whether a different strain of BCG (Tokyo-172) works better than the standard TICE strain for high-grade bladder cancer that hasn't spread into muscle. It also looks at whether giving a BCG vaccine under the skin before the usual bladder treatment h…

This study tests whether combining two drugs—serplulimab and fruquintinib—can prevent kidney cancer from returning after surgery in people with a rare, aggressive type called non-clear cell renal cell carcinoma. About 40 adults at high risk of recurrence will receive both drugs f…

This study tests a new medicine called AK112 (Yivoximab) for people with advanced kidney cancer that has spread. The drug works in two ways: it helps the immune system attack cancer cells and blocks blood vessels that feed tumors. About 60 participants will receive the drug every…

This study looks at whether people with advanced bladder cancer can stop taking immunotherapy drugs (like pembrolizumab or nivolumab) after about a year instead of continuing indefinitely. The goal is to see if stopping early leads to similar survival rates while reducing side ef…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests a drug called ARGX-117 in people who get a kidney from a deceased donor and are at risk for delayed graft function (when the kidney takes time to start working). About 103 participants will receive either the drug or a placebo by IV. The goal is to see if the dru…

This early-phase study tests a new treatment called Prula-cel for people with autoimmune diseases like lupus, scleroderma, and vasculitis. Prula-cel uses donor immune cells engineered to target and destroy faulty immune cells that attack the body. The goal is to find a safe dose …

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This early-phase trial tests a new type of cell therapy for children and young adults with solid tumors that have come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are trained in the lab to recognize and attack multiple cancer…

This phase 2 trial is testing a combination of three drugs—sacituzumab govitecan, zimberelimab, and domvanalimab—given before and after surgery for muscle-invasive bladder cancer. The study includes 70 patients who cannot take standard cisplatin chemotherapy. The main goal is to …

This study compares two methods for placing peritoneal dialysis catheters in adults with advanced chronic kidney disease. The Moncrief-Popovich technique buries the catheter under the skin before use, while the conventional method places it directly. Researchers will track how lo…

This study tests a new treatment called AMDC-USR (iltamiocel) for women who still have stress urinary incontinence after having surgery for it. The treatment uses the patient's own muscle cells injected into the urinary sphincter to strengthen it. Half of the 96 participants get …

This study planned to test a device called RetroPerc that helps doctors reach and remove large kidney stones. It was designed for adults with kidney stones larger than 10 mm. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study tests an oral drug called vadadustat (Vafseo) for treating anemia in people with end-stage kidney disease who are on hemodialysis. About 2,200 adults will be randomly assigned to take vadadustat three times a week or continue standard injectable treatments. The goal is…

This study tests whether a 6-month exercise and personalized diet plan can help patients with obesity (BMI 40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as 'inactive' due to their weight will follow a fitne…

This study tests a new type of daily radiation therapy for muscle-invasive bladder cancer that adapts to changes in the body each day. The goal is to see if this approach lowers the chance of diarrhea and other bowel problems compared to standard radiation. About 110 adults with …

This study looks at whether losing weight with a special very low-calorie diet (Optifast) can lower oxalate levels in urine for obese adults who have had calcium oxalate kidney stones. Fourteen participants will eat a low-oxalate diet and provide urine samples before and after th…

This phase 2 trial is testing a drug called ado-trastuzumab emtansine (Kadcyla) in 131 adults with advanced solid tumors that have a specific HER2 gene change. The drug combines an antibody that targets HER2 with a chemotherapy agent, aiming to deliver treatment directly to cance…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study tests whether a drug called finerenone can reduce scarring and fat buildup in the heart muscle of people with diabetic kidney disease and heart failure. About 40 adults will take the pill daily for 6 months and get advanced heart scans to see if their heart structure i…

This early-phase study tests a new drug called E7386 in about 70 people with advanced solid tumors, including colorectal cancer. The main goal is to check safety and find the right dose. Participants have tumors that no longer respond to standard treatments.

This study tests a new surgical technique called double-face augmentation urethroplasty for men with severe, long urethral strictures (narrowing of the urine tube). The procedure uses a graft taken from the inside of the cheek (buccal mucosa) to widen the urethra from both sides.…

This phase 2 trial is testing a radioactive drug called 177Lu-PSMA-617 (Pluvicto) in 24 people with advanced clear cell kidney cancer that shows a specific marker (PSMA). The drug is given by IV and aims to shrink tumors. Researchers are measuring how many patients respond and tr…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study follows 50 adults with PNH who take danicopan along with their usual medication (eculizumab or ravulizumab). Researchers track serious side effects and infections over time to see if the combination is safe for long-term use. Participants are already in a PNH registry …

This study looks at the long-term safety of danicopan when added to standard treatments (Soliris or Ultomiris) for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Researchers will analyze data from 50 adult patients in an international registry, trac…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage patients with type 2 diabetes and early-stage chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this te…

This trial is testing whether a diagnostic test called KidneyIntelX can help doctors better manage patients with type 2 diabetes and early-stage chronic kidney disease. The test predicts the risk of rapid kidney function decline over five years. Researchers will see if using this…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage type 2 diabetes patients with early to moderate chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this …

This study aimed to test a new two-step PET imaging method to better detect cancers that produce a substance called CA19-9, such as pancreatic, bladder, and gastrointestinal tumors. The plan was to give patients an antibody followed by a radioactive tracer to highlight cancer cel…

This study is testing whether a urine test that looks for DNA markers can help diagnose and monitor upper tract urothelial cancer (UTUC), a rare cancer of the kidney and ureter. Researchers will collect urine samples from 50 patients before surgery and during follow-up visits. Th…

This trial tests whether an AI tool called ENLIGHT can help pathologists more accurately and quickly distinguish between certain lung and kidney cancer subtypes. Pathologists will review digitized slides under three conditions: without AI, with AI as a double-check after their ow…

This trial is developing a new, non-invasive urine test for bladder cancer. It uses a microfluidic chip to isolate tiny particles called exosomes from urine and analyze their genetic and protein content. The goal is to create a diagnostic model that can detect bladder cancer accu…

This study tests whether a new type of PET scan using a radioactive antibody called 124I-cG250 can detect if kidney cancer is responding to targeted therapy (sunitinib or pazopanib) earlier than standard CT scans. The antibody attaches to a protein found on kidney cancer cells, m…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests a bladder stimulation technique (gentle lower back massage and lower abdomen tapping) to collect urine from infants under 6 months in the emergency department. The goal is to see if this method gets cleaner samples faster than the usual adhesive bag. 124 infants …

This study looks at whether measuring bladder wall thickness with an ultrasound can help predict treatment response in children aged 5-17 with lower urinary tract problems or bedwetting. Researchers will compare bladder wall measurements between the two groups and see if thicknes…

This study planned to test a special PET-CT scan (68Ga-PSMA) in people newly diagnosed with advanced kidney cancer. The goal was to see if it could find small cancer spots that standard scans miss. However, the trial was withdrawn before any patients were enrolled, so no results …

This study looks at whether a substance called UDP-glucose in urine can help doctors find kidney injury earlier in children after heart surgery. Current tests often miss early signs, delaying treatment. About 305 children under 8 years old having heart surgery will provide urine …

This study is testing a urine test called BladMetrix to see if it can detect bladder cancer returning after surgery. 500 adults with non-muscle invasive bladder cancer will provide urine samples during routine follow-up visits over 2 years. The test's accuracy will be compared to…

This study compares two CT urography methods for diagnosing urothelial carcinoma (a type of urinary tract cancer). 352 adults with blood in urine or a history of this cancer will be randomly assigned to receive either a single-bolus or split-bolus CT scan. Researchers will compar…

This study tests whether a special MRI can tell the difference between harmless and cancerous kidney growths when standard CT scans cannot see fat. About 44 adults with kidney masses that have no visible fat on CT will get this advanced MRI. The goal is to see if the MRI can iden…

This study tests whether a special type of scan called SPECT/CT can help doctors make better decisions about treating kidney tumors. The scan uses a radioactive tracer to see how tumors behave. Researchers will check if the scan changes what doctors recommend for 102 patients wit…

This study enrolls 4,000 people with urothelial carcinoma to test whether artificial intelligence can predict HER2 expression using MRI scans and pathology images. The goal is to create a model that accurately assesses HER2 status without needing invasive biopsies, helping doctor…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This phase II trial tests whether a low-dose version of the drug rapamycin, called eRapa, can prevent bladder cancer from coming back in people who have already been treated for non-muscle invasive bladder cancer. About 166 participants will take eRapa or a placebo daily for one …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study looks at three different numbing methods to reduce pain in the mouth after a type of urethral surgery called buccal graft urethroplasty. Sixty men will be randomly assigned to one of the methods, and their pain levels and need for painkillers will be tracked. The goal …

This study looks at whether adding a brief sleep program to standard bladder medication can reduce urgent leaks and nighttime urination in women aged 60 and older. About 120 women with frequent urgency incontinence and nocturia will receive either medication alone or medication p…

This trial tests whether one of two ultrasound-guided nerve blocks, when added to a standard arm block, can provide complete pain relief during AV fistula surgery in people with end-stage kidney disease. The two blocks are an intercostobrachial nerve block and an erector spinae p…

This study tests whether a supervised, home-based exercise program can help people with metastatic cancer who are starting oral targeted therapy. Participants are randomly assigned to either a weekly 60-minute session with a trained coach or to a booklet with exercise recommendat…

This study tests whether an artificial intelligence-supported education program can help reduce itching in people with chronic kidney disease who are on hemodialysis. The program teaches patients about causes of itching, skin care, diet, and self-management strategies through an …

This pilot study tests a 16-week physical activity and power training program for up to 30 older Veterans with advanced chronic kidney disease. The main goal is to see if the program is doable and well-tolerated. Participants will be pre-frail or have difficulty walking, and the …

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This study tests whether a special teaching method called Pecha Kucha can help people on hemodialysis better follow their fluid and diet restrictions. The method uses a fast, visual slideshow to make information easier to remember. 70 patients will be split into two groups: one g…

This study tests whether adding pulsed electromagnetic field (PEMF) therapy to standard bladder instillations of heparin and bupivacaine can better reduce chronic pelvic pain in women with interstitial cystitis/bladder pain syndrome. Twenty female adults who already receive bladd…

This study tests whether a live, online exercise program can improve physical function in adults waiting for a kidney transplant. Eighty participants will either join twice-weekly virtual exercise sessions or a health education class. The main goal is to see if they can stand up …

This study tests whether a wearable device, used at home alongside pelvic floor therapy, can help people with multiple sclerosis manage bladder problems. Twenty women with MS will use the device for three months. The main goal is to see if the approach is practical and easy to us…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This pilot study tests whether weekly testosterone injections can increase pelvic floor muscle size and improve stress urinary incontinence in women aged 60 and older. The trial involves 30 participants and uses MRI to measure muscle changes. It is a small, early-stage proof-of-c…

This study tests whether a 9-week tele-nursing program—including education, phone or online check-ins, and counseling—can improve quality of life and health outcomes for people with stage 3 or 4 chronic kidney disease who are not yet on dialysis. Researchers will compare 66 parti…

This study tests whether a non-invasive magnetic brain stimulation technique, called rTMS, can reduce pain in women with interstitial cystitis or bladder pain syndrome. The treatment targets brain areas that control pelvic floor muscles, aiming to lower pain by improving how the …

This study compares two laser methods for breaking up kidney and ureteral stones during surgery. One method uses standard laser pulses, the other uses a newer 'Moses 2.0' pulse mode. Researchers want to see if the newer mode reduces surgery time and improves stone clearance. Abou…

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This study tested a program to help bladder cancer patients recover better after bladder removal surgery. The program included extra monitoring and support before, during, and after the operation to catch problems early. The goal was to reduce complications within 90 days after s…

This study compares two drugs—methocarbamol and oxybutynin—to see which works better for pain and discomfort caused by a ureteral stent placed after kidney stone surgery. About 126 adults aged 18 to 80 who have the surgery will take one of the study drugs along with standard pain…

This study tests whether a 12-week program of online chair-based exercise and health education, combined with a geriatric assessment, is feasible and helpful for adults aged 65+ with certain cancers and their support persons. The program is delivered remotely, and the study will …

This study tests whether magnetic stimulation of the pelvic floor can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 158 adult women will receive the treatment and report their symptoms using questionnaires. The goal is t…

This study tests whether a laser applied to the vagina can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 144 women will receive the laser treatment and be followed for 6 months. The main goal is to see if the treatment r…

This study looks at whether adding diaphragmatic breathing to standard Kegel exercises can improve pelvic floor muscle strength and quality of life in women who have had multiple pregnancies and suffer from stress urinary incontinence (leaking urine when coughing, sneezing, or ex…

This study tests whether a device that sends mild electrical pulses to a nerve in the ankle (transcutaneous tibial nerve stimulation) can reduce overactive bladder symptoms and improve quality of life in women. Twenty-six women with idiopathic overactive bladder will receive the …

This phase 2 study looks at whether people with certain cancers (non-small cell lung cancer, kidney cancer, or melanoma) prefer getting the drug pembrolizumab as a quick shot under the skin instead of a longer IV infusion. About 147 participants will try both methods and then say…

This study is testing whether peppermint oil capsules can improve symptoms of bladder and bowel dysfunction in children aged 8 to 17 who haven't gotten better with standard behavioral therapy. Thirty participants will take peppermint oil three times daily for 8 weeks, and researc…

This study tests whether adding mindfulness (guided meditation) to a group exercise program during dialysis can improve safety, adherence, and quality of life for people with chronic kidney disease. Thirty participants will be split into two groups: one doing exercise plus mindfu…

This study is testing whether a smartphone app that teaches mindfulness can help people with advanced kidney cancer cope with their illness. The trial will enroll 21 patients who are already receiving immunotherapy and have moderate to high fear of their cancer returning. The mai…

This study tests a non-invasive treatment called transcutaneous tibial nerve stimulation for women with overactive bladder who cannot or will not take medication. Thirty women will receive either real or sham stimulation twice a week for six weeks. Researchers will measure change…

This study tests whether a 2-minute perineal massage before a pessary exam can reduce pain and discomfort. 68 women with prolapse or incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, non-drug way to improve comfort during r…

This study tests whether a 6-month program of aerobic and resistance exercises, done during dialysis sessions, can improve body composition, muscle oxygen levels, and physical function in 40 adults with chronic kidney disease. Participants are randomly assigned to either the exer…

This study looks at whether reducing the time BCG stays in the bladder (dwell-time) can lessen severe side effects in people with high-risk non-muscle invasive bladder cancer. About 314 patients from Nordic countries will either get the standard dwell-time or a shorter one based …

This study tests whether a mobile app and a connected device can help women aged 55 and older with stress urinary incontinence do pelvic floor exercises at home. The app guides exercises and provides feedback on muscle contractions. The goal is to see if this approach reduces lea…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study will observe how safe and effective the antibiotic Zavicefta is when used in everyday medical practice in Japan. It includes 59 patients with sepsis (a severe blood infection) or reduced kidney function who are receiving Zavicefta for the first time. Researchers will t…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study investigates whether people with type 2 diabetes who have or are at risk for chronic kidney disease produce too much aldosterone, a hormone that regulates salt and blood pressure. Participants undergo several suppression tests—including oral sodium, saline infusion, an…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This study looks at how the immune system of kidney transplant patients responds to the shingles vaccine and to natural shingles infection. Researchers will track antibody and T-cell levels over time in patients who have had a transplant or are on the waiting list. The goal is to…

This study aims to develop an artificial intelligence-based model to predict serious outcomes in people with chronic kidney disease (CKD), such as disease progression, kidney failure, or death. Researchers will follow over 1,100 adults with moderate CKD in Vietnam for two years, …

This study tests whether a ring-shaped, cuffless device called CART BP Pro can accurately measure blood pressure in people receiving maintenance hemodialysis. Participants will wear the device on their finger for about 48 hours, and its readings will be compared with standard blo…

This observational study explores whether levels of a protein called soluble CD163 in blood or urine can reflect how active IgA nephropathy is and how it might progress. Researchers will compare these levels among people with IgA nephropathy, those with a similar kidney condition…

This study looks at data from over 44,000 patients to find the best way to manage blood pressure during surgery and prevent kidney damage. Researchers will build a computer model that predicts a safe blood pressure target for each individual patient. The goal is to give doctors a…

This study follows 468 people with metastatic kidney cancer to see how their treatment and quality of life change over time in real-world clinics. Researchers will track medication adherence, symptoms, and well-being using patient questionnaires. The goal is to understand what ac…

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This study is developing an artificial intelligence (AI) system to analyze kidney biopsy images from transplant patients. The goal is to see if AI can accurately tell apart different types of rejection, measure how much damage the kidney has, and predict if rejection might come b…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study looks at whether diabetic kidney disease and blood-sugar control before surgery can help predict a common complication called pseudophakic macular edema (PME) — swelling of the central retina — after cataract surgery in people with type 2 diabetes. Researchers will rev…

This observational study looks at whether high-impact sports, like running or jumping, are linked to urinary incontinence in young adults aged 18 to 35. Researchers compare six groups: men and women who do high-impact sports, those who are physically active but avoid high-impact …

This registry follows women who received iltamiocel — an experimental cell therapy — for stress urinary incontinence that came back or persisted after surgery. Researchers are tracking long-term safety and whether the benefit lasts. The goal is to see if this one-time treatment c…

This study looks at how SGLT-2 inhibitors, a common class of diabetes drugs, affect lower urinary tract symptoms such as frequent urination, urgency, and nighttime trips to the bathroom. Researchers will follow adults with type 2 diabetes who are starting an SGLT-2 inhibitor for …

This study looks at how a specific gene change (AGXT) affects oxalate production in people who have had calcium oxalate kidney stones. Four participants will eat a low-oxalate diet for five days and then receive an intravenous dose of glycolate. Researchers will measure oxalate l…

This study in 140 rural secondary schools in Madagascar tests which parts of a hygiene program — new latrines and handwashing stations, peer-led sensitization, or free sanitary pad vouchers — most improve adolescent girls' learning, stress, and physical health. Researchers will m…

This study looks at whether combining CT scan images, tumor features, and patient health information can better predict how well people recover after partial nephrectomy for endophytic kidney cancer. Researchers will analyze data from 406 patients who have already had surgery to …

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery diseas…

This study tests whether the type of filter (membrane) used during hemodialysis changes how immune cells and clotting factors react. Ten adults on long-term dialysis will try three different membranes over one week, with blood samples taken during each session. The goal is to see…

This study follows about 793 people with chronic kidney disease who previously took part in a program designed to help them talk to doctors and family about kidney transplants. Researchers want to see if the program's effects last over time, including whether patients start trans…

This study tracks people who have had or will have a procedure called ablation to destroy kidney tumors. Researchers want to see how effective the procedure is and whether it improves patients' quality of life. Participants fill out questionnaires about their health and well-bein…

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…

This study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

Hispanic/Latino and American Indian patients are less likely to get kidney transplants, even though they have higher rates of kidney failure. This study compares two methods to help them complete the transplant evaluation process: a fast-track evaluation done in one day or within…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This study follows thousands of critically ill adults in intensive care units across China to better understand acute kidney injury (AKI), a common and dangerous complication. Researchers will collect medical data, images, and biological samples to build a large database. The goa…

This study investigates whether a single infusion of L-arginine, an amino acid, can reduce abnormally high sympathetic nerve activity in people with chronic kidney disease (CKD). High nerve activity is linked to increased cardiovascular risk in CKD patients. Researchers will meas…

This study looks at whether a measurement called the stone heterogeneity index (SHI), taken from a CT scan, can predict how well shock wave lithotripsy (SWL) breaks up upper urinary tract stones in children aged 1 to 18. Researchers will follow 286 children for three months after…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study was designed to see if different types of anesthesia could help a surgically created blood vessel connection (called a fistula) work better for dialysis patients. The plan was to compare three methods: a nerve block in the armpit, a nerve block in the neck, and local a…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study tests two ways to help older adults with kidney failure make informed choices about their care. One approach offers education and decision aids; the other adds a supportive care program for those who choose non-dialysis options. Researchers will compare how many patien…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study was designed to see if a new method of measuring the visual field—by projecting vision zones on the ground—helps people with retinitis pigmentosa understand their remaining sight and improve their walking rehabilitation. The trial was withdrawn before enrolling any par…

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how die…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …

This study follows 550 people with bladder cancer to understand how treatments like surgery affect their quality of life. Researchers want to learn what patients go through so doctors can offer better support and clearer information. The goal is to improve care, not to test a new…

This study looks at how canagliflozin (Invokana), a diabetes drug, protects the kidneys in people with type 2 diabetes. Researchers will use advanced imaging, kidney biopsies, and function tests to uncover the mechanisms. The trial involves 45 adults and aims to explain the drug'…

This study observes 400 Japanese patients with muscle-invasive urothelial carcinoma who received nivolumab after surgery to remove their cancer. Researchers will track how long patients stay cancer-free, side effects, and how the drug is actually used in clinics. The goal is to s…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study follows 28 kidney transplant recipients who are switching from one anti-rejection drug (anticalcineurin) to another (belatacept). Researchers want to see how this change affects the immune system's ability to fight the common CMV virus. Participants will have blood tes…

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is…

This study examines stored tumor samples from 15 people with kidney or bladder cancer who initially responded to immune checkpoint therapy but later developed new tumors. Researchers will compare the genetic and tissue features of the original and new tumors to understand how the…

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

This study looks at whether low levels of pyrophosphate, a natural substance that prevents mineral buildup, can predict artery hardening in people with moderate chronic kidney disease. Researchers will measure pyrophosphate in blood samples from 242 patients and track artery chan…

This early-stage study tests a tiny implantable device that releases very small amounts of several cancer drugs directly into bladder tumors. The goal is to see if the device is safe and can help doctors figure out which drugs kill the tumor best. Only 18 people with muscle-invas…

This research study collects tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early, especially in …

This study reviews medical records from 300 cancer patients to see if the makeup of a tumor's surroundings (the tumor microenvironment) is linked to how well antibody-based therapies work. Researchers will analyze tissue samples and blood markers from patients with seven types of…

This study looks at whether people who received a kidney transplant later regret their choice. Researchers will survey 250 patients one year after their transplant to measure feelings of regret and quality of life. The goal is to understand how common regret is and help doctors s…

This study aims to understand why kidney tumors in people with VHL syndrome can be different from each other. Researchers will use advanced imaging, multiple biopsies, and lab-grown tumor models to map these differences. The goal is to learn more about the disease, not to test a …

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study tests a web-based tool called WellPrept that gives patients clear information before their urology procedures. Researchers want to see if it helps patients feel more confident and understand their condition better, and if it shortens clinic visits. About 300 men and wo…

This study is testing whether a detailed MRI scan can provide better information about chronic kidney disease (CKD) than standard tests. Researchers will scan 486 adults with CKD and track their health over time to see if the MRI can predict which patients will get worse. The goa…

This study explores whether having kidney cancer patients report their side effects weekly through a short survey can help doctors manage those side effects better. The surveys ask about symptoms like nausea and fatigue and are sent directly to the care team, who then follow up i…

This study was designed to see how a new experimental drug for chronic kidney disease, nurandociguat, affects the way the body processes two common medicines: rosuvastatin (a cholesterol drug) and dabigatran (a blood thinner). Healthy adults would have taken these drugs alone and…

This study was designed to track the long-term health of hospitalized patients in China who develop acute kidney injury (AKI). Researchers planned to monitor kidney function decline, new heart problems, and death rates over time. However, the study was withdrawn before any partic…

This study is not testing a new drug, but rather doing the early science needed to develop one. Researchers are looking for the right targets (antigens) on adrenocortical carcinoma cells and studying how the tumor suppresses the immune system. The goal is to find a way to create …

This study is creating a large registry of 600 adults who use catheters to empty their bladder due to nerve damage or other causes. Participants will report on their satisfaction, quality of life, and any infections or complications. The goal is to gather real-world data to bette…

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. No new treatme…

This study follows 400 people with adrenocortical carcinoma who are taking mitotane as their first treatment. The goal is to carefully record all side effects, including ones that are not well understood. By collecting this data, researchers hope to improve how side effects are m…

This study aimed to help 4th graders develop healthy bladder habits by providing education, water stations, and changes to classroom bathroom policies. Researchers planned to track bathroom use, symptom scores, and urine volume. However, the study was withdrawn before enrolling a…

This study looks at whether SGLT2 inhibitors, a type of diabetes drug, can help prevent or manage anemia in people with chronic kidney disease. Researchers will analyze data from 15,000 patients in Japan to see how these drugs affect anemia rates, treatments, and costs. The goal …

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This study looks at whether adding AI-powered images to the surgeon's screen during single-port robotic surgery makes the surgeon's job easier or harder. About 90 urology surgeons and residents will fill out a questionnaire after surgery to rate their mental workload. The goal is…

This observational study follows 25 people with end-stage kidney disease who are receiving a living donor kidney transplant. Researchers want to see how protein in the urine (proteinuria) relates to blood flow in the native kidneys before and after transplant. They also check for…

This study looks at whether losing weight over two years can improve how the kidneys use oxygen and how the body responds to insulin in people with autosomal dominant polycystic kidney disease (ADPKD) who are overweight. Researchers will use PET scans and insulin tests to measure…

This study looks at whether a 12-week survivorship program for men with advanced prostate, kidney, bladder, testicular, or penile cancer can be successfully added to their regular follow-up care. Researchers will measure how feasible and acceptable the program is using questionna…

This study is a registry that gathers information from medical records of 500 adults who had a bladder function test using the Glean Urodynamics System. The goal is to see how the system is used in everyday medical practice. No new treatments or procedures are given; it simply co…

This study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study follows 6 patients who previously received an experimental treatment (N-803 plus BCG) for non-muscle invasive bladder cancer. Researchers will collect long-term data on survival, cancer recurrence, and test results to see how well the treatment worked over time. No new…

This study looks at 1000 people who had a first arteriovenous fistula (AVF) created for dialysis. Researchers want to know how many are actually being used for dialysis two years later, and why some are not. The goal is to understand what prevents these fistulas from being used.

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study looks at data from 3,500 kidney transplant patients to understand if a technique called normothermic machine perfusion (NMP) improves outcomes. NMP keeps donated kidneys warm and oxygenated before transplant, but there is no registry field to track it. Researchers will…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study planned to monitor tiny bits of tumor DNA in the blood of people with early breast cancer. Researchers wanted to see how these DNA levels change during treatment and follow-up. The study was withdrawn before any participants were enrolled, so no results are available.

This study looks at how certain blood chemicals and blood vessel function relate to kidney disease severity in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers will measure homocysteine levels and blood vessel health in 80 participants age…

This study follows 600 people with non-muscle invasive bladder cancer to see how changes in smoking habits and body weight after diagnosis affect the chance of cancer coming back. Participants fill out questionnaires and provide saliva or urine samples over time. The goal is to l…

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study is looking at 150 adults having a specific type of kidney stone surgery called FANS-RIRS. Researchers want to see if the results of a routine urine culture, taken before surgery, can predict whether a patient will develop a fever after the operation. The goal is to hel…

This study explores the experiences of young adults aged 16 to 30 who receive haemodialysis in a hospital or clinic. Researchers want to understand what makes social interaction difficult and how to reduce loneliness. Through surveys, interviews, and workshops, they aim to create…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This observational study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) develops during a hospital stay. Researchers will also compare death rates and readmission rates between patients who develop AKI and those who do not…

This study planned to compare how often women get urinary tract infections after giving birth, depending on whether they had a catheter during labour. It aimed to include pregnant women at 37 weeks or more. However, the study was withdrawn before enrolling any participants, so no…

This study looks at blood samples from 25 cancer patients receiving radiation therapy. Researchers want to find specific genes that show how each person's body responds to radiation. The goal is to better understand individual reactions and possibly personalize radiation treatmen…

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study looks at whether a biomarker test (NGAL) can help doctors better manage fluids and dialysis in children with acute kidney injury in the pediatric ICU. Researchers will follow 420 children at risk for kidney problems to see if the test helps make faster, safer treatment…

This study reviews medical records of 50 adults who received a simultaneous liver-kidney transplant between 2015 and 2020. Researchers want to find out how many of them developed BK virus in their blood, which can harm the new kidney. The goal is to better understand this risk in…

This study follows 500 people with urinary tract infections (UTIs) for up to 5 years. Researchers will collect health, lifestyle, and lab data to learn which treatments work best and how to reduce antibiotic resistance. The goal is to improve patient care and guide future studies…

This study is looking at two substances in the blood, called MMP2 and MMP9, to see if they can predict how well certain drugs work for people with advanced kidney cancer. Researchers will measure these markers in 50 patients who are starting treatment with Sunitinib or Pazopanib,…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study uses health records from 17,000 Canadian adults to understand why some people switch from peritoneal dialysis (done at home) to hemodialysis (done in a clinic). Researchers will look at how often this happens, what predicts it, and what happens to patients after the sw…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study follows 1,600 people with chronic kidney disease for 10 years to see how different types of exercise affect harmful toxins in the blood, physical fitness, and overall health. Participants include those in early stages, on dialysis, or with a kidney transplant. The goal…

This study looks at how older adults (65+) with cancer understand their illness and what they value in life before and after a major operation. Researchers will interview 100 patients to learn about their awareness, expectations, and decision-making. No new drug or treatment is b…

This study tests whether a video decision aid helps older adults with advanced kidney disease plan their future medical care. About 456 patients aged 65 and older will watch a video explaining dialysis, non-dialysis management, and CPR, then record their preferences. The goal is …

This study looks back at medical records from 1,000 people with adrenocortical carcinoma (ACC), a rare and serious cancer. Researchers want to see how factors like age, sex, race, and tumor burden relate to survival and treatment response. No new treatments are given; instead, th…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study tests whether a program that trains primary care doctors can improve how they treat women with urinary incontinence. The program includes lectures, checklists, and tools to help doctors provide better care. Researchers will compare clinics that get the training to thos…

This study looks at how to improve dialysis for children with kidney failure. Researchers will measure how well different dialysis settings remove waste from the blood while also tracking how much water is used. The goal is to find the best balance between cleaning the blood and …

This study looks at how bladder cancer treatments affect people's quality of life years later. Researchers will ask 2000 patients in Denmark about their long-term side effects and what factors might make these worse. The goal is to better understand the real-life impact of treatm…

This study is investigating whether a substance called copeptin, which is a stable marker of the hormone vasopressin, is linked to blood pressure changes that happen during hemodialysis. Researchers will measure copeptin levels in routine blood samples from 71 adults on chronic d…